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Elías Humberto Blanco Nahuelqueo

Profesor Asistente

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Role of prohormone convertase 1/3 mutantes in obesity.; Biosynthesis and trafficking of hormone peptides.; Role of hormone peptides in obesity and drug addiction.; Neurobiology of drug addiction.

Bioquímica , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2002
Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
Bioquímica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Profesor Asistente Full Time

UNIVERSIDAD DE ANTOFAGASTA

Facultad de Ciencias de la Salud

Antofagasta, Chile

2015 - A la fecha

Postdoctorado Full Time

Núcleo Milenio Estrés y Adicción (NEDA)

Santiago, Chile

2011 - 2012
Postdoctoral fellow Full Time

University of Maryland

Baltimore, Estados Unidos

2013 - 2015

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Arsenic trioxide-increased MDCK cells proliferation requires activator protein 1-mediated increase of the sodium/proton exchanger 1 activity Figueroa, Manuel; Labarca, Cristian; Toledo, Fernando; Ramirez, Marco A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
Intracellular acidification reduces l-arginine transport via system yL but not via system y/CATs and nitric oxide synthase activity in human umbilical vein endothelial cells. Ramírez, Marco A; Morales, Jorge; Cornejo, Marcelo; Blanco, Elias H; Mancilla-Sierpe, Edgardo; Toledo, Fernando; Beltrán, Ana R; Sobrevia, Luis Article Biochimica et biophysica acta (2018)
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays Lick, Adam N.; Alejandro Posada-Salgado, J.; Martinez-Mayorga, Karina; Johnson, Alan T.; Jiao, Guan-Sheng Article ISI BIOCHEMICAL PHARMACOLOGY (2015)
Revisiting PC1/3 Mutants: Dominant-Negative Effect of Endoplasmic Reticulum-Retained Mutants Ramos-Molina, Bruno Article ISI ENDOCRINOLOGY (2015)
A Novel Familial Mutation in the PCSK1 Gene That Alters the Oxyanion Hole Residue of Proprotein Convertase 1/3 and Impairs Its Enzymatic Activity Wilschanski, Michael; Abbasi, Montaser; Blanco, Elias; Yourshaw, Michael; Zangen, David; Berger, Itai; Shteyer, Eyal; Pappo, Orit; Bar-Oz, Benjamin; Elpeleg, Orly Article ISI PLOS ONE (2014)
Biochemical and Cell Biological Properties of the Human Prohormone Convertase 1/3 Ser357Gly Mutation: A PC1/3 Hypermorph Article ISI ENDOCRINOLOGY (2014)
Defective Transport of the Obesity Mutant PC1/3 N222D Contributes to Loss of Function Prabhu, Yogikala; Liu, Ming; Peinado, Juan R.; Wheeler, Matthew C.; Gekakis, Nicholas; Arvan, Peter Article ISI ENDOCRINOLOGY (2014)
Dopamine D-1 and corticotrophin-releasing hormone type-2 alpha receptors assemble into functionally interacting complexes in living cells Fuenzalida, J.; Galaz, P; Campusano, J.M.; Ciruela, F.; Gysling, K Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2014)
Withdrawal from chronic amphetamine reduces dopamine transmission in the rat lateral septum. Renard, Georgina M; Sotomayor-Zarate, Ramón; Blanco, Elías H; Gysling, Katia Article Journal of neuroscience research (2014)
An amphipathic alpha-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway. Blanco, Elías H; Lagos, Carlos F; Andrés, María Estela; Gysling, Katia Article PloS one (2013)
Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Blanco, Elías H; Zúñiga, Juan Pablo; Andrés, María Estela; Alvarez, Alejandra R; Gysling, Katia Article Neuropeptides (2011)
Activation of GABA-B receptors induced by systemic amphetamine abolishes dopamine release in the rat lateral septum Sotomayor-Zarate, R; Araya, KA; Pereira, P; Blanco, E.; Quiroz, G; Pozo, S; Carreño P.; Andres, ME; FORRAY, MI; Gysling, K Article ISI SCOPUS Journal of Neurochemistry (2010)
Intron retention as an alternative splice variant of the rat urocortin 1 gene Blanco, E.; Rojas, R.; Haeger, P; Cuevas, R; Pérez, C.; Munita, R.; Quiroz, G; Andres, ME; FORRAY, MI; Gysling, K Article ISI SCOPUS NEUROSCIENCE (2006)

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Neuroplastin goes presynaptic - implications for endo-/exocytosis and the exocyst complex PCI (BMBF 20150) Proyecto 2017-2019 Coinvestigador(a)
EFFECT OF PRENATAL ETHANOL EXPOSURE ON NMDA RECEPTOR-MEDIATED LONG TERM PLASTICITY IN RATS=> ROLE OF REACTIVE OXYGEN SPECIES. FONDECYT (1140855) Proyecto 2014-2018 Personal técnico y/o de apoyo
MOLECULAR AND NEUROCHEMICAL MECHANISMS UNDERLYING STRESS-INDUCED RELAPSE TO COCAINE SEEKING FONDECYT (1110392) Proyecto 2011-2015 Personal técnico y/o de apoyo
STUDIES ON THE MECHANISMS UNDERLYING CRH-RECEPTOR MEDIATED NEUROADAPTATIONS IN THE VENTRAL TEGMENTAL AREA OF RATS REPEATEDLY EXPOSED TO COCAINE AND LEADING TO STRESS-INDUCED RELAPSE TO COCAINE SEEKING FONDECYT (1070340) Proyecto 2007-2011 Tesista
ESTUDIOS MOLECULARES Y FUNCIONALES DE UROCORTINA, Y SUS INTERACCIONES CON DOPAMINA Y NORADRENALINA, A NIVEL DEL SISTEMA LIMBICO DE ROEDORES, Y SU PARTICIPACION EN ADICCION A DROGAS FONDECYT (1011017) Proyecto 2001-2005 Tesista