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Rafaella Victoria Zárate Canales

Investigadora Postdoctoral

Universidad de Antofagasta

Antofagasta, Chile

Study of the biological activity of natural compounds in Parkinson's disease, Role of the serotonergic system in Parkinson's disease, Development of optogenetic switches to regulate gene expression,

Biochemistry, UNIVERSIDAD DE ANTOFAGASTA. Chile, 2018
Biological Sciences Mention Molecular and Cellular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2017
Biological Sciences Mention Molecular and Cellular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2020
Biochemistry, UNIVERSIDAD DE ANTOFAGASTA. Chile, 2015

Co-Investigador Part Time

UNIVERSIDAD CATOLICA DEL NORTE

Facultad de Ciencias

Antofagasta, Chile

2022 - 2023
Investigadora Postdoctoral Full Time

UNIVERSIDAD DE ANTOFAGASTA

Instituto Antofagasta

Antofagasta, Chile

2023 - A la fecha

Professional Practice Other

Centro de Biotecnología "Profesor Alberto Ruiz"

Antofagasta, Chile

2016 - 2016
Bioquímica Full Time

Universidad Católica del Norte

Antofagasta, Chile

2020 - 2022

2024-2025
• Título: “Estudio de Parastrephia quadrangularis, una planta altoandina, y su efecto sobre la conducta motora en un modelo de la enfermedad de Parkinson en Drosophila melanogaster.”.
• Estudiante: Branco Cárdenas Zeballos
• Carrera: Bioquímica
• Institución: Universidad de Antofagasta
• Estado: En progreso

2023-2024
• Título: “Detección del Virus Papiloma Humano en orina de hombres para prevenir
cáncer cérvico uterino: Una revisión sistemática entre 2003-2023”.
• Estudiante: Claudia Díaz Frez
• Carrera: Química y Farmacia
• Institución: Universidad Católica del Norte
• Estado: Finalizada


Kanamycin treatment in the pre-symptomatic stage of a Drosophila PD model prevents the onset of non-motor alterations Valderrama, B. P.; Zarate, R. V.; Tamayo-Leiva, J.; Soto-Gonzalez, A.; Guerra-Ayala, S.; Arriagada-Vera, V.; Campusano, J. M. Article ISI NEUROPHARMACOLOGY (2023)
OPTO-BLUE: An Integrated Bidirectional Optogenetic Lentiviral Platform for Controlled Light-Induced Gene Expression Zamorano, Pedro Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Structural characterization, stability, and cytocompatibility study of chitosan BaTiO3@ZnO:Er heterostructures Article ISI INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)
An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster Navarro, Nicole; Rojo-Cortes, Francisca; Oliva, Carlos; Zamorano, Pedro Article ISI CELLS (2022)
Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels Article ISI SCIENTIFIC REPORTS (2021)
Optimization of the Light-On system in a lentiviral platform to a light-controlled expression of genes in neurons Estela Andres, Maria; Zamorano, Pedro Article ISI ELECTRONIC JOURNAL OF BIOTECHNOLOGY (2021)
The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms Hodge, James J. L. Article ISI NEUROCHEMISTRY INTERNATIONAL (2020)
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors Molina-Mateo, Daniela; Escobedo, Pía; Zarate, Rafaella V; Reyes-Parada, Miguel; Fuenzalida-Uribe, Nicolás Article ISI SCOPUS ACS Chemical Neuroscience (2017)
Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model: Unveiling dopaminergic compensatory mechanisms Molina-Mateo, D; Zarate, RV Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2017)