Man

Jorge Campusano

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Biogenic amines; Receptors; Gap Junctions; Behavior; Neurodegeneration; Drosophila; Medicinal Chemistry; Pharmacology; Neurochemistry; Neurobiology; Animal models for brain diseases

Educación

  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1997
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1995

Experiencia Académica

  •   Postdoctoral fellow Full Time

    UNIVERSITY OF CALIFORNIA-IRVINE

    Estados Unidos

    2002 - 2008

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    2009 - 2015

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    2015 - A la fecha

Experiencia Profesional

  •   Postdoctoral fellow Full Time

    University of California Irvine

    Estados Unidos

    2002 - 2008

  •   Assistant Professor Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2009 - A la fecha

  •   Profesor Visitante Full Time

    Universidad de Puerto Rico

    Puerto Rico

    2014 - 2014

Formación de Capital Humano


Training of students.

Postgraduate training. Finished.
Biological Sciences Doctoral Program (PUC)
• Dr. Nicolás Fuenzalida (mention Cell & Molecular Biology). PhD Thesis Title: Study of chemotaxis in Drosophila and neural pathways involved. Thesis Director Jorge Campusano, PhD. 2016.
• Dr. Sergio Hidalgo (mention Cell & Molecular Biology). PhD Thesis Title: Using Drosophila to model Schizophrenia symptoms. Thesis Director Jorge Campusano, PhD. Co-Director James Hodge, PhD (University of Bristol, UK). 2020. Dual PhD degree supported by Conicyt.
• Dr. Rafaella Zárate (mention Cell & Molecular Biology). PhD Thesis Title: Parkinsonian phenotype in a PINK1 Drosophila mutant: Study of the serotonergic neural system in pre-symptomatic stages. Thesis co-directed by Jorge Campusano, PhD and Pedro Zamorano, PhD. 2020.
• Dr. Elsa Fritz (mention Physiological Sciences). PhD Thesis Title: Role of innexins on behaviour coordinated by the circadian rhythm of Drosophila melanogaster. Thesis directed by Juan Carlos Sáez, PhD, co-directed by Jorge Campusano, PhD. 2021.

Masters in Biochemistry Program (Universidad de Chile)
• Vicente Leyton. Thesis Title: Study of the contribution of octopaminergic and muscarinic receptors in Antennal Lobe, on olfactory information processing in Drosophila melanogaster. Thesis Director Jorge Campusano, PhD. 2018.

Postgraduate training. In progress.
Biological Sciences Doctoral Program (PUC)
• Francisca Rojo (mention Cell & Molecular Biology). PhD Thesis Title: Functional characterization of Lipophorin Receptors in the mushroom body of D. melanogaster . Thesis co-directed by Jorge Campusano, PhD and María-Paz Marzolo, PhD. In progress.
• Ivana Gajardo (mention Cell & Molecular Biology). PhD Thesis Title: Study of the role of serotonin on a behavioral paradigm for visuo-spatial learning in Drosophila melanogaster. Thesis co-Directed by Jorge Campusano, PhD and Jimena Sierralta, PhD. In progress.

Chemistry Doctoral Program (PUC)
• Jose A Lozada. PhD Thesis Title: Diseño y síntesis de derivados de 2,3-DICLORONAFTALENO-1,4-DIONA, como potenciales inhibidores de acetilcolinesterasa de Drosophila melanogaster. Thesis co-directed by Flavia Zacconi, PhD and Jorge Campusano, PhD. In progress.

Interdisciplinary Neuroscience Doctoral Program (PUC)
• Daniela Molina, PhD Thesis Title: Changes in dopamine and serotonin levels induced by dysbiosis aggravate the parkinsonian phenotype in Parkinson´s disease model. Thesis Director Jorge Campusano, PhD. In progress.

Undergraduate Programs (in all Jorge Campusano acts as Thesis Director to obtain Professional Title, except when indicated)
• Carolina Vallejos (Biology).
• Nicolás Fuenzalida (Biochemistry).
• Nicolás Goles (Biology).
• Bryon Silva (Biochemistry).
• Francisca Herreros (Biochemistry).
• Sergio Hidalgo (Biochemistry).
• Daniela Molina (Biochemistry).
• Francisca Rojo (Biochemistry). Co-directed by Dr María Paz Marzolo (Faculty Biological Sciences, PUC).
• Nicole Navarro (Biology).
• Benjamin Valderrama (Biology).
• Agustín Robles (Chemistry). Directed by Dr Angélica Fierro (Faculty Chemistry, PUC); Dr Campusano co-director.
• Victoria Tapia (Biology).
• Alejandra Trujillo (Biology).

Undergraduate Research Seminars (1 semester)
• Montserrat Martínez (Biology).
• María Beatriz Ugalde (Biology).
• Eduardo Tognarelli (Biochemistry).
• Karina Pérez (Marine Biology).
• Victoria Tapia (College in Natural Sciences and Mathematics, PUC).
• Candy Roa (Biochemistry).
• Isabella Polizzi (Biology).
• Antonia Soto (Biochemistry).
• Vicente Arriagada (Biochemistry).
• Simón Guerra (Biochemistry).
• Javiera Sánchez (Biology).
• Isidora Almonacid (Biochemistry).

Courses.
Responsible Professor for course "Cell Biology, Bio141c" for undergraduate College Program-PUC (years 2009-2016).
Responsible Professor for course "Laboratory of Cell Biology and Biochemistry" for undergraduate students of Biology, Marine Biology, Engineering, College and Education Schools (2017-2022).
Responsible Professor for course "Cell and Molecular Biomedicine" for undergraduate students of the Biochemistry and Biology programs (2020-2021).
Invited Professor for graduate courses "Neuroscience", "Neurophysiology", "Cell and Molecular Basis of Neurobiology" and "Cell and Molecular Basis of Parkinson's Disease" (all PUC) and "Drosophila Neurobiology" at University of Chile.
International Graduate Course "Small Brains, Big Ideas" (2010 and 2014).


Premios y Distinciones

  •   Travel Grant-Junior Faculty

    International Behavioral and Neural Genetics Society

    Bélgica, 2013

    Travel grant to assist and participate of the annual meeting of the International Behavioral and Neural Genetics Society

  •   Travel Grant

    Freie Universitat

    Alemania, 2012

    For the meeting "Biogenic amines as coordinators and controllers of physiological processes and behaviors”, held in Germany, I was invited to give a talk. I was the only latinamerican scientist invited.

  •   Best Research and Presentation Award-PI Category

    Brain in Flux Meeting

    Francia, 2017

    Prize for the best research and presentation in the Brain in Flux Meeting-PI Category


 

Article (28)

Nicotine suppresses Parkinson’s Disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels
Slit/Robo signaling regulates multiple stages of the development of the Drosophila motion detection system
Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?
Dop1R1, a type 1 dopaminergic receptor expressed in Mushroom Bodies, modulates Drosophila larval locomotion
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila
Study of the release of endogenous amines in Drosophila brain in vivo in response to stimuli linked to aversive olfactory conditioning
The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms
Modeling of the Binding of Octopamine and Dopamine in Insect Monoamine Transporters Reveals Structural and Electrostatic Differences
Unveiling the Dual Role of the Dopaminergic System on Locomotion and the Innate Value for an Aversive Olfactory Stimulus in Drosophila
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors
Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model=> Unveiling dopaminergic compensatory mechanisms
Study of the Contribution of Nicotinic Receptors to the Release of Endogenous Biogenic Amines in Drosophila Brain
Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila
Dopamine D-1 and corticotrophin-releasing hormone type-2 alpha receptors assemble into functionally interacting complexes in living cells
Octopamine and Dopamine differentially modulate the nicotine-induced calcium response in Drosophila Mushroom Body Kenyon Cells
Serotonin Receptors Expressed in Drosophila Mushroom Bodies Differentially Modulate Larval Locomotion
nAChR-induced octopamine release mediates the effect of nicotine on a startle response in Drosophila melanogaster
An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease
Cav2-Type Calcium Channels Encoded by cac Regulate AP-Independent Neurotransmitter Release at Cholinergic Synapses in Adult Drosophila Brain
Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin
NMDA Receptors Mediate an Early Up-regulation of Brain-derived Neurotrophic Factor Expression in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease
Ultrastructural Analysis of Chemical Synapses and Gap Junctions Between Drosophila Brain Neurons in Culture
nAChR-Mediated Calcium Responses and Plasticity in Drosophila Kenyon Cells
Primary Neuronal Cultures from the Brains of Late Stage Drosophila Pupae
Drosophila Mushroom Body Kenyon Cells Generate Spontaneous Calcium Transients Mediated by PLTX-Sensitive Calcium Channels
Novel alternative splicing predicts a truncated isoform of the NMDA receptor subunit 1 (NR1) in embryonic rat brain
Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain
Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra

Abstract (1)

The expression of NMDA receptor subunit 1 and metabotropic glutamate receptor subtypes 1 and 3, is differentially modulated by BDNF and glutamate receptor agonists in mesencephalic cultures

Proyecto (12)

Role of Slit endocytosis during the development of the Drosophila visual system
SERT, the plasma membrane transporter for serotonin=> A key component of serotonergic circuits, modulating the organization and operation of the Drosophila olfactory system
Synthesis of possible biogenic amine neurotransmitter transporter blockers using copper catalysis
Study of the physico-chemical features of the proteins involved in the reuptake of tyramine and octopamine=> a potential target for the generation of insect-specific insecticides
CONTRIBUTION OF METABOTROPIC RECEPTORS FOR BIOGENIC AMINES AND ACETYLCHOLINE TO OLFACTORY FUNCTION IN DROSOPHILA MELANOGASTER
Design, synthesis and evaluation of possible selective agonists of alpha9 and alpha9alpha10 nicotinic acetylcholine receptor subtypes
Molecular and neurochemical mechanisms underlying stress-induced relapse to cocaine seeking
Núcleo Milenio Estrés y Adicción=> Desde las moléculas a la conducta
The interaction of Biogenic Amines and Cholinergic systems in Mushroom Body Kenyon Cells generate cellular events implicated in olfactory learning in the fly Drosophila melanogaster
Study of the properties of the responses gated by biogenic amines in Drosophila Kenyon Cells
The properties of biogenic amine receptors in Drosophila Mushroom Bodies=> Implications in learning and memory
The interaction between glutamate receptors and neurotrophic factors on the dendritic dopamine release in rat substantia nigra
31
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Maria Andres

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

2
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Nicolás Fuenzalida

Becario BNI (Postdoc)

Instituto de Neurociencias Biomedicas

Santiago, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
Carlos Oliva

Profesor Asistente

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

1
Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Rafaella Zárate

Bioquímica

Química y Farmacia

Universidad Católica del Norte

Antofagasta, Chile

1
Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

1
maria gonzalez

candidata a Phd

Ciencias Biológicas

Pontificia Universidad Católica de Chile

santiago, Chile