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Isabel Verónica Castro Masso

Profesora Asociada

Universidad de Chile

Santiago, Chile

Mecanismos celulares y moleculares de la disfunción glandular en pacientes con Enfermedad de Sjögren. Alteraciones en la estructura y función del aparato de Golgi. Glicobiología de las mucinas salivales.

Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2016
Tecnólogo Médico, UNIVERSIDAD DE CHILE. Chile, 2005
Ciencias Biológicas, UNIVERSIDAD DE CHILE. Chile, 2011

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2012 - 2025
Instructor Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2009 - 2011
Ayudante Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2006 - 2008
Profesora Asociada Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2025 - A la fecha

Profesora Asociada Full Time

Universidad de Chile

Santiago, Chile

2025 - A la fecha


Altered mitochondrial ultrastructure in salivary epithelial cells of patients with Sjögren's disease is associated with mitochondrial DNA release and increased activation of pattern recognition receptors: potential use of tofacitinib as therapy Carvajal, Patricia, Castro, Isabel, Urra, Félix, Aguilera, Sergio, González, Sergio, Molina, Claudio, Campos, Salvador, Ramírez, Gonzalo, Chávez, Cristopher, Gutiérrez, Juan, Yáñez, María José, González, María-Julieta, Barrera, María-José. Article WOS ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2026)
Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjogren's disease Castro, Isabel; Carvajal, Patricia; Aguilera, Sergio; Barrera, María-José; Matus, Soledad; Gonzalez, Sergio; Molina, Claudio; González, Maria-Julieta Article ISI SCOPUS Journal of Autoimmunity (2025)
Giantin mediates Golgi localization of Gal3-O-sulfotransferases and affects salivary mucin sulfation in Sjögren's disease patients Nuñez, Matilde, Carvajal, Patricia, Aguilera, Sergio, Barrera, María-José, Matus, Soledad, Couto, Alicia, Landoni, Malena, Boncompain, Gaelle,González, Sergio, Molina, Claudio, Pino, Karina, Indo, Sebastián, Figueroa, Lourdes, González, María-Julieta, Article WOS ISI SCOPUS JCI Insight (2024)
hsa-miR-424–5p and hsa-miR-513c-3p dysregulation mediated by IFN-γ is associated with salivary gland dysfunction in Sjögren's syndrome patients Carvajal, Patricia, Aguilera, Sergio, Jara, Daniela, Indo, Sebastian, Barrera, María-Jose, González, Sergio, Molina, Claudio, Heathcote, Benjamín, Hermoso, Marcela, Castro, Isabel, Gonzalez, María-Julieta Article WOS ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2023)
The integrated stress response is activated in the salivary glands of Sjogren's syndrome patients Bahamondes, Veronica; Jara, Daniela; Matus, Soledad; Hermoso, Marcela Article ISI SCOPUS Frontiers in Medicine (2023)
Identificaciï¿½n de macrï¿½fagos y virus Epstein-Barr en biopsias de pacientes con Sï¿½ndrome de Sjï¿½gren. Gastï¿½n Negro; Isabel Castro; Benjamï¿½n Martï¿½nez; Sergio Aguilera; Claudio Molina; Julieta Gonzï¿½lez; Sergio Gonzï¿½lez Article SCIELO (2022)
Small RNA Expression Profiling Reveals hsa-miR-181d-5p Downregulation Associated With TNF-a Overexpression in Sjögren’s Syndrome Patients. Article ISI SCOPUS Frontiers in Immunology (2022)
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Carvajal, Patricia; Jara, Daniela; Molina, Claudio; González, Sergio; González, María-Julieta Article ISI SCOPUS Autoimmunity Reviews (2021)
Saliva sample for the massive screening of SARS-CoV-2 infection: a systematic review. Article ISI SCOPUS Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2021)
Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren's syndrome Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Matus, Soledad; Carvajal, Patricia; Molina, Claudio; González, Sergio; Jara, Daniela; Hermoso, Marcela; González María-Julieta Article ISI SCOPUS Rheumatology (United Kingdom) (2021)
Type I Interferon dependent hsamiR-145-5p downregulation modulates MUC1 and TLR4 overexpression in salivary glands from Sjögren’s syndrome patients. Article ISI SCOPUS Frontiers in Immunology (2021)
Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Article ISI SCOPUS Rheumatology (United Kingdom) (2020)
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2019)
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients Lagos, Carolina; Jara, Daniela; Leyton, Cecilia Article ISI SCOPUS Clinical Immunology (2018)
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogrens syndrome Article ISI SCOPUS AUTOIMMUNITY REVIEWS (2018)
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients Sepulveda, Denisse; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; Albornoz, Nicolas; Quest, Andrew F. G.; Molina, Claudio; Leyton, Cecilia; Hermoso, Marcela A. Article ISI SCOPUS RHEUMATOLOGY (2018)
Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's syndrome patients Quest, Andrew F.G. Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2016)
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome Sung HH; Castro I.; Gonzalez S.; Aguilera S.; Quest A.F.G.; Bahamondes V.; Alliende C.; Cortes J.; Molina C.; Urzua, U; et al. Article ISI SCOPUS Oral Diseases (2015)
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome? Barrera M.J.; Aguilera S.; Veerman, E; Quest A.F.G.; Diaz-Jimenez D.; Urzua, U; Cortes J.; Gonzalez S.; Castro I.; Molina C.; et al. Article ISI SCOPUS Rheumatology (2015)


Altered Expression of the MicroRNA Biogenesis Machinery Components Correlates with Inflammatory Parameters in Salivary Glands of Patient with Sjogren's Disease Aguilera S.; Carvajal P.; Castro I.; Barrera M.J.; Gonz lez, S; Molina C.; Gonz lez, MJ Abstract ISI ARTHRITIS & RHEUMATOLOGY (2024)
THREE DIMENSIONAL HSG CELLS CULTURE AS A MODEL TO STUDY THE EXOCITIC PROCESS IN SALIVARY GLANDS OF SJOGREN'S SYNDROME PATIENTS Cortes J.; Aguilera S.; Hidalgo J.; Bahamondes V.; Urra H.; Barrera M.J.; Castro I.; Molina C.; Gonzalez S.; Leyton C.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2014)
ARE SALIVARY MUCINS ABLE TO TRIGGER A PROINFLAMMATORY RESPONSE? Barrera M.J.; Aguilera S.; Hermoso M.; Langjahr P.; Cortes J.; Castro I.; Molina C.; Gonzalez S.; Alliende C.; Bahamondes V.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2013)


Mucins in Salivary Gland Development, Regeneration, and Disease with special emphasis on Sjögren’s disease Castro, Isabel, Barrera, María-José, González, Sergio, Aguilera, Sergio, Urzúa, Ulises, Cortés, Juan, Carvajal, Patricia, Jara, Daniela, González, María-Julieta BookSection (2026)
Arquitectura y remodelamiento de la matriz extracelular en glándulas salivales en el síndrome de Sjögren Claudio Molina; Sergio González; Isabel Castro; María-José Barrera; Sergio Aguilera ; María-Julieta González; Anaya, J.M.; Sarmiento-Monroy, J.C.; García-Carrasco, M. BookSection (2017)
Mucins in Salivary Gland Development, Regeneration, and Disease Castro, Isabel; Barrera, María-José; González, Sergio; Aguilera, Sergio; Urzúa, Ulises; Cortés, Juan; González, María- Julieta; Seunghee Cha, DDS, PhD BookSection (2017)


Pro-inflammatory cytokines induce a Golgi stress condition in salivary glands from Sjögren’s syndrome patients and H2S diminishes such stress condition Proyecto (2023)
Cellular stress induced by inflammation alters miRNAs metabolism in salivary glands of Sjögren’s syndrome patients Proyecto (2021)
ASSESSING THE ROLE OF GOLGINS IN THE LOCALIZATION OF GOLGI ENZYMES AND O-GLYCOSYLATION OF SALIVARY MUCINS Castro Masso, Isabel Proyecto (2017)
Cytokines induce alterations in stress response pathways of the endoplasmic reticulum in salivary glands of Sjogrens syndrome patients: can these be modulated by epigenetic mechanisms? Proyecto (2016)


Oral dryness in Sjogren's syndrome patients. Not just a question of water Castro I.; Sepúlveda, D; Cortes J.; Quest A.F.G.; Barrera M.J.; Bahamondes V.; Aguilera S.; Urzua, U; Alliende C.; Molina C.; et al. Review ISI SCOPUS Autoimmunity Reviews (2013)
Sjogren's syndrome and the epithelial target: A comprehensive review Barrera M.J.; Bahamondes V.; Sepúlveda, D; Quest A.F.G.; Castro I.; Cortes J.; Aguilera S.; Urzua, U; Molina C.; Perez P.; et al. Review ISI SCOPUS Journal of Autoimmunity (2013)