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Carlos José Blondel Buijuy

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

El objetivo primordial de mi grupo de investigación es mejorar nuestra comprensión de la evolución de la virulencia microbiana y comprender los factores que impulsan la aparición de enfermedades infecciosas y sus orígenes ecológicos.

Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2011
Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2007

Postdoctoral fellow Full Time

Brigham and Women´s Hospital & Harvard Medical School

Harvard Medical School

Boston, Estados Unidos

2014 - 2016

Profesor Asistente Full Time

Universidad Autonoma de Chile

Santiago, Chile

2016 - 2019
Profesor Asistente Full Time

Universidad Andres Bello

Santiago, Chile

2019 - A la fecha

Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile

Fundación Allende-Connelly

Chile, 2012

Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile.
Pew Latin American Fellow in the Biomedical Sciences. Class 2013

PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

Estados Unidos, 2013

Pew Latin American Fellow in the Biomedical Sciences. Class 2013
HHMI-Gulbenkian International Research Scholar

Howarad Hughes Medical Institute

Chile, 2017

Investigador Internacional del Instituto Médico Howard Hughes y la Fundación Calouste Gulbenkian (HHMI-Gulbenkian International Research Scholar). Premio otorgado por Instituto Médico Howard Hughes, la Fundación Bill & Melinda Gates, Wellcome Trust y la fundación Calouste Gulbenkian.


<i>Vibrio</i> type III secretion system 2 is not restricted to the<i> Vibrionaceae</i> and encodes differentially distributed repertoires of effector proteins Jerez, Sebastian A.; Plaza, Nicolas; Bravo, Veronica; Urrutia, Italo M.; Blondel, Carlos J. Article ISI MICROBIAL GENOMICS (2023)
Whole-genome sequencing reveals changes in genomic diversity and distinctive repertoires of T3SS and T6SS effector candidates in Chilean clinical <i>Campylobacter</i> strains Katz, Assaf; Porte, Lorena; Weitzel, Thomas; Varela, Carmen; Munoz-Rehbein, Cristina; Ugalde, Juan A.; Grim, Christopher; Gonzalez-Escalona, Narjol; Blondel, Carlos J.; Bravo, Veronica Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)
Identification of Type VI Secretion Systems Effector Proteins That Contribute to Interbacterial Competition in Salmonella Dublin Amaya, Fernando A.; Blondel, Carlos J.; Barros-Infante, Maria F.; Rivera, Dacil; Moreno-Switt, Andrea I.; Santiviago, Carlos A.; Pezoa, David Article ISI FRONTIERS IN MICROBIOLOGY (2022)
COVID-19 and City: Towards an Integrated Model of Housing, Microbiology, Environment and Urbanism Encinas, Felipe; Soto-Liebe, Katia; Aguirre-Nunez, Carlos; Gonzalez, Bernardo; Bustamante. Waldo; Schueftan, Alejandra; Ugalde, Juan; Blondel, Carlos; Truffello, Ricardo; Araya, Paz; Freed, Carmen Article ISI Architecture, City and Environment (2021)
Genomic analysis of the diversity, antimicrobial resistance and virulence potential of clinical Campylobacter jejuni and Campylobacter coli strains from Chile Bravo, Veronica; Katz, Assaf; Porte, Lorena; Weitzel, Thomas; Varela, Carmen; Gonzalez-Escalona, Narjol; Blondel, Carlos J. Article ISI PLOS NEGLECTED TROPICAL DISEASES (2021)
Analysis of theZonula occludensToxin Found in the Genome of the Chilean Non-toxigenicVibrio parahaemolyticusStrain PMC53.7 Perez-Reytor, Diliana; Pavon, Alequis; Lopez-Joven, Carmen; Ramirez-Araya, Sebastian; Pena-Varas, Carlos; Plaza, Nicolas; Alegria-Arcos, Melissa; Corsini, Gino; Jana, Victor; Pavez, Leonardo; del Pozo, Talia; Bastias, Roberto; Blondel, Carlos J.; Ramirez, David; Garcia, Katherine Article ISI FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)
Complete Genome Sequences of 17 Clinical Campylobacter jejuni Strains from Chile Bravo, V; Porte, L.; Weitzel, T.; Varela, C.; Blondel, C. J.; Gonzalez-Escalona, N. Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2020)
Draft Whole-Genome Sequences of 51 Campylobacter jejuni and 12 Campylobacter coli Clinical Isolates from Chile Bravo, Veronica; Varela, Carmen; Porte, Lorena; Weitzel, Thomas; Kastanis, George J.; Balkey, Maria; Blondel, Carlos J.; Gonzalez-Escalona, Narjol Article ISI MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2020)
A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion Park, JS; Helble, JD; Lazarus, JE; Yang, G; Blondel CJ; Doench, JG; Starnbach, MN; Waldor, MK Article ISI ISCIENCE (2019)
Antimicrobial resistance in E. coli isolated from dairy calves and bedding material Astorga F.; Navarrete-Talloni M.J.; MirÃ³ M.P.; Bravo V.; Toro M.; Blondel, C. J.; HervÃ©-Claude L.P. Article WOS-ESCI SCOPUS HELIYON (2019)
Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization Warr A.R.; Hubbard T.P.; Munera D.; Blondel, C. J.; Zur Wiesch P.A.; Abel S.; Wang X.; Davis B.M.; Waldor M.K. Article ISI SCOPUS PLOS PATHOGENS (2019)
CRISPR screen reveals that EHEC’s T3SS and Shiga Toxin rely on shared host factors for infection Pacheco A.R.; Lazarus J.E.; Sit B.; Schmieder S.; Lencer W.I.; Blondel, C. J.; Doench J.G.; Davis B.M.; Waldor M.K. Article ISI SCOPUS mBio (2018)
Exploring the Genomic Traits of Non-toxigenic Strains Isolated in Southern Chile. Castillo, Daniel; Pérez-Reytor, Diliana; Plaza, Nicolás; Ramírez-Araya, Sebastián; Blondel, Carlos J; Corsini, Gino; Bastías, Roberto; Loyola, David E; Jaña, Víctor; Pavez, Leonardo; García, Katherine Article Frontiers in microbiology (2018)
CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity. Blondel, Carlos J; Park, Joseph S; Hubbard, Troy P; Pacheco, Alline R; Kuehl, Carole J; Walsh, Michael J; Davis, Brigid M; Gewurz, Benjamin E; Doench, John G; Waldor, Matthew K Article Cell host & microbe (2016)
Genetic analysis of Vibrio parahaemolyticus intestinal colonization. Hubbard, Troy P; Chao, Michael C; Abel, Sören; Blondel, Carlos J; Abel Zur Wiesch, Pia; Zhou, Xiaohui; Davis, Brigid M; Waldor, Matthew K Article Proceedings of the National Academy of Sciences of the United States of America (2016)
Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium Porwollik, S; Santiviago, CA; Cheng, P; Long F.; Desai, P; Fredlund, J; Srikumar, S; Silva, CA; Chu, WP; Chen X.; Canals, R; Reynolds, MM; Bogomolnaya, L; Shields C.; Cui, P; Guo, JB; Zheng Y.; Endicott-Yazdani, T; Yang, HJ; Maple, A; Ragoza, Y; Blondel CJ; Valenzuela C.; Andrews-Polymenis, H; McClelland, M Article ISI SCOPUS PLOS ONE (2014)
Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts Pezoa, D; Blondel, CJ; Silva, CA; Yang, HJ; Andrews-Polymenis, H; Santiviago, CA; Contreras, I Article VETERINARY RESEARCH (2014)
Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts Pezoa, D; Blondel CJ; Silva, CA; Yang, HJ; Andrews-Polymenis, H; Santiviago, CA; Contreras, I Article ISI SCOPUS VETERINARY RESEARCH (2014)
The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected Macrophages Blondel CJ; Jimenez, JC; Leiva, LE; Alvarez, SA; Pinto, BI; Contreras, F; Pezoa, D; Santiviago, CA; Contreras, I Article ISI SCOPUS INFECTION AND IMMUNITY (2013)
The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken Pezoa, D; Yang, HJ; Blondel CJ; Santiviago, CA; Andrews-Polymenis, HL; Contreras, I Article ISI SCOPUS PLOS ONE (2013)
Differential expression of in vivo and in vitro protein profile of outer membrane of Acidovorax avenae subsp. avenae. Ibrahim, Muhammad; Shi, Yu; Qiu, Hui; Li, Bin; Jabeen, Amara; Li, Liping; Liu, He; Kube, Michael; Xie, Guanlin; Wang, Yanli; Blondel, Carlos; Santiviago, Carlos A; Contreras, Ines; Sun, Guochang Article PloS one (2012)
Infection of Mice by Salmonella enterica Serovar Enteritidis Involves Additional Genes That Are Absent in the Genome of Serovar Typhimurium Silva C.A.; Blondel, C. J.; Quezada, C. P.; Porwollik, S; Andrews-Polymenis H.L.; Toro C.S.; Zaldivar, M; Contreras, I; McClelland, M; Santiviago, C. A. Article ISI SCOPUS Infection and Immunity (2012)
The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium Pezoa, D; Andrews-Polymenis, H; Blondel, CJ; Leiva, L; Pinto, B; Alvarez, SA; Santiviago, CA; Contreras, LI Article FEBS JOURNAL (2012)
Salmonella bongori Provides Insights into the Evolution of the Salmonellae Fookes M.; Schroeder, GN; Langridge, GC; Blondel CJ; Mammina C.; Connor, TR; Seth-Smith H.; Vernikos, GS; Robinson, KS; Sanders, M; Petty, NK; Kingsley, RA; Baumler, AJ; Nuccio, SP; Contreras, I; Santiviago, CA; Maskell D.; Barrow P.; Humphrey T.; Nastasi, A.; Roberts, M; Frankel, G; Parkhill J.; Dougan G.; Thomson, NR Article ISI SCOPUS PLOS PATHOGENS (2011)
Type IVB pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner Bravo D.; Blondel CJ; Hoare, A; Leyton, L; Valvano, MA; Contreras, I Article ISI SCOPUS Microbial Pathogenesis (2011)
Contribution of the Type VI Secretion System Encoded in SPI-19 to Chicken Colonization by Salmonella enterica Serotypes Gallinarum and Enteritidis Blondel CJ; Yang, HJ; Castro B.; Chiang S.; Toro, CS; Zaldivar, M; Contreras, I; Andrews-Polymenis, HL; Santiviago, CA Article ISI SCOPUS PLOS ONE (2010)
Spontaneous Excision of the Salmonella enterica Serovar Enteritidis-specific Defective Prophage-Like Element phi SE14 Santiviago, CA; Blondel CJ; quezada cp; Silva, CA; Tobar, PM; Porwollik, S; McClelland, M; Andrews-Polymenis, HL; Toro, CS; Zaldivar, M; Contreras, I Article ISI SCOPUS Journal of Bacteriology (2010)
Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes Blondel CJ; Jimenez, JC; Contreras, I; Santiviago, CA Article ISI SCOPUS BMC GENOMICS (2009)
Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella Bravo D.; Silva C.; Carter, JA; Hoare, A; Alvarez, SA; Blondel CJ; Zaldivar, M; Valvano, MA; Contreras, I Article ISI SCOPUS JOURNAL OF MEDICAL MICROBIOLOGY (2008)
O-antigen modal chain length in Shigella flexneri 2a is growth-regulated through RfaH-mediated transcriptional control of the wzy gene Carter, JA; Blondel CJ; Zaldivar, M; Alvarez, SA; Marolda, CL; Valvano, MA; Contreras, I Article ISI SCOPUS MICROBIOLOGY-SGM (2007)


The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium Pezoa, D; Andrews-Polymenis, H; Blondel CJ; Leiva, L; Pinto, B; Alvarez, SA; Santiviago, CA; Contreras, LI Abstract ISI FEBS JOURNAL (2012)


The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected Macrophages (vol 81, pg 1207, 2013) Blondel CJ; Jimenez, JC; Leiva, LE; Alvarez, SA; Pinto, BI; Contreras, F; Pezoa, D; Santiviago, CA; Contreras, I Errata ISI SCOPUS Infection and Immunity (2015)
Erratum: Differential expression of in Vivo and in Vitro protein profile of outer membrane of Acidovorax avenae Subsp. avenae (PLoS ONE (2013) 8:1 DOI: 10.1371/annotation/683735fe-858f-4f19-8ebd-ad840279ec88) Ibrahim, M; Shi, Y; Qiu, H.; Li B.; Jabeen A.; Li L.; Liu H.; Kube M.; Xie, G.; Wang Y.; Blondel C.; Santiviago, C. A.; Contreras, I; Sun, G Errata SCOPUS PLOS ONE (2013)


Chile's research planning falls short Astudillo, P; Blondel, C. J.; Norambuena, T; Soto K. Letter ISI SCOPUS Science (2012)


HHMI Gulbenkian International Research Scholar HHMI, Bill & Melinda Gates, Wellcome Trust, Gulbenkian Foundation (55008749) Proyecto 2017-2022 Inv. Principal
Red Internacional para la generación de una plataforma de genómica funcional para el estudio de la interacción patógeno-hospedero PCI (REDI170269) Proyecto 2017-2019 Inv. Responsable
VIBRIO PARAHAEMOLYTICUS TYPE III SECRETION SYSTEM II (T3SS2)=> ROLE OF FUCOSE ON ITS SURVIVAL IN THE ENVIRONMENT AND ON ITS EVOLUTION AS A HUMAN PATHOGEN FONDECYT (11160901) Proyecto 2016-2019 Inv. Responsable
"CONTRIBUCION DE LOS SISTEMAS DE SECRECION TIPO VI A LA SUPERVIVENCIA INTRACELULAR DE SALMONELLA TYPHIMURIUM Y SALMONELLA GALLINARUM EN MACROFAGOS E IDENTIFICACION DE NUEVAS PROTEINAS EFECTORAS" FONDECYT (3120175) Proyecto 2011-2013 Inv. Responsable
GENOME-WIDE IDENTIFICATION OF GENES REQUIRED FOR SYSTEMIC COLONIZATION OF BROAD AND NARROW HOST-RANGE SALMONELLA ENTERICA SEROTYPES IN A MURINE MODEL OF SALMONELLOSIS FONDECYT (1110172) Proyecto 2011-2014 Personal técnico y/o de apoyo
TYPE SIX SECRETION SYSTEMS IN SALMONELLA ENTERICA=> ROLE IN PATHOGENICITY AND HOST SPECIFICITY OF SEROTYPES TYPHIMURIUM, DUBLIN, GALLINARUM AND ENTERITIDIS. FONDECYT (1100092) Proyecto 2010-2013 Personal técnico y/o de apoyo
MODULACION AMBIENTAL DE LA EXPRESION DEL ANTIGENO O EN SALMONELLA ENTERICA SEROVAR TYPHI=> ESTUDIO DE LOS MECANISMOS REGULATORIOS Y DE LA IMPORTANCIA DE ESTA MODULACION EN LA CAPACIDAD INFECTIVA DE LA BACTERIA. FONDECYT (1040562) Proyecto 2004-2007 Tesista

Carlos Blondel

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Verónica Bravo

Profesor Asistente

Universidad de Santiago de Chile

Santiago, Chile

Cecilia Silva

Investigador Principal

Biologia

Centro de Estudios Cientificos

Valdivia, Chile

Thomas Weitzel

Head Travel Medicine Program

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Carolina Quezada

Postdoctoral researcher

CIBQA

Universidad Bernardo O'Higgins

Santiago, Chile

Lorenzo Leiva

Asistente de Investigación

Laboratorio de Biología Molecular Bacteriana, Facultad de Medicina, Universidad de Chile

Santiago, Chile

Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Assaf Katz

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

MARIA CARMEN LOPEZ

Assistant professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Talia del Pozo

Académico Investigador

FAVA

Universidad de Las Américas

Santiago, Chile

Gino Corsini

Director Instituto Ciencias Biomédicas

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

Diliana Pérez

Docente con grado de doctor

Universidad Autónoma de Chile

Santiago, Chile

Andrea Moreno

Profesor Asociado

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Roberto Bastías

Profesor

Facultad de Ciencias

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

María Miró

Académico

Facultad de Salud

Universidad Santo Tomás

Valdivia, Chile

Waldo Bustamante

Director

Faculty of Architecture, Design and Urban Studies

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

RICARDO TRUFFELLO

Assistant Professor

School of Architecture, Design and Urban Studies

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Ugalde

Assistant Professor

Facultad de Ciencias de la Vida

Universidad Andrés Bello

Santiago, Chile

CECILIA TORO

PROFESOR ASOCIADO

PROGRAMA DE MICROBIOLOGÍA Y MICOLOGÍA, ICBM

Universidad de Chile

SANTIAGO, Chile

Nicolás Plaza

Profesor

Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

Katia Soto

Académica

Universidad de Chile

Santiago, Chile

Tomás Norambuena

Group Lead del equipo de Data Science y Bioinformática

Data Science y Bioinformática

Meristem SpA

Santiago, Chile

Carlos Aguirre

Investigador

Universidad San Sebastián

Santiago, Chile

Bernardo González

Full Professor

UNIVERSIDAD ADOLFO IBAÑEZ

Santiago, Chile

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Ítalo Urrutia

Profesor Asistente

Universidad Autónoma de Chile

Santiago, Chile

Carlos José Blondel Buijuy

Líneas de Investigación

Educación

Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2011

Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

Postdoctoral fellow Full Time

Experiencia Profesional

Profesor Asistente Full Time

Profesor Asistente Full Time

Premios y Distinciones

Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile

Pew Latin American Fellow in the Biomedical Sciences. Class 2013

HHMI-Gulbenkian International Research Scholar

Article (30)

Abstract (1)

Errata (2)

Letter (1)

Proyecto (7)

HHMI Gulbenkian International Research Scholar

Red Internacional para la generación de una plataforma de genómica funcional para el estudio de la interacción patógeno-hospedero

VIBRIO PARAHAEMOLYTICUS TYPE III SECRETION SYSTEM II (T3SS2)=> ROLE OF FUCOSE ON ITS SURVIVAL IN THE ENVIRONMENT AND ON ITS EVOLUTION AS A HUMAN PATHOGEN

"CONTRIBUCION DE LOS SISTEMAS DE SECRECION TIPO VI A LA SUPERVIVENCIA INTRACELULAR DE SALMONELLA TYPHIMURIUM Y SALMONELLA GALLINARUM EN MACROFAGOS E IDENTIFICACION DE NUEVAS PROTEINAS EFECTORAS"

GENOME-WIDE IDENTIFICATION OF GENES REQUIRED FOR SYSTEMIC COLONIZATION OF BROAD AND NARROW HOST-RANGE SALMONELLA ENTERICA SEROTYPES IN A MURINE MODEL OF SALMONELLOSIS

TYPE SIX SECRETION SYSTEMS IN SALMONELLA ENTERICA=> ROLE IN PATHOGENICITY AND HOST SPECIFICITY OF SEROTYPES TYPHIMURIUM, DUBLIN, GALLINARUM AND ENTERITIDIS.

MODULACION AMBIENTAL DE LA EXPRESION DEL ANTIGENO O EN SALMONELLA ENTERICA SEROVAR TYPHI=> ESTUDIO DE LOS MECANISMOS REGULATORIOS Y DE LA IMPORTANCIA DE ESTA MODULACION EN LA CAPACIDAD INFECTIVA DE LA BACTERIA.