Man

Erix Wiliam Hernández Rodríguez

Academic

Universidad Católica del Maule

Talca, Chile

Líneas de Investigación


- Study of photosensitization in biomolecular systems, using multi-scale molecular modeling techniques. - Application of computational-theoretical methods to systems associated with biomedical problems.

Educación

  •  Doctor in Medical Sciences, Dr.C. (Biomedicine), Universidad de Ciencias Médicas de La Habana. Cuba, 2014
  •  Doctor of Philosophy, Ph.D. (Chemistry: Interdisciplinary Science), Universidad Autónoma de Madrid. España, 2013
  •  Master in Bioinformatics, Instituto Superior de Tecnologías y Ciencias Aplicadas. Cuba, 2011
  •  Doctor in Medicine (Bachelor), Instituto Superior de Ciencias Médicas de La Habana. Cuba, 1998
  •  Clinical Biochemistry Specialist, Universidad de Ciencias Médicas de La Habana. Cuba, 2004

Experiencia Académica

  •   Medical Specialist Full Time

    Centro Nacional de Genética Médica

    Medicina

    La Habana, Cuba

    2004 - 2006

  •   Professor/Academic-Medical Doctor Full Time

    Universidad de Ciencias Médicas de La Habana

    Medicina

    La Habana, Cuba

    2006 - 2015

  •   Professor/Academic-Medical Doctor Full Time

    Universidad de Ciencias Médicas de La Habana

    Facultad de Ciencias Médicas de Artemisa

    Artemisa, Chile

    2015 - 2016

  •   Medical Researcher/Professor Full Time

    Instituto Nacional de Oncología y Radiobiología de Cuba

    La Habana, Chile

    2016 - 2017

  •   Postdoctoral Researcher Full Time

    Universidad de Talca-Universidad Católica del Maule

    Ingeniería Civil en Bioinformática

    Talca, Chile

    2017 - 2020

  •   Academic Full Time

    UNIVERSIDAD CATOLICA DEL MAULE

    Medicina

    Talca, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Physician Full Time

    Policlínico Municipal Docente “Elena Fernández de Castro”

    Los Palacios. Pinar del Río, Cuba

    1998 - 1999

  •   Medical Resident of Clinical Biochemistry Speciality Full Time

    Universidad de Ciencias Médicas de La Habana

    La Habana, Cuba

    1999 - 2004

  •   Medical Specialist Full Time

    Centro Nacional de Genética Médica

    La Habana, Cuba

    2004 - 2006

  •   Principal Professor/Medical Specialist Full Time

    Universidad de Ciencias Médicas de La Habana

    La Habana, Cuba

    2006 - 2015

  •   Principal Professor/Medical Specialist Full Time

    Facultad de Ciencias Médicas de Artemisa

    Artemisa, Cuba

    2015 - 2016

  •   Professor/Researcher/Medical Specialist Full Time

    Instituto Nacional de Oncología y Radiobiología de Cuba

    La Habana, Cuba

    2016 - 2017

  •   Postdoctoral Researcher Full Time

    FONDECYT/Universidad de Talca-Universidad Católica del Maule

    Talca, Chile

    2017 - 2020

  •   Academic Full Time

    Universidad Católica del Maule

    Talca, Chile

    2019 - A la fecha

Formación de Capital Humano


Posgraduate Thesis: 4.

Doctoral Thesis (2):

1) Author of Doctoral Thesis: BSc. José L. Velázquez Libera.
Title of Doctoral Thesis: "Identificación de Mecanismos de Catálisis de la Arginasa I del Humano".
Doctoral Program: "Doctorado en Ciencias".
Institution of Doctoral Program: Universidad de Talca.
Year: 2020.
City: Talca.
Role in the Thesis: Co-tutor.

2) Author of Doctoral Thesis: Eng. Daniel M. Bustos Guajardo.
Title of Doctoral Thesis: "Structural study of K2P channels: from the intracellular gating to the CAP".
Doctoral Program : "Doctorado en Ciencias Aplicadas".
Institution of Doctoral Program: Universidad de Talca.
Year: 2019.
City : Talca.
Role in the Thesis: Co-tutor.

Medical Speciality Thesis (2):

3) Author of Medical Speciality Thesis: Dr. Raidel Correa Aguila..
Title of Medical Speciality Thesis: "Evaluación de la estructura y de la disponibilidad del oxígeno molecular en rodopsinas humanas mutantes".
Medical Speciality Program: Clinical Biochemistry..
Institution of Medical Speciality Program: Universidad de Ciencias Médicas de La Habana.
Year: 2016.
City: La Habana.
Role in the Thesis: Tutor.

4) Author of Medical Speciality Thesis: Dr. Carlos Manuel González Casimiro.
Title of Medical Speciality Thesis: "Relación de la evolución de rodopsinas con requerimientos para la generación foto-inducida del oxígeno singlete".
Medical Speciality Program: Clinical Biochemistry..
Institution of Medical Speciality Program: Universidad de Ciencias Médicas de La Habana.
Year: 2016.
City: La Habana.
Role in the Thesis: Tutor.

Undergraduate Thesis (Bachelor Thesis): 3.

5) Author of Bachelor Thesis: Maira Vidal Valenzuela.
Title of Bachelor Thesis:"Asignación de estados de protonación en rodopsina bovina mediante métodos de modelado molecular".
Bachelor Program: Biotechnology Engineering.
Institution of Bachelor Program: Universidad Católica del Maule.
Year: 2021.
City : Talca.
Role in the Thesis: Tutor.

6) Author of Bachelor Thesis: Julio C. Vieyto Núñez.
Title of Bachelor Thesis:: "Implementación de una metodología teórico-computacional para modelar estructuras sacáridas del serotipo 5 del Streptococcus pneumoniae".
Bachelor Program: Chemistry.
Institution of Bachelor Program: Universidad de La Habana.
Year: 2016.
City: Talca.
Role in the Thesis: Co-tutor.

7) Author of Bachelor Thesis: Roy González Alemán.
Title of Bachelor Thesis:"Efectos de sustituyentes en la conformación de la unidad repetida del serotipo 18C del Streptococcus pneumoniae".
Bachelor Program: Chemistry.
Institution of Bachelor Program: Universidad de La Habana.
Year: 2015.
City : Talca.
Role in the Thesis: Co-tutor.

Profesional practices: 2.

8) Student: Camila A. Fuentes Chamorro.
Curricular Activity: "IBI-413 (Práctica III)".
Practice title: "Modelamiento molecular para racionalizar y predecir propiedades de la rodopsina bovina".
Bachelor Program: Biotechnology Engineering.
Institution of Bachelor Program: Universidad Católica del Maule.
Year: 2020.
City : Talca.
Role in the Training Activity: Tutor.

9) Student: BSc. José L. Velázquez Libera.
Curricular Activity: "Unidad de Investigación I".
Doctoral Program: "Doctorado en Ciencias con Mención en Modelado de Sistemas Químicos y Biológicos".
Institution of Doctoral Program: Universidad de Talca.
Year: 2019.
City : Talca.
Role in the Training Activity: Supervisor.


Difusión y Transferencia


- Founder-Director of Laboratory for Bioinformatics and Computational Chemistry (Laboratorio de Bioinformática y Química Computacional), Facultad de Medicina, Universidad Católica del Maule. 2020 - at present.

- Head of the Commission for the Creation of the Medical Bioengineering Career, Facultad de Medicina, Universidad Católica del Maule, including dissemination and coodination activities, as well as creation of curricular programs for chemistry, biochemistry, biophysics, bioinformatics, among other subjects for basic, inetrmediate, and advanced levels of the Formative Project. 2019-2021.

- Webinar: "I Simposio Online de Bioinformática de la Universidad Católica del Maule, Bioinformática en una Mirada Multidisciplinaria", 2020, Talca, Chile. Lecture (oral presentation): "Introducción a los métodos QM/MM para sistemas biomoleculares" (Author).

- Third International Conference in Bioinformatics, Simulations and Modeling (iC-BSM) 2019, 2019, Talca, Chile. An amino acid substitution improves photosensitization conditions in the rhodopsin binding pocket (Author).

- Third International Conference in Bioinformatics, Simulations and Modeling (iC-BSM) 2019, 2019, Talca, Chile. Molecular dynamics simulations provide insights into the enzyme-substrate complex structure of human Arginase I (Co-author).

- 9th International Symposium on OMICS and Bioinformatics, 2019, La Habana, Cuba. BitClust: Fast conformational clustering of long Molecular Dynamics simulations (Co-author).

- XLII Annual Meeting of the Chilean Biochemistry and Molecular Biology Society. XIV Annual Meeting of the Chilean Society of Plant Biologists, 2019, Iqui-que, Chile. Molecular dynamics simulations provide insights into the enzyme-substrate complex structure of human Arginase I (Co-author).

- XLI Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, 2018, Iquique, Chile. A synchronized mechanism for extracellular pH-sensing in TASK-2 K2P channel (Co-author).

- 11th Seminars of Advanced Studies on Molecular Design and Bioinformatics (SEADIM), 2017, La Habana-Varadero, Cuba. Computing Dioxygen Migration Pathways in Bovine Rhodopsin (Author).

- Second International Conference in Bioinformatics, Simulations and Modeling (iC-BSM) 2017, 2017, Talca, Chile. Modelling Starting Enzyme-Substrate Complexes from Human Arginase I by Satisfaction of Spatial Restraints (Co-author).

- Lecture for Postgraduate Students: “Aplicación de híbridos de mecánica cuántica/mecánica molecular para calcular propiedades espectrales de proteínas fotoactivas”. Course: "Tópicos de Bioinformática" from Program "Doctorado en Ciencias con Mención en Modelado de Sistemas Químicos y Biológicos", 2017, Universidad de Talca, Talca, Chile (Author).

- Lecture for Undergraduate Students: “Modelación computacional de propiedades estructurales y espectrales de rodopsinas, mediante esquemas híbridos de mecánica cuántica/mecánica molecular”. Course: "Biofísica" from Program."Ingeniería Civil en Bioinformática", 2017, Universidad de Talca, Talca, Chile (Author).


Premios y Distinciones

  •   Annual Health Award 2014. Author

    Ministerio de Salud Pública de Cuba

    Cuba, 2014

    Contribution to understanding spectral perturbations of mutant rhodopsins associated with retinal degenerations.

  •   Annual Prize of the Academy of Sciences of Cuba. Co-Author.

    Ministerio de Ciencia, Tecnología y Medio Ambiente de Cuba

    Cuba, 2012

    Contribution to the modelling of electronic properties of nanoscopic systems.


 

Article (13)

Machine learning approach to discovery of small molecules with potential inhibitory action against vasoactive metalloproteases
BitClust: Fast Geometrical Clustering of Long Molecular Dynamics Simulations
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels
Multi-scale simulation reveals that an amino acid substitution increases photosensitizing reaction inputs in Rhodopsins
On the Nature of the Enzyme-Substrate Complex and the Reaction Mechanism in Human Arginase I. A Combined Molecular Dynamics and QM/MM Study
A study of the cis-trans isomerization preference of N-alkylated peptides containing phosphorus in the side chain and backbone
Rationalizing the stability and interactions of 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidin-1-ium 2-hydroxy-3,5-dinitrobenzoate salt
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
Panusin represents a new family of beta-defensin-like peptides in invertebrates
Electron Density Deformations Provide New Insights into the Spectral Shift of Rhodopsins
Defensin like peptide from Panulirus argus relates structurally with beta defensin from vertebrates
Understanding Rhodopsin Mutations Linked to the Retinitis pigmentosa Disease: a QM/MM and DFT/MRCI Study
Patterns of retinal light absorption related to retinitis pigmentosa mutants from in silico model structures of rhodopsin

Proyecto (1)

Modelación computacional de capacidades para la producción fotosensibilizada de oxígeno singlete en rodopsinas mutantes asociadas a degeneración retiniana
16
Erix Hernández

Academic

Laboratorio de Bioinformática y Química Computacional, Escuela de Química y Farmacia, Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

3
Daniel Bustos

Assistant Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

3
Ana Montero

Associate professor

Department of Physics

Universidad Tecnológica Metropolitana

Santiago, Chile

3
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

2
Mauricio Bedoya

Research assistant

Ingeniería

Universidad de Talca

Talca, Chile

2
David Ramirez

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

2
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

2
José Velázquez

Asistente de Investigación

Bioinformática

Universidad de Talca

Talca, Chile

1
Julio Belmar

Académico

Química Orgánica

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

1
Claudio Jimenez

Associate Professor

Organic Chemistry

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS QUÍMICAS

Concepción, Chile

1
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

1
Alexander Fernández

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Francisco Muñoz

Profesor Asociado

Departamento de Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Jannel Acosta

Profesor Asociado

Fisiopatología

Universidad de Concepción, Facultad de Ciencias Biológicas

Concepcion, Chile