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Jorge Campusano

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Biogenic amines; Receptors; Gap Junctions; Behavior; Neurodegeneration; Drosophila; Medicinal Chemistry; Pharmacology; Neurochemistry; Neurobiology; Animal models for brain diseases

Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
Biochemist, UNIVERSIDAD DE CHILE. Chile, 1997
Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1995

Postdoctoral fellow Full Time

UNIVERSITY OF CALIFORNIA-IRVINE

Estados Unidos

2002 - 2008
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2009 - 2015
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2015 - A la fecha

Postdoctoral fellow Full Time

University of California Irvine

Estados Unidos

2002 - 2008
Assistant Professor Full Time

Pontificia Universidad Catolica de Chile

Chile

2009 - A la fecha
Profesor Visitante Full Time

Universidad de Puerto Rico

Puerto Rico

2014 - 2014

Training of students.

Postgraduate training. Finished.
Biological Sciences Doctoral Program (PUC)
• Dr. Nicolás Fuenzalida (mention Cell & Molecular Biology). PhD Thesis Title: Study of chemotaxis in Drosophila and neural pathways involved. Thesis Director Jorge Campusano, PhD. 2016.
• Dr. Sergio Hidalgo (mention Cell & Molecular Biology). PhD Thesis Title: Using Drosophila to model Schizophrenia symptoms. Thesis Director Jorge Campusano, PhD. Co-Director James Hodge, PhD (University of Bristol, UK). 2020. Dual PhD degree supported by Conicyt.
• Dr. Rafaella Zárate (mention Cell & Molecular Biology). PhD Thesis Title: Parkinsonian phenotype in a PINK1 Drosophila mutant: Study of the serotonergic neural system in pre-symptomatic stages. Thesis co-directed by Jorge Campusano, PhD and Pedro Zamorano, PhD. 2020.
• Dr. Elsa Fritz (mention Physiological Sciences). PhD Thesis Title: Role of innexins on behaviour coordinated by the circadian rhythm of Drosophila melanogaster. Thesis directed by Juan Carlos Sáez, PhD, co-directed by Jorge Campusano, PhD. 2021.
• Dr. Francisca Rojo (mention Cell & Molecular Biology). PhD Thesis Title: Functional characterization of Lipophorin Receptors in the mushroom body of D. melanogaster. Thesis co-directed by Jorge Campusano, PhD and María-Paz Marzolo, PhD. 2022.

Interdisciplinary Neuroscience Doctoral Program, PUC
• Dr. Daniela Molina. PhD Thesis Title: Changes in dopamine and serotonin levels induced by dysbiosis aggravate the parkinsonian phenotype in Parkinson´s disease model. Thesis Director Jorge Campusano, PhD. 2022.

Masters in Biochemistry Program (Universidad de Chile)
• Vicente Leyton. Thesis Title: Study of the contribution of octopaminergic and muscarinic receptors in Antennal Lobe, on olfactory information processing in Drosophila melanogaster. Thesis Director Jorge Campusano, PhD. 2018.

Postgraduate training. In progress.
Biological Sciences Doctoral Program (PUC)
• Ivana Gajardo (mention Cell & Molecular Biology). PhD Thesis Title: Study of the role of serotonin on a behavioral paradigm for visuo-spatial learning in Drosophila melanogaster. Thesis co-Directed by Jorge Campusano, PhD and Jimena Sierralta, PhD. In progress.

Chemistry Doctoral Program (PUC)
• Jose A Lozada. PhD Thesis Title: Diseño y síntesis de derivados de 2,3-DICLORONAFTALENO-1,4-DIONA, como potenciales inhibidores de acetilcolinesterasa de Drosophila melanogaster. Thesis co-directed by Flavia Zacconi, PhD and Jorge Campusano, PhD. In progress.

Undergraduate Programs (in all Jorge Campusano acts as Thesis Director to obtain Professional Title, except when indicated)
• Carolina Vallejos (Biology).
• Nicolás Fuenzalida (Biochemistry).
• Nicolás Goles (Biology).
• Bryon Silva (Biochemistry).
• Francisca Herreros (Biochemistry).
• Sergio Hidalgo (Biochemistry).
• Daniela Molina (Biochemistry).
• Francisca Rojo (Biochemistry). Co-directed by Dr María Paz Marzolo (Faculty Biological Sciences, PUC).
• Nicole Navarro (Biology).
• Benjamin Valderrama (Biology).
• Agustín Robles (Chemistry). Directed by Dr Angélica Fierro (Faculty Chemistry, PUC); Dr Campusano co-director.
• Victoria Tapia (Biology).
• Alejandra Trujillo (Biology).
• Candy Roa (Biochemistry). Directed by Dr María Paz Marzolo (Faculty Biological Sciences, PUC); Dr Campusano co-director
• Antonia Soto (Biochemistry). Directed by Dr M. Estela Andrés (Faculty Biological Sciences, PUC); Dr Campusano co-director
• Vicente Arriagada (Biochemistry).
• Simón Guerra (Biochemistry).

Undergraduate Research Seminars (1 semester)
• Montserrat Martínez (Biology).
• María Beatriz Ugalde (Biology).
• Eduardo Tognarelli (Biochemistry).
• Karina Pérez (Marine Biology).
• Victoria Tapia (College in Natural Sciences and Mathematics, PUC).
• Candy Roa (Biochemistry).
• Isabella Polizzi (Biology).
• Antonia Soto (Biochemistry).
• Vicente Arriagada (Biochemistry).
• Simón Guerra (Biochemistry).
• Javiera Sánchez (Biology).
• Isidora Almonacid (Biochemistry).

Courses.
Responsible Professor for course "Laboratory of Cell Biology and Biochemistry" for undergraduate students of Biology, Marine Biology, Engineering, College and Education Schools (2017-2022).
Responsible Professor for course "Laboratory of Biochemistry I" for undergraduate students of Biochemistry Program (2022).
Responsible Professor for course "Cell and Molecular Biomedicine" for undergraduate students of the Biochemistry and Biology programs (2020-2021).
Responsible Professor for course "Cell Biology, Bio141c" for undergraduate College Program-PUC (years 2009-2016).
Invited Professor for graduate courses "Neuroscience", "Neurophysiology", "Cell and Molecular Basis of Neurobiology" and "Cell and Molecular Basis of Parkinson's Disease" (all PUC) and "Drosophila Neurobiology" at University of Chile.
International Graduate Course "Small Brains, Big Ideas" (2010 and 2014).

Travel Grant-Junior Faculty

International Behavioral and Neural Genetics Society

Bélgica, 2013

Travel grant to assist and participate of the annual meeting of the International Behavioral and Neural Genetics Society
Travel Grant

Freie Universitat

Alemania, 2012

For the meeting "Biogenic amines as coordinators and controllers of physiological processes and behaviors”, held in Germany, I was invited to give a talk. I was the only latinamerican scientist invited.
Best Research and Presentation Award-PI Category

Brain in Flux Meeting

Francia, 2017

Prize for the best research and presentation in the Brain in Flux Meeting-PI Category


Nicotine suppresses Parkinson’s Disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels Carvajal-Oliveros, Angel; Domínguez-Baleón, Carmen; Zárate, Rafaella V; Campusano, Jorge M.; Narváez-Padilla, Verónica; Reynaud, Enrique Article ISI SCIENTIFIC REPORTS (2021)
Slit/Robo signaling regulates multiple stages of the development of the Drosophila motion detection system Guzmán-Palma, P Campusano, JM., Sierralta, J., Hassan, BA., Oliva, C.; Contreras, Esteban G.; Mora, N.; Smith, Macarena; González-Ramírez, María-Constanza; Campusano, Jorge M.; Sierralta, Jimena; Hassan, Bassem A.; Oliva, Carlos Article ISI Frontiers in Cell and Developmental Biology (2021)
Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly? Carvajal-Oliveros, Angel; Campusano, Jorge M. Article FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)
Dop1R1, a type 1 dopaminergic receptor expressed in Mushroom Bodies, modulates Drosophila larval locomotion Silva, Bryon; Hidalgo, Sergio; Campusano, Jorge M.; Skoulakis, Efthimios M. C. Article SCOPUS PLOS ONE (2020)
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila Caipo, Lorena; Gonzalez-Ramirez, M. Constanza; Guzman-Palma, Pablo; Contreras, Esteban G.; Palominos, Tomas; Fuenzalida-Uribe, Nicolas; Hassan, Bassem A.; Campusano, Jorge M.; Sierralta, Jimena; Oliva, Carlos Article ISI SCOPUS DEVELOPMENTAL BIOLOGY (2020)
Study of the release of endogenous amines in Drosophila brain in vivo in response to stimuli linked to aversive olfactory conditioning Hidalgo, Sergio; Fuenzalida-Uribe, Nicolás; Molina-Mateo, Daniela; Escobar, Angélica P.; Oliva, Carlos; España, Rodrigo A.; Andrés, María Estela; Campusano, Jorge M. Article ISI JOURNAL OF NEUROCHEMISTRY (2020)
The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms Hidalgo, Sergio; Castro, Christian; Zárate, Rafaella V.; Valderrama, Benjamín P.; Hodge, James J.L.; Campusano, Jorge M. Article ISI NEUROCHEMISTRY INTERNATIONAL (2020)
Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences Arancibia S.; Marambio, M; Campusano J.M.; Fierro A. Article ISI SCOPUS ACS CHEMICAL NEUROSCIENCE (2019)
Unveiling the Dual Role of the Dopaminergic System on Locomotion and the Innate Value for an Aversive Olfactory Stimulus in Drosophila Fuenzalida-Uribe, Nicolas; Campusano, Jorge M. Article ISI SCOPUS NEUROSCIENCE (2018)
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors Hidalgo, Sergio; Molina-Mateo, Daniela; Escobedo, Pía; Zarate, Rafaella V; Fritz, Elsa; Fierro, Angélica; Pérez, Edwin G.; Iturriaga-Vasquez, Patricio; Reyes-Parada, Miguel; Varas, Rodrigo; Fuenzalida-Uribe, Nicolás; Campusano, Jorge M. Article ISI SCOPUS ACS Chemical Neuroscience (2017)
Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model: Unveiling dopaminergic compensatory mechanisms Molina-Mateo, D; Fuenzalida-Uribe, N; Hidalgo, S; Molina-Fernandez, C; Abarca, J; Zarate, RV; Escandon, M; Figueroa, R; Tevy, MF; Campusano, JM Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2017)
Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model=> Unveiling dopaminergic compensatory mechanisms Molina-Mateo, D; Fuenzalida-Uribe, N; Hidalgo, S; Molina-Fernandez, C; Abarca, J; Zarate, RV; Escandon, M; Figueroa, R; Tevy, MF; Campusano, JM Article Biochimica et Biophysica Acta - Molecular Basis of Disease (2017)
Study of the Contribution of Nicotinic Receptors to the Release of Endogenous Biogenic Amines in Drosophila Brain Fuenzalida-Uribe, Nicolas; Hidalgo, Sergio; Varas, Rodrigo; Campusano, Jorge M.; Li, MD Article ISI NICOTINIC ACETYLCHOLINE RECEPTOR TECHNOLOGIES (2016)
Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila Silva, B.; Molina-Fernandez, C; Ugalde, MB; Tognarelli EI; Angel C.; Campusano, JM. Article ISI SCOPUS Neural Plasticity (2015)
Dopamine D-1 and corticotrophin-releasing hormone type-2 alpha receptors assemble into functionally interacting complexes in living cells Fuenzalida, J.; Galaz, P; Araya K.A.; Slater P.G.; Blanco E.H.; Campusano, J.M.; Ciruela, F.; Gysling, K Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2014)
Octopamine and Dopamine differentially modulate the nicotine-induced calcium response in Drosophila Mushroom Body Kenyon Cells Leyton, V; Goles, NI; Fuenzalida-Uribe, N; Campusano, JM. Article ISI SCOPUS NEUROSCIENCE LETTERS (2014)
Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion Silva, B.; Goles, NI; Campusano, JM. Article ISI SCOPUS PLOS ONE (2014)
nAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster Fuenzalida-Uribe, N; Meza, RC; Hoffmann, HA; Varas, R.; Campusano, JM. Article ISI SCOPUS Journal of Neurochemistry (2013)
An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease Riquelme E.; Abarca, J; Campusano, J.M.; Bustos G. Article ISI SCOPUS Parkinson's Disease (2012)
Cav2-Type Calcium Channels Encoded by cac Regulate AP-Independent Neurotransmitter Release at Cholinergic Synapses in Adult Drosophila Brain Gu, HY; Jiang, SJ; Campusano, JM.; Iniguez, J; Su, H; Hoang, AA; Lavian, M; Sun X.; O'Dowd, DK Article ISI JOURNAL OF NEUROPHYSIOLOGY (2009)
Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin Michno, K; Knight, D; van de Hoef, D; Boulianne G.L.; Campussano J.M. Article SCOPUS PLOS ONE (2009)
NMDA Receptors Mediate an Early Up-regulation of Brain-derived Neurotrophic Factor Expression in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease Bustos G.; Abarca, J; Bustos, V; Riquelme E.; Noriega V.; Moya C.; Campusano J. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE RESEARCH (2009)
Ultrastructural Analysis of Chemical Synapses and Gap Junctions Between Drosophila Brain Neurons in Culture Oh, HW; Campusano, JM.; Hilgenberg, LG; Sun X.; Smith, MA; O'Dowd, DK Article ISI Developmental Neurobiology (2008)
nAChR-Mediated Calcium Responses and Plasticity in Drosophila Kenyon Cells Campusano, JM.; Su, H; Jiang, SJ; Sicaeros, B; O'Dowd, DK Article ISI Developmental Neurobiology (2007)
Primary Neuronal Cultures from the Brains of Late Stage Drosophila Pupae Sicaeros, Beatriz; Campusano, Jorge M.; O'Dowd, Diane K. Article ISI Journal of Visualized Experiments (2007)
Drosophila Mushroom Body Kenyon Cells Generate Spontaneous Calcium Transients Mediated by PLTX-Sensitive Calcium Channels Jiang, SJ; Campusano, JM.; Su, H; O'Dowd, DK Article ISI JOURNAL OF NEUROPHYSIOLOGY (2005)
Novel alternative splicing predicts a truncated isoform of the NMDA receptor subunit 1 (NR1) in embryonic rat brain Campusano, JM.; Andres, ME; Magendzo, K; Abarca, J; Tapia-Arancibia, L; Bustos G. Article ISI SCOPUS NEUROCHEMICAL RESEARCH (2005)
Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain Bustos G.; Abarca, J; Campusano J.; Bustos, V; Noriega V.; Aliaga, E Article ISI BRAIN RESEARCH REVIEWS (2004)
Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra Campusano, JM.; Abarca, J; FORRAY, MI; Gysling, K; Bustos G. Article ISI SCOPUS BIOCHEMICAL PHARMACOLOGY (2002)


Increased serotonin release in the brain underlies the effect of 4-MTA on olfactory responses in drosophila Campusano J.; Fuenzalida-Uribe, N; Escobedo, P.; Hidalgo, S.; Molina, DF; Iturriaga-Vasquez, P; Fierro, A.; Varas, R. Abstract ISI JOURNAL OF NEUROCHEMISTRY (2015)
Synthesis, evaluation, and docking of new 4-alkoxybenzyl bicyclic amine ethers as nicotinic acetylcholine receptor antagonists Perez, EG.; Lopez, JJ; Salas, CO; Garcia-Colunga, J; Fierro-Huerta, A; Campusano, JM. Abstract ISI ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2014)
Octopamine and dopamine modulate nicotine-induced calcium increase in Drosophila Kenyon Cells Campusano, JM. Abstract ISI JOURNAL OF NEUROGENETICS (2010)
The expression of NMDA receptor subunit 1 and metabotropic glutamate receptor subtypes 1 and 3, is differentially modulated by BDNF and glutamate receptor agonists in mesencephalic cultures Campusano J.; Tapia-Arancibia, L; Bustos G. Abstract JOURNAL OF NEUROCHEMISTRY (2001)


Role of Slit endocytosis during the development of the Drosophila visual system FONDECYT (1191424) Proyecto 2019-2022 Coinvestigador(a)
SERT, the plasma membrane transporter for serotonin=> A key component of serotonergic circuits, modulating the organization and operation of the Drosophila olfactory system Vicerrectoría de Investigación-Pontificia Universidad Católica de Chile (P-1805) Proyecto 2018-2019 Inv. Principal
Synthesis of possible biogenic amine neurotransmitter transporter blockers using copper catalysis FONDECYT (1171391) Proyecto 2017-2021 Coinvestigador(a)
Study of the physico-chemical features of the proteins involved in the reuptake of tyramine and octopamine=> a potential target for the generation of insect-specific insecticides FONDECYT (1161375) Proyecto 2016-2020 Coinvestigador(a)
CONTRIBUTION OF METABOTROPIC RECEPTORS FOR BIOGENIC AMINES AND ACETYLCHOLINE TO OLFACTORY FUNCTION IN DROSOPHILA MELANOGASTER FONDECYT (1141233) Proyecto 2014-2018 Inv. Responsable
Design, synthesis and evaluation of possible selective agonists of alpha9 and alpha9alpha10 nicotinic acetylcholine receptor subtypes FONDECYT (1130079) Proyecto 2013-2017 Coinvestigador(a)
Molecular and neurochemical mechanisms underlying stress-induced relapse to cocaine seeking FONDECYT (1110392) Proyecto 2011-2015 Coinvestigador(a)
Núcleo Milenio Estrés y Adicción=> Desde las moléculas a la conducta Iniciativa Científica Milenio (P10/063-F) Proyecto 2010-2014 Investigador(a)
The interaction of Biogenic Amines and Cholinergic systems in Mushroom Body Kenyon Cells generate cellular events implicated in olfactory learning in the fly Drosophila melanogaster FONDECYT (1100965) Proyecto 2010-2013 Inv. Responsable
Study of the properties of the responses gated by biogenic amines in Drosophila Kenyon Cells International Society for Neurochemistry-CAEN Program (CAEN09_03) Proyecto 2009-2010 Inv. Responsable
The properties of biogenic amine receptors in Drosophila Mushroom Bodies=> Implications in learning and memory Vicerrectoría de Investigación-Pontificia Universidad Católica de Chile (21-2009) Proyecto 2009-2010 Inv. Responsable
The interaction between glutamate receptors and neurotrophic factors on the dendritic dopamine release in rat substantia nigra PFCHA (2980066) Proyecto 1998-2001 Inv. Responsable