Man

Ute Wohlbier

Associate Professor

Universidad Mayor de Chile

Santiago, Chile

Líneas de Investigación


Neurodegeneration, Amyotrophic Lateral Sclerosis, Protein Disulfide Isomerases, Autophagy, Mesenchymal Stem Cell Therapy

Educación

  •  Ph.D./Dr.rer.nat., UNIVERSITAT HEIDELBERG. Alemania, 2007
  •  M.Sc./Dipl.biol. in Molecular Biology, UNIVERSITAT HEIDELBERG. Alemania, 2003

Experiencia Académica

  •   Associate Professor Full Time

    Universidad Mayor

    Faculty of Science

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad Mayor

    Santiago, Chile

    2013 - 2018

  •   Postdoc Full Time

    Virginia Commonwealth University

    Richmond, Estados Unidos

    2007 - 2010

  •   Postdoc Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - 2013

Formación de Capital Humano


undergrad thesis
1. Catherine Andreu, 2012, Caracterizacion de un modelo murino knockout y transgénico para ERp57 en el sistema nervioso central, Escula de Biotechnologia, Universidad de Chile, co-tutor
2. Fernanda Briceño y Luciano Páez, 2016, Rol de Fam120A en proteopatias asociadas a esclerosis lateral amiotrofica, Facultad de Medicina, Escuela Tecnologia Medico, Universidad Mayor, co-tutor
3. Javiera Arcos, 2016, Caracterización de los niveles de expresión de Beclin1 interactor (BCI), una nueva proteína asociada a autofagia en modelos in vivo de Esclerosis lateral amiotrofica, Facultad de Ciencias, Escuela de Biotecnologia, Universidad Mayor, tutor
4. Constanza Puelles Caceres y Laura Gomez Gomez, 2018, Pacer, una proteina relacionada a la autofagia, y su papel en muerte celular inducida por TNF-? en modelos celulares neuronales, Facultad de Medicina, Escuela Tecnologia Medico, Universidad Mayor, tutor

PhD thesis
1. Sebastian Beltran, 2014-2018, The role of Beclin1 interactor (BCI) in SOD1 protein aggregation, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
2. Emiliano Vicencio, 2016-2021, Network analysis predicts a role for FAM120A in amyotrophic lateral sclerosis (ALS), Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
3. Luis Labrador, 2016-2020, Rubicon-Like, a new link between autophagy and cell death in amyotrophic lateral sclerosis, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
4. Miguel Rubilar, 2020-pres, to be determined, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, co-tutor



 

Article (19)

DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients and a Transgenic Model of the Disease.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly
Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility
ALS-linked protein disulfide isomerase variants cause motor dysfunction
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration
Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients
The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein
Intranasal vaccination in mice with an attenuated Salmonella enterica Serovar 908htr A expressing Cp15 of Cryptosporidium: impact of malnutrition with preservation of cytokine secretion
Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease
Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis
Identification and immunological characterization of three potential vaccinogens against Cryptosporidium species
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion
A multifunctional serine protease primes the malaria parasite for red blood cell invasion
Antibody responses to the merozoite surface protein-1 complex in cerebral malaria patients in India
Analysis of antibodies directed against merozoite surface protein 1 of the human malaria parasite Plasmodium falciparum
Interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite Plasmodium falciparum

Abstract (2)

Bci is a new component of the autophagy pathway
Protein disulfide isomerase gene variants are associated with amyotrophic lateral sclerosis

BookWhole (1)

Systems biology-based approaches applied to vaccine development

Proyecto (5)

The autophagy protein Pacer as a mediator of motoneuron protection in ALS
A novel therapeutic approach to promote motoneuron survival during Amyotrophic lateral sclerosis pathology
DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY.
El papel de la nueva proteina BCI en la conectividad y plasticidad neuronal
THE ROLE OF ER-RESIDENT PROTEIN DISULFIDE ISOMERASES (PDIS) INTHE MISFOLDING AND NEUROTOXICITY OF MUTANT PRP AND SOD1.

Review (4)

Implications of Selective Autophagy Dysfunction for ALS Pathology
The Enigmatic Role of C9ORF72 in Autophagy
Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications
Modulating stress responses by the UPRosome: A matter of life and death
27
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

5
Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

4
Pablo Rozas

Asistente de Investigación

Instituto de Neurociencia Biomédica

Universidad de Chile

Santiago, Chile

4
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

3
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Melissa Calegaro

Investigadora Principal

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

3
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

2
Viviana Pérez

Investigador Postdoctoral

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

2
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

2
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

2
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

2
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

1
JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

1
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

1
René Vidal

Profesor Asistente

Universidad Mayor

Santiago, Chile

1
Valentina Valenzuela

Investigador adjunto

Universidad de Concepcion

Concepción, Chile