Man

Claudio Tomás Molina Castillo

Director Investigación

Universidad San Sebastián

Santiago, Chile

Líneas de Investigación


Síndrome de Sjögren, glándulas salivales, secreción.

Educación

  •  Cirujano Dentista, UNIVERSIDAD DE CHILE. Chile, 1990
  •  Ciencias Odontológicas, UNIVERSIDAD DE CHILE. Chile, 2001
  •  Educación, UNIVERSIDAD MAYOR. Chile, 2008

Experiencia Profesional

  •   Cirujano Dentista Other

    Oficina Particular

    Santiago, Chile

    1990 - A la fecha


 

Article (24)

Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro.
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogrens syndrome
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients
Análisis del ambiente educacional en escuela de odontología chilena
Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients
OSCE as a design enabling test for admission to the dental clinic
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome?
Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients
Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren's Syndrome
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction
Aberrant localization of ezrin correlates with salivary acini disorganization in Sjogren's Syndrome
Disruption of Tight Junction Structure in Salivary Glands From Sjogren's Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure
Gene expression and chromosomal location for susceptibility to Sjogren's syndrome
Severe alterations in expression and localisation of alpha 6 beta 4 integrin in salivary gland acini from patients with Sjogren syndrome
Reduced sulfation of muc5b is linked to xerostomia in patients with Sjogren syndrome
Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome: association with mononuclear cell infiltration
Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjogren's syndrome
Increased acinar damage of salivary glands of patients with Sjögren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios
Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjogren's syndrome patients - Correlation with reduced structural integrity of acini and ducts
Differential expression of matrix metalloproteinases in labial salivary glands of patients with primary Sjogren's syndrome - Mechanisms of exocrine parenchyma destruction

BookSection (3)

Arquitectura y remodelamiento de la matriz extracelular en glándulas salivales
Histopatología de la glándula salival menor
Matriz extracelular de glándulas salivales en el síndrome de Sjögren

Proyecto (9)

CYTOKINES INDUCE ALTERATIONS IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM IN SALIVARY GLANDS OF SÖGREN'S SYNDROME PATIENTS=> CAN THESE BE MODULATED BY EPIGENETIC MECHANISMS?
Cambio en los niveles de metilación de los genes de E-cadherina, MLH1 y p16INK4A y su asociación con la infección por virus papiloma humano, en biopsias de lesiones leucoplásicas
Cambio en los niveles de metilación del DNA y patrones de expresión de miRNA, en muestras de saliva de individuos que consumen tabaco y alcohol. Estudio piloto
ANALYSIS OF MOLECULAR CHANGES IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM AND GOLGI ASSOCIATED WITH SALIVARY GLAND HYPOFUNCTION IN SJOGREN'S SYNDROME PATIENTS
ANALYSIS OF MOLECULAR CHANGES IN STRESS RESPONSE PATHWAYS OF THE ENDOPLASMIC RETICULUM AND GOLGI ASSOCIATED WITH SALIVARY GLAND HYPOFUNCTION IN SJOGREN'S SYNDROME PATIENTS
ALTERACIONES EN LA RUTA EXOCITICA DE GLANDULAS SALIVALES DE PACIENTES CON SINDROME DE SJOGREN Y SUS CONSECUENCIAS EN LA HIPOSECRECION
ALTERACIONES EN LA RUTA EXOCITICA DE GLANDULAS SALIVALES DE PACIENTES CON SINDROME DE SJOGREN Y SUS CONSECUENCIAS EN LA HIPOSECRECION
CARACTERIZACION CELULAR Y MOLECULAR DE COMPLEJOS DE UNION EN ACINOS Y DUCTOS DE GLANDULAS SALIVALES DE PACIENTES CON SINDROME DE SJÖGREN=> EFECTO DE CITOQUINAS.
ALTERACIONES EN LA RELACION MATRIZ EXTRACELULAR- CELULA EPITELIAL=> MECANISMO DE DANO ALTERNATIVOS EN EL SINDROME DE SJOGREN PRIMARIO

Review (4)

Oral manifestations and their treatment in Sjogren's syndrome
Oral dryness in Sjogren's syndrome patients. Not just a question of water
Sjogren's syndrome and the epithelial target: A comprehensive review
Mechanotransduction and epigenetic control in autoimmune diseases
31
Claudio Molina

Director Investigación

Investigación

Universidad San Sebastián

Santiago, Chile

23
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

14
Sergio González

Profesor titular

Patología General y Oral

Universidad Mayor

Santiago, Chile

11
ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

10
Isabel Castro

Profesor Asistente

Tecnología Médica

Universidad de Chile

Santiago, Chile

8
Sergio Aguilera

Reumatólogo

CLÍNICA INDISA

Santiago, Chile

8
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

6
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

5
María Barrera

Profesor Asistente

Odontología

Universidad San Sebastián, Facultad de Odontología

Santiago, Chile

3
Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

3
DENISSE SEPULVEDA

Postdoc

Universidad Mayor de Chile

Santiago, Chile

2
Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Luisa Herrera

Profesor Asociado

Incstituto de Ciencias Biomédicas, Programa de Genética Humana

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA-ICBM

Santiago, Chile

1
Marcela Julio

Profesor Adjunto

Instituto de Química

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

Valparaiso, Chile

1
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
David Diaz

Asistente de Investigación

Instituto de Ciencias Biomédicas, Facultad de Medicina

Universidad de Chile

Santiago, Chile