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DENISSE ELIZABETH SEPULVEDA ALVARADO

Postdoc

Universidad Mayor de Chile

Santiago, Chile

Unfolded protein response (UPR); Endoplasmic reticulum (ER) stress; Autophagy; Exosomal secretion; Neurodegenerative Diseases, Parkinson Disease, Huntington Disease.

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2018
Biología Celular, UNIVERSIDAD DE CHILE. Chile, 2012
Bioingeniera, UNIVERSIDAD DE CONCEPCION. Chile, 2010
Gestión de Calidad , UNIVERSIDAD DE CHILE. Chile, 2011

Profesora Cursos: Fundamentos biológicos y Microbiología Part Time

Universidad del Mar

Ciencias

Santiago, Chile

2012 - 2013

PRODUCT TECHNOLOGIST Full Time

NESTLE

SANTIAGO, Chile

2017 - 2018

Mejor alumna nivel nacional Diplomado Gestión de Calidad y desarrollo organizacional

UNIVERSIDAD DE CHILE-PRODECAL

Chile, 2011

Primer lugar a nivel del nacional del Diplomado Gestión de Calidad y Desarrollo Organizacional. El premio consistió en la asistencia al Foro Mundial de Gestión de Calidad, México, 2012.
Premio Anual Mejor Tesis Doctorado Biología Celular Dr. Federico Leighton 2019

FUNDACIÓN CHILENA PARA LA BIOLOGÍA CELULAR

Chile, 2019

"Investigadora del Instituto Milenio de Neurociencia Biomédica, BNI, obtuvo reconocimiento a la mejor tesis de doctorado, que fue publicada portada y con comentario editorial en prestigiosa revista científica" ..."fue galardonada con el Premio Anual Dr. Federico Leighton, que otorga la Sociedad Chilena de Biología Celular, a la mejor tesis de doctorado."


Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease Sepulveda, Denisse; Cisternas-Olmedo, Marisol; Arcos, Javiera; Nassif, Melissa; Vidal, Rene L. Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)
Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson's disease Sepulveda, Denisse; Grunenwald, Felipe; Vidal, Alvaro; Troncoso-Escudero, Paulina; Cisternas-Olmedo, Marisol; Villagra, Roque; Vergara, Pedro; Aguilera, Carlos; Nassif, Melissa; Vidal, Rene L. Article ISI SCIENTIFIC REPORTS (2022)
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration Vidal, Rene L.; Sepulveda, Denisse; Troncoso-Escudero, Paulina; Garcia-Huerta, Paula; Gonzalez, Constanza; Plate, Lars; Jerez, Carolina; Canovas, Jose; Rivera, Claudia A.; Castillo, Valentina; Cisternas, Marisol; Leal, Sirley; Martinez, Alexis; Grandjean, Julia; Sonia, Donzelli; Lashuel, Hilal A.; Martin, Alberto J. M.; Latapiat, Veronica; Matus, Soledad; Sardi, S. Pablo; Wiseman, R. Luke; Hetz, Claudio Article ISI MOLECULAR THERAPY (2021)
Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response Dufey, Estefanie; Bravo-San Pedro, Jose Manuel; Eggers, Cristian; Gonzalez-Quiroz, Matias; Urra, Hery; Sagredo, Alfredo, I; Sepulveda, Denisse; Pihan, Philippe; Carreras-Sureda, Amado; Hazari, Younis; Sagredo, Eduardo A.; Gutierrez, Daniela; Valls, Cristian; Papaioannou, Alexandra; Acosta-Alvear, Diego; Campos, Gisela; Domingos, Pedro M.; Pedeux, Remy; Chevet, Eric; Alvarez, Alejandra; Godoy, Patricio; Walter, Peter; Glavic, Alvaro; Kroemer, Guido; Hetz, Claudio Article ISI NATURE COMMUNICATIONS (2020)
On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson’s and Huntington’s Disease Troncoso-Escudero, Paulina; Sepulveda, Denisse; Pérez-Arancibia, Rodrigo; Parra, Alejandra V.; Arcos, Javiera; Grunenwald, Felipe; Vidal, Rene L. Article FRONTIERS IN AGING NEUROSCIENCE (2020)
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients Sepúlveda, Denisse; Barrera, María-José; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; González, Sergio; Albornoz, Nicolás; Bahamondes, Verónica; Quest, Andrew F G; Urzúa, Ulises; Molina, Claudio; Leyton, Cecilia; Hermoso, Marcela A; González, María-Julieta Article ISI SCOPUS RHEUMATOLOGY (2018)
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1 alpha Sepulveda, D; Rojas-Rivera, D; Rodriguez, DA; Groenendyk, J; Kohler, A; Lebeaupin, C; Ito, S; Urra, H; Carreras-Sureda, A; Hazari, Y; Vasseur-Cognet, M; Ali, MMU; Chevet, E; Campos, G; Godoy, P; Vaisar, T; Bailly-Maitre, B; Nagata, K; Michalak, M; Sierralta, J; hetz, C Article ISI SCOPUS MOLECULAR CELL (2018)
Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview Dufey E.; Sepulveda D.; Rojas-Rivera, D; hetz C. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis Groenendyk J.; Peng, ZL; Dudek, E; Fan X.; Mizianty, MJ; Dufey E.; Urra, H; Sepulveda D.; Rojas-Rivera, D; Lim, Y; Kim, DH; Baretta, K; Srikanth, S; Gwack, Y; Ahnn, J; Kaufman, RJ; Lee, SK; hetz C.; Kurgan L.; Michalak M. Article ISI SCOPUS SCIENCE SIGNALING (2014)
Oral dryness in Sjögren's syndrome patients. Not just a question of water Castro I, Sepúlveda D; Cortés J, Quest AF; Barrera MJ, Bahamondes V; Aguilera S, Urzúa U; Alliende C, Molina C; González S, Hermoso MA; Leyton C, González MJ. Article Autoimmunity reviews (2013)


ER stress sensing mechanism: Putting off the brake on UPR transducers Rojas-Rivera D.; Rodriguez D.A.; Sepulveda D.; Hetz C. Editorial SCOPUS Oncotarget (2018)


Oral manifestations and their treatment in Sjogren's syndrome Gonzalez S.; Sung, H; Sepulveda D.; Gonzalez, MJ; Molina C. Review ISI ORAL DISEASES (2014)
Sjogren's syndrome and the epithelial target: A comprehensive review Barrera, MJ; Bahamondes, V; Sepulveda D.; Quest, AFG; Castro, I; Cortes, J; Aguilera, S; Urzua, U; Molina C.; Perez, P.; Ewert, P; Alliende C.; Hermoso, MA; Gonzalez S.; Leyton, C; Gonzalez, MJ Review ISI SCOPUS Journal of Autoimmunity (2013)