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Ute Wohlbier

Associate Professor

Universidad Mayor de Chile

Santiago, Chile

Neurodegeneration, Amyotrophic Lateral Sclerosis, Protein Folding, Autophagy, Mesenchymal Stem Cell Therapy, Gene Therapy

Ph.D./Dr.rer.nat., UNIVERSITAT HEIDELBERG. Alemania, 2007
M.Sc./Dipl.biol. in Molecular Biology, UNIVERSITAT HEIDELBERG. Alemania, 2003

Associate Professor Full Time

Universidad Mayor

Faculty of Science

Santiago, Chile

2019 - A la fecha

Assistant Professor Full Time

Universidad Mayor

Santiago, Chile

2013 - 2018
Postdoc Full Time

Virginia Commonwealth University

Richmond, Estados Unidos

2007 - 2010
Postdoc Full Time

Universidad de Chile

Santiago, Chile

2010 - 2013

Undergrad thesis
1. Catherine Andreu, 2012, Caracterizacion de un modelo murino knockout y transgénico para ERp57 en el sistema nervioso central, Escula de Biotechnologia, Universidad de Chile, co-tutor
2. Fernanda Briceño y Luciano Páez, 2016, Rol de Fam120A en proteopatias asociadas a esclerosis lateral amiotrofica, Facultad de Medicina, Escuela Tecnologia Medico, Universidad Mayor, co-tutor
3. Javiera Arcos, 2016, Caracterización de los niveles de expresión de Beclin1 interactor (BCI), una nueva proteína asociada a autofagia en modelos in vivo de Esclerosis lateral amiotrofica, Facultad de Ciencias, Escuela de Biotecnologia, Universidad Mayor, tutor
4. Constanza Puelles Caceres y Laura Gomez Gomez, 2018, Pacer, una proteina relacionada a la autofagia, y su papel en muerte celular inducida por TNF-a en modelos celulares neuronales, Facultad de Medicina, Escuela Tecnologia Medico, Universidad Mayor, tutor
5. Constanza Bidart y Catalina Ibarra, 2022, Expresión del gen Pacer en cáncer de mama, Escuela Tecnologia Medico, Universidad Mayor, co-tutor

PhD thesis
1. Sebastian Beltran, 2014-2018, The role of Pacer in SOD1 protein aggregation, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
2. Luis Labrador, 2016-2020, Pacer, a new link between autophagy and cell death in amyotrophic lateral sclerosis, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
3. Emiliano Vicencio, 2016-2021, Network analysis predicts a role for FAM120A in amyotrophic lateral sclerosis (ALS), Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
4. Miguel Rubilar, 2020-pres, A network-based approach to ALS – Identifying new genes and pathways for disease, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, co-tutor

Postdoc
1. Sebastian Beltran, 2018-2020, Pacer and Rubicon a new autophagy related proteins involved in motoneuron survival.


Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis Medinas, Danilo Bilches; Malik, Sajid; Yildiz-Bolukbasi, Esra; Borgonovo, Janina; Saaranen, Mirva J.; Urra, Hery; Pulgar, Eduardo; Afzal, Muhammad; Contreras, Darwin; Wright, Madison T.; Bodaleo, Felipe; Quiroz, Gabriel; Rozas, Pablo; Mumtaz, Sara; Diaz, Rodrigo; Rozas, Carlos; Cabral-Miranda, Felipe; Pina, Ricardo; Valenzuela, Vicente; Uyan, Ozgun; Reardon, Christopher; Woehlbier, Ute; Brown, Robert H.; Sena-Esteves, Miguel; Gonzalez-Billault, Christian; Morales, Bernardo; Plate, Lars; Ruddock, Lloyd W.; Concha, Miguel L.; Hetz, Claudio; Tolun, Aslihan Article ISI EMBO JOURNAL (2022)
Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease Espinoza, Sandra; Grunenwald, Felipe; Gomez, Wileidy; Garcia, Felipe; Abarzua-Catalan, Lorena; Oyarce-Pezoa, Sebastian; Fernanda Hernandez, Maria; Cortes, Bastian, I; Uhrig, Markus; Ponce, Daniela P.; Duran-Aniotz, Claudia; Hetz, Claudio; SanMartin, Carol D.; Cornejo, Victor H.; Ezquer, Fernando; Parra, Valentina; Isabel Behrens, Maria; Manque, Patricio A.; Rojas-Rivera, Diego; Vidal, Rene L.; Woehlbier, Ute; Nassif, Melissa Article ISI CELLS (2022)
The Autophagy Protein Pacer Positively Regulates the Therapeutic Potential of Mesenchymal Stem Cells in a Mouse Model of DSS-Induced Colitis Bergmann, Cristian A.; Beltran, Sebastian; Maria Vega-Letter, Ana; Murgas, Paola; Fernanda Hernandez, Maria; Gomez, Laura; Labrador, Luis; Cortes, Bastian, I; Poblete, Cristian; Quijada, Cristobal; Carrion, Flavio; Woehlbier, Ute; Manque, Patricio A. Article ISI CELLS (2022)
DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients and a Transgenic Model of the Disease. eyton E, Matus D, Espinoza S, Benitez JM, Cortes BI, Gomez W, Arévalo NB, Murgas P, Manque P, Woehlbier U, Duran-Aniotz C, Hetz C, Behrens MI, SanMartín CD, Nassif M. Article JOURNAL OF ALZHEIMERS DISEASE (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Klionsky, DJ et al. Article AUTOPHAGY (2021)
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis Beltran, S; Nassif M.; Vicencio E.; Arcos J.; Labrador L.; Cortes B.I.; Cortez C.; Bergmann C.A.; Espinoza S.; Hernandez M.F.; Matamala, J. M.; Bargsted L.; Matus S.; Rojas-Rivera D.; Bertrand M.J.M.; Medinas D.B.; Hetz C.; Manque P.A.; Woehlbier U. Article ISI SCOPUS MOLECULAR NEURODEGENERATION (2019)
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis Medinas, Danilo B.; Rozas, Pablo; Martinez Traub, Francisca; Woehlbier, Ute*; Brown, Robert H.; Bosco, Daryl A.; Hetz, Claudio Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly Bolukbasi, EY; Mumtaz, S; Afzal, M; Woehlbier, U; Malik, S; Tolun, A Article ISI SCOPUS JOURNAL OF MEDICAL GENETICS (2018)
Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility Yildirim, Y; Ouriachi, T; Woehlbier, U; Ouahioune, W; Balkan, M; Malik, S; Tolun, A Article ISI SCOPUS EUROPEAN JOURNAL OF HUMAN GENETICS (2018)
ALS-linked protein disulfide isomerase variants cause motor dysfunction Woehlbier, U; Colombo, A; Saaranen M.J.; Pérez V; Ojeda J.; Bustos F.J.; Andreu C.I.; Torres M.; Valenzuela, V.; Medinas D.B.; Rozas P.; Vidal R.L.; Lopez-Gonzalez R.; Salameh J.; Fernandez-Collemann S.; Muñoz, N.; Matus, S; Armisen, R; Sagredo A; Palma K.; Irrazabal T.; Almeida, S.; Gonzalez-Perez P.; Campero, M; Gao F.-B.; Henny, P; van Zundert, B; Ruddock L.W.; Concha, M. L.; Henríquez J.P.; Brown R.H.; hetz C. Article ISI SCOPUS EMBO Journal (2016)
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration Castillo, Valentina; Oate, Maritza; Woehlbier, Ute*; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valds, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz, Claudio; Gillingwater, Thomas H Article ISI SCOPUS PLOS ONE (2015)
Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients Gonzalez-Perez, P; Woehlbier, U; Chian, RJ; Sapp, P; Rouleau, GA; Leblond, CS; Daoud, H; Dion, PA; Landers, JE; hetz C.; Brown, RH Article ISI SCOPUS Gene (2015)
The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein Torres M.; Medinas DB; Matamala, JM; Woehlbier, U; Cornejo, VH; Solda T.; Andreu, C; Rozas P.; Matus, S; Muñoz, N.; Vergara C.; Cartier, L; Soto C.; Molinari M; hetz C. Article ISI SCOPUS Journal of Biological Chemistry (2015)
Intranasal vaccination in mice with an attenuated Salmonella enterica Serovar 908htr A expressing Cp15 of Cryptosporidium: impact of malnutrition with preservation of cytokine secretion Roche, JK; Rojo, AL; Costa, LB; Smeltz, R; Manque P.; Woehlbier, U; Bartelt, L; Galen, J; Buck G.; Guerrant, RL Article SCOPUS Vaccine (2013)
Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease Torres M.; Cartier, L; Matamala, J. M.; Hernández N.; Woehlbier, U; hetz C. Article ISI SCOPUS PLOS ONE (2012)
Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis Manque, Patricio A.; Woehlbier, Ute*; Lara, Ana M.; Tenjo, Fernando; Alves, Joao M.; Buck, Gregory A. Article ISI PLOS ONE (2012)
Identification and immunological characterization of three potential vaccinogens against Cryptosporidium species Manque P.A.; Tenjo, F; Woehlbier, U; Lara A.M.; Serrano M.G.; Xu, P; Alves J.M.; Smeltz R.B.; Conrad D.H.; Buck G.A. Article SCOPUS Clinical and Vaccine Immunology (2011)
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion Woehlbier, Ute*; Epp, Christian; Hackett, Fiona; Blackman, Michael J.; Bujard, Hermann Article ISI MALARIA JOURNAL (2010)
A multifunctional serine protease primes the malaria parasite for red blood cell invasion Koussis, Konstantinos; Withers-Martinez, Chrislaine; Yeoh, Sharon; Child, Matthew; Hackett, Fiona; Knuepfer, Ellen; Juliano, Luiz; Woehlbier, Ute*; Bujard, Hermann; Blackman, Michael J. Article ISI EMBO JOURNAL (2009)
Antibody responses to the merozoite surface protein-1 complex in cerebral malaria patients in India Lucchi, Naomi W.; Tongren, Jon Eric; Jain, Vidhan; Nagpal, Avinash C.; Kauth, Christian W.; Woehlbier, Ute*; Bujard, Hermann; Dash, Aditya P.; Singh, Neeru; Stiles, Jonathan K.; Udhayakumar, Venkatachalam Article ISI MALARIA JOURNAL (2008)
Analysis of antibodies directed against merozoite surface protein 1 of the human malaria parasite Plasmodium falciparum Woehlbier, U; Epp, C; Kauth, CW; Lutz, R; Long, CA; Coulibaly, B; Kouyate, B; Arevalo-Herrera, M; Herrera, S; Bujard, H Article ISI INFECTION AND IMMUNITY (2006)
Interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite Plasmodium falciparum Kauth, Christian W.; Woehlbier, Ute*; Kern, Michaela; Mekonnen, Zeleke; Lutz, Rolf; Muecke, Norbert; Langowski, Joerg; Bujard, Hermann Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2006)


Bci is a new component of the autophagy pathway Manque, PA; Nassif, M; Vicencio E.; Gherardelli C.; Matamala, JM; Vidal, RL; Arias, R.; Rojas M.; Maracaja, V; hetz C.; Woehlbier, U Abstract ISI FEBS JOURNAL (2014)
Protein disulfide isomerase gene variants are associated with amyotrophic lateral sclerosis Woehlbier, U; Gonzalez-Perez, P; Colombo, A; Saaranen MJ.,; Andreu, CI; Bustos F.; Lopez-Gonzalez, R; Ojeda J.; Pérez V; Torres, MS; Valenzuela, V.; Vidal, RL; Medinas D; Fernández S.; Campero, M; Armisen, R; Sagredo A; Palma K.; Salameh J.; Irrazabal T.; Chian, RJ; Sapp, P; Blair, I; Williams K.; Fifita, J; Nicholson, G; Rouleau, G; Leblond, C; Daoud, H; Dion, P; Gao FB; Henny, P; Henriquez, JP; van Zundert, B; Ruddock, L; Concha M.; Brown, RH; hetz C. Abstract ISI FEBS JOURNAL (2014)


Systems biology-based approaches applied to vaccine development Manque P.A.; Woehlbier, U BookWhole SCOPUS Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications (2011)


The autophagy protein Pacer as a mediator of motoneuron protection in ALS Woehlbier, Ute* Proyecto (2020)
A novel therapeutic approach to promote motoneuron survival during Amyotrophic lateral sclerosis pathology Universidad Mayor (PEP I-2019054) Proyecto 2019-2020 Inv. Responsable
DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY. FONDECYT (1150743) Proyecto 2015-2019 Inv. Responsable
El papel de la nueva proteina BCI en la conectividad y plasticidad neuronal Universidad Mayor (FIDUM 2014) Proyecto 2014-2016 Inv. Responsable
THE ROLE OF ER-RESIDENT PROTEIN DISULFIDE ISOMERASES (PDIS) INTHE MISFOLDING AND NEUROTOXICITY OF MUTANT PRP AND SOD1. FONDECYT (3110067) Proyecto 2010-2013 Inv. Responsable


Implications of Selective Autophagy Dysfunction for ALS Pathology Vicencio, E; Beltran, S; Labrador, L; Manque, P; Nassif, M; Woehlbier, U Review ISI CELLS (2020)
The Enigmatic Role of C9ORF72 in Autophagy Nassif M.; Woehlbier U.; Manque P.A. Review ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2017)
Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications Andreu C.I.; Woehlbier, U; Torres M.; hetz C. Review ISI SCOPUS FEBS Letters (2012)
Modulating stress responses by the UPRosome: A matter of life and death Woehlbier, U; hetz C. Review ISI SCOPUS Trends in Biochemical Sciences (2011)

Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

Pablo Rozas

Investigador

SymbiOx

Santiago, Chile

Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

Valentina Valenzuela

Investigador adjunto

Universidad de Concepcion

Concepción, Chile

Víctor Cornejo

Associate Research Scientist

Biological Sciences

Columbia University

New York, Estados Unidos

Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

René Vidal

Profesor Asistente

Universidad Mayor

Santiago, Chile

Felipe Grunenwald

candidato PhD

Cib

Universidad Mayor de Chile

santiago, Chile

Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

Valentina Castillo

Estudiante de Doctorado

Ingeniería

Pontificia Universidad Católica de Chile

Santiago, Chile

Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

Carlos Rozas

Profesor asistente

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Wileidy Gómez

Postdoctorado

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Ute Wohlbier

Líneas de Investigación

Educación

Ph.D./Dr.rer.nat., UNIVERSITAT HEIDELBERG. Alemania, 2007

M.Sc./Dipl.biol. in Molecular Biology, UNIVERSITAT HEIDELBERG. Alemania, 2003

Experiencia Académica

Associate Professor Full Time

Experiencia Profesional

Assistant Professor Full Time

Postdoc Full Time

Postdoc Full Time

Formación de Capital Humano

Article (22)

Abstract (2)

BookWhole (1)

Proyecto (5)

A novel therapeutic approach to promote motoneuron survival during Amyotrophic lateral sclerosis pathology

DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY.

El papel de la nueva proteina BCI en la conectividad y plasticidad neuronal

THE ROLE OF ER-RESIDENT PROTEIN DISULFIDE ISOMERASES (PDIS) INTHE MISFOLDING AND NEUROTOXICITY OF MUTANT PRP AND SOD1.

Review (4)