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Nuria Eugenia Campillo Martín

Científico titular

Centro de Investigaciones Biológicas (CIB-CSIC)

Madrid, España

Medicinal chemistry, Drug Discovery, Drug Design, Cheminformatics, Bioinformatics. Molecular modelling, ligand-based design, receptor-based design, quantitative structure-activity relationships, ligand-receptor interactions, computational chemistry,

Chemistry, UNIVERSIDAD AUTONOMA DE MADRID. España, 1992
Chemistry, UNIVERSIDAD AUTONOMA INDOAMERICA. Chile, 1997

Salvador de Madariaga scolarship

Spanish Ministry of Education and Competitiveness

España, 2017

Awarded a Salvador de Madariaga scholarship from the Spanish Ministry of Education and Competitiveness for a short-term visiting professor stay at the University of Michigan (October 1st through December 31st, 2017. Host: Prof. John Montgomery).
Salvador de Madariaga scolarship

Spanish Ministry of Education and Competitiveness

Chile, 2016

Awarded a Salvador de Madariaga scholarship from the Spanish Ministry of Education and Competitiveness for a short-term visiting professor stay at the University of Cambridge (July 1st through September 31st, 2016. Host: Prof. Tom Blundell).
Parque Científico de Madrid: AITENEA

UNIVERSIDAD COMPLUTENSE DE MADRID

Chile, 2019

IX edición de los Premios Emprendedor Universitario UCM MODALIDAD III. PREMIOS A PROYECTOS EMPRESARIALES Programa Explorer UCM-Santander. Proyecto AITENEA Ganador Nacional Tecnología Disruptiva


Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools Sebastian-Perez, Victor; Garcia-Rubia, Alfonso; el-Din, Sayed H. Seif; Sabra, Abdel-Nasser A.; El-Lakkany, Naglaa M.; William, Samia; Blundell, Tom L.; Maes, Louis; Martinez, Ana; Campillo, Nuria E.; Botros, Sanaa S.; Gil, Carmen Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)
Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations Nunez-Borque, Emilio; Gonzalez-Naranjo, Pedro; Bartolome, Fernando; Alquezar, Carolina; Reinares-Sebastian, Alejandro; Perez, Concepcion; Ceballos, Maria L.; Paez, Juan A.; Campillo, Nuria E.; Martin-Requero, Angeles Article ISI MOLECULAR NEUROBIOLOGY (2020)
Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 Martinez de Iturrate, Paula; Sebastian-Perez, Victor; Nacher-Vazquez, Montserrat; Tremper, Catherine S.; Smirlis, Despina; Martin, Julio; Martinez, Ana; Campillo, Nuria E.; Rivas, Luis; Gil, Carmen Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3 Lourdes Sciu, M.; Sebastian-Perez, Victor; Martinez-Gonzalez, Loreto; Benitez, Rocio; Perez, Daniel I.; Perez, Concepcion; Campillo, Nuria E.; Martinez, Ana; Laura Moyano, E. Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)
Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis Sebastian-Perez, Victor; Schroeder, Susanne; Munday, Jane C.; van der Meer, Tiffany; Zaldivar-Diez, Josefa; Siderius, Marco; de Koning, Harry P.; Brown, Dave; Martinez, Ana; Campillo, Nuria E.; Leurs, Rob; Gil, Carmen Article ISI FUTURE MEDICINAL CHEMISTRY (2019)
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease de Andrade, Peterson; Mantoani, Susimaire P.; Goncalves Nunes, Paulo Sergio; Magadan, Carlos Roca; Perez, Concepcion; Xavier, Danilo Jordao; Sakamoto Hojo, Elza Tiemi; Campillo, Nuria E.; Martinez, Ana; Carvalho, Ivone Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Indazolylketones as new multitarget cannabinoid drugs Gonzalez-Naranjo, Pedro; Perez-Macias, Natalia; Perez, Concepcion; Roca, Carlos; Vaca, Gabriela; Giron, Rocio; Sanchez-Robles, Eva; Isabel Martin-Fontelles, Maria; de Ceballos, Maria L.; Martin-Requero, Angeles; Campillo, Nuria E.; Paez, Juan A. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases Paez, Juan A.; Campillo, Nuria E. Article ISI CURRENT MEDICINAL CHEMISTRY (2019)
QSAR Classification Models for Predicting the Activity of Inhibitors of Beta-Secretase (BACE1) Associated with Alzheimer's Disease Ponzoni, Ignacio; Sebastian-Perez, Victor; Martinez, Maria J.; Roca, Carlos; De la Cruz Perez, Carlos; Cravero, Fiorella; Vazquez, Gustavo E.; Paez, Juan A.; Diaz, Monica F.; Campillo, Nuria E. Article ISI SCIENTIFIC REPORTS (2019)
QSAR Modelling for Drug Discovery: Predicting the Activity of LRRK2 Inhibitors for Parkinson's Disease Using Cheminformatics Approaches Sebastian-Perez, Victor; Martinez, Maria J.; Gil, Carmen; Campillo, Nuria E.; Martinez, Ana; Ponzoni, Ignacio; FdezRiverola, F; Mohamad, MS; Rocha, M; DePaz, JF; Gonzalez, P Article ISI INFORMATION TECHNOLOGY: NEW GENERATIONS (2019)
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease Sebastian-Perez, Victor; Jimena Martinez, Maria; Gil, Carmen; Eugenia Campillo, Nuria; Martinez, Ana; Ponzoni, Ignacio Article ISI JOURNAL OF INTEGRATIVE BIOINFORMATICS (2019)
Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease del Cerro, Patricia; Alquezar, Carolina; Bartolome, Fernando; Gonzalez-Naranjo, Pedro; Perez, Concepcion; Carro, Eva; Paez, Juan A.; Campillo, Nuria E.; Martin-Requero, Angeles Article ISI CNS DRUGS (2018)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Sebastian-Perez, Victor; Martinez-Gonzalez, Loreto; Perez, Daniel I.; Perez, Concepcion; Canales, Angeles; Javier Canada, F.; Campillo, Nuria E.; Carvalho, Ivone; Martinez, Ana Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy Sebastian-Perez, Victor; Hendrickx, Sarah; Munday, Jane C.; Kalejaiye, Titilola; Martinez, Ana; Campillo, Nuria E.; de Koning, Harry; Caljon, Guy; Maes, Louis; Gil, Carmen Article ISI ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators Roca, Carlos; Martinez-Gonzalez, Loreto; Daniel-Mozo, Miguel; Sastre, Javier; Infantes, Lourdes; Mansilla, Alicia; Chaves-Sanjuan, Antonio; Maria Gonzalez-Rubio, Juana; Gil, Carmen; Javier Canada, H. F.; Martinez, Ana; Jose Sanchez-Barrena, Maria; Campillo, Nuria E. Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2018)
Identification of new allosteric sites and modulators of AChE through computational and experimental tools Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Malhotra, Sony; Radoux, Chris; Perez, Concepcion; Martinez, Ana; Antonio Paez, Juan; Blundell, Tom L.; Campillo, Nuria E. Article ISI JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors Gandini, Annachiara; Bartolini, Manuela; Tedesco, Daniele; Martinez-Gonzalez, Loreto; Roca, Carlos; Campillo, Nuria E.; Zaldivar-Diez, Josefa; Perez, Concepcion; Zuccheri, Giampaolo; Miti, Andrea; Feoli, Alessandra; Castellano, Sabrina; Petralla, Sabrina; Monti, Barbara; Rossi, Martina; Moda, Fabio; Legname, Giuseppe; Martinez, Ana; Bolognesi, Maria Laura Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2018)
Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo Victoria Barbado, M.; Medrano, Mayte; Caballero-Velazquez, Teresa; Alvarez-Laderas, Isabel; Ignacio Sanchez-Abarca, Luis; Garcia-Guerrero, Estefania; Martin-Sanchez, Jesus; Valle Rosado, Ivan; Ignacio Piruat, Jose; Gonzalez-Naranjo, Pedro; Eugenia Campillo, Nuria; Antonio Paez, Juan; Antonio Perez-Simon, Jose Article ISI INTERNATIONAL JOURNAL OF CANCER (2017)
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease Chierrito, Talita P. C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Castillo, Willian O.; Moreira, Natalia C. S.; Perez, Concepcion; Sakamoto-Hojo, Elza T.; Takahashi, Catarina S.; Jimenez-Barbero, Jesus; Javier Canada, F.; Campillo, Nuria E.; Martinez, Ana; Carvalho, Ivone Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Hybridizing Feature Selection and Feature Learning Approaches in QSAR Modeling for Drug Discovery Ponzoni, Ignacio; Sebastian-Perez, Victor; Requena-Triguero, Carlos; Roca, Carlos; Martinez, Maria J.; Cravero, Fiorella; Diaz, Monica F.; Paez, Juan A.; Gomez Arrayas, Ramon; Adrio, Javier; Campillo, Nuria E. Article ISI SCIENTIFIC REPORTS (2017)
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome Mansilla, Alicia; Chaves-Sanjuan, Antonio; Campillo, Nuria E.; Semelidou, Ourania; Martinez-Gonzalez, Loreto; Infantes, Lourdes; Maria Gonzalez-Rubio, Juana; Gil, Carmen; Conde, Santiago; Skoulakis, Efthimios M. C.; Ferrus, Alberto; Martinez, Ana; Jose Sanchez-Barrena, Maria Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents Salado, Irene G.; Zaldivar-Diez, Josefa; Sebastian-Perez, Victor; Li, Lingling; Geiger, Larissa; Gonzalez, Silvia; Campillo, Nuria E.; Gil, Carmen; Morales, Aixa V.; Perez, Daniel I.; Martinez, Ana Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits Sebastian-Perez, Victor; Roca, Carlos; Awale, Mahendra; Reymond, Jean-Louis; Martinez, Ana; Gil, Carmen; Campillo, Nuria E. Article ISI JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties Guerra, Angela; Gonzalez-Naranjo, Pedro; Campillo, Nuria E.; Varela, Javier; Lavaggi, Maria L.; Merlino, Alicia; Cerecetto, Hugo; Gonzalez, Mercedes; Gomez-Barrio, Alicia; Escario, Jose A.; Fonseca-Berzal, Cristina; Yaluf, Gloria; Paniagua-Solis, Jorge; Paez, Juan A. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Subtly Modulating Glycogen Synthase Kinase 3 beta: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases Palomo, Valle; Perez, Daniel I.; Roca, Carlos; Anderson, Cara; Rodriguez-Muela, Natalia; Perez, Concepcion; Morales-Garcia, Jose A.; Reyes, Julio A.; Campillo, Nuria E.; Perez-Castillo, Ana M.; Rubin, Lee L.; Timchenko, Lubov; Gil, Carmen; Martinez, Ana Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2017)
New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth Sebastian, Victor; Manoli, Maria-Tsampika; Perez, Daniel I.; Gil, Carmen; Mellado, Emilia; Martinez, Ana; Espeso, Eduardo A.; Campillo, Nuria E. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease Perez, Daniel I.; Martinez, Ana; Gil, Carmen; Campillo, Nuria E. Article ISI CURRENT MEDICINAL CHEMISTRY (2015)
Therapeutic approaches for the future treatment of Fragile X Sastre, Ana; Campillo, Nuria E.; Gil, Carmen; Martinez, Ana Article ISI CURRENT OPINION IN BEHAVIORAL SCIENCES (2015)
Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease Gonzalez-Naranjo, Pedro; Perez-Macias, Natalia; Campillo, Nuria E.; Perez, Concepcion; Aran, Vicente J.; Giron, Rocio; Sanchez-Robles, Eva; Isabel Martin, Maria; Gomez-Canas, Maria; Garcia-Arencibia, Moises; Fernandez-Ruiz, Javier; Paez, Juan A. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Mutagenicity of N-oxide Containing Heterocycles and Related Compounds: Experimental and Theoretical Studies Gabay, Martin; Cabrera, Mauricio; Di Maio, Rossanna; Paez, Juan A.; Campillo, Nuria; Lavaggi, Maria L.; Cerecetto, Hugo; Gonzalez, Mercedes Article ISI CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Multitarget Cannabinoids as Novel Strategy for Alzheimer Disease Gonzalez-Naranjo, Pedro; Campillo, Nuria E.; Perez, Concepcion; Paez, Juan A. Article ISI CURRENT ALZHEIMER RESEARCH (2013)
The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox Prieto, P.; Kinsner-Ovaskainen, A.; Stanzel, S.; Albella, B.; Artursson, P.; Campillo, N.; Cecchelli, R.; Cerrato, L.; Diaz, L.; Di Consiglio, E.; Guerra, A.; Gombau, L.; Herrera, G.; Honegger, P.; Landry, C.; O'Connor, J. E.; Paez, J. A.; Quintas, G.; Svensson, R.; Turco, L.; Zurich, M. G.; Zurbano, M. J.; Kopp-Schneider, A. Article ISI Toxicology in vitro : an international journal published in association with BIBRA. (2013)
Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities Redondo, Miriam; Soteras, Ignacio; Brea, Jose; Gonzalez-Garcia, Alejandro; Isabel Cadavid, Maria; Isabel Loza, Maria; Martinez, Ana; Gil, Carmen; Campillo, Nuria E. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3 Palomo, Valle; Perez, Daniel I.; Perez, Concepcion; Morales-Garcia, Jose A.; Soteras, Ignacio; Alonso-Gil, Sandra; Encinas, Arantxa; Castro Ana; Campillo, Nuria E.; Perez-Castillo, Ana; Gil, Carmen; Martinez, Ana Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2012)
Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain Merlino, Alicia; Benitez, Diego; Campillo, Nuria E.; Paez, Juan A.; Tinoco, Luzineide W.; Gonzalez, Mercedes; Cerecetto, Hugo Article ISI MEDCHEMCOMM (2012)
Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds Redondo, Miriam; Brea, Jose; Perez, Daniel I.; Soteras, Ignacio; Val, Cristina; Perez, Concepcion; Morales-Garcia, Jose A.; Alonso-Gil, Sandra; Paul-Fernandez, Nuria; Martin-Alvarez, Rocio; Isabel Cadavid, Maria; Isabel Loza, Maria; Perez-Castillo, Ana; Mengod, Guadalupe; Campillo, Nuria E.; Martinez, Ana; Gil, Carmen Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2012)
Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice Redondo, Miriam; Palomo, Valle; Brea, Jose; Perez, Daniel I.; Martin-Alvarez, Rocio; Perez, Concepcion; Paul-Fernandez, Nuria; Conde, Santiago; Isabel Cadavid, Maria; Isabel Loza, Maria; Mengod, Guadalupe; Martinez, Ana; Gil, Carmen; Campillo, Nuria E. Article ISI ACS Chemical Neuroscience (2012)
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model Redondo, Miriam; Zarruk, Juan G.; Ceballos, Placido; Perez, Daniel I.; Perez, Concepcion; Perez-Castillo, Ana; Moro, Maria A.; Brea, Jose; Val, Cristina; Cadavid, Maria I.; Loza, Maria I.; Campillo, Nuria E.; Martinez, Ana; Gil, Carmen Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation Ramos, Javier; Cruz, Victor L.; Martinez-Salazar, Javier; Campillo, Nuria E.; Paez, Juan A. Article ISI PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2011)
Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation Cavities Palomo, Valle; Soteras, Ignacio; Perez, Daniel I.; Perez, Concepcion; Gil, Carmen; Eugenia Campillo, Nuria; Martinez, Ana Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2011)
Chagas Disease: Progress and New Perspectives Sanchez-Sancho, F.; Campillo, N. E.; Paez, J. A. Article ISI CURRENT MEDICINAL CHEMISTRY (2010)
Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-binding Motif Bustamante, Noemi; Campillo, Nuria E.; Garcia, Ernesto; Gallego, Cristina; Pera, Benet; Diakun, Gregory P.; Saiz, Jose Luis; Garcia, Pedro; Diaz, J. Fernando; Menendez, Margarita Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Development of second generation amidinohydrazones, thio- and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1,3-dioxide core scaffolds Merlino, Alicia; Benitez, Diego; Chavez, Santiago; Da Cunha, Jonathan; Hernandez, Paola; Tinoco, Luzineide W.; Campillo, Nuria E.; Paez, Juan A.; Cerecetto, Hugo; Gonzalez, Mercedes Article ISI MEDCHEMCOMM (2010)
Neural computational prediction of oral drug absorption based on CODES 2D descriptors Guerra, A.; Campillo, N. E.; Paez, J. A. Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
p-Coumaric acid decarboxylase from Lactobacillus plantarum: Structural insights into the active site and decarboxylation catalytic mechanism Rodriguez, Hector; Angulo, Ivan; de las Rivas, Blanca; Campillo, Nuria; Paez, Juan A.; Munoz, Rosario; Mancheno, Jose M. Article ISI PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
Cannabinoid System in Neurodegeneration: New Perspectives in Alzheimer's Disease Campillo, N. E.; Paez, J. A. Article ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae Molina, Rafael; Gonzalez, Ana; Stelter, Meike; Perez-Dorado, Inmaculada; Kahn, Richard; Morales, Maria; Campuzano, Susana; Campillo, Nuria E.; Mobashery, Shahriar; Garcia, Jose L.; Garcia, Pedro; Hermoso, Juan A. Article ISI EMBO REPORTS (2009)
Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae (vol 10, pg 246, 2009) Molina, Rafael; Gonzalez, Ana; Stelter, Meike; Perez-Dorado, Inmaculada; Kahn, Richard; Morales, Maria; Moscoso, Miriam; Campuzano, Susana; Campillo, Nuria E.; Mobashery, Shahriar; Garcia, Jose L.; Garcia, Pedro; Hermoso, Juan A. Article ISI EMBO REPORTS (2009)
Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity Lopez, Gloria V.; Gomez, Luis E.; Campillo, Nuria; Paez, Juan A.; Giles, Kaleigh; Atkinson, Jeffrey; Gonzalez, Mercedes; Rubbo, Homero; Cerecetto, Hugo Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors Castano, Tania; Wang, Huanchen; Campillo, Nuria E.; Ballester, Sara; Gonzalez-Garcia, Coral; Hernandez, Javier; Perez, Concepcion; Cuenca, Jimena; Perez-Castillo, Ana; Martinez, Ana; Huertas, Oscar; Luis Gelpi, Jose; Javier Luque, F.; Ke, Hengming; Gil, Carmen Article ISI CHEMMEDCHEM (2009)
Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties Isabel Fernandez-Bachiller, Maria; Perez, Concepcion; Eugenia Campillo, Nuria; Antonio Paez, Juan; Cristina Gonzalez-Munoz, Gema; Usan, Paola; Garcia-Palomero, Esther; Lopez, Manuela G.; Villarroya, Mercedes; Garcia, Antonio G.; Martinez, Ana; Isabel Rodriguez-Franco, Maria Article ISI CHEMMEDCHEM (2009)
Artificial neural networks in ADMET modeling: Prediction of blood-brain barrier permeation Guerra, Angela; Paez, Juan A.; Campillo, Nuria E. Article ISI QSAR COMBINATORIAL SCIENCE (2008)
Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase Castano, Tania; Encinas, Arantxa; Perez, Concepcion; Castro Ana; Campillo, Nuria E.; Gil, Carmen Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin Reina, Jose J.; Diaz, Irene; Nieto, Pedro M.; Campillo, Nuria E.; Paez, Juan A.; Tabarani, Georges; Fieschi, Franck; Rojo, Javier Article ISI ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
PDE7 inhibitors as new drugs for neurological and inflammatory disorders Gil, Carmen; Campillo, Nuria E.; Perez, Daniel I.; Martinez, Ana Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2008)
Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1 Perez-Dorado, Inmaculada; Campillo, Nuria E.; Monterroso, Begona; Hesek, Dusan; Lee, Mijoon; Paez, Juan A.; Garcia, Pedro; Martinez-Ripoll, Martin; Garcia, Jose L.; Mobashery, Shahriar; Menendez, Margarita; Hermoso, Juan A. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
In vivo anti-chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives Porcal, Williams; Hernandez, Paola; Boiani, Mariana; Aguirre, Gabriela; Boiani, Lucia; Chidichimo, Agustina; Cazzulo, Juan J.; Campillo, Nuria E.; Paez, Juan A.; Castro Ana; Krauth-Siegel, R. Luise; Davies, Carolina; Basombrio, Miguel Angel; Gonzalez, Mercedes; Cerecetto, Hugo Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2007)
The role of cofactor binding in tryptophan accessibility and conformational stability of His-tagged D-amino acid oxidase from Trigonopsis variabilis Arroyo, Miguel; Menendez, Margarita; Garcia, Jose Luis; Campillo, Nuria; Hormigo, Daniel; de la Mata, Isabel; Castillon, Maria Pilar; Acebal, Carmen Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2007)
The tautomerism of 5-amino-3-oxo-1,2,4-thiadiazole: An experimental and theoretical study Encinas, Arantxa; Castro Ana; Campillo, Nuria E.; Paez, Juan A. Article ISI EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2007)
Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase Baerga-Ortiz, A; Popovic, B; Siskos, AP; O'Hare, HM; Spiteller, D; Williams, MG; Campillo, N; Spencer, JB; Leadlay, PF Article ISI CHEMISTRY BIOLOGY (2006)
Glycopyrrolate combinations for the treatment of respiratory diseases Guerra, A.; Campillo, N. E.; Paez, J. A. Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2006)
Homology modelling and active-site-mutagenesis study of the catalytic domain of the pneumococcal phosphorylcholine esterase Campillo, NE; Paez, JA; Lagartera, L; Gonzalez, A Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study Montero, C; Campillo, NE; Goya, P; Paez, JA Article ISI EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2005)
Unravelling the structure of the pneumococcal autolytic lysozyme Monterroso, B; Lopez-Zumel, C; Garcia, JL; Saiz, JL; Garcia, P; Campillo, NE; Menendez, M Article ISI BIOCHEMICAL JOURNAL (2005)
A study of peculiar tautomerism of pyrido[2,3-c] [1,2,6]thiadiazine 2,2-dioxide system Campillo, NE; Montero, C; Paez, JA Article ISI JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM (2004)
Synthesis and nematocide activity of S-glycopyranosyl-6,7-diarylthioinmazines Alho, MAM; D'Accorso, NB; Ochoa, C; Castro, A; Calderon, F; Chana, A; Reviriego, F; Paez, JA; Campillo, NE; Martinez-Grueiro, M; Cruz, AMLS; Martinez, AR Article ISI BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase Gonzalez, B; Campillo, N; Garrido, F; Gasset, M; Sanz-Aparicio, J; Pajares, MA Article ISI BIOCHEMICAL JOURNAL (2003)
On the reactivity of 1H-pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxide and derivatives: Nucleophilic substitution, amination, aldol-type condensation, oxidation, and hydrolysis Campillo, N; Paez, JA; Goya, P Article ISI HELVETICA CHIMICA ACTA (2003)
Plant-based heterologous expression of Mal d 2, a thaumatin-like protein and allergen of apple (Malus domestica), and its characterization as an antifungal protein Krebitz, M; Wagner, B; Ferreira, F; Peterbauer, C; Campillo, N; Witty, M; Kolarich, D; Steinkellner, H; Scheiner, O; Breiteneder, H Article ISI JOURNAL OF MOLECULAR BIOLOGY (2003)
The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense Campillo, N; Carrington, M Article ISI MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2003)
Novel bronchodilators in the treatment of asthma and COPD Campillo, N; Paez, JA Article ISI EXPERT OPINION ON THERAPEUTIC PATENTS (2002)
Unconventional alkoxylation of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides mediated by N-halosuccinimides Campillo, N; Paez, JA; Goya, P Article ISI EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2002)
Phosphoribosyltransferase superfamily: A comparative structural analysis Campillo, N; Nagarajaram, HA; Ghosh, I Article ISI Journal of Molecular Modeling (2001)
Novel bronchodilators: Synthesis, transamination reactions, and pharmacology of a series of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides Campillo, N; Garcia, C; Goya, P; Alkorta, I; Paez, JA Article ISI JOURNAL OF MEDICINAL CHEMISTRY (2000)
Novel arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides as inhibitors of platelet aggregation. 1. Synthesis and pharmacological evaluation Campillo, N; Garcia, C; Goya, P; Paez, JA; Carrasco, E; Grau, M Article ISI JOURNAL OF MEDICINAL CHEMISTRY (1999)
Novel arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides as platelet aggregation inhibitors. 2. Optimization by quantitative structure-activity relationships Campillo, N; Goya, P; Paez, JA Article ISI JOURNAL OF MEDICINAL CHEMISTRY (1999)
Ring strain and hydrogen bond acidity Alkorta, I; Campillo, N; Rozas, I; Elguero, J Article ISI Journal of Organic Chemistry (1998)
Solvent effect on the tautomerism of 4-aminopyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides Campillo, N; Alkorta, I; Paez, JA; Goya, P Article ISI JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (1998)


Nueva Familia de Derivados Carbonílicos de 1-Indazolilo Con Propiedades Cannabinoides y/o Colinérgicas y/o Reguladoras Del Péptido Beta-Amiloide Páez, J.; Campillo, N; Pérez, C; González-Naranjo, P; Pérez-Macias, N; de Ceballos, M; Martín-Requero, A; Alquézar, C; Martín, M; Girón, R; Sánchez-Robles, E; Romero, J Patent (2015)
Una nueva familia de éteres de 3-indazolilo con propiedades cannabinoides y/o colinérgicas. Paez, J; Campillo, N; González,P; Pérez, C; Arán, V.J; Martín, I.M; Girón, R; Sánchez, E.M Patent (2011)
Derivados de Indazol para el Tratamiento del Cancer Indazole Derivatives For Cancer Treatment • Perez-Simon, J; Barbado, M; Medrano, M; Campillo, N; Páez, J; Gonzalez-Naranjo, P Patent


Análisis científico, filosófico y social del covid19: repercusión social, implicaciones éticas y cultura de la prevención frente a las pandemias Cañelles, Matilde Proyecto (2020)
Target- and ligand-based drugs to control SARS-CoV-2 pandemic Gil, Carmen Proyecto (2020)
Combinación de estrategias computacionales, biológicas y sintéticas con aplicación al desarrollo de fármacos Campillo, N Proyecto (2019)
Locking cell against Ebola virus Gil, Carmen Proyecto (2019)
Development and long-term sustainability of new pan-European research infrastructures Fecke, Wolgang Proyecto (2018)
Diseño y desarrollo de fármacos innovadores para la Esclerosis Lateral Amiotrófica Martínez, A Proyecto (2018)
Red de Investigación Colaborativa en Enfermedades Tropicales RICET Benito, Agustín Proyecto (2017)
Chemi-computation to discovery of multitarget drugs for the treatment of Alzheimer's disease Campillo, N Proyecto (2016)
Desarrollo de farmacos innovadores para la enfermedad de Chagas Páez, Juan Proyecto (2010)
Nuevas Aproximaciones para el Descubrimiento y Desarrollo de Fármacos Innovadores en el Tratamiento de Enfermedades Neurodegenerativas Campillo, N Proyecto (2010)
Optimisation and Pre-Validation of an In Vitro Test Strategy for Predicting Human Acute Toxicity Campillo, N Proyecto (2005)