Man

Ute Wohlbier

Associate Professor

Universidad Mayor de Chile

Santiago, Chile

Líneas de Investigación


Neurodegeneration, Amyotrophic Lateral Sclerosis, Protein Folding, Autophagy, Mesenchymal Stem Cell Therapy, Gene Therapy

Educación

  •  Ph.D./Dr.rer.nat., UNIVERSITAT HEIDELBERG. Alemania, 2007
  •  M.Sc./Dipl.biol. in Molecular Biology, UNIVERSITAT HEIDELBERG. Alemania, 2003

Experiencia Académica

  •   Associate Professor Full Time

    Universidad Mayor

    Faculty of Science

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad Mayor

    Santiago, Chile

    2013 - 2018

  •   Postdoc Full Time

    Virginia Commonwealth University

    Richmond, Estados Unidos

    2007 - 2010

  •   Postdoc Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - 2013

Formación de Capital Humano


Undergrad theses
1. Catherine Andreu, 2012, Caracterizacion de un modelo murino knockout y transgénico para ERp57 en el sistema nervioso central, Escula de Biotechnologia, Universidad de Chile, co-tutor
2. Fernanda Briceño y Luciano Páez, 2016, Rol de Fam120A en proteopatias asociadas a esclerosis lateral amiotrofica, Facultad de Medicina, Escuela Tecnologia Medico, Universidad Mayor, co-tutor
3. Javiera Arcos, 2016, Caracterización de los niveles de expresión de Beclin1 interactor (BCI), una nueva proteína asociada a autofagia en modelos in vivo de Esclerosis lateral amiotrofica, Facultad de Ciencias, Escuela de Biotecnologia, Universidad Mayor, tutor
4. Constanza Puelles Caceres y Laura Gomez Gomez, 2018, Pacer, una proteina relacionada a la autofagia, y su papel en muerte celular inducida por TNF-a en modelos celulares neuronales, Facultad de Medicina, Escuela Tecnologia Medico, Universidad Mayor, tutor
5. Constanza Bidart y Catalina Ibarra, 2022, Expresión del gen Pacer en cáncer de mama, Escuela Tecnologia Medico, Universidad Mayor, co-tutor

PhD theses
1. Sebastian Beltran, 2014-2018, The role of Pacer in SOD1 protein aggregation, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
2. Luis Labrador, 2016-2020, Pacer, a new link between autophagy and cell death in amyotrophic lateral sclerosis, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
3. Emiliano Vicencio, 2016-2021, Network analysis predicts a role for FAM120A in amyotrophic lateral sclerosis (ALS), Programa de Doctorado en Genomica Integrativa, Universidad Mayor, tutor
4. Miguel Rubilar, 2020-pres, A network-based approach to ALS – Identifying new genes and pathways for disease, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, co-tutor
5. Barbara Saavedra, 2022-pres, The Role of IGF2 Signaling in synapse maintenance and plasticity during aging, Programa de Doctorado en Neurobiologia, Universidad Mayor, co-Tutor
6. Giselle Espinosa, 2022-pres, Role of noradrenaline in the development of Amyotrophic Lateral Sclerosis, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, (ANID Doctoral Fellowship), Tutor
7. Carla Alarcon, 2023-pres, Targeting autophagy deficiencies in autism spectrum disorders to balance neuronal connectivity and stereotypical behaviors, Programa de Doctorado en Neurobiologia, Universidad Mayor, (ANID Doctoral Fellowship), Tutor
8. Leonardo Rodriguez, 2024-pres, Study of the differential effect of gene therapeutic reconstitution of autophaguc protein PACER in two pre-symptomatic stages of amyotrophic lateral sclerosis, Programa de Doctorado en Genomica Integrativa, Universidad Mayor, Tutor

Postdoc
1. Sebastian Beltran, 2018-2020, Pacer and Rubicon a new autophagy related proteins involved in motoneuron survival.



 

Article (28)

Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice

Morgado-Caceres, Pablo; Huerta, Hernan; Bergman, Cristian; Figueroa, Reinaldo; Farias, Paula; Quiroz, Gabriel; Woehlbier, Ute; Mella, Karen; Diaz-Rivera, Osman; Linsambarth, Sergio; et al.

Article ISI
AGING AND DISEASE  (2026)

Expression of protein disulfide isomerase A3Q481K variant associated with amyotrophic lateral sclerosis triggers disease features in mice

Sepulveda, M; Traub, FM; Ojeda, P; Pérez, V; Ojeda, J; Mella, J; Diaz, R; Rozas, P; Mansilla-Jaramillo, M; Zuleta, A; et al.

Article ISI
NEUROBIOLOGY OF DISEASE  (2025)

Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model

Labrador, Luis; Rodríguez, Leonardo; Beltran, Sebastian; Hernandez, Fernanda; Gomez, Laura; Ojeda, Patricia; Bergmann, Cristian; Calegaro-Nassif, Melissa; Kerr, Bredford; Medinas, Danilo B.; et al.

Article ISI
BIOLOGICAL RESEARCH  (2024)

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

Abarzua, Lorena; Hernandez, Fernanda; Manque, Patricio A.

Article ISI
AUTOPHAGY  (2024)

Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome

Vidal, Mabel A.; Henriquez-Beltran, Mario E.; Antilef, Barbara E.; Aguilar, Kevin P.; Castillo, Daniela A.; Llerena, Faryd J.; Figueroa, Marco Fraga; Nazal, Mauricio; Castro, Eritson; Lastra, Jaime J.; et al.

Article ISI
FRONTIERS IN MEDICINE  (2023)

The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains

Rucatti, Guilherme Gischkow; Sanhueza, Mario

Article ISI
SCIENTIFIC REPORTS  (2023)

Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis

Medinas, Danilo Bilches; Malik, Sajid; Yildiz-Bolukbasi, Esra; Borgonovo, Janina; Saaranen, Mirva J.; Pulgar, Eduardo; Contreras, Darwin; Bodaleo, Felipe; Quiroz, Gabriel; Rozas, Pablo; et al.

Article ISI
EMBO JOURNAL  (2022)

Neuronal Rubicon Represses Extracellular APP/Amyloid beta Deposition in Alzheimer's Disease

Oyarce-Pezoa, Sebastian; Fernanda Hernandez, Maria; Uhrig, Markus; Cornejo, Victor H.; Manque, Patricio A.

Article ISI
CELLS  (2022)

The Autophagy Protein Pacer Positively Regulates the Therapeutic Potential of Mesenchymal Stem Cells in a Mouse Model of DSS-Induced Colitis

Bergmann, Cristian A.; Poblete, Cristian; Quijada, Cristobal; Manque, Patricio A.

Article ISI
CELLS  (2022)

DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients and a Transgenic Model of the Disease.

eyton E, Matus D, Espinoza S, Benitez JM, Cortes BI, Gomez W, Arévalo NB, Murgas P, Manque P, Woehlbier U, Duran-Aniotz C, Hetz C, Behrens MI, SanMartín CD, Nassif M.

Article
JOURNAL OF ALZHEIMERS DISEASE  (2021)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)



Article
AUTOPHAGY  (2021)

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

Beltran, S; Vicencio, E; Arcos, J; Labrador L.; Cortes B.I.; Bergmann C.A.; Hernandez M.F.; Matamala, J. M.; Bargsted L.; Manque, PA

Article ISI SCOPUS
MOLECULAR NEURODEGENERATION  (2019)

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis

Rozas, Pablo; Woehlbier, Ute; Bosco, Daryl A.

Article ISI SCOPUS
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  (2018)

Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly

Bolukbasi, EY; Mumtaz, S; Woehlbier, U; Malik, S

Article ISI SCOPUS
JOURNAL OF MEDICAL GENETICS  (2018)

Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility

Yildirim, Y; Ouriachi, T; Ouahioune, W; Balkan, M

Article ISI SCOPUS
EUROPEAN JOURNAL OF HUMAN GENETICS  (2018)

ALS-linked protein disulfide isomerase variants cause motor dysfunction

Woehlbier, U; Colombo, A; Pérez, V; Ojeda, J; Andreu, CI; Torres, M; Valenzuela, V; Rozas, P; Vidal, RL; Salameh J.; et al.

Article ISI SCOPUS
EMBO JOURNAL  (2016)

Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration

Castillo, Valentina; Oate, Maritza; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas, Danilo; Valds, Pamela; Osorio, Fabiola; Mercado, Gabriela; Kerr, Bredford; et al.

Article ISI SCOPUS
PLOS ONE  (2015)

Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients

Gonzalez-Perez, P; Woehlbier, U; Chian, RJ; Sapp, P; Rouleau, GA; Leblond, CS; Daoud, H; Dion, PA; Landers, JE; Hetz, C; et al.

Article ISI SCOPUS
Gene  (2015)

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

Torres, M; Medinas, DB; Matamala, JM; Woehlbier, U; Cornejo, VH; Solda T.; Andreu, C; Rozas, P; Matus, S; Muñoz, N; et al.

Article ISI SCOPUS
Journal of Biological Chemistry  (2015)

Intranasal vaccination in mice with an attenuated Salmonella enterica Serovar 908htr A expressing Cp15 of Cryptosporidium: impact of malnutrition with preservation of cytokine secretion

Roche, JK; Rojo, AL; Costa, LB; Smeltz, R; Manque, P; Woehlbier, U; Bartelt, L; Galen, J; Buck G.

Article SCOPUS
Vaccine  (2013)

Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease

Torres, M; Cartier, L; Matamala, J. M.; Hernandez, N; Woehlbier, U; Hetz, C

Article ISI SCOPUS
PLOS ONE  (2012)

Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis

Manque, Patricio A.; Woehlbier, Ute; Lara, Ana M.; Tenjo, Fernando; Alves, Joao M.; Buck, Gregory A.

Article ISI
PLOS ONE  (2012)

Identification and immunological characterization of three potential vaccinogens against Cryptosporidium species

Manque, PA; Tenjo, F; Woehlbier, U; Lara A.M.; Serrano M.G.; Xu, P; Alves J.M.; Smeltz R.B.; Conrad D.H.

Article SCOPUS
Clinical and Vaccine Immunology  (2011)

Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion

Woehlbier, Ute; Epp, Christian; Hackett, Fiona; Blackman, Michael J.; Bujard, Hermann

Article ISI
MALARIA JOURNAL  (2010)

A multifunctional serine protease primes the malaria parasite for red blood cell invasion

Koussis, Konstantinos; Withers-Martinez, Chrislaine; Yeoh, Sharon; Child, Matthew; Knuepfer, Ellen; Juliano, Luiz; Woehlbier, Ute

Article ISI
EMBO JOURNAL  (2009)

Antibody responses to the merozoite surface protein-1 complex in cerebral malaria patients in India

Tongren, Jon Eric; Jain, Vidhan; Nagpal, Avinash C.; Kauth, Christian W.; Woehlbier, Ute; Dash, Aditya P.; Singh, Neeru; Stiles, Jonathan K.

Article ISI
MALARIA JOURNAL  (2008)

Analysis of antibodies directed against merozoite surface protein 1 of the human malaria parasite Plasmodium falciparum

Epp, C; Kauth, CW; Lutz, R; Long, CA; Coulibaly, B; Kouyate, B; Arevalo-Herrera, M; Bujard, H

Article ISI
INFECTION AND IMMUNITY  (2006)

Interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite Plasmodium falciparum

Woehlbier, Ute; Kern, Michaela; Mekonnen, Zeleke; Lutz, Rolf; Muecke, Norbert; Langowski, Joerg

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (2006)

BookWhole (1)

Systems biology-based approaches applied to vaccine development

Manque, PA; Woehlbier, U

BookWhole SCOPUS
Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications  (2011)

Proyecto (5)

The autophagy protein Pacer as a mediator of motoneuron protection in ALS



Proyecto
 (2020)

A novel therapeutic approach to promote motoneuron survival during Amyotrophic lateral sclerosis pathology

Universidad Mayor (PEP I-2019054)

Proyecto
2019-2020
Inv. Responsable

DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY.

FONDECYT (1150743)

Proyecto
2015-2019
Inv. Responsable

El papel de la nueva proteina BCI en la conectividad y plasticidad neuronal

Universidad Mayor (FIDUM 2014)

Proyecto
2014-2016
Inv. Responsable

THE ROLE OF ER-RESIDENT PROTEIN DISULFIDE ISOMERASES (PDIS) INTHE MISFOLDING AND NEUROTOXICITY OF MUTANT PRP AND SOD1.

FONDECYT (3110067)

Proyecto
2010-2013
Inv. Responsable

Review (4)

Implications of Selective Autophagy Dysfunction for ALS Pathology



Review ISI
CELLS  (2020)

The Enigmatic Role of C9ORF72 in Autophagy



Review ISI SCOPUS
FRONTIERS IN NEUROSCIENCE  (2017)

Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications

Andreu, CI; Woehlbier, U; Torres, M; Hetz, C

Review ISI SCOPUS
FEBS Letters  (2012)

Modulating stress responses by the UPRosome: A matter of life and death

Woehlbier, U; Hetz, C

Review ISI SCOPUS
Trends in Biochemical Sciences  (2011)

10
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Luis Quinones

PROFESOR TITULAR

ONCOLOGIA BASICO-CLINICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Alicia Colombo

Profesora Asociada/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

1
Felipe Zuñiga

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

2
JUAN PABLO HENRIQUEZ

Full Professor

Instituto de Anatomía, Histología y Patología

Universidad Austral de Chile

Valdivia, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

3
René Vidal

Profesor Asociado

Universidad Mayor

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

5
Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

1
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

3
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Paola Murgas

Profesor Investigador Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Puerto Montt, Chile

2
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

1
Julio Cardenas

Associated Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Maria-Isabel Yuseff

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

1
Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

1
Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

1
Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

2
Víctor Cornejo

Profesor Asistente

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Karina Palma

Postdoctorado

Instituto de Neurociencia Biomédica BNI

Universidad de Chile

Santiago, Chile

3
Melissa Calegaro

Principal Investigator, head lab

Research Vice Presidency

Universidad Mayor

Santiago, Chile

1
Claudia Duran-Aniotz

Profesor Asociado

Escuela de Psicología

Universidad Adolfo Ibánez

Santiago, Chile

1
Mario Sanhueza

Regional Director of Research

Universidad Mayor

Temuco, Chile

1
Natalia Salvadores

Profesora Asistente

Centro de Resiliencia, Adaptación y Mitigación

Universidad Mayor de Chile

Temuco, Chile

1
Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

1
Estefania Nova

Associate Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

4
Catherine Andreu

Estudiante de Doctorado

Escuela de Psicología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

34
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

1
Janina Borgonovo

PhD

Programa de Anatomía y Biología del Desarrollo

Universidad de Chile, Facultad de Medicina

Santiago, Chile

1
Gonzalo Labarca

Assistant Profesor in Medicine

Medicina interna

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Mabel Vidal

Associate Professor

Computer Science

Universidad de Concepción

Concepcion, Chile

1
sergio sanhueza

Asistente de investigación

Biquímica Clínica e Inmunología

Universidad de Concepción

Concepcion, Chile

1
Romina Quiroga

Asistente de investigación

Universidad de Concepción

Concepción, Chile

1
Mauricio Hernandez

Chief Laboratory Officer

Proteogenomica

MELISA Institute

San Pedro de la Paz, Chile

1
Jorge Ojeda

Académico investigador

Ciencias Básicas y Morfología

Universidad Católica de la Santisima Concepción

Concepción, Chile

1
Viviana Pérez

Profesor Asistente

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Carlos Rozas

Profesor asistente

Biologia

Universidad de Santiago de Chile

Santiago, Chile

5
Pablo Rozas

Investigador

SymbiOx

Santiago, Chile

1
Mario Henríquez

Investigador

CIBERES

CIBER

Lleida / Lérida, España

1
Wileidy Gómez

Postdoctorado

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Valentina Castillo

Investigadora Postdoctoral

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Grunenwald

Postdoctoral Researcher

CIIB

Universidad de Los Andes

santiago, Chile

3
sandra espinoza

asistente de investigacion

Laboratorio Neuroinmunologia

Fundacion Ciencias para la Vida/Universidad San Sebastian

Santiago, Chile

2
Emiliano Vicencio