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Carlos José Blondel Buijuy

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Líneas de Investigación


El objetivo primordial de mi grupo de investigación es mejorar nuestra comprensión de la evolución de la virulencia microbiana y comprender los factores que impulsan la aparición de enfermedades infecciosas y sus orígenes ecológicos.

Educación

  •  Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Postdoctoral fellow Full Time

    Brigham and Women´s Hospital & Harvard Medical School

    Harvard Medical School

    Boston, Estados Unidos

    2014 - 2016

Experiencia Profesional

  •   Profesor Asistente Full Time

    Universidad Autonoma de Chile

    Santiago, Chile

    2016 - 2019

  •   Profesor Asistente Full Time

    Universidad Andres Bello

    Santiago, Chile

    2019 - A la fecha

Premios y Distinciones

  •   Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile

    Fundación Allende-Connelly

    Chile, 2012

    Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile.

  •   Pew Latin American Fellow in the Biomedical Sciences. Class 2013

    PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

    Estados Unidos, 2013

    Pew Latin American Fellow in the Biomedical Sciences. Class 2013

  •   HHMI-Gulbenkian International Research Scholar

    Howarad Hughes Medical Institute

    Chile, 2017

    Investigador Internacional del Instituto Médico Howard Hughes y la Fundación Calouste Gulbenkian (HHMI-Gulbenkian International Research Scholar). Premio otorgado por Instituto Médico Howard Hughes, la Fundación Bill & Melinda Gates, Wellcome Trust y la fundación Calouste Gulbenkian.


 

Article (20)

A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion
CRISPR screen reveals that EHEC’s T3SS and Shiga Toxin rely on shared host factors for infection
Exploring the Genomic Traits of Non-toxigenic Strains Isolated in Southern Chile.
CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity.
Genetic analysis of Vibrio parahaemolyticus intestinal colonization.
Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium
Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts
Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts
The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected Macrophages
The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken
Differential expression of in vivo and in vitro protein profile of outer membrane of Acidovorax avenae subsp. avenae.
Infection of Mice by Salmonella enterica Serovar Enteritidis Involves Additional Genes That Are Absent in the Genome of Serovar Typhimurium
The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium
Salmonella bongori Provides Insights into the Evolution of the Salmonellae
Type IVB pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner
Contribution of the Type VI Secretion System Encoded in SPI-19 to Chicken Colonization by Salmonella enterica Serotypes Gallinarum and Enteritidis
Spontaneous Excision of the Salmonella enterica Serovar Enteritidis-specific Defective Prophage-Like Element phi SE14
Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes
Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella
O-antigen modal chain length in Shigella flexneri 2a is growth-regulated through RfaH-mediated transcriptional control of the wzy gene

Abstract (1)

The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium

Errata (2)

The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected Macrophages (vol 81, pg 1207, 2013)
Erratum: Differential expression of in Vivo and in Vitro protein profile of outer membrane of Acidovorax avenae Subsp. avenae (PLoS ONE (2013) 8:1 DOI: 10.1371/annotation/683735fe-858f-4f19-8ebd-ad840279ec88)

Letter (1)

Chile's research planning falls short

Proyecto (7)

HHMI Gulbenkian International Research Scholar
Red Internacional para la generación de una plataforma de genómica funcional para el estudio de la interacción patógeno-hospedero
VIBRIO PARAHAEMOLYTICUS TYPE III SECRETION SYSTEM II (T3SS2)=> ROLE OF FUCOSE ON ITS SURVIVAL IN THE ENVIRONMENT AND ON ITS EVOLUTION AS A HUMAN PATHOGEN
"CONTRIBUCION DE LOS SISTEMAS DE SECRECION TIPO VI A LA SUPERVIVENCIA INTRACELULAR DE SALMONELLA TYPHIMURIUM Y SALMONELLA GALLINARUM EN MACROFAGOS E IDENTIFICACION DE NUEVAS PROTEINAS EFECTORAS"
GENOME-WIDE IDENTIFICATION OF GENES REQUIRED FOR SYSTEMIC COLONIZATION OF BROAD AND NARROW HOST-RANGE SALMONELLA ENTERICA SEROTYPES IN A MURINE MODEL OF SALMONELLOSIS
TYPE SIX SECRETION SYSTEMS IN SALMONELLA ENTERICA=> ROLE IN PATHOGENICITY AND HOST SPECIFICITY OF SEROTYPES TYPHIMURIUM, DUBLIN, GALLINARUM AND ENTERITIDIS.
MODULACION AMBIENTAL DE LA EXPRESION DEL ANTIGENO O EN SALMONELLA ENTERICA SEROVAR TYPHI=> ESTUDIO DE LOS MECANISMOS REGULATORIOS Y DE LA IMPORTANCIA DE ESTA MODULACION EN LA CAPACIDAD INFECTIVA DE LA BACTERIA.
18
Carlos Blondel

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

5
Cecilia Silva

Investigador Principal

Biologia

Centro de Estudios Cientificos

Valdivia, Chile

2
Lorenzo Leiva

Asistente de Investigación

Laboratorio de Biología Molecular Bacteriana, Facultad de Medicina, Universidad de Chile

Santiago, Chile

2
Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Carolina Quezada

Postdoctoral researcher

CIBQA

Universidad Bernardo O'Higgins

Santiago, Chile

2
Anilei Hoare

Profesora Asistente

Medicina y Patología Oral

Universidad de Chile

SANTIAGO, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Katia Soto

Académica

Universidad de Chile

Santiago, Chile