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Ariela Patricia Vergara Jaque

Assistant Professor

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Computational Structural Biology; Molecular Modeling and Molecular Dynamics Simulation of Membrane Proteins; Protein-Protein interactions

Educación

  •  Bioinformatics Engineer, UNIVERSIDAD DE TALCA. Chile, 2009
  •  Applied Sciences, UNIVERSIDAD DE TALCA. Chile, 2013

Experiencia Académica

  •   Profesor Conferenciante Full Time

    UNIVERSIDAD DE TALCA

    Nucleo Cientifico Multidisciplinario

    Talca, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Postdoctorado Full Time

    National Institutes of Health

    Bethesda, Estados Unidos

    2014 - 2015

  •   Postdoctorado Full Time

    Kansas State University

    Manhattan, Estados Unidos

    2015 - 2016

  •   Profesor Conferenciante Full Time

    Universidad de Talca

    Talca, Chile

    2016 - 2016

  •   Assistant Professor Full Time

    Universidad de Talca

    Talca, Chile

    2020 - A la fecha

Formación de Capital Humano


Mariela Gonzalez. Undergraduate thesis student (2019)
Javiera Baeza. Undergraduate thesis student (2019)
Dr. Adriana Treuer Moya. Postdoctoral reseacher (2018-2021)
Ivana Orellana. Undergraduate thesis student (2018-2019)
Genoveva Rojas. Undergraduate thesis student (2018-2019)


Difusión y Transferencia


Symposium Present and Future of Science in Chile, Santiago, Chile. Organizing Committee (2019)
Academic program "Al laboratorio con mi profesor", Millennium Nucleus of Ion Channels-Associated Diseases (MINICAD), Universidad de Talca, Talca. Advisor (2018)
Explora project's reviewer "Investigacion Cientifica Escolar", Talca. (2018)
Talk for High School "How many opportunities I will have in life if I Study a Bachelor's Degree", Liceo Abate Molina, Talca. (2014)
Explora program "Mil Cientifi cos, mil aulas", Colegio Alborada de Linares, Linares. (2013)


Premios y Distinciones

  •   L'Oréal-UNESCO For Women in Science

    L'Oréal-UNESCO

    Chile, 2013

    En Chile, For Women in Science busca reconocer desde 2007 la vocación científica femenina en nuestro país, invitando a todas las chilenas estudiantes de doctorado en Ciencias de la Vida o la Materia de todas las Universidades, a participar de esta prestigiosa distinción.

  •   Rising Talents - L'Oréal-UNESCO For Women in Science

    L'Oréal-UNESCO

    Francia, 2015

    The L’Oréal-UNESCO For Women in Science International Rising Talents are presented to fifteen promising young women, from each world region.


 

Article (35)

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles
KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis
New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative
Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins
Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins.
A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels
An extracellular cation coordination site influences ion conduction of OsHKT2;2
EB1-and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion
Polymeric substances for the removal of ochratoxin A from red wine followed by computational modeling of the complexes formed
Study of the affinity between the protein kinase PKA and homoarginine-containing peptides derived from kemptide: Free energy perturbation (FEP) calculations
Iodide Binding in Sodium-Coupled Cotransporters
Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis
Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.
The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism
The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism.
Family resemblances: A common fold for some dimeric ion-coupled secondary transporters
Family resemblances: A common fold for some dimeric ion-coupled secondary transporters.
Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1.
Populus deltoides Kunitz trypsin inhibitor 3 confers metal tolerance and binds copper, revealing a new defensive role against heavy metal stress
Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation
Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation.
Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms
Functionally important carboxyls in a bacterial homologue of the vesicular monoamine transporter (VMAT).
In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics.
Study of the affinity between the protein kinase PKA and peptide substrates derived from kemptide using molecular dynamics simulations and MM/GBSA.
Computationally efficient methodology for atomic-level characterization of dendrimer-drug complexes: a comparison of amine- and acetyl-terminated PAMAM.
K� conduction and Mg²� blockade in a shaker Kv-channel single point mutant with an unusually high conductance.
Molecular Basis of Drug Resistance in A/H1N1 Virus
Molecular basis of drug resistance in A/H1N1 virus.
Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations.
Investigation of the differences in activity between hydroxycycloalkyl N1 substituted pyrazole derivatives as inhibitors of B-Raf kinase by using docking, molecular dynamics, QM/MM, and fragment-based de novo design: study of binding mode of diastereomer
Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site.
Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase.
Insights into the structural basis of N2 and O6 substituted guanine derivatives as cyclin-dependent kinase 2 (CDK2) inhibitors: prediction of the binding modes and potency of the inhibitors by docking and ONIOM calculations.
Study of specific interactions in inclusion complexes of amine-terminated PAMAM dendrimer/flavonoids by experimental and computational methods

Abstract (2)

Mg2+ Blockade in a Kv Potassium Channel Mutant having an Unusually High Conductance
A Molecular Model for the Bkca Channel and the Location of B1 in the B1/A Subunit Complex

Proyecto (9)

Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner.
Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner
Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases.
Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases.
Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD)
Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD)
Design of Nanocarriers for Control of Crop Pests.
Understanding of the structural basis of the function of secondary active transporters.
Simulación molecular de nanopartículas dendronizadas interactuando con compuestos fenólicos.

Review (1)

Exploring the fundamental role of potassium channels in novel model plants
24
Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

3
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

2
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

2
Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

2
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

2
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

2
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
VALERIA MARQUEZ

Profesor Asistente

Centro de Nanotecnologia Aplicada

Universidad Mayor de Chile

SANTIAGO, Chile

1
Horacio Poblete

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Ivana Orellana

asistente de investigacion /bioinformatica

genomica y bioinformatica

universidad ma

Santiago, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Víctor Laurie

Profesor Titular

Horticultura

Universidad de Talca

Talca, Chile

1
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Adolfo Marican

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

1
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile