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Ariela Patricia Vergara Jaque

Associate Professor

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Computational Structural Biology; Molecular Modeling and Molecular Dynamics Simulation of Membrane Proteins; Protein-Protein interactions

Educación

  •  Bioinformatics Engineer, UNIVERSIDAD DE TALCA. Chile, 2009
  •  Applied Sciences, UNIVERSIDAD DE TALCA. Chile, 2013

Experiencia Académica

  •   Profesor Conferenciante Full Time

    UNIVERSIDAD DE TALCA

    Nucleo Cientifico Multidisciplinario

    Talca, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Postdoctorado Full Time

    National Institutes of Health

    Bethesda, Estados Unidos

    2014 - 2015

  •   Postdoctorado Full Time

    Kansas State University

    Manhattan, Estados Unidos

    2015 - 2016

  •   Profesor Conferenciante Full Time

    Universidad de Talca

    Talca, Chile

    2016 - 2016

  •   Assistant Professor Full Time

    Universidad de Talca

    Talca, Chile

    2020 - A la fecha

  •   Associate Professor Full Time

    Universidad de Talca

    Talca, Chile

    2024 - A la fecha

Formación de Capital Humano


Mariela Gonzalez. Undergraduate thesis student (2019)
Javiera Baeza. Undergraduate thesis student (2019)
Dr. Adriana Treuer Moya. Postdoctoral reseacher (2018-2021)
Ivana Orellana. Undergraduate thesis student (2018-2019)
Genoveva Rojas. Undergraduate thesis student (2018-2019)


Difusión y Transferencia


Symposium Present and Future of Science in Chile, Santiago, Chile. Organizing Committee (2019)
Academic program "Al laboratorio con mi profesor", Millennium Nucleus of Ion Channels-Associated Diseases (MINICAD), Universidad de Talca, Talca. Advisor (2018)
Explora project's reviewer "Investigacion Cientifica Escolar", Talca. (2018)
Talk for High School "How many opportunities I will have in life if I Study a Bachelor's Degree", Liceo Abate Molina, Talca. (2014)
Explora program "Mil Cientifi cos, mil aulas", Colegio Alborada de Linares, Linares. (2013)


Premios y Distinciones

  •   L'Oréal-UNESCO For Women in Science

    L'Oréal-UNESCO

    Chile, 2013

    En Chile, For Women in Science busca reconocer desde 2007 la vocación científica femenina en nuestro país, invitando a todas las chilenas estudiantes de doctorado en Ciencias de la Vida o la Materia de todas las Universidades, a participar de esta prestigiosa distinción.

  •   Rising Talents - L'Oréal-UNESCO For Women in Science

    L'Oréal-UNESCO

    Francia, 2015

    The L’Oréal-UNESCO For Women in Science International Rising Talents are presented to fifteen promising young women, from each world region.


 

Article (32)

Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily

Espinoza-Arcos, LG; González-Avendaño, M; Zuñiga-Bustos, M; Zamora R.A.; Vergara-Jaque A.; Poblete, H.

Article ISI
The Journal of general physiology  (2025)

Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes

Sánchez-Hernández, R; Benítez-Angeles, M; Talyzina, IA; Llorente, I; González-Avendaño, M; Sierra F.; Méndez-Reséndiz, A; Mercado F.; Vergara-Jaque A.; Sobolevsky A.I.; et al.

Article ISI
Proceedings of the National Academy of Sciences of the United States of America  (2025)

The power of computational proteomics platforms to decipher protein-protein interactions

González-Avendaño, M; Lopez, J; Vergara-Jaque A.; Cerda, O

Article ISI
 (2024)

Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel

Benítez-Angeles, M; Romero, AEL; Llorente, I; Hernandez-Araiza, I; Vergara-Jaque A.; Real, FH; Castaneda, OEG; Arciniega, M; Morales-Buenrostro, LE; Torres-Quiroz, F; et al.

Article ISI SCOPUS
Journal of Physiology  (2023)

Beta-1,3 oligoglucans specifically bind to immune receptor cd28 and may enhance t cell activation

Comer J.; Bassette M.; Burghart R.; Loyd M.; Ishiguro S.; Singam E.R.A.; Vergara-Jaque A.; Nakashima A.; Suzuki K.; Geisbrecht B.V.; et al.

Article SCOPUS
International journal of molecular sciences  (2021)

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

Foo A.C.Y.; Matyas A.; Asikhia I.; Kosenko T.; Goto N.K.; Lagace T.A.

Article ISI SCOPUS
Journal of Biological Chemistry  (2020)

KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis

Lavanderos, Boris; Paz Saldias, Maria; Pulgar, Eduardo; Cruz, Pablo; Colombo, Alicia; Poblete, Horacio; Cerda, Oscar

Article ISI SCOPUS
FASEB Journal  (2020)

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

Rossino G.; Schepmann D.; Wünsch B.; Rui M.; González-Avendaño M.; Collina S.

Article ISI SCOPUS
Journal of Chemical Information and Modeling  (2020)

Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins

Genoveva Rojas; Ivana Orellana; Roberto Rosales-Rojas; Jennie García-Olivares; Jeffrey Comer; Ariela Vergara-Jaque

Article SCOPUS
Journal of Chemical Information and Modeling  (2020)

Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins.

Rojas, Genoveva; Orellana, Ivana; Rosales-Rojas, Roberto; Garcia-Olivares, Jennie

Article
Journal of Chemical Information and Modeling  (2020)

A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels

de la Cruz Landrau A.

Article ISI SCOPUS
BIOPHYSICAL JOURNAL  (2019)

An extracellular cation coordination site influences ion conduction of OsHKT2;2

Riedelsberger J.

Article ISI SCOPUS
BMC PLANT BIOLOGY  (2019)

EB1-and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion

Blanco, Constanza; Morales, Danna; Mogollones, Ignacio; Vargas, Carla; Alvarez, Alhejandra; Riquelme, Denise; Maureira, Diego; Aldunate, Ismael; Cerda, Oscar

Article ISI SCOPUS
FASEB JOURNAL  (2019)

Polymeric substances for the removal of ochratoxin A from red wine followed by computational modeling of the complexes formed

Marican A.; Laurie V.F.

Article ISI SCOPUS
FOOD CHEMISTRY  (2018)

Study of the affinity between the protein kinase PKA and homoarginine-containing peptides derived from kemptide: Free energy perturbation (FEP) calculations



Article ISI SCOPUS
JOURNAL OF COMPUTATIONAL CHEMISTRY  (2018)

Iodide Binding in Sodium-Coupled Cotransporters

Fong, PY

Article ISI SCOPUS
Journal of Chemical Information and Modeling  (2017)

Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis

Yaffe, D; Vergara-Jaque, A; Forrest, LR; Schuldiner, S

Article ISI
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  (2016)

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism

Mulligan, C; Fenollar-Ferrer, C; Fitzgerald, GA; Vergara-Jaque, A; Kaufmann, D; Li, Y; Forrest, LR; Mindell, JA

Article ISI
NATURE STRUCTURAL & MOLECULAR BIOLOGY  (2016)

Family resemblances: A common fold for some dimeric ion-coupled secondary transporters

Vergara-Jaque, A; Fenollar-Ferrer, C; Mulligan, C; Mindell, JA; Forrest, LR

Article ISI
JOURNAL OF GENERAL PHYSIOLOGY  (2015)

Family resemblances: A common fold for some dimeric ion-coupled secondary transporters.

Fenollar-Ferrer, Cristina; Mindell, JA; Forrest, Lucy

Article
JOURNAL OF GENERAL PHYSIOLOGY  (2015)

Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1

Mansour-Hendili, L; Blanchard A.; Le Pottier, N; Roncelin, I; Lourdel S.; Treard, C; Gonzalez, W.; Vergara-Jaque A.; Morin, G; Colin, E; et al.

Article ISI SCOPUS
Human Mutation  (2015)

Populus deltoides Kunitz trypsin inhibitor 3 confers metal tolerance and binds copper, revealing a new defensive role against heavy metal stress

Guerra F.P.; Reyes L.; Vergara-Jaque A.; Campos-Hernandez C.; Gutierrez A.; Perez-Diaz, J; Pérez-Díaz, R; Blaudez D.; Ruiz-Lara S.

Article ISI SCOPUS
ENVIRONMENTAL AND EXPERIMENTAL BOTANY  (2015)

Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation

Comer, J; Chen, R; Poblete, H; Vergara-Jaque, A; Riviere, JE

Article ISI
ACS Nano  (2015)

Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms



Article ISI
FRONTIERS IN PHARMACOLOGY  (2015)

In situ and in silico evaluation of amine- and folate-terminated dendrimers as nanocarriers of anesthetics

Carrasco-Sanchez, V; Vergara-Jaque A.; Zuniga, M.; Comer J.; John, A; Nachtigall, F. M.; Valdes O.; Sandoval, C; Santos, L. S.

Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY  (2014)

Computationally Efficient Methodology for Atomic-Level Characterization of Dendrimer-Drug Complexes: A Comparison of Amine- and Acetyl-Terminated PAMAM

Vergara-Jaque A.; Comer J.; Monsalve L.; Gonzalez-Nilo F.D.; Sandoval, C

Article ISI SCOPUS
Journal of Physical Chemistry B  (2013)

K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance

Moscoso C.; Vergara-Jaque A.; Marquez-Miranda V.; Sepúlveda, RV; Valencia I.; Diaz-Franulic I.; Gonzalez-Nilo F.; Naranjo D.

Article ISI SCOPUS
Biophysical Journal  (2012)

Molecular Basis of Drug Resistance in A/H1N1 Virus

Vergara-Jaque, A; Poblete, H; Lee, EH; Schulten, K; Gonzalez-Nilo, F; Chipot, C

Article ISI
Journal of Chemical Information and Modeling  (2012)

Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations

Muñoz, C; Adasme, F; Vergara-Jaque A.; Kniess T.; Caballero J.

Article ISI SCOPUS
Journal of Molecular Graphics and Modelling  (2012)

Investigation of the Differences in Activity between Hydroxycycloalkyl N1 Substituted Pyrazole Derivatives As Inhibitors of B-Raf Kinase by Using Docking, Molecular Dynamics, QM/MM, and Fragment-Based De Novo Design: Study of Binding Mode of Diastereomer Compounds

Caballero J.; Vergara-Jaque A.

Article ISI SCOPUS
Journal of Chemical Information and Modeling  (2011)

Computational Study on the Interaction of N1 Substituted Pyrazole Derivatives with B-Raf Kinase: An Unusual Water Wire Hydrogen-Bond Network and Novel Interactions at the Entrance of the Active Site

Alzate-Morales, JH; Vergara-Jaque A.; Caballero J.

Article ISI SCOPUS
Journal of Chemical Information and Modeling  (2010)

Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase

Caballero J.; Vergara-Jaque A.; Fernández, M; Coll D.

Article ISI SCOPUS
MOLECULAR DIVERSITY  (2009)

Abstract (6)

Regulation of the activity of TRPC6 channels by VAPA and its role in cell migration

Orellana-Serradell, OA; Lavanderos, B; Torres, C; Silva, I; González, M; Rivera, B.; Maureira, D; Gonzalez, C.; Madrid R.; Gonzalez, W.; et al.

Abstract ISI
 (2024)

Shaker channel voltage-sensor activation is modulated by protons

Orozco-Contreras, M; Rangel-Yescas, GE; Vergara-Jaque A.; Islas L.D.

Abstract ISI
 (2024)

Track: Protein and Ligand - A New Marriage Between an Old Couple Understanding the Differences of Danusertibs Residence Time in Aurora Kinases A/B: Dissociation Paths and Key Residues Identified Using Conventional and Enhanced Molecular Dynamics Simulations.

Bravo-Moraga F.; Bedoya M.; Vergara-Jaque A.; Alzate-Morales J.

Abstract ISI
PROTEIN SCIENCE  (2023)

Proton Permeation in Ci-Hv1 Voltage-Gated Proton Channels occurs through a Proton Wire Involving Residues D160 and D222 and It is Modulated by N264

Pupo A.; Baez-Nieto D.; Otarola E.; Yañez, O; Vergara-Jaque A.; Gonzalez, W.; Castillo K.; Contreras G.; Larsson H.P.; Latorre R.; et al.

Abstract ISI
BIOPHYSICAL JOURNAL  (2015)

Mg2+ Blockade in a Kv Potassium Channel Mutant having an Unusually High Conductance

Naranjo D.; Moscoso C.; Vergara A.; Marquez, V; Sepulveda, R; Valencia I.; Diaz-Franulic I.; Gonzalez-Nilo F.

Abstract ISI
BIOPHYSICAL JOURNAL  (2012)

A Molecular Model for the Bkca Channel and the Location of B1 in the B1/A Subunit Complex

Zaelzer, CA; Hyde C.; Vergara A.; Poblete, H.; Aguayo D.; Sandtner, W; Gonzalez-Nilo F.D.; Bezanilla F.; Latorre R.

Abstract ISI
BIOPHYSICAL JOURNAL  (2010)

Proyecto (3)

Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner

Adriana Treuer; Sponsoring Researcher

Proyecto
 (2018)

Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases.

Ariela Vergara

Proyecto
 (2017)

Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD)

Oscar Cerda; Young Investigator

Proyecto
 (2017)

Review (1)

Exploring the fundamental role of potassium channels in novel model plants



Review ISI SCOPUS
JOURNAL OF EXPERIMENTAL BOTANY  (2019)

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

2
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

1
Víctor Laurie

Profesor Titular

Horticultura

Universidad de Talca

Talca, Chile

1
Hilda Gutiérrez

Directora de Investigación corporativo

Universidad Autónoma de Chile

Santiago, Chile

1
Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

4
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

1
claudia sandoval

Secretaria Académica de Facultad

Instituto de Ciencias Químicas Aplicadas

Universidad Autónoma de Chile

santiago, Chile

5
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

2
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

1
Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

2
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

1
Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

1
IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

6
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Fernando Guerra

Associate Professor

Instituto de Ciencias Biológicas

Universidad de Talca

Talca, Chile

1
Deysma Coll

Instructor adjunto

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis Monsalve

Gestor Curricular

Facultad de Ciencias de la Ingeniería

Universidad Católica del Maule

Talca, Chile

1
Adolfo Marican

Profesor Asistente

UNIVERSIDAD DE TALCA

Talca, Chile

1
Ignacio Diaz

Profesor asistente

Centro e Bioinformatica y Biologia Integrativa

Universidad Andrés Bello

Santiago, Chile

43
Ariela Vergara

Associate Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

2
Horacio Poblete

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Francisco Adasme

Académico Investigador

Universidad Católica del Maule

Talca, Chile

2
Claudia Sandoval

Secretaria Académica Facultad de Ingeniería

Instituto de Ciencias Químicas Aplicadas

Universidad Autónoma de Chile

Santiago, Chile

1
Darwin Leiva

Associate professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
John Amalraj

Associate Professor

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Janin Riedelsberger

Profesora Asistente

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

2
Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

2
VALERIA MARQUEZ

Profesor Asistente

Centro de Bioinformatica y Biologia Integrativa

Universidad Andrés Bello

SANTIAGO, Chile

1
Ivana Orellana

asistente de investigacion /bioinformatica

genomica y bioinformatica

universidad ma

Santiago, Chile

1
Fabian Gonzalez

PhD(c)

Universidad de Talca

TALCA, Chile

1
Romina Sepúlveda

Profesor Investigador

Facultad de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile