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Rene Felipe Baudrand Biggs

Profesor Asociado

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


I am interested in clinical and translational research regarding the dysregulation of adrenal hormones (aldosterone and cortisol) in cardiometabolic disorders such as hypertension, metabolic syndrome, dyslipidemia, insulin resistance and fatty liver.

Educación

  •  Médico-cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
  •  Internista, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005
  •  Endocrinologo, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Cardiovascular Endocrinology, HARVARD UNIVERSITY. Estados Unidos, 2014

Experiencia Académica

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2009 - A la fecha

Experiencia Profesional

  •   Post Doctoral Fellow Full Time

    Brigham and Womens Hospital

    Boston, Estados Unidos

    2012 - 2014

  •   Clínico Part Time

    Red de Salud UC

    Santiago, Chile

    2002 - A la fecha


 

Article (52)

Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome
Detection of a novel severe mutation affecting the CYP21A2 gene in a Chilean male with salt wasting congenital adrenal hyperplasia
Urinary sodium-to-potassium ratio and plasma renin and aldosterone concentrations in normotensive children
The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism
Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome
Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism
Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism.
Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency.
Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation.
The Expanding Spectrum of Primary Aldosteronism=> Implications for Diagnosis, Pathogenesis, and Treatment.
The Low-Renin Hypertension Phenotype=> Genetics and the Role of the Mineralocorticoid Receptor.
Continuum of Renin-Independent Aldosteronism in Normotension
Continuum of Renin-Independent Aldosteronism in Normotension.
Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort
Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity
Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity.
The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension A Cohort Study
The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension=> A Cohort Study.
Tumor-induced osteomalacia: experience from a South American academic center
Tumor-induced osteomalacia=> experience from a South American academic center.
Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis
Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis.
Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension.
Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism
Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism.
Usefulness and Pitfalls in Sodium Intake Estimation=> Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults
Usefulness and Pitfalls in Sodium Intake Estimation=> Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults.
A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics
Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis
Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake.
Variants in Striatin Gene Are Associated With Salt-Sensitive Blood Pressure in Mice and Humans
High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome
Identification of novel 11 beta-HSD1 inhibitors by combined ligand- and structure-based virtual screening
LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids
Long-term dietary sodium restriction increases adiponectin expression and ameliorates the proinflammatory adipokine profile in obesity
Polymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population
Statins and Musculoskeletal Adverse Events
Age-Related Changes in 11 beta-Hydroxysteroid Dehydrogenase Type 2 Activity in Normotensive Subjects
The estimation of visceral adipose tissue with a body composition monitor predicts the metabolic syndrome
11 beta-Hydroxysteroid Dehydrogenase Type 2 Polymorphisms and Activity in a Chilean Essential Hypertensive and Normotensive Cohort
A New Presentation of the Chimeric CYP11B1/CYP11B2 Gene With Low Prevalence of Primary Aldosteronism and Atypical Gene Segregation Pattern
Overexpression of 11 beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease
An Ultrasound Model to Discriminate the Risk of Thyroid Carcinoma
Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and beta cell dysfunction
Overexpression of hepatic 5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients
11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
Hypoadiponectinemia and its Association with Liver Fibrosis in Morbidly Obese Patients
Non-alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C-reactive protein in Hispanics

BookWhole (1)

Endocrinologia Clínica

EditorialMaterial (1)

Mineralocorticoid receptor throughout the vessel: a key to vascular dysfunction in obesity

Letter (1)

Response to Letter Regarding Article, "statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects"

Proyecto (9)

ADRENAL DYSREGULATION IN CHILDREN BORN EXTREMELY PRETERM=> THE ROLE OF INCREASED MINERALOCORTICOID RECEPTOR ACTIVATION ON BLOOD PRESSURE AND VASCULAR DAMAGE
ALDOSTERONE DYSREGULATION IN METABOLIC SYNDROME, OBESITY AND INFLAMMATION=> CLINICAL AND IN VITRO STUDIES.
“Nuevos Métodos para el diagnóstico de Hipercortisolismo subclínico de origen suprarrenal"
LIVER INJURY IN NON-ALCOHOLIC FATTY LIVER DISEASE=> EXPLORING NEW MODULATORS AND BIOMARKERS
NOVEL BIOCHEMICAL AND EPIGENETIC STUDIES IN 11BETA-HYDROXYSTEROID DEHYDROGENASE 2 GENE AS A TARGET FOR ENDOCRINE HYPERTENSION.
"Aldosterone dysregulation and cardiometabolic risk factors"
SALT INTAKE IN ESSENTIAL HYPERTENSION=> STUDIES OF NEW BIOCHEMICAL AND GENETIC MECHANISMS TO IDENTIFY ITS ETIOLOGY
“NUEVOS FÁRMACOS PARA EL TRATAMIENTO DE LA HIPERTENSIÓN Y EL SÍNDROME METABÓLICO”
Desarrollo de test diagnostico para la determinación de etiología de hipertensión

Review (6)

The Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and Treatment
The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor
Aldosterone Production and Signaling Dysregulation in Obesity
Cortisol dysregulation in obesity-related metabolic disorders
Aldosterone's mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin
Adipose tissue as an endocrine modulator: Hormonal changes associated with obesity
45
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

20
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

14
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

7
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

6
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

5
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

4
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

4
jose dominguez

Profesor Asistente

Endocrinologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

4
Alex Escalona

Assistant Professor

Cirugía Digestiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

4
Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

3
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

3
Paul Vöhringer

Profesor Asociado

Psyquiatría

CLINICA PSIQUIÁTRICA UNIVERSITARIA

Santiago, Chile

2
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Javiera Cornejo

Academica

Medicina Preventiva

FAVET, Universidad de Chile

Santiago, Chile

2
Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

2
Javiera Sateler

Profesor instructor

Ciencias Clínicas

Universidad Católica del Maule

Talca, Chile

2
Betty San Martin

Directora

Ciencias Clínicas

UNIVERSIDAD DE CHILE, FAC. CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Pamela Trejo

Endocrinologist

Internal Medicine

Clinica Alemana Santiago

Santiago, Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pablo Florenzano

Instructor

Endocrinologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Roberto Candia

Profesor Asistente

Gastroenterologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Manuel Espinoza

Profesor Asociado

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Juan Tichauer

Bioquímico

Medicina intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Macarena Jiménez

Residente

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gilberto González

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Arab

Assistant Professor

Gastroenterologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Jose Garcia

Profesor Asistente Adjunto

Estadistica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María Rodríguez

Profesora Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pia Villarroel

Docente investigador

UNIVERSIDAD MAYOR

Santiago, Chile

1
Carolina Loureiro

Instructor Adjunto

Pediatria

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis Toro

Profesor Asistente

Departamento de Medicina

Universidad de Chile

Santiago, Chile