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Ariela Patricia Vergara Jaque

Assistant Professor

UNIVERSIDAD DE TALCA

Talca, Chile

Computational Structural Biology; Molecular Modeling and Molecular Dynamics Simulation of Membrane Proteins; Protein-Protein interactions

Bioinformatics Engineer, UNIVERSIDAD DE TALCA. Chile, 2009
Applied Sciences, UNIVERSIDAD DE TALCA. Chile, 2013

Profesor Conferenciante Full Time

UNIVERSIDAD DE TALCA

Nucleo Cientifico Multidisciplinario

Talca, Chile

2017 - A la fecha

Postdoctorado Full Time

National Institutes of Health

Bethesda, Estados Unidos

2014 - 2015
Postdoctorado Full Time

Kansas State University

Manhattan, Estados Unidos

2015 - 2016
Profesor Conferenciante Full Time

Universidad de Talca

Talca, Chile

2016 - 2016
Assistant Professor Full Time

Universidad de Talca

Talca, Chile

2020 - A la fecha

Mariela Gonzalez. Undergraduate thesis student (2019)
Javiera Baeza. Undergraduate thesis student (2019)
Dr. Adriana Treuer Moya. Postdoctoral reseacher (2018-2021)
Ivana Orellana. Undergraduate thesis student (2018-2019)
Genoveva Rojas. Undergraduate thesis student (2018-2019)

Symposium Present and Future of Science in Chile, Santiago, Chile. Organizing Committee (2019)
Academic program "Al laboratorio con mi profesor", Millennium Nucleus of Ion Channels-Associated Diseases (MINICAD), Universidad de Talca, Talca. Advisor (2018)
Explora project's reviewer "Investigacion Cientifica Escolar", Talca. (2018)
Talk for High School "How many opportunities I will have in life if I Study a Bachelor's Degree", Liceo Abate Molina, Talca. (2014)
Explora program "Mil Cientificos, mil aulas", Colegio Alborada de Linares, Linares. (2013)

L'Oréal-UNESCO For Women in Science

L'Oréal-UNESCO

Chile, 2013

En Chile, For Women in Science busca reconocer desde 2007 la vocación científica femenina en nuestro país, invitando a todas las chilenas estudiantes de doctorado en Ciencias de la Vida o la Materia de todas las Universidades, a participar de esta prestigiosa distinción.
Rising Talents - L'Oréal-UNESCO For Women in Science

L'Oréal-UNESCO

Francia, 2015

The L’Oréal-UNESCO For Women in Science International Rising Talents are presented to fifteen promising young women, from each world region.


A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles Sarkar S.K.; Foo A.C.Y.; Matyas A.; Asikhia I.; Kosenko T.; Goto N.K.; Vergara-Jaque A.; Lagace T.A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis Rivas, Jose; Diaz, Nicolas; Silva, Ian; Morales, Danna; Lavanderos, Boris; Alvarez, Alhejandra; Paz Saldias, Maria; Pulgar, Eduardo; Cruz, Pablo; Maureira, Diego; Flores, Guillermo; Colombo, Alicia; Blanco, Constanza; Contreras, Hector R.; Jana, Fabian; Gallegos, Ivan; Concha, Miguel L.; Vergara-Jaque, Ariela; Poblete, Horacio; Gonzalez, Wendy; Varela, Diego; Trimmer, James S.; Caceres, Monica; Cerda, Oscar Article ISI FASEB JOURNAL (2020)
New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative Rossino G.; Orellana I.; Caballero J.; Schepmann D.; WÃ¼nsch B.; Rui M.; Rossi D.; GonzÃ¡lez-AvendaÃ±o M.; Collina, S; Vergara-Jaque A. Article ISI SCOPUS JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins Genoveva Rojas; Ivana Orellana; Roberto Rosales-Rojas; Jennie García-Olivares; Jeffrey Comer; Ariela Vergara-Jaque Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins. Rojas, Genoveva; Orellana, Ivana; Rosales-Rojas, Roberto; Garcia-Olivares, Jennie; Comer, Jeffrey; Vergara-Jaque, Ariela Article JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels Vergara-Jaque A.; Palma-Cerda F.; Lowet A.S.; de la Cruz Landrau A.; Poblete H.; Sukharev A.; Comer J.; Holmgren M. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2019)
An extracellular cation coordination site influences ion conduction of OsHKT2;2 Riedelsberger J.; Vergara-Jaque A.; PiÃ±eros M.; Dreyer I.; GonzÃ¡lez W. Article ISI SCOPUS BMC Plant Biology (2019)
EB1-and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion Blanco, Constanza; Morales, Danna; Mogollones, Ignacio; Vergara-Jaque, Ariela; Vargas, Carla; Alvarez, Alhejandra; Riquelme, Denise; Leiva-Salcedo, Elias; Gonzalez, Wendy; Morales, Diego; Maureira, Diego; Aldunate, Ismael; Caceres, Monica; Varela, Diego; Cerda, Oscar Article ISI SCOPUS FASEB JOURNAL (2019)
Polymeric substances for the removal of ochratoxin A from red wine followed by computational modeling of the complexes formed Carrasco-Sanchez, V; Marican, A.; Vergara-Jaque, A; Folch-Cano, C; Comer, J; Laurie, VF Article ISI SCOPUS FOOD CHEMISTRY (2018)
Study of the affinity between the protein kinase PKA and homoarginine-containing peptides derived from kemptide: Free energy perturbation (FEP) calculations Mena-Ulecia K, Gonzalez-Norambuena F, Vergara-Jaque A, Poblete H, Tiznado W, Caballero J Article ISI SCOPUS JOURNAL OF COMPUTATIONAL CHEMISTRY (2018)
Iodide Binding in Sodium-Coupled Cotransporters Vergara-Jaque, A; Fong, PY; Comer, J Article ISI SCOPUS JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis Yaffe, D; Vergara-Jaque, A; Forrest, LR; Schuldiner, S Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis. Yaffe, Dana; Vergara-Jaque, Ariela; Forrest, Lucy R; Schuldiner, Shimon Article Proceedings of the National Academy of Sciences of the United States of America (2016)
The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism Mulligan, C; Fenollar-Ferrer, C; Fitzgerald, GA; Vergara-Jaque, A; Kaufmann, D; Li, Y; Forrest, LR; Mindell, JA Article ISI NATURE STRUCTURAL MOLECULAR BIOLOGY (2016)
The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism. Mulligan, Christopher; Fenollar-Ferrer, Cristina; Fitzgerald, Gabriel A; Vergara-Jaque, Ariela; Kaufmann, Desirée; Li, Yan; Forrest, Lucy R; Mindell, Joseph A Article Nature structural & molecular biology (2016)
Family resemblances: A common fold for some dimeric ion-coupled secondary transporters Vergara-Jaque, A; Fenollar-Ferrer, C; Mulligan, C; Mindell, JA; Forrest, LR Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2015)
Family resemblances: A common fold for some dimeric ion-coupled secondary transporters. Vergara-Jaque, Ariela; Fenollar-Ferrer, Cristina; Mulligan, C; Mindell, JA; Forrest, Lucy Article JOURNAL OF GENERAL PHYSIOLOGY (2015)
Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1. Mansour-Hendili, Lamisse; Blanchard, Anne; Le Pottier, Nelly; Roncelin, Isabelle; Lourdel, Stéphane; Treard, Cyrielle; González, Wendy; Vergara-Jaque, Ariela; Morin, Gilles; Colin, Estelle; Holder-Espinasse, Muriel; Bacchetta, Justine; Baudouin, Véronique; Benoit, Stéphane; Bérard, Etienne; Bourdat-Michel, Guylhène; Bouchireb, Karim; Burtey, Stéphane; Cailliez, Mathilde; Cardon, Gérard; Cartery, Claire; Champion, Gerard; Chauveau, Dominique; Cochat, Pierre; Dahan, Karin; De la Faille, Renaud; Debray, François-Guillaume; Dehoux, Laurenne; Deschenes, Georges; Desport, Estelle; Devuyst, Olivier; Dieguez, Stella; Emma, Francesco; Fischbach, Michel; Fouque, Denis; Fourcade, Jacques; François, Hélène; Gilbert-Dussardier, Brigitte; Hannedouche, Thierry; Houillier, Pascal; Izzedine, Hassan; Janner, Marco; Karras, Alexandre; Knebelmann, Bertrand; Lavocat, Marie-Pierre; Lemoine, Sandrine; Leroy, Valérie; Loirat, Chantal; Macher, Marie-Alice; Martin-Coignard, Dominique; Morin, Denis; Niaudet, Patrick; Nivet, Hubert; Nobili, François; Novo, Robert; Faivre, Laurence; Rigothier, Claire; Roussey-Kesler, Gwenaëlle; Salomon, Remi; Schleich, Andreas; Sellier-Leclerc, Anne-Laure; Soulami, Kenza; Tiple, Aurélien; Ulinski, Tim; Vanhille, Philippe; Van Regemorter, Nicole; Jeunemaître, Xavier; Vargas-Poussou, Rosa Article Human mutation (2015)
Populus deltoides Kunitz trypsin inhibitor 3 confers metal tolerance and binds copper, revealing a new defensive role against heavy metal stress Guerra F.P.; Reyes, L; Vergara-Jaque, A; Campos-Hernandez C.; Gutierrez, A; Perez-Diaz, J; Perez-Diaz, R; Blaudez D.; Ruiz-Lara, S Article Environmental and Experimental Botany (2015)
Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation Comer, J; Chen, R; Poblete, H; Vergara-Jaque, A; Riviere, JE Article ISI ACS NANO (2015)
Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation. Comer, Jeffrey; Chen, Ran; Poblete, Horacio; Vergara-Jaque, Ariela; Riviere, Jim E Article ACS nano (2015)
Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms Vergara-Jaque, A; Fenollar-Ferrer, C; Kaufmann, D; Forrest, LR Article ISI FRONTIERS IN PHARMACOLOGY (2015)
Functionally important carboxyls in a bacterial homologue of the vesicular monoamine transporter (VMAT). Yaffe, Dana; Vergara-Jaque, Ariela; Shuster, Yonatan; Listov, Dina; Meena, Sitaram; Singh, Satinder K; Forrest, Lucy R; Schuldiner, Shimon Article The Journal of biological chemistry (2014)
In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics. Carrasco-Sánchez, Verónica; Vergara-Jaque, Ariela; Zuñiga, Matías; Comer, Jeffrey; John, Amalraj; Nachtigall, Fabiane M; Valdes, Oscar; Duran-Lara, Esteban F; Sandoval, Claudia; Santos, Leonardo S Article European journal of medicinal chemistry (2014)
Study of the affinity between the protein kinase PKA and peptide substrates derived from kemptide using molecular dynamics simulations and MM/GBSA. Mena-Ulecia, Karel; Vergara-Jaque, Ariela; Poblete, Horacio; Tiznado, William; Caballero, Julio Article PloS one (2014)
Computationally efficient methodology for atomic-level characterization of dendrimer-drug complexes: a comparison of amine- and acetyl-terminated PAMAM. Vergara-Jaque, Ariela; Comer, Jeffrey; Monsalve, Luis; González-Nilo, Fernando D; Sandoval, Claudia Article The journal of physical chemistry. B (2013)
Kâ�º conduction and MgÂ²â�º blockade in a shaker Kv-channel single point mutant with an unusually high conductance. Moscoso, Cristian; Vergara-Jaque, Ariela; Márquez-Miranda, Valeria; Sepúlveda, Romina V; Valencia, Ignacio; Díaz-Franulic, Ignacio; González-Nilo, Fernando; Naranjo, David Article Biophysical journal (2012)
Molecular Basis of Drug Resistance in A/H1N1 Virus Vergara-Jaque, A; Poblete, H; Lee, EH; Schulten, K; Gonzalez-Nilo, F; Chipot, C Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Molecular basis of drug resistance in A/H1N1 virus. Vergara-Jaque, Ariela; Poblete, Horacio; Lee, Eric H; Schulten, Klaus; González-Nilo, Fernando; Chipot, Christophe Article Journal of chemical information and modeling (2012)
Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. Muñoz, Camila; Adasme, Francisco; Alzate-Morales, Jans H; Vergara-Jaque, Ariela; Kniess, Torsten; Caballero, Julio Article Journal of molecular graphics & modelling (2012)
Investigation of the differences in activity between hydroxycycloalkyl N1 substituted pyrazole derivatives as inhibitors of B-Raf kinase by using docking, molecular dynamics, QM/MM, and fragment-based de novo design: study of binding mode of diastereomer Caballero, Julio; Alzate-Morales, Jans H; Vergara-Jaque, Ariela Article Journal of chemical information and modeling (2011)
Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site. Alzate-Morales, Jans H; Vergara-Jaque, Ariela; Caballero, Julio Article Journal of chemical information and modeling (2010)
Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase. Caballero, Julio; Vergara-Jaque, Ariela; Fernández, Michael; Coll, Deysma Article Molecular diversity (2009)
Insights into the structural basis of N2 and O6 substituted guanine derivatives as cyclin-dependent kinase 2 (CDK2) inhibitors: prediction of the binding modes and potency of the inhibitors by docking and ONIOM calculations. Alzate-Morales, Jans H; Caballero, Julio; Vergara Jague, Ariela; González Nilo, Fernando D Article Journal of chemical information and modeling (2009)
Study of specific interactions in inclusion complexes of amine-terminated PAMAM dendrimer/flavonoids by experimental and computational methods Vergara-Jaque, Ariela; Comer, Jeffrey; Sepúlveda-Boza, Silvia; S. Santos, Leonardo; Mascayano, Carolina; Sandoval-Yáñez, Claudia Article International Journal of Polymeric Materials and Polymeric Biomaterials (0)


Mg2+ Blockade in a Kv Potassium Channel Mutant having an Unusually High Conductance Naranjo, D; Moscoso, C.; Vergara A.; Marquez, V; sepulveda, r; Valencia I.; Diaz-Franulic, I; Gonzalez-Nilo, F Abstract ISI BIOPHYSICAL JOURNAL (2012)
A Molecular Model for the Bkca Channel and the Location of B1 in the B1/A Subunit Complex Zaelzer, CA; Hyde, C.; Vergara A.; Poblete, H.; Aguayo, D; Sandtner, W; Gonzalez-Nilo, FD; Bezanilla, F; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2010)


Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner. FONIS (3180484) Proyecto 2018-2020 Inv. Patrocinante
Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner Adriana Treuer; Sponsoring Researcher Proyecto (2018)
Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases. FONDECYT (11170223) Proyecto 2017-2020 Inv. Principal
Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases. Ariela Vergara Proyecto (2017)
Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD) Ministerio de Economía, Fomento y Turismo - Chile (s/n) Proyecto 2017-2021 Investigador(a)
Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD) Oscar Cerda; Young Investigator Proyecto (2017)
Design of Nanocarriers for Control of Crop Pests. XSEDE computational resources, USA (-) Proyecto 2016-2016 Postdoctorado
Understanding of the structural basis of the function of secondary active transporters. L’Oreal-Unesco, France (-) Proyecto 2015-2016 Inv. Responsable
Simulación molecular de nanopartículas dendronizadas interactuando con compuestos fenólicos. L’Oreal-Unesco, Chile (-) Proyecto 2013-2014 Inv. Responsable


Exploring the fundamental role of potassium channels in novel model plants Dreyer I.; Vergara-Jaque A.; Riedelsberger J.; GonzÃ¡lez W. Review ISI SCOPUS JOURNAL OF EXPERIMENTAL BOTANY (2019)

Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Ivana Orellana

asistente de investigacion /bioinformatica

genomica y bioinformatica

universidad ma

Santiago, Chile

Horacio Poblete

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Víctor Laurie

Profesor Titular

Horticultura

Universidad de Talca

Talca, Chile

William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Adolfo Marican

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

Fabian Gonzalez

PhD(c)

Universidad de Talca

TALCA, Chile

David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

Ariela Patricia Vergara Jaque

Líneas de Investigación

Educación

Bioinformatics Engineer, UNIVERSIDAD DE TALCA. Chile, 2009

Applied Sciences, UNIVERSIDAD DE TALCA. Chile, 2013

Experiencia Académica

Profesor Conferenciante Full Time

Experiencia Profesional

Postdoctorado Full Time

Postdoctorado Full Time

Profesor Conferenciante Full Time

Assistant Professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

L'Oréal-UNESCO For Women in Science

Rising Talents - L'Oréal-UNESCO For Women in Science

Article (35)

Abstract (2)

Proyecto (9)

Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner.

Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases.

Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD)

Design of Nanocarriers for Control of Crop Pests.

Understanding of the structural basis of the function of secondary active transporters.

Simulación molecular de nanopartículas dendronizadas interactuando con compuestos fenólicos.

Review (1)