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David Mauricio Ramirez Sanchez

Profesor Asistente

Universidad de Concepción

Concepcion, Chile

Multi-target Drug Design, Medicinal Chemistry, Molecular Simulation, Computer-aided Drug Design, Pharmacology, Polypharmacology

Licenciatura en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009
Doctorado en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2017
Farmacia, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012
Químico Farmacéutico, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012
Licenciado en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009

Profesor asistente Part Time

UNIVERSIDAD AUTONOMA DE CHILE

Facultad de Ciencias de la Salud

Talca, Chile

2016 - 2017
Asistente de investigación Part Time

UNIVERSIDAD DE TALCA

Facultad de Ingeniería

Talca, Chile

2015 - 2016
Postdoctoral fellow Full Time

WORCESTER POLYTECHNIC INSTITUTE

Worcester, Estados Unidos

2017 - 2018
Postdoctorado Part Time

UNIVERSIDAD DE TALCA

Facultad de Ingenieria

Talca, Chile

2016 - 2017
Profesor asistente Part Time

UNIVERSIDAD AUTONOMA DE CHILE

Facultad de Ciencias de la Salud

Santiago, Chile

2019 - A la fecha
Profesor Asistente Full Time

UNIVERSIDAD DE CONCEPCION

Facultad de Ciencias Biológicas

Concepción, Chile

2021 - A la fecha

Químico Farmacéutico de Producción Full Time

Unidossis

Bogotá, Colombia

2012 - 2013
Químico Farmacéutico Full Time

Hospital Universitario Mayor MEDERI

bogotá, Colombia

2013 - 2013
Asistente de investigación Part Time

Universidad de Talca

Talca, Chile

2015 - 2016
Postdoctoral fellow Full Time

Worcester Polytechnic Institute

Worcester, Estados Unidos

2017 - 2018

GRADUATE THESIS ADVISOR
• 2021 – current: Diego Alvarado. Master in Neurosciences, Universidad Autónoma de Chile.
• 2021 – current: Alexis Sepúlveda. Master in Neurosciences, Universidad Autónoma de Chile.
• 2020 – current: Jonathan Hurtado. PhD in Biomedical Sciences. Universidad Autónoma de Chile.
• 2020 – current: José Carlos Márquez. PhD in Sciences, Universidad de Talca. Consensual local anesthetic binding site
among atrial fibrillation relevant ion channels.
• 2021. Lily Arrué. Master in Neurosciences, Universidad Autónoma de Chile. Targeting Alzheimer's disease through
computational polypharmacology.

UNDERGRADUATE THESIS ADVISOR
• 2021: Victoria Oviedo. Department of Pharmacy. Universidad Autónoma de Chile.
• 2021: Alexandra Cigna. Department of Pharmacy. Universidad Autónoma de Chile.
• 2021: Jordán Alegría. Department of Pharmacy. Universidad Autónoma de Chile. Study of polypharmacological
profiles in key targets against Alzheimer disease.
• 2018: Laura Sánchez. Department of Chemistry, Universidad del Quindío. Study and identification of novel ROP18
modulators with potential therapeutic activity against Toxoplasma gondii.
• 2017: Carlos Peña. Bioinformatics Engineer School. Universidad de Talca. Thesis: Structural analysis of the blocker
A1899 pathway to the binding site in TASK1 potassium channels.

Bachelor thesis Distinguished with meritorious mention

UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS

Colombia, 2009

Bachelor thesis: "Experimental and theoretical exploration of synthesis’ routes to obtain analogous to natural rubber" Distinguished with meritorious mention
Scholarship for Ph.D. studies

UNIVERSIDAD DE TALCA

Chile, 2013

Scholarship for Ph.D. studies from 2013 to 2017
Research internship grant

UNIVERSIDAD DE TALCA

Chile, 2016

“Estadías de estudiantes de postgrado dirigidas a prospectar innovaciones en el area de alimentos saludables, en entidades de nivel internacional” Framed in the “Convenio de desempeño para el apoyo a la innovación en la educación superior”
Top 2% most cited Scientist (position 332.071) in 2020

UNIVERSIDAD AUTONOMA DE CHILE

Estados Unidos, 2020

Top 2% most cited Scientist (position 332.071) in 2020 according to Stanford University study published in Plos Biology.


Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines Guiza, Fausto M.; Rodriguez-Nunez, Yeray A.; Ramirez, David; Romero Bohorquez, Arnold R.; Antonio Henao, Jose; Toro, Robert A.; Miguel Delgado, Jose; Diaz de Delgado, Graciela Article ISI JOURNAL OF MOLECULAR STRUCTURE (2022)
Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology McGoverna, Andrew; González, Janneth; Ramírez, David; Barreto, George E. Article INTERNATIONAL IMMUNOPHARMACOLOGY (2022)
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking Pena-Varas, Carlos; Kanstrup, Christa; Vergara-Jaque, Ariela; Gonzalez-Avendano, Mariela; Crocoll, Christoph; Mirza, Osman; Dreyer, Ingo; Nour-Eldin, Hussam; Ramirez, David Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy Nozal, Vanesa; Martinez Gonzalez, Loreto; Gomez-Almeria, Marta; Gonzalo-Consuegra, Claudia; Santana, Paula; Chaikuad, Apirat; Pérez-Cuevas, Eva; Knapp, Stefan; Lietha, Daniel; Ramírez, David; Petralla, Sabrina; Monti, Barbara; Gil, Carmen; Martín-Requero, Ángeles; Palomo, Valle; de Lago, Eva; Martinez, Ana Article JOURNAL OF MEDICINAL CHEMISTRY (2022)
Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis Vesga-Jimenez, Diego J.; Martín?Jiménez, Cynthia; Rodríguez, Adriana; Aristizábal?Pachón, Andrés; Pinzón, Andrés; Barreto, George E.; Ramírez, David; González, Janneth Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis Ramirez, David; Mejia-Gutierrez, Melissa; Insuasty, Braulio; Rinne, Susanne; Kiper, Aytug K.; Platzk, Magdalena; Mueller, Thomas; Decher, Niels; Quiroga, Jairo; De-la-Torre, Pedro; Gonzalez, Wendy Article ISI MOLECULES (2021)
Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups Guzman, Luis; Parra-Cid, Cristobal; Guerrero-Munoz, Etiennette; Pena-Varas, Carlos; Polo-Cuadrado, Efrain; Duarte, Yorley; Castro, Ricardo I.; Nerio, Luz Stella; Araya-Maturana, Ramiro; Asefa, Tewodros; Echeverria, Javier; Ramirez, David; Forero-Doria, Oscar Article ISI BIOORGANIC CHEMISTRY (2021)
Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors Gallego-Yerga, Laura; Ochoa, Rodrigo; Lans, Isaias; Pena-Varas, Carlos; Alegria-Arcos, Melissa; Cossio, Pilar; Ramirez, David; Pelaez, Rafael Article ISI COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis Nozal, Vanesa; Garcia-Rubia, Alfonso; Cuevas, Eva P.; Perez, Concepcion; Tosat-Bitrian, Carlota; Bartolome, Fernando; Carro, Eva; Ramirez, David; Palomo, Valle; Martinez, Ana Article ISI ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods Ginex, Tiziana; Garaigorta, Urtzi; Ramirez, David; Castro, Victoria; Nozal, Vanesa; Maestro, Ines; Garcia-Carceles, Javier; Campillo, Nuria E.; Martinez, Ana; Gastaminza, Pablo; Gil, Carmen Article ISI Pharmaceuticals (2021)
Identification of a critical binding site for local anaesthetics in the side pockets of K(v)1 channels Kiper, Aytug K.; Bedoya, Mauricio; Stalke, Sarah; Marzian, Stefanie; Ramirez, David; de la Cruz, Alicia; Peraza, Diego A.; Vera-Zambrano, Alba; Marquez Montesinos, Jose C. E.; Arevalo Ramos, Barbara A.; Rinne, Susanne; Gonzalez, Teresa; Valenzuela, Carmen; Gonzalez, Wendy; Decher, Niels Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2021)
PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds Valdes-Jimenez, Alejandro; Pena-Varas, Carlos; Borrego-Munoz, Paola; Arrue, Lily; Alegria-Arcos, Melissa; Nour-Eldin, Hussam; Dreyer, Ingo; Nunez-Vivanco, Gabriel; Ramirez, David Article ISI MOLECULES (2021)
Screening for Interacting Proteins with Peptide Biomarker of Blood-Brain Barrier Alteration under Inflammatory Conditions Vargas-Sanchez, Karina; Losada-Barragan, Monica; Mogilevskaya, Maria; Novoa-Herran, Susana; Medina, Yehidi; Buendia-Atencio, Cristian; Lorett-Velasquez, Vaneza; Martinez-Bernal, Jessica; Gonzalez-Reyes, Rodrigo E.; Ramirez, David; Petry, Klaus G. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Screening for Interacting Proteins with Peptide Biomarker of Blood–Brain Barrier Alteration under Inflammatory Conditions Vargas-Sanchez, Karina; Losada-Barragán, M; Mogilevskaya, Maria; Novoa-Herrán, S; Medina, Y; Buendía-Atencio, C; Lorett-Velásquez, V; Martínez-Bernal, J; Gonzalez-Reyes, R; Ramírez, David; Petry, K Article ISI, SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral Rojas-Prats, Elisa; Martinez-Gonzalez, Loreto; Gonzalo-Consuegra, Claudia; Liachko, Nicole F.; Perez, Concepcion; Ramirez, David; Kraemer, Brian C.; Martin-Requero, Angeles; Perez, Daniel, I; Gil, Carmen; de Lago, Eva; Martinez, Ana Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Analysis of theZonula occludensToxin Found in the Genome of the Chilean Non-toxigenicVibrio parahaemolyticusStrain PMC53.7 Perez-Reytor, Diliana; Pavon, Alequis; Lopez-Joven, Carmen; Ramirez-Araya, Sebastian; Pena-Varas, Carlos; Plaza, Nicolas; Alegria-Arcos, Melissa; Corsini, Gino; Jana, Victor; Pavez, Leonardo; del Pozo, Talia; Bastias, Roberto; Blondel, Carlos J.; Ramirez, David; Garcia, Katherine Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)
COVID-19: Drug Targets and Potential Treatments Gil, Carmen; Ginex, Tiziana; Maestro, Inés; Nozal, Vanesa; Barrado-Gil, Lucía; Cuesta-Geijo, Miguel Ángel; Urquiza, Jesús; Ramírez, David; Alonso, Covadonga; Campillo, Nuria E.; Martinez, Ana Article JOURNAL OF MEDICINAL CHEMISTRY (2020)
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels Bustos, Daniel; Bedoya, Mauricio; Ramirez, David; Concha, Guierdy; Zuniga, Leandro; Decher, Niels; Hernandez-Rodriguez, Erix W.; Sepulveda, Francisco V.; Martinez, Leandro; Gonzalez, Wendy Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Identification of Mycobacterium tuberculosis CtpF as a target for designing new antituberculous compounds Santos, Paola; Lopez-Vallejo, Fabian; Ramírez, David; Caballero, Julio; Mata Espinosa, Dulce; Hernández-Pando, Rogelio; Soto, Carlos Y. Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2020)
Structural and functional computational analysis of nicotine analogs as potential neuroprotective compounds in Parkinson disease Becerra, Gina Paola; Rojas-Rodriguez, Felipe; Ramirez, David; Loaiza, Alix E.; Tobar-Tosse, Fabian; Mejia, Sol M.; Gonzalez, Janneth Article ISI COMPUTATIONAL BIOLOGY AND CHEMISTRY (2020)
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening Ramirez, David; Concha, Guierdy; Arevalo, Barbara; Prent-Penaloza, Luis; Zuniga, Leandro; Kiper, Aytug K.; Rinne, Susanne; Reyes-Parada, Miguel; Decher, Niels; Gonzalez, Wendy; Caballero, Julio Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine Ramirez, David; Bedoya, Mauricio; Kiper, Aytug K.; Rinne, Susanne; Morales-Navarro, Samuel; Hernandez-Rodriguez, Erix W.; Sepulveda, Francisco V.; Decher, Niels; Gonzalez, Wendy Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
TASK Channels Pharmacology: New Challenges in Drug Design Bedoya, Mauricio; Rinne, Susanne; Kiper, Aytug K.; Decher, Niels; Gonzalez, Wendy; Ramirez, David Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2019)
The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa Novoa-Aponte, Lorena; Ramirez, David; Arguello, Jose M. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels Rinne, S; Kiper, AK; Vowinkel, KS; Ramirez, D; Schewe, M; Bedoya, M; Aser, D; Gensler, I; Netter, MF; Stansfeld, PJ; Baukrowitz, T; Gonzalez, W; Decher, N Article eLife (2019)
Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases Morales-Navarro, Samuel; Prent-Penaloza, Luis; Rodriguez Nunez, Yeray A.; Sanchez-Aros, Laura; Forero-Doria, Oscar; Gonzalez, Wendy; Campilllo, Nuria E.; Reyes-Parada, Miguel; Martinez, Ana; Ramirez, David Article ISI SCOPUS PROCESSES (2019)
An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study Parmar, Jignesh H.; Quintana, Julia; Ramirez, David; Laubenbacher, Reinhard; Arguello, Jose M.; Mendes, Pedro Article ISI MOLECULAR MICROBIOLOGY (2018)
Computational Studies of Snake Venom Toxins Ojeda, Paola G.; Ramirez, David; Alzate-Morales, Jans; Caballero, Julio; Kaas, Quentin; Gonzalez, Wendy Article ISI SCOPUS Toxins (2018)
HCN Channels=> New Therapeutic Targets for Pain Treatment Rami&#769, rez; David, Zú n&#771, iga; Rafael, Concha; Guierdy, Zú n&#771, iga Article MOLECULES (2018)
Is It Reliable to Take the Molecular Docking Top Scoring Position as the Best Solution without Considering Available Structural Data? Ramírez, David; Caballero, Julio Article ISI SCOPUS MOLECULES (2018)
Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections Forero-Doria, Oscar; Castro, Ricardo; Gutierrez, Margarita; González, Diego; Santos, Leonardo; Ramírez, David; Guzman, Luis Article MOLECULES (2018)
Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom Resende L.M.; Almeida J.R.; Schezaro-Ramos R.; Collaço R.C.O.; Simioni L.R.; Ramírez D.; González W.; Soares A.M.; Calderon L.A.; Marangoni S.; da Silva S.L. Article ISI SCOPUS TOXICON (2017)
Origin and evolution of transporter substrate specificity within the NPF family Morten Egevang Jørgensen; Deyang Xu; Christoph Crocoll; David Ramírez; Mohammed Saddik Motawia; Carl Erik Olsen; Hussam Hassan Nour-Eldin; Barbara Ann Halkier Article SCOPUS eLife (2017)
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels Ramírez, David; Arévalo, Bárbara; Martínez, Gonzalo; Rinné, Susanne; Sepúlveda, Francisco V.; Decher, Niels; González, Wendy Article ISI SCOPUS MOLECULAR PHARMACEUTICS (2017)
Structure-Based Discovery of Potential Two-Pore-Domain Potassium Channel Task-3 (K(2P)9.1) Modulators Ramírez, David; Caballero, Julio; Zúñiga, Leandro; Arévalo, Bárbara; Kiper, Aytug; Rinne, Susanne; Decher, Niels; Gonzalez, Wendy Article ISI BIOPHYSICAL JOURNAL (2017)
CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles Almeida, J.R.; Lancellotti, M.; Soares, A.M.; Calderon, L.A.; Ramírez, D.; González, W.; Marangoni, S.; Da Silva, S.L. Article ISI SCOPUS TOXICON (2016)
Computational methods applied to rational drug design Ramirez, D Article SCOPUS Open Medicinal Chemistry Journal (2016)
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels Goldstein M.; Rinne, S; Kiper, AK; Ramirez, D; Netter, MF; Bustos, D; Ortiz-Bonnin, B; Gonzalez, W; Decher, N Article ISI SCOPUS SCIENTIFIC REPORTS (2016)
Is it reliable to use common molecular docking methods for comparing the binding affinities of enantiomer pairs for their protein target? Ramirez, D; Caballero, J Article ISI SCOPUS international journal of mole (2016)
Novel N -allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors Rodríguez, Yeray A.; Gutiérrez, Margarita; Ramírez, David; Alzate-Morales, Jans; Bernal, Cristian C.; Güiza, Fausto M.; Romero Bohórquez, Arnold R. Article ISI SCOPUS CHEMICAL BIOLOGY DRUG DESIGN (2016)
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Kiper, AK; Rinne, S; Rolfes, C; Ramirez, D; Seebohm, G.; Netter, MF; Gonzalez, W; Decher, N Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel Sabogal-Arango, Angélica; Barreto, George; Ramírez, David; González, Juan; Barreto, Viviana; Morales, Ludis; González, Janneth Article Bioinformatics and Biology Insights (2014)
Theoretical and Experimental Exploration of Organic Synthesis Routes to Obtain Natural Rubber Analogues David Ramírez; Danilo González; Pablo Ramos; Luis-Carlos Garcia Article Journal of Materials Science and Engineering A (2014)


Towards systems pharmacology to design multi-target directed ligands as therapeutic alternatives for Alzheimer’s disease. Ramírez, David; Salas, Alexis Marcelo; Gutierrez, Margarita; Reyes Parada, Miguel Proyecto (2022)
Development of novel therapeutic alternatives for alcohol-use disorders: a multidisciplinary approach. Karahanian, Eduardo; Ramirez, David Proyecto (2021)
Identificación de moduladores del canal iónico TMC1 como alternativa terapéutica para el tratamiento de la sordera. Ramirez, David Proyecto (2021)
Reposicionamiento de medicamentos para tratamiento de la pandemia por coronavirus (COVID-19) Ramirez, David; Reyes-Parada, Miguel; Renard, Georgina; Ampuero, Estibaliz Proyecto (2020)
Multi-target drug design against neurodegenerative diseases. Ramirez, David; Ortiz, Fernando; Reyes-Parada M.; Gonzalez, W; Corsini, Gino R. Proyecto (2019)
Scholarship Programme for Young Professors and Researchers from Latin American Universities Coimbra Group (2019) Proyecto 2019-2019 Inv. Responsable
Structural insights into the substrate specificity and transport mechanisms in the Nitrate/Peptide Transporter (NPF) Family. FONDECYT (11180604) Proyecto 2018-2021 Inv. Principal
Análisis metabolómico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con ácido palmítico Conciencias (120377757268) Proyecto 2017-2020 Investigador(a)
Development of a novel protocol to predict what class of secondary metabolite is transported by a specific plant transporter Universidad de Talca (RU-915-2016) Proyecto 2016-2016 Inv. Principal
STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY FONDECYT (1150054) Proyecto 2015-2019 Personal técnico y/o de apoyo
UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS FONDECYT (1140624) Proyecto 2014-2018 Personal técnico y/o de apoyo
Development and functional evaluation of synthetic molecules as TASK-3 potassium channel inhibitors for treatramnt of solid tumors FONDEF (CA13I10223) Proyecto 2013-2014 Personal técnico y/o de apoyo
Identificación de reacciones controladoras de lipotoxicidad inducida por ácido palmítico en un modelo computacional multiómico astrocitario. González, Janneth; Ramirez, D; Pinzón, A Proyecto (0)
InSecTr – International Network to Study Secondary Metabolite Transport in Plants Dreyer, I; Ramirez, D; Vergara-Jaque, A; Goznalez, W Proyecto (0)


Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels Ramirez, D; Gonzalez, W; Fissore, RA; Carvacho, I Review ISI SCOPUS MARINE DRUGS (2017)
K-2P channels in plants and animals González, Wendy; Valdebenito, Braulio; Caballero, Julio; Riadi, Gonzalo; Riedelsberger, Janin; Martínez, Gonzalo; Ramirez, David; Zúñiga, Leandro; Sepúlveda, Francisco V.; Dreyer, Ingo; Janta, Michael; Becker, Dirk Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)

David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

Mauricio Bedoya

Research assistant

Ingeniería

Universidad de Talca

Talca, Chile

Daniel Bustos

Auxiliar Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Erix Hernández

Full Professor/Departamento de Medicina Traslacional, Académico-Investigador

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Braulio Valdebenito

TALCA, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

Diliana Pérez

Docente con grado de doctor

Universidad Autónoma de Chile

Santiago, Chile

Ingrid Carvacho

Profesora Auxiliar/Directora de Investigación

Biología y Química

Universidad Católica del Maule

Talca, Chile

Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Yeray Rodríguez

Investigador

Universidad de Talca

talca, Chile

Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

Talia del Pozo

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

MARIA CARMEN LOPEZ

Assistant professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Nicolás Plaza

Profesor

Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

David Mauricio Ramirez Sanchez

Líneas de Investigación

Educación

Licenciatura en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009

Doctorado en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2017

Farmacia, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012

Químico Farmacéutico, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012

Licenciado en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009

Experiencia Académica

Profesor asistente Part Time

Asistente de investigación Part Time

Postdoctoral fellow Full Time

Postdoctorado Part Time

Profesor asistente Part Time

Profesor Asistente Full Time

Experiencia Profesional

Químico Farmacéutico de Producción Full Time

Químico Farmacéutico Full Time

Asistente de investigación Part Time

Postdoctoral fellow Full Time

Formación de Capital Humano

Premios y Distinciones

Bachelor thesis Distinguished with meritorious mention

Scholarship for Ph.D. studies

Research internship grant

Top 2% most cited Scientist (position 332.071) in 2020

Article (43)

Proyecto (14)

Scholarship Programme for Young Professors and Researchers from Latin American Universities

Structural insights into the substrate specificity and transport mechanisms in the Nitrate/Peptide Transporter (NPF) Family.

Ana&#769;lisis metabolo&#769;mico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con a&#769;cido palmi&#769;tico

Development of a novel protocol to predict what class of secondary metabolite is transported by a specific plant transporter

STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY

UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS

Development and functional evaluation of synthetic molecules as TASK-3 potassium channel inhibitors for treatramnt of solid tumors

Review (2)

Análisis metabolómico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con ácido palmítico