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Daniel Matías Bustos Guajardo

Auxiliar Professor

Universidad Católica del Maule

Talca, Chile

Líneas de Investigación


Computer-Aided Drug Design, Bioinformatics, Biophysics of potassium channels, Molecular Dynamics simulations, Molecular Modeling, Protein-ligand interactions, Machine Learning

Educación

  •  PhD. in Applied Sciences, UNIVERSIDAD DE TALCA. Chile, 2019
  •  Bioinformatics Engineer, Universidad de Talca. Chile, 2014

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD CATÓLICA DEL MAULE

    Engineering

    TALCA, Chile

    2019 - 2020

  •   Assistant Professor Full Time

    UNIVERSIDAD CATÓLICA DEL MAULE

    Vicerrectoría de Investigación y Postgrado

    Talca, Chile

    2020 - A la fecha

Experiencia Profesional

  •   Auxiliar Professor Full Time

    Universidad Católica del Maule

    Talca, Chile

    2019 - A la fecha

  •   Academic Part Time

    IP los Lagos

    Talca, Chile

    2019 - 2020

Formación de Capital Humano


Direction of undergraduate theses:

I)
Student: Enzo Tomás Viera Fica
Thesis title: Comparative molecular study of the nitrate and auxin binding sites present in the NRT1.1 transceiver
Year: 2015
Career / University: Bioinformatics Engineering / University of Talca.

II)
Student: Maira Vidal Valenzuela
Thesis title: Prediction of protonation states in proteins by molecular modeling
Year: 2021
Career / University: Biotechnology Engineering / Universidad Católica del Maule.

III)
Student: Paulina Valenzuela Hormazabal
Thesis title: Implementación de una estrategia basada en métodos teórico-computacionales para la búsqueda de nuevos inhibidores en la enzima ureasa de Helicobacter pylori
Year: 2022
Career / University: Bioinformatics Engineering / Universidad Católica del Maule.

IV)
Student: Gabriela Urra Gajardo
Thesis title: Reposicionamiento de fármacos y proteómica sustractiva en Pseudomonas aeruginosa
Year: 2022-2023
Career / University: Biotechnology Engineering / Universidad Católica del Maule.

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Direction of Master theses:

I)
Student: Natalia Morales Rosales
Thesis title: Propiedades fisicoquímicas utilizadas como criterios de filtrado para construir clasificadores basados en algoritmos de aprendizaje automático: inhibidores de ureasa como caso de estudio
Year: 2021-2022
Program / University: Magíster en Ciencias de la Computación / Universidad Católica del Maule.

II)
Student: Jaime González Díaz
Thesis title: Reposicionamiento de Drogas en el Canal Iónico TRPV1 Mediante un Enfoque Computacional
Year: 2021-2022
Program / University: Magíster en Ciencias de la Computación / Universidad Católica del Maule.

III)
Student: Verónica Leddermann Gutiérrez
Thesis title: Implementación de diferentes estrategias de funciones multiparámetros aplicados al diseño de fármacos.
Year: 2022-2023
Program / University: Magíster en Ciencias de la Computación / Universidad Católica del Maule.

VI)
Student: Camila Flores Morales
Thesis title: Análisis del espacio químico de los inhibidores en proteínas escenciales para la sobrevivencia de Helicobacter pylori.
Year: 2022-2023
Program / University: Magíster en Ciencias de la Computación / Universidad Católica del Maule.

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Direction of PhD. theses:

Student: Elizabeth Valdés Muñoz
Thesis title: Diseño de fármacos antimicrobianos
Year: 2022-2025
Program / University: Doctorado en Biotecnología Traslacional / Universidad Católica del Maule.

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Professional practices:

I)
Student: Paulina Valenzuela Hormazabal
Practice title: Structural characterization of coumarins with inhibitory potential in Helicobacter pylori ureases
Year: 2021
Career / University: Bioinformatics Engineering / Universidad Católica del Maule

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Thesis evaluation:

I)
Student: Javier Riquelme Pizarro
Master's thesis title: Efficient kNN query processing on a multi-node / multi-GPU platform
Years: 2021
Program / University: Master in Computer Science / Universidad Católica del Maule.


Difusión y Transferencia


I) Co-creation of the Bioinformatics and Computational Chemistry Laboratory (Laboratorio de Bioinformática y Química Computacional, LBQC), Facultad de Medicina, Universidad Católica del Maule.

II) Participation as an expert consulted in the field of Bioinformatics for the creation of the Medical Bioengineering career, as well as the contribution to the formation of thematic programs and contents of the courses of Mathematics and Computing I and II, Biophysics, Bioinformatics and Artificial Intelligence.

III) Oral presentation at the First Online Symposium on Bionformatics at the Universidad Católica del Maule, Talca, Chile, 2020.

IV) Presentation at the Society for Biochemistry and Molecular Biology of Chile, Iquique, Chile, 2018.

V) Organizer and speaker of the cycle of talks "Ciencias computacionales al servicio de problemáticas en química medicinal y ambiental"



 

Article (12)

Structural effects of pH variation and calcium amount on the microencapsulation of glutathione in alginate polymers
Structural Insights into the Inhibition Site in the Phosphorylcholine Phosphatase Enzyme of Pseudomonas aeruginosa
A Novel Theoretical Probabilistic Model for Opportunistic Routing with Applications in Energy Consumption for WSNs
Physicochemical and computational analysis of the melamine resin derivative for the glyphosate absorption from water using Langmuir-type model
Use of Poly(vinyl alcohol)-Malic Acid (CLHPMA) Hydrogels and Chitosan Coated Calcium Alginate (CCCA) Microparticles as Potential Sorbent Phases for the Extraction and Quantitative Determination of Pesticides from Aqueous Solutions
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels
Chalcone derivatives as non-canonical ligands of TRPV1
The Insensitivity of TASK-3 K2P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure (vol 19, 2437, 2018)
PrMATE1 Is Differentially Expressed in Radiata Pine Exposed to Inclination and the Deduced Protein Displays High Affinity to Proanthocyanidin Substrates by a Computational Approach
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia
Cooperation through competition—dynamics and microeconomics of a minimal nutrient trade system in Arbuscular Mycorrhizal Symbiosis
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels

Proyecto (2)

A robust theoretical and experimental drug design strategy to discover new and highly potent urease inhibitors for Helicobacter pylori based on coumarin derivatives
Subtractive genomics, drug repurposing and polypharmacology as a strategy to combat resistant Pseudomonas aeruginosa bacteria
17
Daniel Bustos

Auxiliar Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

4
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

2
David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

2
Erix Hernández

Full Professor/Departamento de Medicina Traslacional, Académico-Investigador

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

1
Daniela Urbina

Profesor Instructor

Facultad de recursos naturales renovables

Universidad Arturo Prat

iquique, Chile

1
Mauricio Bedoya

Research assistant

Ingeniería

Universidad de Talca

Talca, Chile

1
Braulio Valdebenito

.

.

.

TALCA, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

1
Bruna Benso

Profesora Asistente

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

1
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

1
Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

1
Raúl Herrera

Académico

Biología Molecular y Biotecnología

Universidad de Talca

Talca, Chile

1
Luis Morales

Profesor Asistente

Intituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

1
Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile

1
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile