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LEONARDO SILVA SANTOS

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

Líneas de Investigación


SINTESIS ASIMETRICAS; DESARROLLO DE METODOLOGIA; ORGANOMETALICOS; Polimeros conductores; Simulaciones computacionales; Electroqui­mica; Espectrometria de Masas

Educación

  •  QUIMICA, UNIVERSIDADE ESTADUAL DE CAMPINAS. Brasil, 2003
  •  QUIMICA, UNIVERSIDADE ESTADUAL DE CAMPINAS. Brasil, 1999
  •  QUIMICA, UNIVERSIDADE DE BRASILIA. Chile, 1996

Experiencia Académica

  •   PROFESOR TITULAR Full Time

    UNIVERSIDAD DE TALCA

    TALCA, Chile

    2006 - A la fecha

  •   INVESTIGADOR Full Time

    UNIVERSITAT OLDENBURG

    QUIMICA

    OLDENBURGO, Alemania

    2004 - 2006

  •   INVESTIGADOR Full Time

    UNIVERSIDADE ESTADUAL DE CAMPINAS

    QUIMICA

    CAMPINAS, Brasil

    2003 - 2004

Experiencia Profesional

  •   DIRECTOR Part Time

    FUNDACION FRAUNHOFER CHILE

    TALCA, Chile

    2011 - 2017

  •   INVESTIGADOR Part Time

    MINISTERIO DE MINAS Y ENERGIA

    BRASILIA, Brasil

    1995 - 1996

Formación de Capital Humano


PhD Thesis Direction
1. Marlene Espinoza-Moraga, “Novedosas Metodologías para la Síntesis Asimétrica de Productos Bioactivos. Estudios de ?-Carbolinas como Potenciales Agentes Anti-Alzheimer y Anti-psicóticos.” Universidad de Talca, 2008-2011. (Tutor)
2. Esteban F. Duran Lara, “Actividad inmunosupresora de derivados de rapamicina, síntesis de indolizidinas con centros cuaternarios y nanodetección de células tumorales.” Universidad de Talca, Chile, 2008-2011. (Tutor)
3. Veronica Carrasco Sanchez, “Sintesis de nanopartículas dendronizadas (dendrímeros) con capacidad de transporte y liberación de drogas.” Universidad de Talca, 2009-2012. (Tutor)
4. Nagula Markandeya,¬ ”Simple conversion of aromatic amines into azides.” Indian Institute of Chemical Technology, Hyderabad, India, 2006-2010. (Co-tutorship)
5. Wender A. da Silva, “Estudos de vias sintéticas para potenciais agentes imunossupressores e concepção de análogos assistidas por métodos computaciona.” Universidade de Brasilia, Brazil, 2006-2009. (Co-tutorship)
6. Bárbara Vasconcellos da Silva, “Síntese de ferroceniloxindóis e o estudo da cloração de derivados da isatina com ácido tricloroisocianúrico.” Universidade Federal do Rio de Janeiro, Brazil, 2006-2010. (Co-tutorship)
7. Yaneris Miraball, “Nuevos Catalisadores para Hidrogenaciones Asimetricas – Sintesis de Compuestos Bioactivos.” Universidad de Talca, Chile, 2010-2013. (Tutor)
8. Ariela Patricia Vergara Jaque, “Estudios Computacionales de Interacciones Supramoleculares entre Dendrimeros y Flavonoides.” Universidad de Talca, Chile, 2010-2013. (Tutor)
9. Luis Guzman Jofre, “Empleo de Polimeros Inteligentes en Nanodetoxicacion por Metales Pesados in vivo.” Universidad de Talca, Chile, 2011-2014. (Tutor)
10. Claudia C. Z. Vergara, “Desarrollo de procesos de captura de metales pesados en aguas contaminadas.” Universidad de Talca, Chile, 2011-2016. (Tutor)
11. Ricardo Castro, “Síntesis de POLIMEROS para uso industrial” Universidad de Talca, Chile, 2013-2016. (Tutor)
12. Radha Pyarasani, “Identification of Biomarkers for Alzheimer’s disease and Fragile X syndrome by Modern MS and MALDI-IMS Techniques” Universidad de Talca, Chile, 2012-2016. (Tutor)
13. Fabian Avila, “Diseño, caracterización y estudio de interacciones intermoleculares de nanopolimeros afines a sustratos de interés agroindustrial utilizando una estrategia híbrida in silicio/experimental” Universidad de Talca, Chile, 2012-2016. (Tutor)
14. Oscar Forero Doria, “Sintesis de compuestos quirales a través de nuevos suportes en quimica de estado solido” Universidad de Talca, Chile, 2013-2016. (Tutor)
15. Xaviera Lopez , “Implementacion de Plataforma de analisis basadas en MALDI-Tof y Mineria de Datos para deteccion de enfermedades Acuicolas” Universidad de Talca, Chile, 2013-2017. (Tutor)
16. Wendy Donoso, “Complejos supramoleculares PAMAM-Quantum dots para la detección de Listeria monocytogenes” Universidad de Talca, Chile, 2012-2018. (Tutor)
17. Francisco Monsalve, “Evaluación del complejo RID?? como posible inhibidor de la vía de señalización del receptor de superficie celular RAGE” Universidad de Talca, Chile, 2012-2019. (Tutor)
18. Moises Rojas, “Diseño, estudio y síntesis de nanohidrogeles poliméricos con nanopartículas metálicas para aplicaciones antimicrobianas: un enfoque in-silico/experimental”, Universidad de Talca, Chile, 2017-current.
19. Alfredo Pereira Toloza, “Detección temprana de las enfermedades postcosecha, Moho Azul, Moho Gris y Ojo de Buey, en manzanas de exportación “Cripps Pink” mediante MALDI-TOF-MS y herramientas bioinformáticas”, Universidad de Talca, Chile, 2017-current.
20. César Sepúlveda Orellana, “Detección de Marcadores de Enfermedades Orales Recurrentes en Muestras Salivales y Biopsias FFPE Empleando Espectrometría de Masas”, Universidad de Talca, Chile, 2018-current.

MSc Degree Direction
1. Tania Petta, Estudos de biotranformacoes e biocatalise. Universidade de São Paulo (USP), Brazil, 2008-2009. (Co-tutorship)

Undergraduate Thesis Direction
1. Marlene Espinoza-Moraga, “Actividad gastroprotectora y citotoxicidad de nuevos derivadossemisintéticos del ferruginol.” Universidad de Talca, 2007. Co-tutorship.
2. Marco Vasquez Vasquez, “Biocatalisis y Enzimas en la sintesis asimetrica del inhibidor de fosfodiesterasa 5.” Universidad de Talca, 2009. Tutor.
3. Ana Gloria Caceres Vargas, “Empleo de Auxiliares Quirales para la Produccion de Alcaloides con Actividad Biologica Conocida.” Universidad de Talca, 2009. Tutor.
4. Claudia Arancibia Bravo, “Reduccion de grupos aromaticos azidas empleando Ni2B: Sintesis de pirrolobenzodiazepinas con funcion anticancer.” Universidad de Talca, 2009. Tutor.
5. Carla Villalobos Villalobos, “Nanobiomarcadores de Celulas Tumorales Basados en Polimeros Inteligentes con Quantum Dots” Universidad de Talca, 2010. Tutor.
6. Katherine Angelica Fuentes Rojas, “Empleo de Auxiliares Quirales para la Induccion de Alquilaciones en la Sintesis de Derivados Cuaternarios de Acido Pipecolico.” Universidad de Talca, 2010. Tutor.
7. Hou-yi Huang Chang, “Produccion de Prolinas No Naturales Aplicables en la Industria Farmaceutica.” Universidad de Talca, 2010. Tutor.
8. Veronica Castillo Sandoval, “Empleo de Microondas en la Produccion de Beta-Carbolinas con Actividad Biologica Conocida.” Universidad de Talca, 2010. Tutor.
9. Natalia Arenas Mella, “Espectrometría de masas por Ionización y Desorción a Láser Asistida por Matriz (MALDI-MS) en el Análisis de Péptidos y Proteínas”. Universidad de Talca, 2010. Tutor.
10. Roxana Cornejo, “Primera Sintesis Enantioselectiva y Configuracion Absoluta de la Cetona (S)-(+)-Chichimol: La Secrecion Defensiva de Agathemera elegans, un Insecto de los Andes Chileno.” Universidad de Talca, 2011. Tutor.
11. Maria Noemi Valdivia Galaz, “Sintesis Enantioselectiva del Repelente Bayrepel (Autan) Empleando Reacciones de Oxidacion Anodica” Universidad de Talca, 2011. Tutor.
12. Francisco Antonio Ortega Bravo, “Droga alternativa contra el paludismo o malaria: nueva sintesis de la Angustureína a partir de metodos electronquímicos”. Universidad de Talca, 2011. Tutor.
13. Cristofer Jorge Andres Aravena Sepulveda, “Medicamientos Empleados en las Enfermedades de Parkinson y Alzheymer”. Universidad de Talca, 2011. Tutor.
14. José Miguel Gonzalez Morales, “Síntesis y actividad inmunosupresora de derivados de rapamicina”. Universidad de Talca, 2012. Tutor.
15. Carla Muñoz Benavides, “Determinación de Afinidad de dendrímeros de PAMAM G0.0 con uranilo y otros metales en solución acuosa a través del análisis de espectrometría de masas”. Universidad de Talca, 2012. Tutor.
16. Johanna Piérola Maldonado, “Síntesis asimétrica de Lennoxamina”. Universidad de Talca, 2012. Tutor.
17. Armando González Altamirano, “Nonopurificación de Arsénico en aguas contaminadas”. Universidad de Talca, 2012. Tutor.
18. Pierina Henríquez Grandón, “Liberacion controlada de cloxacilina y naproxeno desde dendrímeros de PAMAM”. Universidad de Talca, 2012. Tutor.
19. Cristhian Galaz Careaga, “Afinidad y biocompatibilidad de derivados de dendrímeros PAMAM con los principales metabolitos sanguíneos”. Universidad de Talca, 2012. Tutor.
20. Monserrat Valdés Cabello, “Análisis de biomarcadores lipídicos presentes en hígado de salmón en presencia de agentes infecciosos: comparación de perfiles mediante la técnica de MALDI-TOF-MS”. Universidad de Talca, 2016. Tutor.
21. Patricia Alejandra Castro Vásquez, “Avances en la deteccion de Psirickettsia salmonis y tratamiento de la psirickettsiosis”. Universidad de Talca, 2019. Tutor


Difusión y Transferencia


Libros
1. Santos, L. S. (ed.) In Reactive Intermediates: MS Investigations in Solution, Wiley-VCH, ISBN: 978-3-527-32351-7, February 2010, 341 pages. Wiley-VCH, Germany. http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527323511.html

Patentes
1. Santos, L. S., Duran-Lara, E., John, A., Carrasco-Sanchez, V., Nachtigall, F. M. “PAMAM, spacer molecule and cafestol polymers”. USPTO 2015, US9198973 B2 (1 December 2015, GRANTED).
2. Santos, L. S., Laurie, V. F., John, A., Carrasco-Sanchez, V., Nachtigall, F. M. “Toxic phenolic compound removal by selective binding of phenolic compounds using smart polymers”. USPTO 2016, US 8,927,042 B1 (6 January 2015, GRANTED).
3. Santos, L. S., John, A., Laurie, V. F. “Clarification and selective binding of phenolic compounds from liquid foodstuff or beverages using smart polymers”. USPTO 2014, US 8,883,239 B2 (11 November 2014, GRANTED).
4. Santos, L. S., Nachtigall, F. M., Guzman, L., Fischer, R., Derivatized dendrimer with low citotoxicity for in vivo, ex vivo, in vitro or in situ chelation of heavy metals or actinides. USPTO 2014, US 2015/0148415 A1 (May 28, 2015).
5. Duran-Lara, E., Guzman, L., John, A., Santos, L. S. “PAMAM dendrimer derivatives for antithrombotic therapy”. USPTO 2013, US 61/856,233 (19 July 2013).
6. Gonzalez-Nilo, F. D., Fischer, R., Santos, L. S. "Synthetic proteins based on dendrimers". USPTO 2012, US 61/692,464.
7. Santos, L.; Espinoza Moraga, M.; Shankaraiah, N. "Enantioselective synthesis of asymmetric beta-carboline intermediates" PCT Int. Appl. 2010, 38pp. CODEN: PIXXD2 WO 2010060228 A1 20100603. USPTO 2011, US 2011/0245503 A1.
8. Santos, L. S., Espinoza-Moraga, M., Shankaraiah, N. “Eficiente síntesis enantoselectiva dederivados de pirrolo-quinolonas inhibidores de PDE” ICPI 2008, BR 2003002250 (April 2015. GRANTED).
9. Santos, L. S., Pilli, R. A. “Processo de Obtenção dos Anestésicos Levobupivacaína e (S)-L-Mepivacaína” INPI 2003, PI0302.250-1 (19 April 2005. GRANTED).


Premios y Distinciones

  •   Recognition by Permanent Representation of the Republic of Chile to the OPCW

    Organisation for the Prohibition of Chemical Weapons

    Holanda, 2007

    Programme for Support of Research

  •   Member of Honor

    Sociedad Argentina de Espectrometría de Masas

    Argentina, 2016

    Member of Honor of Sociedad Argentina de Espectrometria de Masas

  •   Recognition by Indian Society of Chemistry and Biology

    BITS Pilani

    India, 2008

    Indian Society of Chemistry and Biology

  •   Recognition for Developing Mass Spectrometry

    UNIVERSIDADE FEDERAL DO RIO DE JANEIRO

    Brasil, 2009

    Distinción


 

Article (127)

Detection of SARS-CoV-2 in nasal swabs using MALDI-MS
Development of eco-friendly polyurethane foams based on Lesquerella fendleri (A. Grey) oil-based polyol
Comparison of the Oxidative Stability and Antioxidant Activity of Extra-Virgin Olive Oil and Oils Extracted from Seeds of Colliguaya integerrima and Cynara cardunculus under Normal Conditions and After Thermal Treatment
Preparation of Hydrogel/Silver Nanohybrids Mediated by Tunable-Size Silver Nanoparticles for Potential Antibacterial Applications
Ru(II)-Catalyzed Regioselective Hydroxymethylation of beta-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening
Simple approach for cleaning up 2,4,6-trichloroanisole from alcoholic-beverage-reconstituted solutions using polymeric materials
Substitution Effects of NaCl by KCl and CaCl2 on Lipolysis of Salted Meat
Synthesis of New 1,2,3-Triazolo-naphthalimide/phthalimide Conjugates via 'Click' Reaction: DNA Intercalation and Cytotoxic Studies
Inhibition of IL-2 Production by Novel Small Molecules Using Building Blocks from Reduced Chalcones and a Substituted Proline
Intermolecular stabilization in new 2-iminopyridine derivatives complexes of Pd(II) and their reactivity towards alkenes
MALDI coupled to modified traveling wave ion mobility mass spectrometry for fast enantiomeric determination
Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections
Polyaniline Based Materials as a Method to Eliminate Haloanisoles in Spirits Beverages
Rational Development of a Novel Hydrogel as a pH-Sensitive Controlled Release System for Nifedipine
Selective and Efficient Arsenic Recovery from Water through Quaternary Amino-Functionalized Silica
Effect of Sulfamic Acid on 1,3-Dipolar Cycloaddition Reaction: Mechanistic Studies and Synthesis of 4-Aryl-NH-1,2,3-triazoles from Nitroolefins
Fast detection of Listeria monocytogenes through a nanohybrid quantum dot complex
Fast detection of pathogens in salmon farming industry
New Multicomponent Reaction for the Direct Synthesis of beta-Aryl-gamma-nitroesters Promoted by Hydrotalcite-Derived Mixed Oxides as Heterogeneous Catalyst
Polymer-supported (-)-8-phenylmenthyl Auxiliary as an Effective Solid-phase Chiral Inductor in the Addition of Nucleophiles to N-acyliminium Ions
Rose Wine Fining Using Polyvinylpolypyrrolidone: Colorimetry, Targeted Polyphenomics, and Molecular Dynamics Simulations
Study of specific interactions in inclusion complexes of amine-terminated PAMAM dendrimer/flavonoids by experimental and computational methods
A new multicomponent reaction for direct synthesis of primary gama-nitroamides
Fast detection of Piscirickettsia salmonis in Salmo salar serum through MALDI-TOF-MS profiling
New polymer for removal of wine phenolics: Poly(N-(3-(N-isobutyrylisobutyramido)-3-oxopropyl)acrylamide) (P-NIOA)
New polymer for removal of wine phenolics: poly(N-(3-(N-isobutyrylisobutyroamido)-3-oxopropyl)acrylamide) (P-NIOA)
PAMAM built-on-silicon wafers thin-layer extraction devices for selective metal contamination detection
Relationship between oxidative stability and antioxidant activity of oil extracted from the peel of Mauritia flexuosa fruits
TBAI/TBHP-catalyzed [3+2]cycloaddition/oxidation/aromatization cascade and online ESI-MS mechanistic studies: synthesis of pyrrolo[2,1-a] isoquinolines and indolizino[8,7-b]indoles
Chemotaxonomic Fingerprinting of Chilean Lichens Through MALDI and Electrospray Ionization Mass Spectrometry
Correlating experimental electrochemistry and theoretical calculations in 2 '-hydroxy chalcones: the role of the intramolecular hydrogen bond
Experimental and Theoretical Binding Affinity Between Polyvinylpolypyrrolidone and Selected Wine Phenolic Compounds
In Vivo Nanodetoxication for Acute Uranium Exposure
Investigation of Lysine-Functionalized Dendrimers as Dichlorvos Detoxification Agents
Lewis Acid Enhanced Ethene Dimerization and Alkene Isomerization - ESI-MS Identification of the Catalytically Active Pyridyldimethoxybenzimidazole Nickel(II) Hydride Species
Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives
Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation
Photophysical studies of the interactions of poly(amidoamine) generation zero (PAMAM G0) with copper and zinc ions
Removal of 4-Ethylphenol and 4-Ethylguaiacol with Polyaniline-Based Compounds in Wine-Like Model Solutions and Red Wine
Synthesis and characterization of an insoluble polymer based on polyamidoamine: Applications for the decontamination of metals in aqueous systems
Computational study of the complexation of metals ions with poly(amidoamine) PAMAM GO dendrimers
In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics
Intramolecular Hydrogen Bond in Biologically Active o-Carbonyl Hydroquinones
pH-dependent nano-capturing of tartaric acid using dendrimers
Production and Characterization of Surface-active Compounds from Gordonia amicalis
The binding of 4-ethylguaiacol with polyaniline-based materials in wines
Asymmetric total synthesis of Tofacitinib
Effect of Tomato Industrial Processing on Phenolic Profile and Antiplatelet Activity
PAMAM dendrimer derivarives as a potential drug for antithrombotic therapy
Stereoselective bioreduction of beta-carboline imines through cell-free extracts from earthworms (Eisenia foetida)
1-Benzyl-1,2,3,4-Tetrahydro-beta-Carboline as Channel Blocker of N-Methyl-D-Aspartate Receptors
Dendritic Catalysis in Asymmetric Synthesis
Enantioselective Total Synthesis of (S)-(+)-Lennoxamine Through Asymmetric Hydrogenation Mediated by L-Proline Ruthenium Catalyst
On-line monitoring of stevioside sweetener hydrolysis to steviol in acidic aqueous solutions
Reactivity of 3-sulfanyl-1-hexanol and catechol-containing phenolics in vitro
Short Synthesis of Indolo[2,3-a]quinolizidine Ring through the Addition of 1-Siloxyfurans to Imines
Study of Interaction Energies Between PAMAM Dendrimer and non-Steroidal anti-Inflammatory Drug Using a Distributed Computational Strategy and Experimental Analysis by ESI-MS
Supramolecular Host-Guest Asymmetric Induction In Organic Synthesis
Varietal discrimination of Chilean wines by direct injection mass spectrometry analysis combined with multivariate statistics
A One-Pot Azido Reductive Tandem Mono-N-Alkylation Employing Dialkylboron Triflates: Online ESI-MS Mechanistic Investigation
Anthocyanin composition in aged Chilean Cabernet Sauvignon red wines
Fast Analysis of Taurine in Energetic Drinks by Electrospray Ionization Mass Spectrometry
Monitoring of beta-Blockers Ozone Degradation via Electrospray Ionization Mass Spectrometry
Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology
Short Total Synthesis of (-)-Lupinine and (-)-Epiquinamide by Double Mitsunobu Reaction
Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells
The mechanism of Sandmeyer's cyclization reaction by electrospray ionization mass spectrometry
Total Synthesis of Rutaecarpine and Analogues by Tandem Azido Reductive Cyclization Assisted by Microwave Irradiation
What do We Know about Reaction Mechanism? The Electrospray Ionization Mass Spectrometry Approach
Asymmetric syntheses of piperidino-benzodiazepines through 'cation-pool' host/guest supramolecular approach and their DNA-binding studies
Bioreduction of beta-carboline imines to amines employing Saccharomyces bayanus
Short synthesis of noscapine, bicuculline, egenine, capnoidine, and corytensine alkaloids through the addition of 1-siloxy-isobenzofurans to imines
Antiproliferative activity of arborescidine alkaloids and derivatives
Enantioselective total synthesis of pyrroloquinolone as a potent PDE5 inhibitor
Novel Supramolecular Palladium Catalyst for the Asymmetric Reduction of Imines in Aqueous Media
One-Pot Microwave-Assisted Selective Azido Reduction/Tandem Cyclization in Condensed and Solid Phase with Nickel Boride
Palladium asymmetric reduction of beta-carboline imines mediated by chiral auxiliaries assisted by microwave irradiation
Studies towards the Construction of Quaternary Indolizidines by [2,3]-Sigmatropic Rearrangement Cocatalyzed by Ionic Liquid
Synthesis and absolute configuration of (S)-(+)-chichimol ketone: the defensive secretion of walking stick Agathemera elegans
Enantioselective total syntheses of ropivacaine and its analogues
Enantioselective total synthesis of (S)-(-)-quinolactacin B
New gastroprotective ferruginol derivatives with selective cytotoxicity against gastric cancer cells
On-line monitoring of Brookhart polymerization by electrospray ionization mass spectrometry
Biotransformation of jatrophone by Aspergillus niger ATCC 16404
Cloud point extraction applied to casein proteins of cow milk and their identification by mass spectrometry
Electrospray ionization mass spectrometric characterization of key Te(IV) cationic intermediates for the addition of TeCl4 to alkynes
Probing the mechanism of direct Mannich-type alpha-methylenation of ketoesters via electrospray ionization mass spectrometry
The mechanism of the stille reaction investigated by electrospray ionization mass spectrometry
The mechanism of Troger's base formation probed by electrospray ionization mass spectrometry
tri-n-butyltin hydride-mediated radical reaction of a 2-iodobenzamide: Formation of an unexpected carbon-tin bond
Chemotaxonomic markers of organic, natural, and genetically modified soybeans detected by direct infusion electrospray ionization mass spectrometry
Intrinsic Acidity of Dimethylhalonium Ions: Evidence for Hyperconjugation in Dimethylhalonium Ylides in the Gas Phase
Investigation of reaction mechanisms by electrospray ionization mass spectrometry: characterization of intermediates in the degradation of phenol by a novel iron /magnetite/hydrogen peroxide heterogeneous oxidation system
Mimicking the atmospheric OH-radical-mediated photooxidation of isoprene: formation of cloud-condensation nuclei polyols monitored by electrospray ionization mass spectrometry
On the species involved in the vaporization of imidazolium ionic liquids in a steam-distillation-like process
Oxidation of Tertiary Homoallylic Alcohols by Thallium Trinitrate: Fragmentation vs. Ring Contraction
Preparative Droplet Counter-Current Chromatography for the Separation of the New Nor-Seco-Triterpene and Pentacyclic Triterpenoids from Qualea Parviflora
Study of Homogeneously Catalyzed Ziegler-Natta Polymerization of Ethene Using Electrospray Ionization Mass Spectrometry
Synthesis and Characterization of Sb(V)-Adenosine and Sb(V)-Guanosine Complexes
Synthesis and crystal structure of 2,4-dihydro-4-[(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)imino]-5-methyl-2-phenyl-3H-pyrazol-3-one and its copper(II) complex
The role of ionic liquids in co-catalysis of Baylis-Hillman reaction: interception of supramolecular species via electrospray ionization mass spectrometry
Untersuchung der homogen katalysierten Ziegler-Natta-Polymerisation von Ethen mittels ESI-MS
Adsorption of Silanes Bearing Nitrogenated Lewis Bases on SiO2/Si (100) Model Surfaces
Advanced Oxidation of Caffeine in Water: On-Line and Real-Time Monitoring by Electrospray Ionization Mass Spectrometry
Eletrospray Ionization Mass and Tandem Mass Spectra of a Series of N-Pyrazolylmethyl and N-Triazolylmethyl N-Phenylpiperazines: New Dopaminergic Ligands with Potential Antipsychotic Properties
Fast High-Throughput Screening of Aflatoxins by MALDI-TOF Mass Spectrometry Analysis
Investigation of chemical reactions in solution using API-MS
Mechanistic Study in the Synthesis of GABA restrict Conformational Analogs Applying ESI(+)-MS/MS
New Lignan and Antioxidant Phenols from Nectandra grandiflora
On-line Monitoring of Bioreductions via Membrane Introduction Mass Spectrometry
The Proton-Bound Dimer of Acetone
die Einheit der Baylis-Hillman Reaktion Durch Electrospray Ionization Masse und Tandemmassenspektrometrie Prüfend
Enantioselective Total Synthesis of Arborescidines A, B and C Through the Noyori Asymmetric Hydrogenation
Gaseous Supramolecules of Imidazolium Ionic Liquids: “Magic” Numbers for Clustering and Intrinsic Strengths of Hydrogen Bonds
Improved Procedure for the Coupling of Vinylic Tellurides with Alkynes Catalyzed by Palladium Dichloride
Intrinsic Reactivity of Gaseous Halocarbocations Toward Prototype Aromatic Compounds
Mechanisms of Nucleophilic Substitution Reactions of Methylated Hydroxylamines with Bis(2,4-dinitrophenyl)phosphate. Mass Spectrometric Identification of Key Intermediates
Probing the Mechanism of the Baylis-Hillman Reaction by Electrospray Ionization Mass and Tandem Mass Spectrometry
Rapid Screening of Synthetic Alkaloids Through a Two-Dimension Analyses by TLC-MALDI-TOF
Reaction of Bis(2,4-dinitrophenyl) Phosphate with Hydrazine and Hydrogen Peroxide. Comparing O- and N- Phosphorylation
Synthesis of Unexpected Twelve-Membered Macrocycles by Free-Radical Carbocyclisation on Carbohydrate Templates
A Novel Asymmetric Reduction of Dihydro-b-Carboline Derivatives Using Calix[6]Arene/Chiral Amine as a Host Complex
Probing the Mechanism of the Petasis Olefination Reaction by Atmospheric Pressure Chemical Ionization Mass Spectrometry
Studies Towards the Construction of Alkylidene Quinolizidines. The Total Synthesis of Homopumiliotoxin 223G
The Intramolecular Heck Reaction and the Synthesis of Indolizidinone, Quinolizidinone and Benzoazepinone Derivatives
Diastereoselection of the Addition of Silyloxyfurans to Five-, Six- and Seven-Membered N-Acyliminium Ions
Total Synthesis of (±)-Homopumiliotoxin 223G

Errata (1)

Enantioselective total synthesis of pyrroloquinolone as a potent PDE5 inhibitor (vol 50, pg 520, 2009)

Letter (2)

On-bead MALDI-MS monitoring of solid-supported N-acyliminium ion reactions
Transient intermediates of the Tebbe reagent intercepted and characterized by atmospheric pressure chemical ionization mass spectrometry

Patent (9)

Derivatized dendrimer with low citotoxicity for in vivo, ex vivo, in vitro or in situ chelation of heavy metals or actinides
Eficiente síntesis enantoselectiva dederivados de pirrolo-quinolonas inhibidores de PDE
PAMAM, spacer molecule and cafestol polymers
Processo de Obtenção dos Anestésicos Levobupivacaína e (S)-L-Mepivacaína
Toxic phenolic compound removal by selective binding of phenolic compounds using smart polymers
Clarification and selective binding of phenolic compounds from liquid foodstuff or beverages using smart polymers
PAMAM dendrimer derivatives for antithrombotic therapy
SYNTHETIC PROTEINS BASED ON DENDRIMERS
Enantioselective synthesis of asymmetric beta-carboline intermediates

Review (5)

Heterocyclic Curcumin Derivatives of Pharmacological Interest: Recent Progress
Recent developments of chiral induction in the syntheses of biologically important alkaloids
Chemoselective Aromatic Azido Reduction with Concomitant Aliphatic Azide Employing Al/Gd Triflates/NaI and ESI-MS Mechanistic Studies
The Morita-Baylis-Hillman Reaction: Insights into Asymmetry and Reaction Mechanisms by Electrospray Ionization Mass Spectrometry
Online mechanistic investigations of catalyzed reactions by electrospray ionization mass spectrometry: A tool to intercept transient species in solution
144
LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

11
Adolfo Marican

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

9
Oscar Valdés

Académico

Universidad Católica del Maule

Talca, Chile

7
Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

7
John Amalraj

Professor Assistant

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

6
Esteban Durán

Profesor Conferenciante

Depto de Microbiologia

UNIVERSIDAD DE TALCA

Talca, Chile

6
Oscar Forero

Asesor científico

Instituto de química de productos naturales

Universidad de Talca

Talca, Chile

6
Fabiane Manke

Académico Docente Investigador

Universidad Autónoma de Chile

Talca, Chile

5
Daniela Geraldo

DEPARTAMENTO DE CIENCIA QUIMICAS, FACULTAD DE CIENCIAS EXACTAS, UNIVERSIDAD ANDRES BELLO,

SANTIAGO, Chile

4
Ricardo Castro

investigador

Ciencias Biomedicas

Universidad Autonomade Chile

Talca, Chile

4
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

4
Víctor Laurie

Profesor Titular

Horticultura

Universidad de Talca

Talca, Chile

4
MARIO SIMIRGIOTIS

Associate professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
YANERIS MIRABAL

Docente-Investigador

Química aplicada

Universidad Autónoma de Chile

Talca, Chile

3
Maria Aguirre

Professor

Quimica de los materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Diana Abril

Académico

Biología y Quimica

Universidad Católica del Maule

Talca, Chile

3
Maria Del Pilar Caramantin

Profesor Conferenciante

Instituto de Química de Productos Naturales

UNIVERSIDAD DE TALCA

Talca, Chile

3
Ramiro Araya

UNIVERSIDAD DE CHILE, FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS, DPTO. QUÍMICA ORGÁNICA Y FISICOQUÍMICA

Santiago, Chile

3
xaviera lopez

academico

Departamento de Computación e Industrias

Universidad Católica del Maule

Talca, Chile

3
Claudia Sandoval

Secretaria Académica Facultad de Ingeniería

Instituto de Ciencias Químicas Aplicadas

Universidad Autónoma de Chile

Santiago, Chile

2
Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile

2
Leonora Mendoza

Académico JC

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

2
Simonet Torres

Académico/Investigador

Núcleo Química y Bioquímica

Universidad Mayor

Santiago, Chile

2
Fabián Avila

INVESTIGADOR

FACULTAD DE CIENCIAS

UNIVERSIDAD MAYOR

Santiago, Chile

2
Jorge Villaseñor

Académico

Instituto de Química de Recursos NAturales

Universidad de Talca

Talca, Chile

2
RADHA PYARASANI

Profesora Asistente

Centro de investigacion de estudios avanzados del maule (CIEAM))

Universidad Católica del Maule

Talca, Chile

2
Mauricio Isaacs

Full Professor

Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

1
Alan Cabrera

Profesor Asistente

Departamento de Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Vásquez

profesor titular

Ciencias Ecológicas

IEB, DEPTO. CS. ECOL., FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alexander Fernández

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Veronica Olate

INVESTIGADOR ASESOR

AGRICULTURE

FUNDACION FRAUNHOFER CHILE RESEARCH

SANTIAGO, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Ricardo Salazar

Profesor Asociado

Química de Los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE (USACH)

Santiago, Chile

1
Rene Rojas Guerrero Rojas

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Francisco Gracia

Associate Professor

Departament of Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Felipe Arenas

Profesor Asociado

Biología

UNIVERSIDAD SANTIAGO DE CHILE

Santiago, Chile

1
Eduardo Fuentes

Profesor Asociado

Universidad de Talca

Talca, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Yeray Rodríguez

Investigador

Universidad de Talca

talca, Chile

1
Maria Zúñiga

Proffesor

Química Inorgánica y Analitica

Universidad de Chile

Santiago, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

1
Eduardo Agosin

Full Professor

Chemical and Bioprocess Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

1
Evelyn Villagra

Académico

Ciencias Agrarias y Forestales

UNIVERSIDAD CATÓLICA DEL MAULE

Talca, Chile

1
Esteban Vargas

Asesor Científico

Transferencia Tecnológica

CEDENNA

Santiago, Chile

1
Alejandro Yévenes

Profesor Asistente

Química-Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
claudia sandoval

Secretaria Académica de Facultad

Instituto de Ciencias Químicas Aplicadas

Universidad Autónoma de Chile

santiago, Chile

1
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Cristina Quispe

ACADEMICO

FACULTAD DE CIENCIAS DE LA SALUD

UNIVERSIDAD ARTURO PRAT

IQUIQUE, Chile

1
Gustavo Cabrera

Senior Researcher

Biomaterials

Technological Development Unit (UDT)-University of Concepcion

Coronel, Chile

1
MARIANO PERTINO

Profesor conferenciante

UNIVERSIDAD DE TALCA, INSTITUTO DE QUÍMICA DE RECURSOS NATURALES

TALCA, Chile