Man

CLAUDIO ANTONIO SAITZ BARRIA

Associate Prof.

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

Líneas de Investigación


ESTUDIOS EN QUIMICA SUPRAMOLECULAR DE CALIXARENOS Y CICLODEXTRINAS, SINTESIS, ESTUDIOS CONFORMACIONALES. STUDY BY FLUORESCENCE OF CALIXARENE BEARING HETEROCYCLES : COMPLEXATION OF IONS ; PHOTOREDUCTION OF HETEROCYCLES BY AMINES ;

Educación

  •  Chemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1991
  •  chemist, UNIVERSIDAD DE CHILE. Chile, 1985
  •  Chemistry, UNIVERSIDAD DE CHILE. Chile, 1985

Experiencia Académica

  •   AYUDANTE. Full Time

    UNIVERSIDAD DE CHILE

    CIENCIAS QUIMICAS Y FARMACEUTICAS

    Chile

    1989 - 1991

  •   INSTRUCTOR Full Time

    UNIVERSIDAD DE CHILE

    CIENCIAS QUIMICAS Y FARMACEUTICAS

    Chile

    1991 - 1993

  •   ASSISTANT PROF. Full Time

    UNIVERSIDAD DE CHILE

    CIENCIAS QUIMICAS Y FARMACEUTICAS

    Chile

    1993 - 2009

  •   ASSOCIATED PROF. Full Time

    UNIVERSIDAD DE CHILE

    CIENCIAS QUIMICAS Y FARMACEUTICAS

    Chile

    2009 - A la fecha

Experiencia Profesional

  •   Post-doctorando Full Time

    Universidad de Granada, España

    Granada, España

    1988 - 1989

  •   Profesor por horas Part Time

    Universidad Andres Bello (UNAB)

    Santiago, Chile

    2000 - 2009

Formación de Capital Humano


In the laboratory, in the last 5 years, 4 PhD students and 2 Master's have graduated. Six undergraduate students have also graduated. Currently a master's and a graduate student are developing their theses.Thus, 2 postdoctoral researchers have joined the work



 

Article (34)

Elucidating sensing mechanisms of a pyrene excimer-based calix[4]arene for ratiometric detection of Hg(II) and Ag (I) and chemosensor behaviour as INHIBITION or IMPLICATION logic gates
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer’s disease
Synthesis and characterization of the first cyrhetrenyl-appended calix[4] arene macrocycle and its application as an electrochemical sensor for the determination of Cu(II) in bivalve mollusks using square wave anodic stripping voltammetry
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core
A Study about Regioisomeric Hydroquinones with Multiple Intramolecular Hydrogen Bonding
Nanodecoration of Single Crystals of 5,1,17,23-Tetra-tert-butyl-25,27-bis(Cyanomethoxy)-26,28-dihydroxicalix [4]arene
Nanodecoration of single crystals of 5,11,17,23-tetra-tert-butyl-25,27- bis(cyanomethoxy)-26,28-dihydroxycalix[4]arene
Synthesis of Bifunctional receptor for Fluoride and Cadmium based on calix4arene with thiourea moieties
Spectral and Kinetic Study of 3-Methylquinoxalin-2-ones Photoreduced by Amino Acids: N-Phenylglycine Radical Chain Reactions and N-Acetyltryptophan Decarboxylation
Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New 3 Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT
Synthesis of Novel p-tert-Butylcalix[4]arene Derivative: Structural Characterization of a Methanol Inclusion Compound
Study by Fluorescence of Calix4arenes Bearing Heterocycles by Anions: Highly Selective Detection of Iodide
Study of Fluorescence of Calix4arenes Bearing Heterocycles with Divalent Metals: Highly selective detection of Pb(II)
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor
Unexpected Imidazoquinoxalinone Annulation Products in the Photoinitiated Reaction of Substituted-3-Methyl-Quinoxalin-2-Ones with N-Phenylglycine
Synthesis, 5-HT1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives
Synthesis, Docking studies and biological evaluation of benzo(b)thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives on 5-HT1A serotonin receptor
Drimenol: A Versatile Synthon for Compounds with trans-Drimane Skeleton
Oxoisoaporphines: Regioselective deuterium labelling involving the metastable hydrogenated photoproduct anions
Synthesis of 1-benzyl-3( 4-aryl-1-piperazinyl)carbonyl)-1-H-indoles. Novel Ligands with potential D4 dopaminergic activity
SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES. NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
Photoreduction of Oxoisoaporphines by Amines: Laser Flash and Steady-State Photolysis, Pulse Radiolysis, and TD-DFT Studies
Solvent-free microwave-promoted Michael addition of aza-nucleophiles to benzo[b] thiophen-2-yl-2-propenone
SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
Solvent-free Microwave Synthesis 0f 3-(4-benzo(b)thiophene-2-carbonyl)-1-piperazinyl-1-benzo(b)thiophen-2-yl-1-propanones. New Hetero bis-ligands with potential 5-HT1A serotonergic activity
Synthesis of calix[4]arenes bearing benzothiazolyl, benzoxazolyl and benzoimidazolyl heterocycles
Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity
SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIFUNGAL EVALUATION OF NOVEL BENZIMIDAZO[1,2-c]QUINAZOLINES
Photoreduction of oxoisoaporphine dyes by amines: Transient-absorption and semiempirical quantum-chemical studies
Surface-Enhanced Micro-Raman Detection and Characterization of Calix[4]arene-Polycyclic Aromatic Hydrocarbon Host-Guest Complexes
Unexpected Diastereotopic Behahaviour in the 1HNMR Spectrum of 1,4-DiHydropiridine Derivatives Triggered by Chiral and Prochiral Centres.
Unexpected Formation of 1-Diethylaminobutadiene in Photosensitized Oxidation of Triethylamine Induced by 2.3-dihydro-oxoisoaporphine Dyes. A 1H NMR and Isotopic Exchange Study
Photoreduction of oxoisoaporphines. Another example of a formal hydride-transfer mechanism
Selective molecular recognition of polycyclic aromatic hydrocarbons (PAHs) on calix[4]arene-functionalized Ag nanoparticles by surface-enhanced Raman scattering

ConferencePoster (13)

Synthesis and characterization of bifunctional fluorescense receptors bsed on calix[4]arene with the presenceof thiourea and amide groups linked to pyridine in the bridge. Study on ion recognition using spectroscopic methods.
Foto-oxidación de N-acetil triptófano por 3-metil-quinoxalin-2-ona
Synthesis of new calixarenes linked heterocycles through thiourea or amide bridge. Study their binding properties for spectroscopic methods
Synthesis of calix[4]arene bearing heterocycles, studies by spectroscopic methods as ion sensor
Synthesis of derivative p-tert-butyl calix[4]arene with thiourea and Schiff bases and study of ion recognition
Synthesis of new calix[4]arene bearing heterocycles in the upper rim as sensor for recognition of ions
Synthesis of new calixarenes bearing heterocycles for recognition of ions
Síntesis de calixareno (cono y 1,3-alternado) unidos a pirazolo[3,4-b]piridina a través de un puente bis-tiourea. Estudios de reconocimiento de iones
Cristales de Calix4arenos como soporte de Nanomateriales
Study By Fluorescence of Calix4arenes bearing heterocycles with divalent metals: Highly selective detection of Pb (II)
Síntesis de calix4arenos unidos a benzotiazol por puentes de tio-urea. Estudios de reconocimiento como fluoróforos
Utilization of 25,27-di(cyanomethoxy)-26.28-dihidroxy-5,11,17,23-tetra-tert-butylcalix(4)arene for camping gold nanoparticles
Síntesis de nuevos receptores para reconocimiento de aniones: Calix4arenos 1,3-ditiourea-heterociclos

Proyecto (20)

Design, Synthesis and Characterization of Polymers containing Calixarenes as extraction agents
PROPOSAL TITLE=> DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL CALIXARENES FOR GENE DELIVERY AND ION RECOGNITION PROCESSES.
Synthesis of Novel Derivatives Targeting=> Serotonergic (SERT inhibition/5Ht4 Agonisy Activity), Cholinergic(Acetylcholinesterasa Inhibition) and Beta.amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer's Disease
Design, synthesis and characterization of novel calixarenes bearing heterocycles containing amide or thiourea moiety for ion recognition
DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL CALIXARENES BEARING HETEROCYCLES CONTAINING AMIDE OR THIOUREA MOIETY FOR ION RECOGNITION.
Time resolved Spectroscopic studies of photochemically induced processes involving quinoxalin-2-one derivatives and amino acids
TIME RESOLVED SPECTROSCOPIC STUDY OF PHOTOCHEMICALLY INDUCED RADICAL PROCESSES INVOLVING QUINOXALIN-2-ONE DERIVATIVES AND AMINO ACIDS.
A synthetic Approach towards novel senries of 3-(3-(1-piperazinyl)propyl-1H.indole derivatives as monoaminergic multi-target agents. Docking Studies and pharmacological evaluation at sert. D2 and MAO-receptors
A SYNTHETIC APPROACH TOWARDS NOVEL SERIES OF 3-3(1-PIPERAZINYIL PROPYL)-1H-INDOLE DERIVATIVES AS MONOAMINERGIC MULTITARGENT AGENTS. DOCKING STUDIES AND PHARMACOLOGICAL EVALUATION AT SERT,D2 AND MAO-RECEPTOR
Spectroscopic and kinetic study of radicals generated by electron transfer from selected amino-acids and amines to quinaxolin-2-one drug scaffold.
SPECTROSCOPIC AND KINETIC STUDY OF RADICALS GENERATED BY ELECTRON TRANSFER FROM SELECTED AMINO-ACIDS AND AMINES TO QUINOXALIN-2-ONE DRUG SCAFFOLD.
Synthesis of calix(4)arenes containing thiourea moiety as building block/molecular scaffolds. Design of Novel selective anion recptors and sensors
SYNTHESIS OF CALIX[4]ARENES CONTAINING THIOUREA MOIETY AS BUILDING BLOCKS/MOLECULAR SCAFFOLDS. DESIGN OF NOVEL SELECTIVE ANION RECEPTORS AND SENSORS
A Rational Synthetic Approach to 3-IndoleAlkyl (Aryl)Piperazine Derivatives as New Hetero and Homobivalent ligando with potencial Serotonergic Activity.
A rational Synthetic Approach to 3-indolealkyl (Aryl)piperazine derivatives as new hetero and homobivalent ligando with potential serotonergic activity.
Synthesis of Calix(4)arene scaffold containing urea anad thio-urea moieties: Design of new sensor for anions.
Estudio de Síntesis de derivados de 2-benzotiazinil- y 4(aril piperazinil).azoalquil benzo(b) tiofenos y de analogos triciclicos semiridigizados de benzotieno(2,3-d)azepina. Una propuesta sintétiva orientada ala busqueda de ligandos serotoninérgicos de mecanismo dual.
Síntesis de calix(4)arenos quirales. Estudios de discriminación quiral por métodos espectroscopicos.
Estudio del mecanismo de Fotorreducción de Oxoisoaporfinas por aminas alifáticas. Evaluación como fotoconversores de energía electromagnetica y como actinometros re-utilizables
S´,ntesis de Calixarenos quirales. Estudio de discriminación quiral por métodos espectroscópicos

Review (1)

Drimenol: A Versatile Synthon for Compounds with trans-Drimane Skeleton
55
CLAUDIO SAITZ

Associate Prof.

Organic and Phisycal Chemistry

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

11
Julio De La Fuente

Profesor Asociado

Química Orgánica y Fisicoquímica

FAC. CS. QUÍMICAS Y FARMACÉUTICAS, UNIVERSIDAD DE CHILE

Santiago, Chile

5
CAROLINA JULLIAN

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

5
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

2
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ramiro Araya

UNIVERSIDAD DE CHILE, FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS, DPTO. QUÍMICA ORGÁNICA Y FISICOQUÍMICA

Santiago, Chile

1
Mario Faúndez

Profesor Asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Maria Zúñiga

Proffesor

Química Inorgánica y Analitica

Universidad de Chile

Santiago, Chile

1
Andres Vega

Director

Departamento de Química

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Paul Silva

Profesor

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Claudio Méndez

Investigador en Estudios Clínicos

Farmacia

Clínica Santa María

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Paul Jara

Académico

Química

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
silvana moris

Investigadora

vicerrectoria de investigacion y postgrado

Universidad Católica del Maule

Talca, Chile

1
Wilson Cardona

Chemistry Department Area Coordinator

Chemistry

Universidad Andrés Bello

Talcahuano, Chile

1
Maximiliano Martínez

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Eduardo Gallardo

Tesista de doctorado

Química farmacológica y toxicológica

Universidad de Chile

Santiago, Chile

1
Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Carlos Gallardo

Director Médico

Laboratorio Ximena Polanco

Santiago, Chile

1
MASIEL CERÒN

investigadora asociada

Universidad Bernardo O'Higgins

Santiago, Chile

1
Jaime Pizarro

Postdoctorando

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile