PDI - Resultado de Búsqueda

Patricio Ernesto Iturriaga Vasquez

Profesor Asociado A

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

ORGANIC SYNTHESIS; NATURAL PRODUCTS; PHARMACOLOGY; STRUCTURE-ACTIVY RELATIONSHIPS AND RATIONAL DESIGN OF DRUGS ACTING ON MONOAMINERGIC SYNAPSES.

Química, UNIVERSIDAD DE CHILE. Chile, 2001

Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2006 - 2014
Profesor Asociado A Full Time

University of La frontera

Ingeniería y Ciencias

Temuco, Chile

2015 - A la fecha

Profesor Asociado Full Time

Universida de Chile

Santiago, Chile

2006 - 2014
Profesor Asociado A Full Time

Universidad de La Frontera

Temuco, Chile

2015 - A la fecha

2013-2014
Diseño, síntesis y evaluación biológica de inhibidores de acetilcolinesterasa con posible potenciación alostérica del receptor nicotínico de acetilcolina (Tesis Doctoral ). Manuel Faundez Parraguez, Facultad de Ciencias, Universidad de Chile.
2013-2014
Síntesis de difenil pentanos sustituidos y su evaluación como ligando del transportador de serotonina (Tesis Magister). Juana Molina Hidalgo, Facultad de Ciencias, Universidad de Chile.
2013-2014
Optimización de la Sintesis de alquiltioisopropilaminas mediante reordenamiento de Newman-Kwart (Tesis Magister). Susana Arredondo Gutierrez, Facultad de Ciencias, Universidad de Chile.
2006-2009
Síntesis y evaluación enzimática de posibles inhibidores de monoaminooxidasa (Tesis Doctoral). Susan Lühr Sierra, Facultad de Ciencias, Universidad de Chile. (Tutor. B. Cassels; Co-Tutor. P. Iturriaga)
2007-2009
Síntesis y evaluación farmacológica de derivados de naftilisopropilaminas como posibles inhibidores de monoaminooxidasa (Tesis Magister). Marcelo Vilches Herrera, Facultad de Ciencias, Universidad de Chile. (Tutor. B. Cassels; Co-Tutor. P. Iturriaga).


Amphetamine Derivatives as Monoamine Oxidase Inhibitors Reyes-Parada, Miguel; Iturriaga-Vasquez, Patricio; Cassels, Bruce Article FRONTIERS IN PHARMACOLOGY (2020)
Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish Viscarra, Franco; Gonzalez-Gutierrez, Juan; Esparza, Erica; Figueroa, Carla; Paillali, Pablo; Hodar-Salazar, Martin; Cespedes, Camilo; Quiroz, Gabriel; Sotomayor-Zarate, Ramon; Reyes-Parada, Miguel; Bermudez, Isabel; Iturriaga-Vasquez, Patricio Article MOLECULES (2020)
Synthesis, in Vitro Evaluation and Molecular Docking of a New Class of Indolylpropyl Benzamidopiperazines as Dual AChE and SERT Ligands for Alzheimer's Disease Rodríguez-Lavado, Julio; Gallardo-Garrido C.; Mallea, Michael; Bustos,Victor; Osorio, Rodrigo; Hodar Salazar, Martin; Chung, Hery; Araya-Maturana, Ramiro; Lorca,Marcos; Pessoa-Mahana, C. David; Mella-Raipan, Jaime; Saitz,Claudio; Jaque, Pablo; Reyes Parada, Migue; Iturriaga-Vasquez, Patricio; Pessoa-Mahana, Hernán Article EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues Gonzalez-Gutierrez J.P.; Hodar M.; Viscarra F.; Paillali P.; Guerra-DÃaz N.; Pessoa-Mahana H.; HernÃ¡ndez-Morantes J.J.; PÃ©rez-SÃ¡nchez H.; BermÃºdez I.; Reyes-Parada M.; Iturriaga-VÃ¡squez P. Article ISI SCOPUS MOLECULES (2019)
Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine alpha 4 beta 2, Dopamine and Serotonin Transporters GonzÃ¡lez-GutiÃ©rrez J.P.; Pessoa-Mahana H.A.; Iturriaga-VÃ¡squez P.E.; Reyes-Parada M.I.; Guerra-DÃaz N.E.; Hodar-Salazar M.; Viscarra F.; Paillali P.; NÃºÃ±ez-Vivanco G.; Lorca-Carvajal M.A.; Mella-RaipÃ¡n J.; ZÃºÃ±iga M.C. Article ISI SCOPUS MOLECULES (2019)
UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats Quiroz G.; Sotomayor-ZÃ¡rate R.; GonzÃ¡lez-Gutierrez J.P.; Vizcarra F.; Moraga F.; Bermudez I.; Reyes-Parada M.; Quintanilla M.E.; Lagos D.; Rivera-Meza M.; Iturriaga-VÃ¡squez P. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
3D similarities between the binding sites of monoaminergic target proteins Nunez-Vivanco, Gabriel; Fierro, Angelica; Moya, Pablo; Iturriaga-Vasquez, Patricio; Reyes-Parada, Miguel Article ISI SCOPUS PLOS ONE (2018)
Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats Quiroz, Gabriel; Guerra-Díaz, Nicolás; Iturriaga-Vásquez, Patricio; Rivera-Meza, Mario; Quintanilla, María Elena; Sotomayor-Zárate, Ramón Article ISI SCOPUS BEHAVIOURAL BRAIN RESEARCH (2018)
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core Mendez-Rojas, C; Quiroz, G; Faundez, M; Gallardo-Garrido, C; Pessoa-Mahana, CD; Chung, H; Gallardo-Toledo, E; Saitz-Barria, C; Araya-Maturana, R; Kogan, MJ; Zuniga-Lopez, MC; Iturriaga-Vasquez, P; Valenzuela-Gutierrez, C; Pessoa-Mahana, H Article ISI SCOPUS ARCHIV DER PHARMAZIE (2018)
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors Hidalgo, Sergio; Molina-Mateo, Daniela; Escobedo, Pía; Zarate, Rafaella V; Fritz, Elsa; Fierro, Angélica; Pérez, Edwin G.; Iturriaga-Vasquez, Patricio; Reyes-Parada, Miguel; Varas, Rodrigo; Fuenzalida-Uribe, Nicolás; Campusano, Jorge M. Article ISI SCOPUS ACS Chemical Neuroscience (2017)
Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of alpha 4 beta 2 Nicotinic Acetylcholine Receptors Alcaino C.; Musgaard M.; Minguez T.; Mazzaferro S.; Faundez M.; Iturriaga-Vasquez P.; Biggin P.C.; Bermudez I. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT Pessoa-Mahana, Hernán; Silva-Matus, Paul; Pessoa-Mahana, C. David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata-Torres, Gerald; Saitz-Barría, Claudio; Araya-Maturana, Ramiro; Reyes-Parada, Miguel Article ISI SCOPUS ARCHIV DER PHARMAZIE (2017)
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor. Romero-Parra, Javier; Mella-Raipán, Jaime; Palmieri, Vittoria; Allarà, Marco; Torres, Maria Jose; Pessoa-Mahana, Hernán; Iturriaga-Vásquez, Patricio; Escobar, Rossy; Faúndez, Mario; Di Marzo, Vincenzo; Pessoa-Mahana, C David Article European journal of medicinal chemistry (2016)
The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors. Reyes-Parada, Miguel; Iturriaga-Vasquez, Patricio Article Expert opinion on drug discovery (2016)
Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1 Espinosa-Bustos, C; Lagos C.F., Romero-Parra J.; Zarate A.M., Mella-Raipan J.; Pessoa-Mahana H., Recabarren-Gajardo G.; Iturriaga-Vasquez, P; Tapia R.A., Pessoa-Mahana C.D. Article Archiv der Pharmazie (2015)
Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy. Iturriaga-Vásquez, Patricio; Alzate-Morales, Jans; Bermudez, Isabel; Varas, Rodrigo; Reyes-Parada, Miguel Article Pharmacological research (2015)
Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile. Möller-Acuña, Patricia; Contreras-Riquelme, J Sebastián; Rojas-Fuentes, Cecilia; Nuñez-Vivanco, Gabriel; Alzate-Morales, Jans; Iturriaga-Vásquez, Patricio; Arias, Hugo R; Reyes-Parada, Miguel Article PloS one (2015)
Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction. Sotomayor-Zárate, Ramón; Jara, Pablo; Araos, Patricio; Vinet, Raúl; Quiroz, Gabriel; Renard, Georgina M; Espinosa, Pedro; Hurtado-Guzmán, Claudio; Moya, Pablo R; Iturriaga-Vásquez, Patricio; Gysling, Katia; Reyes-Parada, Miguel Article Basic & clinical pharmacology & toxicology (2014)
Molecular Characterization and In Silico Analysis of the Pheromone-Binding Protein of the European Grapevine Moth Lobesia botrana (Denis & Schiffermuller) (Lepidoptera, Tortricidae) Mutis A., Palma R; Venthur, H; Iturriaga-Vasquez, P; Faundez-Parraguez, M; Mella-Herrera, R; Kontodimas, D; Lobos C., Quiroz A. Article Neotropical Entomology (2014)
Non-equivalent Ligand Selectivity of Agonist Sites in (alpha 4 beta 2)(2)alpha 4 Nicotinic Acetylcholine Receptors A KEY DETERMINANT OF AGONIST EFFICACY Mazzaferro S., Gasparri; F., New; K., Alcaíno C.; Faundez M., Iturriaga-Vasquez; P, Vijayan; R., Biggin; P. C., Bermudez Article Journal of Biological Chemistry (2014)
Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter Ojeda-Gómez, Claudia; Pessoa-Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa-Mahana, Carlos David; Recabarren-Gajardo, Gonzalo; Méndez-Rojas, Claudio Article Archiv der Pharmazie (2014)
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands Mella-Raipan, JA; Lagos CF, Recabarren-Gajardo G.; Espinosa-Bustos, C; Romero-Parra J., Pessoa-Mahana H.; Iturriaga-Vasquez, P; Pessoa-Mahana, CD Article Molecules (2013)
Experimental and theoretical study on the oxidation mechanism of dopamine in n-octyl pyridinium based ionic liquids-carbon paste modified electrodes Díaz, C.; Garcia C.; Iturriaga-Vasquez, P; AGUIRRE, MJ; Muena, JP; Contreras R.; Ormazabal-Toledo, R; Isaacs, M. Article ISI SCOPUS Electrochimica Acta (2013)
Experimental and theoretical study on the oxidation mechanism of dopamine in n-octyl pyridinium based ionic liquids-carbon paste modified electrodes Díaz, C.; Garcia C, Iturriaga-Vasquez; P, Aguirre; MJ, Muena; JP, Contreras; R., Ormazabal-Toledo; R, Isaacs M. Article Electrochimica Acta (2013)
Neonicotinic analogues=> Selective antagonists for alpha 4 beta 2 nicotinic acetylcholine receptors Faundez-Parraguez, M; Farias-Rabelo, N; Gonzalez-Gutierrez, JP; Etcheverry-Berrios, A; Alzate-Morales, J; Adasme-Carreno, F; Varas, R; Bermudez, I; Iturriaga-Vasquez, P Article BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor Pessoa-Mahana H., Gonzalez-Lira; C, Fierro A.; Zapata-Torres, G; Pessoa-Mahana, CD; Ortiz-Severin, J; Iturriaga-Vasquez, P; Reyes-Parada, M; Silva-Matus, P; Saitz-Barria, C; Araya-Maturana, R Article BIOORGANIC & MEDICINAL CHEMISTRY (2013)
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo Sotomayor-Zarate, R; Quiroz G, Araya K.A.; Abarca J, Ibanez M.R.; Montecinos A., Guajardo C.; Nuñez G., Fierro A.; Moya P.R., Iturriaga-Vasquez; P, Gomez-Molina C.; Gysling K, Reyes-Parada Article Basic & clinical pharmacology & toxicology (2012)
Functional expression of the alpha 7 and alpha 4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body Meza R.C., Ortiz F.C.; Bravo E., Iturriaga-Vasquez; P, Eugenin J.L.; Varas, R Article NEUROCHEMISTRY INTERNATIONAL (2012)
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrina fusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS Garcia-Beltran, O; Soto-Delgado, J; Iturriaga-Vasquez, P; Areche C., Cassels B.K. Article Journal of the Chilean Chemical Society (2012)
Synthesis, 5-Hydroxytryptamine(1A) Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-piperazinyl)-propyl]-1H-Indole Derivatives Pessoa-Mahana H., Nunez; CU, Araya-Maturana; R, Barria; CS, Zapata-Torres; G, Pessoa-Mahana; CD, Iturriaga-Vasquez; P, Mella-Raipan J.; Reyes-Parada, M; Celis-Barros, C Article CHEMICAL & PHARMACEUTICAL BULLETIN (2012)
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors Luhr, S; Vilches-Herrera, M; Fierro A., Ramsay; RR, Edmondson; DE, Reyes-Parada; M, Cassels; BK, Iturriaga-Vasquez Article BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line Paris, I; Perez-Pastene, C; Cardenas, S; Muñoz P; Caviedes P.; Segura-Aguilar, J; Iturriaga-Vasquez, P; Couve, E. Article NEUROTOXICITY RESEARCH (2010)
Molecular Determinants for Competitive Inhibition of alpha 4 beta 2 Nicotinic Acetylcholine Receptors Iturriaga-Vasquez, P; Carbone, A; Garcia-Beltran, O; Livingstone, PD; Biggin, PC; Cassels, BK; Wonnacott, S; Zapata-Torres, G; Bermudez, I Article Molecular Pharmacology (2010)
Crystal structure of (2R,13bS)-2,6,8,9-tetrahydro-2,12-dimethoxy-1H-indolo[1-a]isoquinolin-11-ol, C18H21NO3, Erysodine Iturriaga-Vasquez, P; Garcia-Beltran, O; Haddow, MF Article ISI SCOPUS Zeitschrift für Kristallographie - New Crystal Structures (2009)
Crystal structure of (2R,13bS)-2,6,8,9-tetrahydro-2,12-dimethoxy-1H-indolo[1-a]isoquinolin-11-ol, C18H21NO3, Erysodine Iturriaga-Vasquez, P; Garcia-Beltran, O; Haddow, MF Article Zeitschrift für Kristallographie - New Crystal Structures (2009)
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors Vilches-Herrera, M; Miranda-Sepulveda, J; Rebolledo-Fuentes, M; Fierro A., Luhr; S, Iturriaga-Vasquez; P, Cassels; BK, Reyes-Parada Article BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers Iturriaga-Vasquez, P; Perez, EG; Slater, EY; Bermudez, I; Cassels, BK Article BIOORGANIC & MEDICINAL CHEMISTRY (2007)
C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists Abin-Carriquiry, JA; Voutilainen, MH; Barik, J; Cassels, BK; Iturriaga-Vasquez, P; Bermudez, I; Durand, C; Dajas, F; Wonnacott, S Article EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture=> Effects of cytisine and its bromo derivatives Varas, R; Valdes, V; Iturriaga-Vasquez, P; Cassels, BK; Iturriaga R, Alcayaga Article Brain Research (2006)
N-substitution and alpha(1)-adrenergic receptor affinity of laudanosine analogues Iturriaga-Vasquez, P; Cassels, BK; Ivorra, MD; D'Ocon, MP Article Journal of the Chilean Chemical Society (2006)
SYNTHESIS OF 2-ARYL-1,3-PROPANEDIAMINES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE Iturriaga-Vasquez, P; Luhr-Sierra, S; Rezende, MC; Cassels, BK Article Journal of the Chilean Chemical Society (2006)
Crystal structure of isotetrandrine,C38H42N2O6 Galdamez A., Iturriaga-Vasquez; P, Cassels; BK, Manriquez V. Article Zeitschrift für Kristallographie - New Crystal Structures (2005)
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors Exley, R; Iturriaga-Vasquez, P; Lukas, RJ; Sher, E; Cassels, BK; Bermudez, I Article BRITISH JOURNAL OF PHARMACOLOGY (2005)
1-benzyl-1,2,3,4-tetrahydroisoquinolines. H-1 NMR conformational studies and rotational barriers Iturriaga-Vasquez, P; Zapata-Torres, G; Rezende, MC; Cassels, BK Article Journal of the Chilean Chemical Society (2004)
Geometrical isomerism in beta-nitrostyrenes=> Preferred conformations of (E)- and (Z)-1-(4-methylthiophenyl)-2-nitrobutenes Hurtado-Guzman, C; Iturriaga-Vasquez, P; Zapata-Torres, G; Cassels, BK Article Journal of the Chilean Chemical Society (2004)
Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine Hurtado-Guzman, C; Fierro A., Iturriaga-Vasquez; P, Sepulveda-Boza; S, Cassels; BK, Reyes-Parada Article JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2003)
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action Iturriaga-Vasquez, P; Miquel R., Ivorra; MD, D'Ocon; MP, Cassels Article JOURNAL OF NATURAL PRODUCTS. (2003)


Multisteric drugs: Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites Reyes-Parada, Miguel; Iturriaga-Vasquez, Patricio Proyecto (2017)
Synthesis of Novel Indole Derivatives Targeting: Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease Pessoa-Mahana, Hernán; Iturriaga-Vasquez, Patricio Proyecto (2017)
DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET and DAT). A POLY-PHARMACOLOGY APPROACH TO TREAT AND UNDERSTAND THE NICOTINIC WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPTOR TARGETS FONDECYT (1150615) Proyecto 2015-2018 Inv. Principal
BIOTRANSFORMATION PROCESSES CATALYZED BY LIGNINOLYTIC ENZYMES FROM PHANEROCHAETE CHRYSOSPORIUM=> RATIONAL PROTEIN DESIGN FROM COMPUTATIONAL CALCULATIONS AND SITE-DIRECTED MUTAGENESIS STUDIES FONDECYT (1140618) Proyecto 2014-2018 Coinvestigador(a)
A SYNTHETIC APPROACH TOWARDS NOVEL SERIES OF 3-(3-(1-PIPERAZINYL)PROPYL -1H-INDOLE DERIVATIVES AS MONOAMINERGIC MULTI-TARGET AGENTS. DOCKING STUDIES AND PHARMACOLOGICAL EVALUATION AT SERT, D2, AND MAO-A RECEPTORS. FONDECYT (1130347) Proyecto 2013-2017 Coinvestigador(a)
FISHING FOR COMPLEMENTS=> DESIGN OF COMPOUNDS THAT SIMULTANEOUSLY INTERACT WITH MONOAMINERGIC PROTEINS AND NICOTINIC RECEPTORS, BASED ON SIMILARITIES BETWEEN THEIR LIGAND BINDING SITES FONDECYT (1130185) Proyecto 2013-2017 Coinvestigador(a)
DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF DUAL NICOTINIC AGONIST AND MOA-B INHIBITORS ACTIVITY FOR REGULATION OF DOPAMINE LEVEL IN THE BRAIN. FONDECYT (1100542) Proyecto 2010-2014 Inv. Responsable
THE MONOAMINERGIC "RECEPTOPHORE". SIMILARITIES AMONG THE ACTIVE SITES OF MONOAMINERGIC TARGET PROTEINS, BASED ON THEIR CRYSTAL STRUCTURES=> IMPLICATIONS FOR THE DEVELOPMENT OF SELECTIVE AND NON-SELECTIVE LIGANDS. FONDECYT (1090037) Proyecto 2009-2013 Coinvestigador(a)
AISLACION DE ALCALOIDES DE ERYTHRINA FALCATA, SINTESIS DE ANALOGOS SIMPLIFICADOS DE ERISODINA Y ESTUDIOS DE AFINIDAD POR RECEPTORES NICOTINICOS DE ACETILCOLINA. FONDECYT (7070276) Proyecto 2007-2008 Inv. Responsable
AISLACION DE ALCALOIDES DE ERYTHRINA FALCATA, SINTESIS DE ANALOGOS SIMPLIFICADOS DE ERISODINA Y ESTUDIOS DE AFINIDAD POR RECEPTORES NICOTINICOS DE ACETILCOLINA. FONDECYT (11060502) Proyecto 2006-2009 Inv. Responsable
MONOAMINE OXIDASE INHIBITORS. bINDING MODE, RATIONAL DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION BASED ON THE ENZYMES CRYSTAL STRUCTURES FONDECYT (1060199) Proyecto 2006-2009 Coinvestigador(a)


Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host Maya, JD; Cassels, BK; Iturriaga-Vasquez, P; Ferreira J.; Faundez, M; Galanti N.; Ferreira A.; Morello A. Review ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR INTEGRATIVE PHYSIOLOGY (2007)

Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Gabriel Quiroz

ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Franco Viscarra

Juan González

HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

Mario Faúndez

Profesor Asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

CLAUDIO SAITZ

Associate Prof.

Organic and Phisycal Chemistry

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

Claudio Méndez

Investigador en Estudios Clínicos

Farmacia

Clínica Santa María

Santiago, Chile

Paul Silva

Profesor

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Maria Zúñiga

Proffesor

Química Inorgánica y Analitica

Universidad de Chile

Santiago, Chile

Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Rafaella Zárate

Bioquímica

Química y Farmacia

Universidad Católica del Norte

Antofagasta, Chile

Eduardo Gallardo

Tesista de doctorado

Química farmacológica y toxicológica

Universidad de Chile

Santiago, Chile

Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

Carlos Gallardo

Director Médico

Laboratorio Ximena Polanco

Santiago, Chile

Maria Aguirre

Professor

Quimica de los materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Mauricio Isaacs

Full Professor

Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

Carlos Díaz

Investigador Proyecto Fondef

Ingeniería Geográfica

Universidad de Santiago de Chile

Santiago, Chile

Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

Felipe Moraga

Profesor a Contrata

Departamento de Ciencias Químicas y Recursos Naturales

Universidad de La Frontera

Temuco, Chile

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Patricio Ernesto Iturriaga Vasquez

Líneas de Investigación

Educación

Química, UNIVERSIDAD DE CHILE. Chile, 2001

Experiencia Académica

Profesor Asociado Full Time

Profesor Asociado A Full Time

Experiencia Profesional

Profesor Asociado Full Time

Profesor Asociado A Full Time

Formación de Capital Humano

Article (47)

Proyecto (11)

DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET and DAT). A POLY-PHARMACOLOGY APPROACH TO TREAT AND UNDERSTAND THE NICOTINIC WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPTOR TARGETS

BIOTRANSFORMATION PROCESSES CATALYZED BY LIGNINOLYTIC ENZYMES FROM PHANEROCHAETE CHRYSOSPORIUM=> RATIONAL PROTEIN DESIGN FROM COMPUTATIONAL CALCULATIONS AND SITE-DIRECTED MUTAGENESIS STUDIES

A SYNTHETIC APPROACH TOWARDS NOVEL SERIES OF 3-(3-(1-PIPERAZINYL)PROPYL -1H-INDOLE DERIVATIVES AS MONOAMINERGIC MULTI-TARGET AGENTS. DOCKING STUDIES AND PHARMACOLOGICAL EVALUATION AT SERT, D2, AND MAO-A RECEPTORS.

FISHING FOR COMPLEMENTS=> DESIGN OF COMPOUNDS THAT SIMULTANEOUSLY INTERACT WITH MONOAMINERGIC PROTEINS AND NICOTINIC RECEPTORS, BASED ON SIMILARITIES BETWEEN THEIR LIGAND BINDING SITES

DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF DUAL NICOTINIC AGONIST AND MOA-B INHIBITORS ACTIVITY FOR REGULATION OF DOPAMINE LEVEL IN THE BRAIN.

THE MONOAMINERGIC "RECEPTOPHORE". SIMILARITIES AMONG THE ACTIVE SITES OF MONOAMINERGIC TARGET PROTEINS, BASED ON THEIR CRYSTAL STRUCTURES=> IMPLICATIONS FOR THE DEVELOPMENT OF SELECTIVE AND NON-SELECTIVE LIGANDS.

AISLACION DE ALCALOIDES DE ERYTHRINA FALCATA, SINTESIS DE ANALOGOS SIMPLIFICADOS DE ERISODINA Y ESTUDIOS DE AFINIDAD POR RECEPTORES NICOTINICOS DE ACETILCOLINA.

AISLACION DE ALCALOIDES DE ERYTHRINA FALCATA, SINTESIS DE ANALOGOS SIMPLIFICADOS DE ERISODINA Y ESTUDIOS DE AFINIDAD POR RECEPTORES NICOTINICOS DE ACETILCOLINA.

MONOAMINE OXIDASE INHIBITORS. bINDING MODE, RATIONAL DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION BASED ON THE ENZYMES CRYSTAL STRUCTURES

Review (1)