Man

Rómulo Eduardo Melo Monsalve

Neurosurgeon

Instituto de Neurocirugía Dr. Asenjo

Santiago, Chile

Líneas de Investigación


Multiple drugs resistance; glioblastoma; chemotherapy; Molecular epidemiology of pathogen agents; TUMORES CEREBRALES; PATOLOGIA DE NERVIO PERIFERICO; PATOLOGIA CEREBRO VASCULAR.

Educación

  •  Medical Doctor, UNIVERSIDAD DE CONCEPCION. Chile, 1985
  •  Neurosurgery, UNIVERSIDAD DE CHILE. Chile, 1989

Experiencia Académica

  •   Assistant Neurosurgery Other

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    1992 - 1995

  •   Instructor of Neurosurgery Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1995 - 2001

  •   Assistant Professor of Neurosurgery Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2001 - 2011

  •   Associate Professor of Neurosurgery Other

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2011 - 2017

  •   Chief Residency Program in Neurosurgery Department. Neurological Sciences Fac. Of Medicine U of Chile in Asenjo Neurosurgery Institute Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1992 - 2017

  •   Neurosurgeon Full Time

    Instituto de Neurocirugía Dr. Asenjo

    Santiago, Chile

    1992 - A la fecha

Experiencia Profesional

  •   Neurological Surgeon Other

    Hospital Base Puerto Montt

    Puerto Montt, Chile

    1989 - 1992

  •   Neurological Surgeon Other

    Inst. de Neurocirugía Dr. Asenjo

    Santiago, Chile

    1992 - A la fecha

  •   Neurological Surgeon Other

    Hospital de Urgencia Asistencia Pública

    Santiago, Chile

    1996 - A la fecha

  •   Neurological Surgeon Other

    Clínica Alemana

    Santiago, Chile

    2005 - A la fecha

  •   Chief Residency Program in Neurosurgery Department. Neurological Sciences Fac. Of Medicine U of Chile in Asenjo Neurosurgery Institute Other

    Universidad de Chile

    Santiago, Chile

    1992 - 2017

  •   Director del Departamento de Ciencias Neurológicas Oriente. Facultad de Medicina. Other

    Universidad de Chile

    Santiago, Chile

    2010 - 2017

Formación de Capital Humano


-Chief Residency Program in Neurosurgery Department. Neurological Sciences Medicine Faculty Universidad de Chile in Asenjo Neurosurgery Institute. 1992-2017
-Examen Especialidad Victor Zepeda 30/07/2010
-Examen especialida Eduardo Wichman 23 al 29 de Agosto 2010
-Examen Especialidad Jaime Fuentes 30 agosto al 3 de Septiembre 2010


Difusión y Transferencia


Diffusion
-Conference "Neuromiotizations in irreparable nerve injuries" Symposium Pain and Neurophysiology Latin American Congress of Neurology, March 1 to 3, 2012, Santa Cruz Bolivia.
-Conference "Neurophysiological monitoring, a neurosurgical vision" Symposium Pain and Neurophysiology Latin American Congress of Neurology, March 1 to 3, 2012, Santa Cruz Bolivia.
-Conference "Surgery of the nervous entrapments" Symposium Pain and Neurophysiology Latin American Congress of Neurology, March 1 to 3, 2012, Santa Cruz Bolivia.
-Conference "My transfers in irreparable brachial plexus injuries" 35th Latin American Congress of Neurosurgery March 31 to April 4, 2012 Rio De Janeiro Brazil.
-Conference "Training of Neurosurgeons in Chile" XXV Winter Conference Neurosurgery Society of Chile 22 and 23 June 2012. Santa Cruz, Chile
-Conference "Usefulness of electrophysiological monitoring in peripheral nerve surgery" X Congress of the Society of Neurological Surgery of the Southern Cone June 27 to 29, 2013, Puerto Varas, Chile
-Table Chair in Section "Peripheral Nerve" X Congress of the Society of Neurological Surgery of the Southern Cone 27-29 June 2013, Puerto Varas, Chile
-Conference "Cirugia en la ulnar entrapment" Cycle of Controversies in Neurology. LXVIII Chilean Congress of Neurology, Psychiatry and Neurosurgery October 17 to 19, 2013 Viña del Mar, Chile.
-Conference "Evaluation of neurological deterioration in the sedated patient" XXVI Panamerican Congress of Trauma and LXXXVI Chilean and International Congress of Surgery, November 17 to 22, 2013, Santiago, Chile
-Director of the Symposium "Controversies in Neurology and Neurosurgery" "LXIX Chilean Congress of Neurology, Psychiatry and Neurosurgery October 09 to 11, 2014 Puerto Varas, Chile.
-Conference "Brain Death" Committee on Asiatic Ethics Emergency Hospital Public Assault, Santiago, Chile May 2015
-Conference "Teaching at the Institute of Neurosurgery" Induction Workshop Institute of Neurosurgery Asenjo December 9 and 16, 2015.Santiago, Chile
-Conference "What should we know in the management of a peripheral nerve injury? 60th Congress American College of Surgeon 8-11 May 2016 Viña del Mar. Chile.
-Conference "Urgency management in peripheral nerves" in Neurosurgical Emergency Course for non-specialist professionals 2016. July 14 and 15, 2016 Asenjo Neurosurgery Institute, Santiago, Chile
-Conference "Cerebral death and state of minimum awareness" Bioethics Conference HOSPITAL DE URGENCIA Public Assistance September 27, 2016, Santiago, Chile
-Conference "What should we know in the management of a peripheral nerve injury? Course of Emergencies in Neurosurgery. Dept. of Emergency Clinica Alemana de Santiago November 25, 2016
-Conference "Traumatic Brain Injuries in Emergency Services" Third International Congress of Paramedical Technicians Santiago March 29 and 30, 2017
-Conference "Acute injuries of peripheral nerves" Third International Congress of paramedical technicians Santiago 29 and 30 March 2017

Relevant Activities
-Member Committee of Scientific Ethics SSMO 2012 2013
-Member of the Technical Committee for Clinical Guides in TEC in Adult, program AUGE, Ministry of Health, Chile Nov. and December 2012
-Member of the Health Care Ethics Committee of the HUAP 2011-2013
-Invited Professor PUC to the Neurosurgery Program 2013 Title Examination Commission
-President of the Accreditation Commission for Neurosurgical Training Programs, APICE (U Católica Oct. and Nov. 2013)
-Member of the Ministerial Commission for Updating Clinical Guides of TEC Ministry of Health 2013.
-General Coordinator of the LXIX Chilean Congress of Neurology, Psychiatry and Neurosurgery October 09 to 11, 2014 Puerto Varas, Chile.
-Coordinator of the First Neurology Olympics of Sonepsyn held at the LXIX Chilean Congress of Neurology, Psychiatry and Neurosurgery October 09 to 11, 2014 Puerto Varas, Chile.
-President HUAP Ethical Assistance Committee since September 2014
-Extension Act "TEC in prehospital care" First Prehospital Rescue course October 17 and 18, 2014, Acteprech and Universidad Catolica Silva Henriquez
-Coordinator LVII Chilean Congress of Neurosurgery, 6,7, and 8 of November of 2014, Puerto Varas, Chile.
-Reviewer of works Chilena Chilean Academy of Neurology, Psychiatry and Neurosurgery, work "Ethmoidal lesions with secondary extension. Surgical strategy and complications
-Class "Encephalocranial Trauma" Adult Traumatology Module 2015, October 2015.
-Reviewer of works for the LIX Chilean Congress of Neurosurgery October 2016
-Reviewer of oral works "VII medical-surgical days, medical students" Campus Oriente U of Chile, October 2016
-Coordinator of the LIX Chilean Congress of Neurosurgery 06 to October 2016, La Serena, Chile.
-General Coordinator of the LXXI Chilean Congress of Neurology, Psychiatry and Neurosurgery 05 to 09 October 2016 La Serena, Chile.
-Poster reviewer and oral works of the LIX Chilean Congress of Neurosurgery 06 to October 2016, La Serena, Chile.
-President of the poster sessions of the LIX Chilean Congress of Neurosurgery 06 to October 2016, La Serena, Chile
-Director of postgraduate course "Surgical accesses of skull and spine" April 11, 2017 Department of Neurological Sciences Oriente.

Other relevant activities
• Review of works at the VI Surgical Conference of Medical Students of the Headquarters of Oriente. 2012
• Member of the Ministerial Commission for Updating Clinical Guidelines of TEC. Ministry of Health November and December 2012.
• Professor invited to Neurosurgery exam. Pontificia Universidad Católica de Chile. MAY 2013
• Member CONACEM
• Treasurer of the Neurosurgery Society of Chile.
• Lecturer Course Neuroanatomy for residents of Neurology and Neurosurgery 2014 Anatomy of the brachial plexus and lumbosacral.
• Lecturer Course "Neurological Semiology" 2014 Universidad de Chile


Premios y Distinciones

  •   Honorific mention

    XXI Congreso Latinoamericano de Neurocirugía

    Venezuela, 1984

    Latinamerican congress of neurosurgery.  "Experimental model for the study of cerebral vasospasm secondary to Subarachnoid Hemorrhage"

  •   Best free job award

    49° Congreso Chileno de Neurologia, Psiquiatria y Neurocirugia

    Chile, 1994

    "Thrombolytic therapy in intraventricular hemorrhage"

  •   Award for Best Free Work Section posters

    50º Congreso Chileno de Neurologia, Psiquiatria y Neurocirugia Viña del Mar

    Chile, 1995

    "Surgery in carpal tunnel syndrome"

  •   "Foreign Honorary Member"

    Sociedad Argentina de Neurología.

    Argentina, 1998

    Argentine Association of Neurosciences. Argentine Society of Neurology. Argentine Society of Neurosurgery and Argentine Society of Psychiatry and Mental Health June 1998.

  •   Best work in the field of Neurosurgery

    59º Congreso Chileno de Neurología, Psiquiatría y Neurocirugia Iquique

    Chile, 2004

    "Neurorrhaphy in acute nerve sections"

  •   Honorific mention

    62º Congreso Chileno de Neurología, Psiquiatría y Neurocirugía

    Chile, 2007

    "Trapping of the median nerve in the carpal tunnel Results in 2304 cases operated".

  •   Honorable mention

    63º Congreso Chileno de Neurología, Psiquiatría y Neurocirugía

    Chile, 2008

    Continuous Electromyographic Monitoring and Myotonic Discharge Record in Peripheral Nerve Surgery.

  •   First place Poster in Neurosurgery Specialty

    64º Congreso Chileno de Neurología, Psiquiatría y Neurocirugía

    Chile, 2009

    "Study of Multiple Drug Resistance in Primary Culture of Human Glioblastoma". Dra. Claudia Quezada and Dr. Rómulo Melo

  •   First place in poster

    LXVI Congreso Chileno de Neurología, Psiquiatría y Neurocirugía

    Chile, 2011

    "Endo-endoanastomosis as a repair technique in traumatic neuromas".

  •   Honorable Mention in Oral Mode to Scientific Work

    LV Congreso Chileno de Neurocirugía

    Chile, 2012

    "Chemo-resistance in Glioblastoma Multiforme mediated by CD73". Dra. Claudia Quezada and Dr. Rómulo Melo

  •   Second prize in Neurosurgery to the scientific work

    LXVII Congreso Chileno de Neurologia, Psiquiatría y Neurocirugía

    Chile, 2012

    Effect of inhibition of CD73 on the chemoresistance in high grade gliomas. Dra. Claudia Quezada and Dr. Rómulo Melo

  •   First Place Poster

    LVI Congreso Chileno de Neurocirugía

    Chile, 2013

    “Characterization of the highly chemoresistant subpopulation of glioblastoma starter cells” Dra. Claudia Quezada and Dr. Rómulo Melo

  •   University Scientific Research Award

    Santander Universidades and Mercurio

    Chile, 2013

    Cure and Prevention of Cancer Santander Universities and El Mercurio - 2013 version for the study "Study of the chemoresistance of human glioblastoma multiforme", November 2013. Co-investigator. Principal research Dra. Claudia Quezada


 

Article (7)

Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells
Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement
5 '-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells
Combined Use of Anticancer Drugs and an Inhibitor of Multiple Drug Resistance-Associated Protein-1 Increases Sensitivity and Decreases Survival of Glioblastoma Multiforme Cells In Vitro
Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme
Carpal tunnel syndrome and anesthesia Anestesia y sindrome del tunel del carpo
Peripheral nerve tumors Tumores de nervios perifericos

Proyecto (7)

Role of hypoxia and adenosine on chemoresistance mediated by multidrug resistance-associated proteins 1 and 3 in glioblastoma stem like cells
MGMT (O6-methylguanine-DNA-methyltransferase) promoter mutilation study in Chilean patients with Glioblastoma multiforme: In search of prognostic factors.
Prevalence of Glioblastoma multiforme in Chile and study of resistance to chemotherapy mediated by ABC transporters
Inhibition of multiple resitance proteína -1 (MRP-1) by tacrolimus in glioblastoma multiforme cells.
Continuous electrophysiological monitoring and nerve conduction in peripheral nerve surgeries
Pharmacokinetic and clinical study of an extended release formulation of zolpidem
TRATAMIENTO DE LA HEMORRAGIA INTRAVENTRICULAR POR INFUSION DE ESTREPTOKINASA

Review (1)

Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement
16
Rómulo Melo

Neurosurgeon

Department of Neurosurgery

Instituto de Neurocirugía Dr. Asenjo

Santiago, Chile

6
Rody San Martín

Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Claudia Quezada

Full Professor

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

2
Juan Carcamo

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Ramón Rodrigo

PROFESOR TITULAR

INSTITUTO DE CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

1
Daniel Uribe

Profesor Adhonorem

Institute of Biochemistry and Microbiology

Universidad Austral de Chile

Valdivia, Chile

1
María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

1
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Katia Fernández

Académico - Profesor Asociado

Facultad de Salud y Odontología

Universidad Diego Portales

Santiago, Chile

1
Jose Matamala

Assistant Professor of Neurology

Department of Neurological Science

University of Chile

Santiago, Chile

1
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Rodrigo Fernández

Instructor Adjunto

Ciencias Neurológicas Oriente

Universidad de Chile

Santiago, Chile

1
Carlos Oyarzún

Profesor Adjunto Asociado

Ciencias

Universidad Austral de Chile

Valdivia, Chile

1
Ángelo Torres

Postdoctorado/Profesor Adjunto

Microbiología y Bioquímica

Universidad Austral de Chile

Valdivia, Chile

1
RODRIGO CARRASCO

CLINICAL FELLOW

CARDIOLOGIA

UNIVERSITY OF TORONTO

Toronto, Canada