Man

Patricio Ernesto Iturriaga Vasquez

Profesor Asociado A

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Líneas de Investigación


ORGANIC SYNTHESIS; NATURAL PRODUCTS; PHARMACOLOGY; STRUCTURE-ACTIVY RELATIONSHIPS AND RATIONAL DESIGN OF DRUGS ACTING ON MONOAMINERGIC SYNAPSES.

Educación

  •  Química, UNIVERSIDAD DE CHILE. Chile, 2001

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2006 - 2014

  •   Profesor Asociado A Full Time

    University of La frontera

    Ingeniería y Ciencias

    Temuco, Chile

    2015 - A la fecha

Experiencia Profesional

  •   Profesor Asociado Full Time

    Universida de Chile

    Santiago, Chile

    2006 - 2014

  •   Profesor Asociado A Full Time

    Universidad de La Frontera

    Temuco, Chile

    2015 - A la fecha

Formación de Capital Humano


2013-2014
Diseño, síntesis y evaluación biológica de inhibidores de acetilcolinesterasa con posible potenciación alostérica del receptor nicotínico de acetilcolina (Tesis Doctoral ). Manuel Faundez Parraguez, Facultad de Ciencias, Universidad de Chile.
2013-2014
Síntesis de difenil pentanos sustituidos y su evaluación como ligando del transportador de serotonina (Tesis Magister). Juana Molina Hidalgo, Facultad de Ciencias, Universidad de Chile.
2013-2014
Optimización de la Sintesis de alquiltioisopropilaminas mediante reordenamiento de Newman-Kwart (Tesis Magister). Susana Arredondo Gutierrez, Facultad de Ciencias, Universidad de Chile.
2006-2009
Síntesis y evaluación enzimática de posibles inhibidores de monoaminooxidasa (Tesis Doctoral). Susan Lühr Sierra, Facultad de Ciencias, Universidad de Chile. (Tutor. B. Cassels; Co-Tutor. P. Iturriaga)
2007-2009
Síntesis y evaluación farmacológica de derivados de naftilisopropilaminas como posibles inhibidores de monoaminooxidasa (Tesis Magister). Marcelo Vilches Herrera, Facultad de Ciencias, Universidad de Chile. (Tutor. B. Cassels; Co-Tutor. P. Iturriaga).



 

Article (47)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish
Synthesis, in Vitro Evaluation and Molecular Docking of a New Class of Indolylpropyl Benzamidopiperazines as Dual AChE and SERT Ligands for Alzheimer's Disease
Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues
Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine alpha 4 beta 2, Dopamine and Serotonin Transporters
UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats
3D similarities between the binding sites of monoaminergic target proteins
Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors
Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of alpha 4 beta 2 Nicotinic Acetylcholine Receptors
Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.
The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.
Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1
Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy.
Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile.
Improving amphetamine therapeutic selectivity: N,N-dimethyl-MTA has dopaminergic effects and does not produce aortic contraction.
Molecular Characterization and In Silico Analysis of the Pheromone-Binding Protein of the European Grapevine Moth Lobesia botrana (Denis & Schiffermuller) (Lepidoptera, Tortricidae)
Non-equivalent Ligand Selectivity of Agonist Sites in (alpha 4 beta 2)(2)alpha 4 Nicotinic Acetylcholine Receptors A KEY DETERMINANT OF AGONIST EFFICACY
Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands
Experimental and theoretical study on the oxidation mechanism of dopamine in n-octyl pyridinium based ionic liquids-carbon paste modified electrodes
Experimental and theoretical study on the oxidation mechanism of dopamine in n-octyl pyridinium based ionic liquids-carbon paste modified electrodes
Neonicotinic analogues=> Selective antagonists for alpha 4 beta 2 nicotinic acetylcholine receptors
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo
Functional expression of the alpha 7 and alpha 4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body
STRUCTURAL REASSIGNMENT OF EPIERYTHRATIDINE, AN ALKALOID FROM Erythrina fusca, BASED ON NMR STUDIES AND COMPUTATIONAL METHODS
Synthesis, 5-Hydroxytryptamine(1A) Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-piperazinyl)-propyl]-1H-Indole Derivatives
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors
Erratum to: Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line
Molecular Determinants for Competitive Inhibition of alpha 4 beta 2 Nicotinic Acetylcholine Receptors
Crystal structure of (2R,13bS)-2,6,8,9-tetrahydro-2,12-dimethoxy-1H-indolo[1-a]isoquinolin-11-ol, C18H21NO3, Erysodine
Crystal structure of (2R,13bS)-2,6,8,9-tetrahydro-2,12-dimethoxy-1H-indolo[1-a]isoquinolin-11-ol, C18H21NO3, Erysodine
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers
C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists
Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture=> Effects of cytisine and its bromo derivatives
N-substitution and alpha(1)-adrenergic receptor affinity of laudanosine analogues
SYNTHESIS OF 2-ARYL-1,3-PROPANEDIAMINES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE
Crystal structure of isotetrandrine,C38H42N2O6
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
1-benzyl-1,2,3,4-tetrahydroisoquinolines. H-1 NMR conformational studies and rotational barriers
Geometrical isomerism in beta-nitrostyrenes=> Preferred conformations of (E)- and (Z)-1-(4-methylthiophenyl)-2-nitrobutenes
Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action

Proyecto (11)

Multisteric drugs: Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites
Synthesis of Novel Indole Derivatives Targeting: Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease
DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET and DAT). A POLY-PHARMACOLOGY APPROACH TO TREAT AND UNDERSTAND THE NICOTINIC WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPTOR TARGETS
BIOTRANSFORMATION PROCESSES CATALYZED BY LIGNINOLYTIC ENZYMES FROM PHANEROCHAETE CHRYSOSPORIUM=> RATIONAL PROTEIN DESIGN FROM COMPUTATIONAL CALCULATIONS AND SITE-DIRECTED MUTAGENESIS STUDIES
A SYNTHETIC APPROACH TOWARDS NOVEL SERIES OF 3-(3-(1-PIPERAZINYL)PROPYL -1H-INDOLE DERIVATIVES AS MONOAMINERGIC MULTI-TARGET AGENTS. DOCKING STUDIES AND PHARMACOLOGICAL EVALUATION AT SERT, D2, AND MAO-A RECEPTORS.
FISHING FOR COMPLEMENTS=> DESIGN OF COMPOUNDS THAT SIMULTANEOUSLY INTERACT WITH MONOAMINERGIC PROTEINS AND NICOTINIC RECEPTORS, BASED ON SIMILARITIES BETWEEN THEIR LIGAND BINDING SITES
DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF DUAL NICOTINIC AGONIST AND MOA-B INHIBITORS ACTIVITY FOR REGULATION OF DOPAMINE LEVEL IN THE BRAIN.
THE MONOAMINERGIC "RECEPTOPHORE". SIMILARITIES AMONG THE ACTIVE SITES OF MONOAMINERGIC TARGET PROTEINS, BASED ON THEIR CRYSTAL STRUCTURES=> IMPLICATIONS FOR THE DEVELOPMENT OF SELECTIVE AND NON-SELECTIVE LIGANDS.
AISLACION DE ALCALOIDES DE ERYTHRINA FALCATA, SINTESIS DE ANALOGOS SIMPLIFICADOS DE ERISODINA Y ESTUDIOS DE AFINIDAD POR RECEPTORES NICOTINICOS DE ACETILCOLINA.
AISLACION DE ALCALOIDES DE ERYTHRINA FALCATA, SINTESIS DE ANALOGOS SIMPLIFICADOS DE ERISODINA Y ESTUDIOS DE AFINIDAD POR RECEPTORES NICOTINICOS DE ACETILCOLINA.
MONOAMINE OXIDASE INHIBITORS. bINDING MODE, RATIONAL DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION BASED ON THE ENZYMES CRYSTAL STRUCTURES

Review (1)

Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host
19
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

6
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

3
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

2
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Mario Faúndez

Profesor Asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
CLAUDIO SAITZ

Associate Prof.

Organic and Phisycal Chemistry

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

1
Claudio Méndez

Investigador en Estudios Clínicos

Farmacia

Clínica Santa María

Santiago, Chile

1
Paul Silva

Profesor

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Maria Zúñiga

Proffesor

Química Inorgánica y Analitica

Universidad de Chile

Santiago, Chile

1
Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

1
EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Rafaella Zárate

Bioquímica

Química y Farmacia

Universidad Católica del Norte

Antofagasta, Chile

1
Eduardo Gallardo

Tesista de doctorado

Química farmacológica y toxicológica

Universidad de Chile

Santiago, Chile

1
Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carlos Gallardo

Director Médico

Laboratorio Ximena Polanco

Santiago, Chile

1
Maria Aguirre

Professor

Quimica de los materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Mauricio Isaacs

Full Professor

Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Díaz

Investigador Proyecto Fondef

Ingeniería Geográfica

Universidad de Santiago de Chile

Santiago, Chile

1
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

1
Felipe Moraga

Profesor a Contrata

Departamento de Ciencias Químicas y Recursos Naturales

Universidad de La Frontera

Temuco, Chile

1
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile