Man

Ana Martinez Gil

Research Professor

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

Líneas de Investigación


Pharmaceutical Chemistry, Medicinal chemistry, Biological Chemistry, Drug design, anti-neurodegenerative drugs

Educación

  •  Organic Chemistry , UNIVERSIDAD COMPLUTENSE DE MADRID. España, 1984
  •  Medicinal Chemistry, UNIVERSIDAD COMPLUTENSE DE MADRID. Chile, 1987
  •  Bussiness Development, UNIVERSIDAD DE NAVARRA. Chile, 2005

Premios y Distinciones

  •   Annual Scientic Prize

    Royal Spanish Pharmacy Academy

    España, 2018

    Annual Scientic Prize from the Royal Spanish Pharmacy Academy (RANF)

  •   Award to the best patent.

    Madrid+d

    Chile, 2015

    Madrid+d award to the best patent.

  •   Almirall

    Sociedad Española de Química Terapéutica

    Chile, 1989

    Almirall-SEQT award for young reserachers

  •   PhD Thesis

    Caja Madrid

    Chile, 1988

    Caja Madrid award for PhD Thesis

  •   Extraordinary University award to PhD

    UNIVERSIDAD COMPLUTENSE DE MADRID

    Chile, 1987

    Extraordinary University award to PhD

  •   SEQT award for young researchers in medicinal chemistry

    UNIVERSIDAD CENTRAL DE CHILE

    Chile, 1985

    SEQT award for young researchers in medicinal chemistry


 

Article (219)

Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)
Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases
Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3
1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation
A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential
A Triazolotriazine-Based Dual GSK-3 beta/CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3
Correction of Glycogen Synthase Kinase 3 beta in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice
Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis
GSK-3 Inhibitors: From the Brain to the Retina and Back Again
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3 beta, beta-secretase, and casein kinase 1 delta
QSAR Modelling for Drug Discovery: Predicting the Activity of LRRK2 Inhibitors for Parkinson's Disease Using Cheminformatics Approaches
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease
Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients
Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases
TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis
Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
Amyloid beta-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators
High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses
Identification of new allosteric sites and modulators of AChE through computational and experimental tools
Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors
The adiponectin promoter activator NP-1 induces high levels of circulating TNF alpha and weight loss in obese (fa/fa) Zucker rats
TNF alpha, disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice
A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice
Biological and Pharmacological Characterization of BenzothiazoleBased CK-1 delta Inhibitors in Models of Parkinson's Disease
Drugs in clinical development for the treatment of amyotrophic lateral sclerosis
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015)
GSK-3 inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice
Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3?
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome
Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents
Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits
Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease
Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo
Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis
Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa
Subtly Modulating Glycogen Synthase Kinase 3 beta: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases
Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects
The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis
Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity
Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders
New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth
Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors
Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy
Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior
Targeting TDP-43 phosphorylation by Casein Kinase-1 delta inhibitors: a novel strategy for the treatment of frontotemporal dementia
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3 beta Inhibitors
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3 beta Fragment Hits against Alzheimer's Disease
Analysis of beta-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum
Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity
From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease
Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3
Morphometric and neurochemical alterations found in L-BMAA treated rats
Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3 beta Inhibitors
PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis
Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats
Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice
Therapeutic approaches for the future treatment of Fragile X
cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases
CB1 Blockade Potentiates Down-Regulation of Lipogenic Gene Expression in Perirenal Adipose Tissue in High Carbohydrate Diet-Induced Obesity
Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders
Glycogen Synthase Kinase-3 Inhibitors Reverse Deficits in Long-term Potentiation and Cognition in Fragile X Mice
Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors
Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases
beta-N-methylamino-L-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS
Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis
Dual inhibitor of PDE7 and GSK-3-VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice
Emerging Drugs and Targets for Parkinson's Disease
Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin
Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease.
Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival
Lessons Learnt from Glycogen Synthase Kinase 3 Inhibitors Development for Alzheimer's Disease
Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease
Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3
Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities
5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3
5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3 beta (GSK-3 beta) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood-brain barrier penetration and binding to human serum albumin
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation
Adiponectin promoter activator NP-1 reduces body weight and hepatic steatosis in high-fat diet-fed animals
Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds
Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo
Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model
The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury
An application of two MIFs-based tools (Volsurf plus and Pentacle) to binary QSAR: The case of a palinurin-related data set of non-ATP competitive Glycogen Synthase Kinase 3 beta (GSK-3 beta) inhibitors
Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities
GSK-3 inhibitors: preclinical and clinical focus on CNS
PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury
Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease
Protein Kinases CK1 and CK2 as New Targets for Neurodegenerative Diseases
Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity
Switching Reversibility to Irreversibility in Glycogen Synthase Kinase 3 Inhibitors: Clues for Specific Design of New Compounds
Emerging Drugs and Targets for Alzheimer's Disease, Vol 2: Neuronal Plasticity, Neuronal Protection and Other Miscellaneous Strategies
Anticonvulsant and Neuroprotective Effects of the Novel Calcium Antagonist NP04634 on Kainic Acid-Induced Seizures in Rats
NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells
Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors
Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties
The first enantioselective synthesis of palinurin
Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools
Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice
CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example
Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: Implication of ERK1/2 and PPAR gamma receptors
Non-ATP competitive glycogen synthase kinase 3 beta (GSK-3 beta) inhibitors: Study of structural requirements for thiadiazolidinone derivatives
PDE7 inhibitors as new drugs for neurological and inflammatory disorders
Polyaniline-based microelectrodes for sensing ascorbic acid in beverages
Potent beta-amyloid modulators
Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs
Electron Correlated Ab Initio Study of Amino Group Flexibility for Improvement of Molecular Mechanics Simulations on Nucleic Acid Conformations and Interactions
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease
NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disorders
Dual binding site acetylcholinesterase inhibitors - Potential new disease-modifying agents for AD
Enantioselective LC/MS method for the determination of an antimalarial agent fenozan B07 in dog plasma
Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases
Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors
Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyryleholinesterase
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: New disease-modifying agents for Alzheimer's disease
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE
Good oral absorption prediction on non-nucleoside benzothiadiazine dioxide human cytomegalovirus inhibitors using combined chromatographic and neuronal network techniques
Marine compounds for the therapeutic treatment of neurological disorders
Molecular mechanics description of cytosine energy and geometry using preliminary ab initio results
Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation
SAR and 3D-QSAR studies on thiadiazolidinone derivatives: Exploration of structural requirements for glycogen synthase kinase 3 inhibitors
Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetyl-cholinesterase inhibitors
CODES/Neural network model: a useful tool for in silico prediction of oral absorption and blood-brain barrier permeability of structurally diverse drugs
GSK-3 inhibitors: Discoveries and developments
Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice
AMPA Glutamate Receptors and Neuropathic Pain
Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. Study of structural requirements for biological activity
Synthesis and muscarinic activities of O-[benzyl- or benzoylpyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone
Thienyl and phenyl alpha-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3 beta) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?
Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimer's Disease
Anti-HIV-1 activity of benzothiadiazine dioxide
CoMFA of benzyl derivatives of 2,1,3-benzo and benzothieno[3,2-a]thiadiazine 2,2-dioxides: clues for the design of phosphodiesterase 7 inhibitors
Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimer's Disease
Recent strategies in the development of new human cytomegalovirus inhibitors
Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: Synthesis and comparative molecular field analysis
Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors
Hindered inversion/rotation in diheteroaryl alkyl amines with a N-(1-pyrazolyl) group: Dynamic NMR and molecular modelling studies
Inhibition of tau phosphorylation: a new therapeutic strategy for the treatment of Alzheimer's disease and other neurodegenerative disorders
Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives
N-benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors
Nonnucleoside human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives
Novel agents for the treatment of human cytomegalovirus infection
Prediction of drug half-life values of antihistamines based on the CODES/neural network model
Regioselective lipase-catalysed gamma-monoamidation of D-glutamic acid diesters: effect of the N-protecting group
Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties
Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity
Candida antarctica lipase B catalysed amidation of pyroglutamic acid derivatives. A reaction survey
Chlorophenylmethyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors
Imidazothiadiazine dioxides: Synthesis and antiviral activity
Intramolecular oxidative cyclizations in heteroarylthioureas: A versatile pathway to bridgehead heterocyclic systems
Novel potential agents for human cytomegalovirus infection: Synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides
On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds
Selective dopamine receptors: Synthesis, complexing properties, and molecular modelling studies of new podands derived from 4-hydroxy-1H-pyrazole
Synthesis and potential muscarinic receptor binding and antioxidant properties of 3-(thiadiazolyl)pyridine 1-oxide compounds
Enzymatic alcoholysis of SO2-uracil analog diacyclonucleosides. Long-distance effect of the substituents on the regioselectivity
Lipase catalysed amidation of diethyl glutamate derivatives: peculiarities of ethyl S- and R-pyroglutamate
Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds
Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol by lipase mediated enantioselective alcoholysis, hydrolysis and acylation
Synthesis of nonsymmetrically 3,4-disubstituted 1,2,5-thiadiazole dioxides
Towards lipophilic derivatives of S-adenosyl-L-methionine
Applications of a statistical model to the analysis of the kinetic parameters in isothermal and non-isothermal crystallization of polymer blends based on PVDF
Arylimino-1,2,4-thiadiazolidinones: A new family of potassium channel openers
Base promoted transformation on thiadiazolopyridinium chlorides
Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infections
Comparative molecular field analysis (CoMFA) on [6]+[6] fused pyrazines with nematocide properties
Molecular modeling of (E)-1-Alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase
Regioselective lipase catalyzed synthesis of diester crowns. New asymmetric macrocycles containing a 1,3-bis(1H-pyrazol-1-yl)propane unit
Regioselective lipase-catalyzed synthesis of L-glutamic alpha-monoamide derivatives. Effect of the N-blocking group
Selective carriers of norepinephrine and ammonium ions: Ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit
Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides
Conformation and ortho steric effects in a series of 2-(pyrazol-1-yl)quinolines
New synthetic route to 1,2,4-thiadiazolines and 1,3-thiazolines via thiadiazolopyridinium salts
DIOXIDES OF BICYCLIC THIADIAZINES - A NEW FAMILY OF SMOOTH-MUSCLE RELAXANTS
NEW 1,2,6-THIADIAZINE DIOXIDE ACYCLONUCLEOSIDES - SYNTHESIS AND ANTIVIRAL EVALUATION
REGIOSELECTIVE MUCOR-MIEHEI LIPASE-CATALYZED SYNTHESIS OF PODANDS CONTAINING A 1,3-BIS(1H-PYRAZOL-1-YL)PROPANE UNIT
SEMIEMPIRICAL (AM1, PM3 AND SAM1) CALCULATIONS OF THE PROTONATION ENTHALPIES OF PROTON SPONGES RELATED TO 1,8-DIAMINONAPHTHALENE - ESTIMATION OF THE AQUEOUS BASICITY OF NEW DESIGNED SUPERBASES
THE REGIOCONTROLLED AND STEREOCONTROLLED RING-OPENING OF HETEROARYLGLYCIDATES WITH NITROGEN NUCLEOPHILES
THE STRUCTURE OF THE COMPOUNDS RESULTING FROM THE REACTION OF ARYLHYDRAZINES WITH DEHYDROACETIC ACID - AN NMR AND CRYSTALLOGRAPHIC STUDY
REGIOSELECTIVE LIPASE-MEDIATED ACYLATION-DEACYLATION IN THIADIAZINE DIACYCLONUCLEOSIDES
TAUTOMERISM OF BENZOPENTA AND CYCLOPENTA-[1,2,6]THIADIAZINE S,S-DIOXIDES
APPLICATION OF ULTRASONIC NEBULIZATION FOR THE DETERMINATION OF RARE-EARTH ELEMENTS IN PHOSPHATES AND RELATED SEDIMENTARY-ROCKS USING INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRY WITH COMMENTS ON DISSOLUTION PROCEDURES
SO2 EXTRUSION IN 1,2,6-THIADIAZINE 1,1-DIOXIDES - A NOVEL SYNTHESIS OF PYRAZOLES
SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-QUINOLONE RIBOSIDES
THE MOLECULAR-STRUCTURE OF 3(5)-METHYL-4,5(3)-TRIMETHYLENEPYRAZOLE HYDROCHLORIDE AND ITS C-13 AND N-15 NMR-SPECTROSCOPY
THE PROBLEM OF THE EXISTENCE OF C(AR)-H...N INTRAMOLECULAR HYDROGEN-BONDS IN A FAMILY OF 9-AZAPHENYL-9H-CARBAZOLES
(E)-1-ALKYL-[2-(1H-AZOL-2-YL)VINYL]PYRIDINIUM SALTS - THEORETICAL-ANALYSIS, SYNTHESIS AND EVALUATION OF THEIR INTERACTION WITH CHOLINE-ACETYLTRANSFERASE
TAUTOMERISM AND ACIDITY IN 4-QUINOLONE-3-CARBOXYLIC ACID-DERIVATIVES
LIPASE-MEDIATED ACYLATION OF ACYCLONUCLEOSIDES - APPLICATION TO NOVEL FLUOROQUINOLONE DERIVATIVES
SYNTHESIS AND NMR-SPECTROSCOPY (H-1, C-13) OF 1-(2'-BENZOTHIAZOLYL)-3(5),4-POLYMETHYLENEPYRAZOLES AND RELATED-COMPOUNDS
SYNTHESIS OF PSI-[CH(CN)NH] PSEUDOPEPTIDES - A NEW PEPTIDE-BOND SURROGATE
A H-1 AND C-13 NMR-STUDY OF THE STRUCTURE AND TAUTOMERISM OF 4-PYRAZOLYLPYRAZOLINONES
GLYCOSIDES OF PYRIDO[2,3-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES
ROTATIONAL-ISOMERISM IN 6-BETA-D-GLUCOPYRANOSIDES OF METHYL-1,2,6-THIADIAZIN-3(2H)-ONE 1,1-DIOXIDES
STRUCTURE OF 1,2,6-THIADIAZINE 1,1-DIOXIDES
ON THE TAUTOMERISM OF 2-PHENACYL-4-PYRIMIDINONES AND RELATED-COMPOUNDS
REACTION OF 4-HYDRAZINOQUINOLINES WITH BETA-DIKETONES - SYNTHESIS AND SPECTROSCOPY (H-1, C-13 NMR, MS) OF SOME PYRAZOLYLQUINOLINES
SYNTHESIS AND CYTOSTATIC SCREENING OF AN SO2 ANALOG OF DORIDOSINE
SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF N-AZOLYLPROPANAMIDES
SYNTHESIS OF 2S-DIOXO ISOSTERES OF PURINE AND PYRIMIDINE NUCLEOSIDES .4. SELECTIVE GLYCOSYLATION OF 4-AMINO-5H-IMIDAZO [4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDE
N-GLUCOSYL-5-AMINO-4-CARBAMOYLIMIDAZOLES AND 4-ETHOXYCARBONYLIMIDAZOLES AS POTENTIAL PRECURSORS OF 4-OXOIMIDAZO[4,5-C]-1,2,6-THIADIAZINE 2,2-DIOXIDES
SYNTHESIS AND INTRAMOLECULAR CYCLIZATION OF BISTHIADIAZINYLMETHANE DERIVATIVES

Patent (6)

Quinazolinas S-Sustituidas y sus aplicaciones terapéuticas para el tratamiento de enfermedades mediadas por PDE7
GSK-3 Alosteric modulators
5-imino substituted 1,2,4-thiadiazoles useful in the treatment of neurodegenerative diseases
Use of quinazoline derivatives and their pharmaceutical compositions in the treatment of neurodegenerative diseases
GSK-3 Inhibitors
Thiadiazolidindiones as GSK-3 inhibitors

Proyecto (11)

Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond
Investigación clínica en esclerosis lateral amiotrofica
Diseño y desarrollo de fármacos innovadores para el tratamiento de la esclerosis lateral amiotrofica
Driving next generation autophagy researchers towards translation
El ojo como ventana diagnóstica del cerebro
Modulación de proteínas quinasas y BACE/1 con moléculas pequeñas de diseño multidiana: una nueva aproximación para la prevención y tratamiento de las enfermedades cognitivas
Red Española de Descubrimientos de Fármacos.
Desarrollo de un fármaco innovador para la enfermedad de Parkinson. Seguridad clínica y nuevas terapias con S14
Inhibidores de quinasas efectivos para la esclerosis lateral amiotrófica
Desarrollo de terapias innovadoras para la enfermedad de Parkinson
Evaluation of cognition and hippocampal neurogenesis after oral administration of a phosphodiesterase 7 inhibitor in an Alzheimer disease mice mode
236
Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

29
Nuria Campillo

Científico titular

Biología Físico-Química

Centro de Investigaciones Biológicas (CIB-CSIC)

Madrid, España

1
Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

1
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile