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David Mauricio Ramirez Sanchez

Profesor Asistente

Universidad de Concepción

Concepcion, Chile

Líneas de Investigación


Multi-target Drug Design, Medicinal Chemistry, Molecular Simulation, Computer-aided Drug Design, Pharmacology, Polypharmacology

Educación

  •  Licenciatura en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009
  •  Doctorado en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2017
  •  Farmacia, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012
  •  Químico Farmacéutico, UNIVERSIDAD NACIONAL DE COLOMBIA. Colombia, 2012
  •  Licenciado en Química, UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS. Colombia, 2009

Experiencia Académica

  •   Profesor asistente Part Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Facultad de Ciencias de la Salud

    Talca, Chile

    2016 - 2017

  •   Asistente de investigación Part Time

    UNIVERSIDAD DE TALCA

    Facultad de Ingeniería

    Talca, Chile

    2015 - 2016

  •   Postdoctoral fellow Full Time

    WORCESTER POLYTECHNIC INSTITUTE

    Worcester, Estados Unidos

    2017 - 2018

  •   Postdoctorado Part Time

    UNIVERSIDAD DE TALCA

    Facultad de Ingenieria

    Talca, Chile

    2016 - 2017

  •   Profesor asistente Part Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Facultad de Ciencias de la Salud

    Santiago, Chile

    2019 - A la fecha

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CONCEPCION

    Facultad de Ciencias Biológicas

    Concepción, Chile

    2021 - A la fecha

Experiencia Profesional

  •   Químico Farmacéutico de Producción Full Time

    Unidossis

    Bogotá, Colombia

    2012 - 2013

  •   Químico Farmacéutico Full Time

    Hospital Universitario Mayor MEDERI

    bogotá, Colombia

    2013 - 2013

  •   Asistente de investigación Part Time

    Universidad de Talca

    Talca, Chile

    2015 - 2016

  •   Postdoctoral fellow Full Time

    Worcester Polytechnic Institute

    Worcester, Estados Unidos

    2017 - 2018

Formación de Capital Humano


GRADUATE THESIS ADVISOR
• 2021 – current: Diego Alvarado. Master in Neurosciences, Universidad Autónoma de Chile.
• 2021 – current: Alexis Sepúlveda. Master in Neurosciences, Universidad Autónoma de Chile.
• 2020 – current: Jonathan Hurtado. PhD in Biomedical Sciences. Universidad Autónoma de Chile.
• 2020 – current: José Carlos Márquez. PhD in Sciences, Universidad de Talca. Consensual local anesthetic binding site
among atrial fibrillation relevant ion channels.
• 2021. Lily Arrué. Master in Neurosciences, Universidad Autónoma de Chile. Targeting Alzheimer's disease through
computational polypharmacology.

UNDERGRADUATE THESIS ADVISOR
• 2021: Victoria Oviedo. Department of Pharmacy. Universidad Autónoma de Chile.
• 2021: Alexandra Cigna. Department of Pharmacy. Universidad Autónoma de Chile.
• 2021: Jordán Alegría. Department of Pharmacy. Universidad Autónoma de Chile. Study of polypharmacological
profiles in key targets against Alzheimer disease.
• 2018: Laura Sánchez. Department of Chemistry, Universidad del Quindío. Study and identification of novel ROP18
modulators with potential therapeutic activity against Toxoplasma gondii.
• 2017: Carlos Peña. Bioinformatics Engineer School. Universidad de Talca. Thesis: Structural analysis of the blocker
A1899 pathway to the binding site in TASK1 potassium channels.


Premios y Distinciones

  •   Bachelor thesis Distinguished with meritorious mention

    UNIVERSIDAD DISTRITAL FRANCISCO JOSE DE CALDAS

    Colombia, 2009

    Bachelor thesis: "Experimental and theoretical exploration of synthesis’ routes to obtain analogous to natural rubber" Distinguished with meritorious mention

  •   Scholarship for Ph.D. studies

    UNIVERSIDAD DE TALCA

    Chile, 2013

    Scholarship for Ph.D. studies from 2013 to 2017

  •   Research internship grant

    UNIVERSIDAD DE TALCA

    Chile, 2016

    “Estadías de estudiantes de postgrado dirigidas a prospectar innovaciones en el area de alimentos saludables, en entidades de nivel internacional” Framed in the “Convenio de desempeño para el apoyo a la innovación en la educación superior”

  •   Top 2% most cited Scientist (position 332.071) in 2020

    UNIVERSIDAD AUTONOMA DE CHILE

    Estados Unidos, 2020

    Top 2% most cited Scientist (position 332.071) in 2020 according to Stanford University study published in Plos Biology.


 

Article (43)

Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines
Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy
Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis
5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis
Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups
Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis
Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods
Identification of a critical binding site for local anaesthetics in the side pockets of K(v)1 channels
PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds
Screening for Interacting Proteins with Peptide Biomarker of Blood-Brain Barrier Alteration under Inflammatory Conditions
Screening for Interacting Proteins with Peptide Biomarker of Blood–Brain Barrier Alteration under Inflammatory Conditions
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral
Analysis of theZonula occludensToxin Found in the Genome of the Chilean Non-toxigenicVibrio parahaemolyticusStrain PMC53.7
COVID-19: Drug Targets and Potential Treatments
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels
Identification of Mycobacterium tuberculosis CtpF as a target for designing new antituberculous compounds
Structural and functional computational analysis of nicotine analogs as potential neuroprotective compounds in Parkinson disease
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
TASK Channels Pharmacology: New Challenges in Drug Design
The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels
Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases
An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study
Computational Studies of Snake Venom Toxins
HCN Channels=> New Therapeutic Targets for Pain Treatment
Is It Reliable to Take the Molecular Docking Top Scoring Position as the Best Solution without Considering Available Structural Data?
Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections
Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom
Origin and evolution of transporter substrate specificity within the NPF family
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels
Structure-Based Discovery of Potential Two-Pore-Domain Potassium Channel Task-3 (K(2P)9.1) Modulators
CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles
Computational methods applied to rational drug design
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels
Is it reliable to use common molecular docking methods for comparing the binding affinities of enantiomer pairs for their protein target?
Novel N -allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel
Theoretical and Experimental Exploration of Organic Synthesis Routes to Obtain Natural Rubber Analogues

Proyecto (14)

Towards systems pharmacology to design multi-target directed ligands as therapeutic alternatives for Alzheimer’s disease.
Development of novel therapeutic alternatives for alcohol-use disorders: a multidisciplinary approach.
Identificación de moduladores del canal iónico TMC1 como alternativa terapéutica para el tratamiento de la sordera.
Reposicionamiento de medicamentos para tratamiento de la pandemia por coronavirus (COVID-19)
Multi-target drug design against neurodegenerative diseases.
Scholarship Programme for Young Professors and Researchers from Latin American Universities
Structural insights into the substrate specificity and transport mechanisms in the Nitrate/Peptide Transporter (NPF) Family.
Análisis metabolómico de los efectos neuroprotectores de la tibolona en un modelo astrocitico humano de lipotoxicidad con ácido palmítico
Development of a novel protocol to predict what class of secondary metabolite is transported by a specific plant transporter
STRUCTURAL AND FUNCTIONAL UNDERSTANDING OF ION CHANNELS OF THE ALMT (ALUMINUM ACTIVATED MALATE TRANSPORTER) FAMILY
UNDERSTANDING THE STRUCTURAL MECHANISM OF SELECTIVE BLOCKERS OF PH-GATED K2P CHANNELS
Development and functional evaluation of synthetic molecules as TASK-3 potassium channel inhibitors for treatramnt of solid tumors
Identificación de reacciones controladoras de lipotoxicidad inducida por ácido palmítico en un modelo computacional multiómico astrocitario.
InSecTr – International Network to Study Secondary Metabolite Transport in Plants

Review (2)

Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels
K-2P channels in plants and animals
47
David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

12
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

7
Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

4
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

4
Daniel Bustos

Auxiliar Professor

Vicerrectoría de Investigación y Postgrado

Universidad Católica del Maule

Talca, Chile

4
Mauricio Bedoya

Research assistant

Ingeniería

Universidad de Talca

Talca, Chile

3
Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

3
Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

3
Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

2
Erix Hernández

Full Professor/Departamento de Medicina Traslacional, Académico-Investigador

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

2
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

2
Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

1
Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

1
Braulio Valdebenito

.

.

.

TALCA, Chile

1
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Ingrid Carvacho

Profesora Auxiliar/Directora de Investigación

Biología y Química

Universidad Católica del Maule

Talca, Chile

1
Diliana Pérez

Docente con grado de doctor

Universidad Autónoma de Chile

Santiago, Chile

1
Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

1
Yeray Rodríguez

Investigador

Universidad de Talca

talca, Chile

1
Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

1
Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Talia del Pozo

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
MARIA CARMEN LOPEZ

Assistant professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

1
Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

1
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile