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Juan Pablo Arab Verdugo

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


My main interests are translational and clinical research in alcohol-related liver disease and non-alcoholic fatty liver disease. As well as its complications such as liver fibrosis, cirrhosis, and hepatocellular carcinoma.

Educación

  •  Medical Doctor, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
  •  Medicina Interna, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
  •  Gastroenterología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2016
  •  Gastroenterology & Hepatology, MAYO CLINIC FOUNDATION. Estados Unidos, 2017
  •  Clinical and Transplant Hepatology, Hepatobiliary Neoplasia Fellowship, MAYO CLINIC FOUNDATION. Chile, 2018

Experiencia Académica

  •   Instructor of Medicine Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2016 - 2018

  •   Assistant Professor of Medicine Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Residente Medicina Interna Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2011 - 2014

  •   Residente Gastroenterología Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2014 - 2016

  •   Académico Gastroenterología y Hepatología Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2016 - A la fecha

Premios y Distinciones

  •   Beca escuela de medicina- Medicina Interna

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2011

    En soporte a la residencia de Medicina Interna

  •   Beca Escuela de medicina-Gastroenterología

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2014

    Beca para cursar la residencia de Gastroenterología

  •   Presentación plenaria

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2014

    XLI Chilean Congress of Gastroenterology.“High frequency of PNPLA3 rs738409 (I148M) polymorphism in the Chilean population: association with non-alcoholic fatty liver disease risk and histological severity”

  •   Premio San Lucas

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2014

    "Premio al residente que representa la unión entre academia y vocación de servicio"

  •   Mención Honrosa

    II Latin-American Conference on Residency Education

    Chile, 2015

    Presentación Oral. "Burnout among residents of specialties and subspecialties: quantitative analysis and associations"

  •   Clinical and Translational Research Fellowship in Liver Diseases Award

    American Association for the Study of Liver Diseases (AASLD)/ Liver Institute and Foundation for Education and Research (LIFER)

    Estados Unidos, 2016

    Premio a la residencia en investigación clínica y traslacional en enfermedades hepáticas.

  •   Young Investigator Full Bursary

    American Association for the Study of Liver Diseases (AASLD)/ European Association for the study of the liver (EASL)

    Reino Unido, 2017

    EASL-AASLD joint meeting “Definition, therapeutic advances and clinical endpoints in alcoholic liver disease and alcoholic hepatitis”

  •   Premio al mejor estudio chileno publicado durante el 2016

    SOCIEDAD MEDICA DE SANTIAGO

    Chile, 2017

    Congreso Chileno de Medicina Interna 2017

  •   Representante de Chile

    Asociación Latinoamericana para el Estudio del Higado (ALEH)

    Chile, 2017

    Representante de Chile para el comité de investigadores jóvenes.

  •   Fellow Travel Award

    American Association for the Study of Liver Diseases (AASLD)

    Estados Unidos, 2018

    AASLD Foundation Fellow Travel Award for the abstract "Transcriptional Dysregulation of Inflammatory Gene Networks in Alcoholic Hepatitis is Associated with Genome-wide Reconfiguration of Epigenetic States"

  •   Premio a la mejor investigación original en el campo de la Hepatología

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2018

    XLV Congreso Chileno de Gastroenterología.

  •   Premio "Dr. Jaime Chesta Riquelme"

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2018

    Premio "Dr. Jaime Chesta Riquelme" para el Investigador joven en Gastroenterología XLV Congreso Chileno de Gastroenterología.

  •   Premio a la mejor investigación original.

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2018

    XLV Congreso Chileno de Gastroenterología.


 

Article (84)

Baveno VI and Expanded Baveno VI criteria successfully predicts the absence of high-risk gastro-oesophageal varices in a Chilean cohort
Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles
Circulating extracellular vesicles carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis
Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12
Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis
The L‐α‐lysophosphatidylinositol/GPR55 system induces the development of non‐alcoholic steatosis and steatohepatitis
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.
Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension.
"Old remedies to heal the liver=> novel effects of digoxin in hepatic sterile inflammation".
Gut-liver axis, cirrhosis and portal hypertension: the chicken and the egg
Gut-liver axis, cirrhosis and portal hypertension=> the chicken and the egg.
Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease.
Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease=> Beneficial Hepatic and Systemic Effects of Hormone Supplementation.
The Evolving Role of Liver Biopsy in Non-alcoholic Fatty Liver Disease
The Evolving Role of Liver Biopsy in Non-alcoholic Fatty Liver Disease
[Direct antivirals for the treatment of chronic hepatitis C virus infection. Experience in 106 patients].
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis.
Bile Acids and Nonalcoholic Fatty Liver Disease: Molecular Insights and Therapeutic Perspectives
Bile acids and nonalcoholic fatty liver disease=> Molecular insights and therapeutic perspectives.
Bile Acids and Portal Hypertension
Bile Acids in Cholestasis and its Treatment.
Nuevas terapias orales de acción directa para tratamiento de virus de hepatitis C (VHC)
Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.
Use of Statins in Patients with Chronic Liver Disease and Cirrhosis=> Current Views and Prospects.
High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic patients.
[Chilean consensus of prevention, diagnosis and treatment of Clostridium difficile-associated diarrhea].
[Persistent elevation of aspartate aminotransferase (AST) due to the presence of macro-AST=> Report of one case].
Achieving protection against HBV in HIV patients=> Finding the best strategy.
CD4/CD8 ratio as a predictor of the response to HBV vaccination in HIV-positive patients: A prospective cohort study
CD4/CD8 ratio as a predictor of the response to HBV vaccination in HIV-positive patients=> A prospective cohort study.
Chilean consensus of prevention, diagnosis and treatment of Clostridium difficile-associated diarrhea
Statins and portal hypertension=> A tale of two models.
Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome=> A Delphi technique-based consensus.
[Assessment for learning=> experience in an undergraduate medical theoretical course].
[Development of MEDUC-PG14 survey to assess postgraduate teaching in medical specialties].
[Introduction of virtual patients to clinical case portfolios for undergraduate medical students].
Assessment for learning: experience in an undergraduate medical theoretical course
Assessment for learning: Experience in an undergraduate medical theoretical course [Evaluación para el aprendizaje: Experiencia en un curso teórico de pregrado en medicina]
Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis
Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis.
Development of MEDUC-PG14 survey to assess postgraduate teaching in medical specialties
Evaluación de docentes clínicos de Postgrado: desarrollo y propiedades psicométricas del instrumento MEDUC-PG14
Evaluación para el aprendizaje: experiencia en un curso teórico de pregrado en medicina
Gastrointestinal neuroendocrine tumor with unresectable liver metastases: An example of multimodal therapeutic approach
Incorporación de paciente virtual en portafolio de estudiantes de medicina de pregrado
Intrahepatic portal vein blood volume estimated by non-contrast magnetic resonance imaging for the assessment of portal hypertension
Intrahepatic portal vein blood volume estimated by non-contrast magnetic resonance imaging for the assessment of portal hypertension.
Introduction of virtual patients to clinical case portfolios for undergraduate medical students
[Treatment of diabetic ketoacidosis using 2009 American Diabetes Association guidelines].
Bile acid supplementation improves established liver steatosis in obese mice independently of glucagon-like peptide-1 secretion
Bile acid supplementation improves established liver steatosis in obese mice independently of glucagon-like peptide-1 secretion.
Cetoacidosis diabética: Casuística 2008-2012, epidemiología y fisiopatología
Effects of bile acid sequestration on hepatic steatosis in obese mice
Management of Helicobacter pylori infection in Latin America=> a Delphi technique-based consensus.
Management of nonalcoholic fatty liver disease: An evidence-based clinical practice review
Management of nonalcoholic fatty liver disease=> an evidence-based clinical practice review.
Treatment of diabetic ketoacidosis using 2009 American Diabetes Association guidelines
[Serum levels of alanine aminotransferase in Chilean population=> analysis of results of the national health survey 2009-2010].
Hepatic encephalopathy in a liver transplant recipient with stable liver function
Hepatic encephalopathy in a liver transplant recipient with stable liver function.
Niveles séricos de alanino-aminotransferasa en población chilena: análisis de los resultados de la encuesta nacional de salud 2009-2010
Serum levels of alanine aminotransferase in Chilean population: analysis of results of the national health survey 2009-2010
[Basic cardiopulmonary resuscitation=> knowledge, practical skills and effectiveness of maneuvers of general physicians].
Basic cardiopulmonary resuscitation: knowledge, practical skills and effectiveness of maneuvers of general physicians
Reanimación cardiopulmonar básica: conocimiento teórico, desempeño práctico y efectividad de las maniobras en médicos generales
Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs.
Plasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease
[Pneumonia caused by Streptococcus pyogenes. Report of one case].
Pneumonia caused by Streptococcus pyogenes. Report of one case
Pneumonia caused by Streptococcus pyogenes. Report of one case Bacteriemia por streptococcus pyogenes. Presentación de un caso clínico con aparición tardía de neumonía
Effects of Japanese herbal medicine inchin-ko-to on endotoxin-induced cholestasis in the rat
Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice
Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice.
Alcohol-related liver disease=> Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH).
Black hairy tongue during interferon therapy for hepatitis C.
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Early warning of liver disease in diabetics.
Effects of bile acid sequestration on hepatic steatosis in obese mice.
Effects of Japanese herbal medicine Inchin-ko-to on endotoxin-induced cholestasis in the rat.
Gastrointestinal neuroendocrine tumor with unresectable liver metastases=> an example of multimodal therapeutic approach.
Plasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease.
Serum cytokeratin-18 fragment levels as noninvasive marker of nonalcoholic steatohepatitis in the chilean population.
 High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic patients.

Abstract (3)

High prevalence of PNPLA3 rs738409 (I148M) polymorphism in Chilean latino population and its association to non-alcoholic fatty liver disease risk and histological disease severity
High prevalence of undiagnosed liver cirrhosis and advanced fibrosis in type 2 diabetic outpatients
Downregulation of the ileal enterokine fibroblast growth factor-15 during pregnancy in mice

BookWhole (2)

UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications
Liver Disease: A Neglected Complication of Diabetes Mellitus

CaseReport (2)

Aumento aislado y sostenido de aspartato aminotransferasa por presencia de macroenzimas: Caso clínico
Bacteriemia por Streptococcus pyogenes: Presentación de un caso clínico con aparición tardía de neumonía

Note (1)

Black hairy tongue during interferon therapy for hepatitis C

Proyecto (4)

Assessing the role of bile acids (BA) in NASH-related hepatocellular carcinoma
Dissecting therapeutic role of Growth Hormone and Insulin-like Growth Factor 1 in chronic liver disease=> balancing between hepatocyte protection and oncogenic potential
Liver injury in alcoholic liver disease=> exploring new modulators and biomarkers
DESARROLLO Y VALIDACION DE UN INSTRUMENTO DE MEDICION DEL AMBIENTE EDUCACIONAL EN EL PROCESO DE APRENDIZAJE EN PROGRAMAS DE POSGRADO EN MEDICINA AMBULATORIA.

Review (4)

Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH)
Concurrent nonalcoholic fatty liver disease and type 2 diabetes: diagnostic and therapeutic considerations
Gut microbiota in non-alcoholic fatty liver disease and alcohol-related liver disease: Current concepts and perspectives
Early warning of liver disease in diabetics
50
Juan Arab

Assistant Professor

Gastroenterologia

Pontificia Universidad Católica de Chile

Santiago, Chile

27
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

16
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

12
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

11
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Alberto Sarfatis

Profesor Clínico Asistente

Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

4
Andres Aizman

Assitant Professor

Internal Medicine

Pontificia Universidad Católica de Chil

Santiago, Chile

3
Roberto Candia

Profesor Asistente

Gastroenterologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
luis rojas

Profesor asistente

Medicina Interna

Pontificia Universidad católica de Chile. Facultad de Medicina, Escuela de Medicina

Santiago, Chile

2
Alejandro Delfino

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
paula margozzini

Académico investigador y profesor Asistente

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marcela Bitran

Profesor Asociado

Escuela de Medicina

Pontificia Universidad Catolica de Chile

Santiago , Chile

1
Gonzalo Latorre

Médico Internista

Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Martinez

Profesor Encargado de Asignatura

Medicina Interna

UNIVERSIDAD ANDRÉS BELLO

Viña del Mar, Chile

1
Eduardo Abbott

Profesor Asistente

Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alberto Espino

Jefe Unidad Endoscopia Hospital Clínico UC-Christus

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jose Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Facultad de Odontologia, Universidad de Chile

Santiago, Chile

1
Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Marcela Quintanilla

Coordinadora Unidad de Investigación

Facultad Enfermeria y Obstetricia

Universidad de los Andes

Santiago, Chile

1
Rodrigo Quera

Gastroenterólogo

Gastroenterología

CLÍNICA LAS CONDES, SERVICIO DE GASTROENTEROLOGÍA

Santiago, Chile

1
Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Cristian Tejos

Associate professor

Department of Electrical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Hugo Monrroy

Instructor Adjunto

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Guerra

Jefe Unidad de Trasplante

Cirugia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alex Escalona

Assistant Professor

Cirugía Digestiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Danisa Ivanovic-Zuvic

Fellowship en Investigación

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandra Hernández

Investigador postdoctoral

Gastroenterología

CARE-Chile

Santiago, Chile

1
Valentina Serrano

PROFESOR ASISTENTE

NUTRICION, DIABETES Y METABOLISMO

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Maria Cuellar

Medico Reumatologo

Medicina

Hospital del Salvador

santiago, Chile