Man

Patricio Andres Manque Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

Líneas de Investigación


Genomics, Neurodegeneration, Vaccine Development, Systems Biology, Genetics

Educación

  •  Medical Technologist, UNIVERSIDAD DE ANTOFAGASTA. Chile, 1995
  •  Microbiology and Immunology, ESCOLA PAULISTA DE MEDICINA. Brasil, 2001

Experiencia Académica

  •   Post Doctoral Fellow Full Time

    ESCOLA PAULISTA DE MEDICINA

    Medicine

    Sao Paulo, Brasil

    2001 - 2002

  •   Post Doctoral Fellow Full Time

    VIRGINIA COMMONWEALTH UNIVERSITY

    Medicine

    Richmond, Estados Unidos

    2002 - 2006

  •   Senior Research Associate Full Time

    VIRGINIA COMMONWEALTH UNIVERSITY

    Medicine

    Richmond, Chile

    2006 - 2009

  •   Fellow Other

    VIRGINIA COMMONWEALTH UNIVERSITY

    Center for the Study of Biological Complexity

    Richmond, Chile

    2002 - 2009

Experiencia Profesional

  •   Associate Professor, Director Center for Genomics and Bioinformatics Full Time

    Universidad Mayor

    Santiago, Chile

    2009 - 2015

  •   Dean, Faculty of Sciences Full Time

    Universidad Mayor

    Santiago, Chile

    2013 - A la fecha

  •   FULL PROFESSOR, CENTER FOR INTEGRATIVE BIOLOGY Full Time

    UNIVERSIDAD MAYOR

    Chile

    2016 - A la fecha

  •   VICE PRESIDENT OF RESEARCH Full Time

    UNIVERSIDAD MAYOR

    Chile

    2016 - A la fecha

Formación de Capital Humano


Undergraduate Thesis:
Camila Gherardelli and Emiliano Vicencio (2011-­?2012). Biotechnology thesis. Universidad Mayor
Javiera Quintana and Romina Paillao (2011-­?2012). Biotechnology thesis. Universidad Mayor
Jose Escalona and Michel Leiva (2011). Medical technology thesis. Universidad Mayor

Undergradate Research Program (Pre thesis)
Valeria Labra, Biotechnology major, Universidad Mayor
Javiera Arcos, Biotechnology major, Universidad Mayor

Ph.D. Students:
Jose Manuel Matamala (2011-­?present, co-­?advisor with Claudio Hetz). Ph.D. program in medical sciences, neurology. Department of Neurological sciences. University of Chile
Sebastian Beltran, Ph.D. Program in Integrative Genomics, Universidad Mayor (2014-2018)
Cristian Muñoz, Ph.D. Program in Integrative Genomics, Universidad Mayor (2014-2018)

Post-­doctoral fellows
Dr. Fernando Tenjo (2006-2009)
Dr. Nicole Trombert (2011-­?2012)
Dr.Melissa Calegaro Nassif (2013-2016)



 

Article (36)

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis.
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs.
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.
The Enigmatic Role of C9ORF72 in Autophagy.
High quality RNA extraction from Maqui berry for its application in next-generation sequencing.
Deep Sequencing Reveals the Complete Genome and Evidence for Transcriptional Activity of the First Virus-Like Sequences Identified in Aristotelia chilensis (Maqui Berry)
Revisiting the reference genomes of human pathogenic Cryptosporidium species: reannotation of C. parvum Iowa and a new C. hominis reference
Draft Genome Sequence of Virulent Strain AUSTRAL-005 of Piscirickettsia salmonis, the Etiological Agent of Piscirickettsiosis.
Draft Genome Sequence of Virulent Strain AUSTRAL-005 of Piscirickettsia salmonis, the Etiological Agent of Piscirickettsiosis.
The Effect of Tunicamycin on the Glucose Uptake, Growth, and Cellular Adhesion in the Protozoan Parasite Crithidia fasciculata
Intranasal vaccination in mice with an attenuated Salmonella enterica Serovar 908htr A expressing Cp15 of Cryptosporidium: impact of malnutrition with preservation of cytokine secretion
Results of external quality assessment for proviral DNA testing of HIV tropism in the Maraviroc Switch collaborative study
Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis
Identification and characterization of a novel calcium-activated apyrase from Cryptosporidium parasites and its potential role in pathogenesis.
Identification and immunological characterization of three potential vaccinogens against Cryptosporidium species
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes
A genome-scale metabolic model of Cryptosporidium hominis
Protein and mRNA content of TcDHH1-containing mRNPs in Trypanosoma cruzi
Proteomic analysis reveals the dynamic association of proteins with translated mRNAs in Trypanosoma cruzi
Putative cis-regulatory elements associated with heat shock genes activated during excystation of Cryptosporidium parvum
Sera of Chagasic patients react with antigens from the tomato parasite Phytomonas serpens
Over-expression and localization of a host protein on the membrane of Cryptosporidium parvum infected epithelial cells
Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi
T-bet-dependent regulation of CD8+ T-cell expansion during experimental Trypanosoma cruzi infection
The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
Cryptosporidium hominis infection of the human respiratory tract
Genome of the opportunistic pathogen Streptococcus sanguinis
The genome of Cryptosporidium hominis
Cell adhesion and Ca2+ signaling activity in stably transfected Trypanosoma cruzi epimastigotes expressing the metacyclic stage-specific surface molecule gp82
Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi
Characterization of the cell adhesion site of Trypanosoma cruzi metacyclic stage surface glycoprotein gp82
Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells
Infectivity of Trypanosoma cruzi strains is associated with differential expression of surface glycoproteins with differential Ca2+ signalling activity.
Serum antibodies to Trypanosoma cruzi antigens in Atacameños patients from highland of northern Chile
Levels of anti-Gal antibodies in persons infected and non-infected with Trypanosoma cruzi. Probably induced by bacteria and by the parasite

BookSection (2)

ystems Biology-­‐based Approaches Applied to Vaccine Development
Cell co-­‐ infections with non-­‐viral pathogens and the construction of doubly infected phagosomes

BookWhole (1)

Systems biology-based approaches applied to vaccine development

Proyecto (15)

DEFINING THE ROLE OF KIAA0226L/C13ORF18 IN THE AUTOPHAGY/ENDOLYSOSOMAL PATHWAY DURING ALS PATHOLOGY.
LOSS OF KEY FUNCTIONS DRIVES SALMONELLA TYPHI ADAPTIVE PATHOGENESIS TO HUMANS
ANALYSIS OF GENE REGULATORY NETWORKS THAT MODULATE BEHAVIOR UPON BACTERIAL PATHOGENESIS
Analysis of gene regulatory networks that modulate behavior upon bacterial pathogenesis.
C13ORF18/BECLIN1-INTERACTING PROTEIN(BCI)=>DEFINING THE ROLE OF A NOVEL AUTOPHAGY-RELATED PROTEIN TO AMYOTROPHIC LATERAL SCLEROSIS
DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS
DIAPAUSE FORMATION SIGNALED BY THE RNAI MACHINERY AS A NOVEL INNATE DEFENSE MECHANISM AGAINST BACTERIAL PATHOGENS.
Neuronal network-based initiative (NBI): Understanding the causes of neuronal vulnerability in disease
Iniciativa de Red Neuronal (IRN)=> Entendiendo las Causas de la Vulnerabilidad Neuronal Diferencial en Enfermedades
The usefulness of Maraviroc in patients with limited therapeutic options and current undetectable VL with previous failure. Genetic tropism by ultra-sequencing techniques
Functional genomics of Cryptosporidium parvum
Cryptosporidium parvum genomics, pathogenesis and vaccinology
ryptosporidium parvum genomics, pathogenesis and vaccinology
Functional genomics of metacyclogenesis in T. cruzi
Functional genomics of Cryptosporidium parvum
38
Patricio Manque

VICE PRESIDENT FOR RESEARCH AND FULL PROFESSOR

UNIVERSIDAD MAYOR

Santiago, Chile

5
Ute Wohlbier

Associate Professor

Center for Integrative Biology

Universidad Mayor de Chile

Santiago, Chile

2
Jorge Araya

Profesor Asociado

Departamento de Tecnología Médica

Universidad de Antofagasta

Antofagasta, Chile

1
Danilo Bilches

Staff Scientist

Instituto de Neurociencia Biomedica

Santiago, Chile

1
Esteban Cordero

Assistant Professor

Universidad Mayor

Santiago, Chile

1
Diego Rojas

Assistant Professor

Center for Integrative Biology

Universidad Mayor

Santiago, Chile

1
Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

1
Ulises Vergara

Profesor Titular

Patología

Facultad de Ciencias Veterinarias y Pecuarias- Universidad de Chile

Santiago, Chile

1
Vinicius Ramos Henriques

Profesor Asistente

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

1
Carolina Sanchez

Assistant Professor, Faculty of Science; Principal Investigator of Advanced Genomics Laboratory; Head of DNA Sequencing Core of the Center for Genomics and Bioinformatics

Center for Genomics and Bioinformatics

Universidad Mayor

Santiago, Chile

1
Claudio Hetz

Deputy Director

INSTITUTO DE CIENCIAS BIOMÉDICAS, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
RUBEN MERCADO

Academico

Pediatria y Cirugia Infantil Occidente

UNIVERSIDAD DE CHILE. FACULTAD DE MEDICINA. UNIDAD DOCENTE DE PARASITOLOGÍA.

Santiago, Chile