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Carlos José Blondel Buijuy

Profesor Asistente

Universidad Andrés Bello

Santiago, Chile

El objetivo primordial de mi grupo de investigación es mejorar nuestra comprensión de la evolución de la virulencia microbiana y comprender los factores que impulsan la aparición de enfermedades infecciosas y sus orígenes ecológicos.

Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2011
Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2007

Postdoctoral fellow Full Time

Brigham and Women´s Hospital & Harvard Medical School

Harvard Medical School

Boston, Estados Unidos

2014 - 2016

Profesor Asistente Full Time

Universidad Autonoma de Chile

Santiago, Chile

2016 - 2019
Profesor Asistente Full Time

Universidad Andres Bello

Santiago, Chile

2019 - A la fecha

Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile

Fundación Allende-Connelly

Chile, 2012

Premio Mejor Tesis Doctoral en el área de biología de la Universidad de Chile.
Pew Latin American Fellow in the Biomedical Sciences. Class 2013

PEW LATIN AMERICAN FELLOWS PROGRAM IN BIOMEDICAL SCIENCES

Estados Unidos, 2013

Pew Latin American Fellow in the Biomedical Sciences. Class 2013
HHMI-Gulbenkian International Research Scholar

Howarad Hughes Medical Institute

Chile, 2017

Investigador Internacional del Instituto Médico Howard Hughes y la Fundación Calouste Gulbenkian (HHMI-Gulbenkian International Research Scholar). Premio otorgado por Instituto Médico Howard Hughes, la Fundación Bill & Melinda Gates, Wellcome Trust y la fundación Calouste Gulbenkian.


A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion Park, JS; Helble, JD; Lazarus, JE; Yang, G; Blondel, CJ; Doench, JG; Starnbach, MN; Waldor, MK Article ISI iScience (2019)
CRISPR screen reveals that EHEC’s T3SS and Shiga Toxin rely on shared host factors for infection Pacheco A.R.; Lazarus J.E.; Sit B.; Schmieder S.; Lencer W.I.; Blondel, C. J.; Doench J.G.; Davis B.M.; Waldor M.K. Article ISI SCOPUS mBio (2018)
Exploring the Genomic Traits of Non-toxigenic Strains Isolated in Southern Chile. Castillo, Daniel; Pérez-Reytor, Diliana; Plaza, Nicolás; Ramírez-Araya, Sebastián; Blondel, Carlos J; Corsini, Gino; Bastías, Roberto; Loyola, David E; Jaña, Víctor; Pavez, Leonardo; García, Katherine Article Frontiers in microbiology (2018)
CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity. Blondel, Carlos J; Park, Joseph S; Hubbard, Troy P; Pacheco, Alline R; Kuehl, Carole J; Walsh, Michael J; Davis, Brigid M; Gewurz, Benjamin E; Doench, John G; Waldor, Matthew K Article Cell host & microbe (2016)
Genetic analysis of Vibrio parahaemolyticus intestinal colonization. Hubbard, Troy P; Chao, Michael C; Abel, Sören; Blondel, Carlos J; Abel Zur Wiesch, Pia; Zhou, Xiaohui; Davis, Brigid M; Waldor, Matthew K Article Proceedings of the National Academy of Sciences of the United States of America (2016)
Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium Porwollik, S; Santiviago, CA; Cheng, P; Long F.; Desai, P; Fredlund, J; Srikumar, S; Silva, CA; Chu, WP; Chen X.; Canals, R; Reynolds, MM; Bogomolnaya, L; Shields C.; Cui, P; Guo, JB; Zheng Y.; Endicott-Yazdani, T; Yang, HJ; Maple, A; Ragoza, Y; Blondel, CJ; Valenzuela C.; Andrews-Polymenis, H; McClelland, M Article ISI SCOPUS PLOS ONE (2014)
Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts Pezoa, D; Blondel, CJ; Silva, CA; Yang, HJ; Andrews-Polymenis, H; Santiviago, CA; Contreras, I Article VETERINARY RESEARCH (2014)
Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts Pezoa, D; Blondel, CJ; Silva, CA; Yang, HJ; Andrews-Polymenis, H; Santiviago, CA; Contreras, I Article ISI SCOPUS VETERINARY RESEARCH (2014)
The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected Macrophages Blondel, CJ; Jimenez, JC; Leiva, LE; Alvarez, SA; Pinto, BI; Contreras, F; Pezoa, D; Santiviago, CA; Contreras, I Article ISI SCOPUS INFECTION AND IMMUNITY (2013)
The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken Pezoa, D; Yang, HJ; Blondel, CJ; Santiviago, CA; Andrews-Polymenis, HL; Contreras, I Article ISI SCOPUS PLOS ONE (2013)
Differential expression of in vivo and in vitro protein profile of outer membrane of Acidovorax avenae subsp. avenae. Ibrahim, Muhammad; Shi, Yu; Qiu, Hui; Li, Bin; Jabeen, Amara; Li, Liping; Liu, He; Kube, Michael; Xie, Guanlin; Wang, Yanli; Blondel, Carlos; Santiviago, Carlos A; Contreras, Ines; Sun, Guochang Article PloS one (2012)
Infection of Mice by Salmonella enterica Serovar Enteritidis Involves Additional Genes That Are Absent in the Genome of Serovar Typhimurium Silva C.A.; Blondel, C. J.; Quezada, C. P.; Porwollik, S; Andrews-Polymenis H.L.; Toro C.S.; Zaldivar, M; Contreras, I; McClelland, M; Santiviago, C. A. Article ISI SCOPUS Infection and Immunity (2012)
The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium Pezoa, D; Andrews-Polymenis, H; Blondel, CJ; Leiva, L; Pinto, B; Alvarez, SA; Santiviago, CA; Contreras, LI Article FEBS JOURNAL (2012)
Salmonella bongori Provides Insights into the Evolution of the Salmonellae Fookes M.; Schroeder, GN; Langridge, GC; Blondel, CJ; Mammina C.; Connor, TR; Seth-Smith H.; Vernikos, GS; Robinson, KS; Sanders, M; Petty, NK; Kingsley, RA; Baumler, AJ; Nuccio, SP; Contreras, I; Santiviago, CA; Maskell D.; Barrow P.; Humphrey T.; Nastasi, A.; Roberts, M; Frankel, G; Parkhill J.; Dougan G.; Thomson, NR Article ISI SCOPUS PLOS PATHOGENS (2011)
Type IVB pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner Bravo D.; Blondel, CJ; Hoare, A; Leyton, L; Valvano, MA; Contreras, I Article ISI SCOPUS Microbial Pathogenesis (2011)
Contribution of the Type VI Secretion System Encoded in SPI-19 to Chicken Colonization by Salmonella enterica Serotypes Gallinarum and Enteritidis Blondel, CJ; Yang, HJ; Castro B.; Chiang S.; Toro, CS; Zaldivar, M; Contreras, I; Andrews-Polymenis, HL; Santiviago, CA Article ISI SCOPUS PLOS ONE (2010)
Spontaneous Excision of the Salmonella enterica Serovar Enteritidis-specific Defective Prophage-Like Element phi SE14 Santiviago, CA; Blondel, CJ; quezada cp; Silva, CA; Tobar, PM; Porwollik, S; McClelland, M; Andrews-Polymenis, HL; Toro, CS; Zaldivar, M; Contreras, I Article ISI SCOPUS Journal of Bacteriology (2010)
Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes Blondel, CJ; Jimenez, JC; Contreras, I; Santiviago, CA Article ISI SCOPUS BMC GENOMICS (2009)
Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella Bravo D.; Silva C.; Carter, JA; Hoare, A; Alvarez, SA; Blondel, CJ; Zaldivar, M; Valvano, MA; Contreras, I Article ISI SCOPUS JOURNAL OF MEDICAL MICROBIOLOGY (2008)
O-antigen modal chain length in Shigella flexneri 2a is growth-regulated through RfaH-mediated transcriptional control of the wzy gene Carter, JA; Blondel, CJ; Zaldivar, M; Alvarez, SA; Marolda, CL; Valvano, MA; Contreras, I Article ISI SCOPUS MICROBIOLOGY-SGM (2007)


The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium Pezoa, D; Andrews-Polymenis, H; Blondel, CJ; Leiva, L; Pinto, B; Alvarez, SA; Santiviago, CA; Contreras, LI Abstract ISI FEBS JOURNAL (2012)


The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected Macrophages (vol 81, pg 1207, 2013) Blondel, CJ; Jimenez, JC; Leiva, LE; Alvarez, SA; Pinto, BI; Contreras, F; Pezoa, D; Santiviago, CA; Contreras, I Errata ISI SCOPUS Infection and Immunity (2015)
Erratum: Differential expression of in Vivo and in Vitro protein profile of outer membrane of Acidovorax avenae Subsp. avenae (PLoS ONE (2013) 8:1 DOI: 10.1371/annotation/683735fe-858f-4f19-8ebd-ad840279ec88) Ibrahim, M; Shi, Y; Qiu, H.; Li B.; Jabeen A.; Li L.; Liu H.; Kube M.; Xie, G.; Wang Y.; Blondel C.; Santiviago, C. A.; Contreras, I; Sun, G Errata SCOPUS PLOS ONE (2013)


Chile's research planning falls short Astudillo, P; Blondel, C. J.; Norambuena, T; Soto K. Letter ISI SCOPUS Science (2012)


HHMI Gulbenkian International Research Scholar HHMI, Bill & Melinda Gates, Wellcome Trust, Gulbenkian Foundation (55008749) Proyecto 2017-2022 Inv. Principal
Red Internacional para la generación de una plataforma de genómica funcional para el estudio de la interacción patógeno-hospedero PCI (REDI170269) Proyecto 2017-2019 Inv. Responsable
VIBRIO PARAHAEMOLYTICUS TYPE III SECRETION SYSTEM II (T3SS2)=> ROLE OF FUCOSE ON ITS SURVIVAL IN THE ENVIRONMENT AND ON ITS EVOLUTION AS A HUMAN PATHOGEN FONDECYT (11160901) Proyecto 2016-2019 Inv. Responsable
"CONTRIBUCION DE LOS SISTEMAS DE SECRECION TIPO VI A LA SUPERVIVENCIA INTRACELULAR DE SALMONELLA TYPHIMURIUM Y SALMONELLA GALLINARUM EN MACROFAGOS E IDENTIFICACION DE NUEVAS PROTEINAS EFECTORAS" FONDECYT (3120175) Proyecto 2011-2013 Inv. Responsable
GENOME-WIDE IDENTIFICATION OF GENES REQUIRED FOR SYSTEMIC COLONIZATION OF BROAD AND NARROW HOST-RANGE SALMONELLA ENTERICA SEROTYPES IN A MURINE MODEL OF SALMONELLOSIS FONDECYT (1110172) Proyecto 2011-2014 Personal técnico y/o de apoyo
TYPE SIX SECRETION SYSTEMS IN SALMONELLA ENTERICA=> ROLE IN PATHOGENICITY AND HOST SPECIFICITY OF SEROTYPES TYPHIMURIUM, DUBLIN, GALLINARUM AND ENTERITIDIS. FONDECYT (1100092) Proyecto 2010-2013 Personal técnico y/o de apoyo
MODULACION AMBIENTAL DE LA EXPRESION DEL ANTIGENO O EN SALMONELLA ENTERICA SEROVAR TYPHI=> ESTUDIO DE LOS MECANISMOS REGULATORIOS Y DE LA IMPORTANCIA DE ESTA MODULACION EN LA CAPACIDAD INFECTIVA DE LA BACTERIA. FONDECYT (1040562) Proyecto 2004-2007 Tesista