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Diego Andrés Rojas Rivera

Assistant Professor

Universidad Mayor

Santiago, Chile

Líneas de Investigación


Cell Death, ER stress, TNF signaling pathway, Apoptosis, Necroptosis. Pharmacology, Bioassays.

Educación

  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2006

Experiencia Académica

  •   Postdoctoral Researcher Full Time

    UNIVERSITY OF GENT

    Inflammation Research Center

    Gent, Bélgica

    2016 - 2018

  •   Postdoctoral Researcher Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2013 - 2015

  •   Assistant professor Full Time

    Universidad Mayor

    Ciencias

    Santiago, Chile

    2018 - A la fecha

  •   Phd student Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2007 - 2012

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad Mayor

    Santiago, Chile

    2018 - A la fecha

Formación de Capital Humano


2016 Study of the contribution of the UPR to TNF-mediated inflammatory response and cell death induction. Scientific supervisor of Master thesis of Science in Biochemistry and Biotechnology, Ghent University. Belgium.

2014-2018 Role of HSP47 on the regulation of IRE1alfa. Co-Advisor of Ph.D. thesis in Biomedical Sciences, University of Chile, Chile.

2019 chairman of self-evaluation committee for the Neurobiology doctoral program, Universidad Mayor, Chile.


Difusión y Transferencia


2013-2014: Coordinator of Seminars “Talks about Neuromedicine” at the Biomedical Neuroscience Institute, Medicine Faculty. University of Chile.


Premios y Distinciones

  •   Mejor Tesis Doctoral

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2015

    Doctoral thesis: “TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis”.

  •   Mejor tesis doctoral en biologia celular de Chile

    Fundación Allende-Connelly

    Chile, 2013

    Doctoral thesis: “TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis”.

  •   Young Scientist Program award

    IUBMB & FEBS

    Chile, 2012

    Premio otorgado por IUBMB & FEBS, 2012

  •   Keystone Symposia Award

    Keystone Symposia

    Chile, 2010

    For assisting “Cell Death Pathways: Apoptosis, Autophagy and Necrosis (X3)”. Vancouver, British Columbia, Canadá.


 

Article (23)

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
ER stress sensing mechanism: Putting off the brake on UPR transducers
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha
BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response (vol 30, pg 4465, 2011)
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress
Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis.
When ER stress reaches a dead end
BAX/BAK and Cyclophilin D-independent intrinsic apoptosis pathway
BH3-only proteins are part of a regulatory network that control the sustained signaling of the UPR sensor IRE1alpha.
TMBIM3/GRINA is a novel Unfolded Protein Response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis.
Alternative functions of the BCL-2 protein family at the endoplasmic reticulum
BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response.
Integrating stress signals at the endoplasmic reticulum=> The BCL-2 protein family rheostat.
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1
Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species.
Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas
Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes

BookReview (1)

Alternative functions of the BCL-2 protein family at the endoplasmic reticulum.

Note (1)

Calcium & ROS: Two orchestra directors for the requiem of death

Review (1)

TMBIM protein family: ancestral regulators of cell death
15
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

3
DENISSE SEPULVEDA

Postdoc

Universidad Mayor de Chile

Santiago, Chile

2
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Melissa Calegaro

Investigadora Principal

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

1
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

1
Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

1
Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

1
Alvaro Glavic

Associate Professor

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

1
Valentina Valenzuela

Investigador adjunto

Universidad de Concepcion

Concepción, Chile

1
Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

1
René Vidal

Profesor Asistente

Universidad Mayor

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile