Man

Lorena Patricia Varela Nallar

Assistant Professor

Universidad Andres Bello

Santiago, Chile

Líneas de Investigación


Wnt signaling in adult neurogenesis Adult neurogenesis in Alzheimer's disease Epigenetics in Alzheimer's disease

Educación

  •  Biochemist, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2000
  •  Biological Sciences- Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Associate Professor Full Time

    Universidad Andres Bello

    Faculty of Biological Sciences

    Santiago, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Postdoctoral Researcher Full Time

    Pontificia Universidad Católica de Chile, Center for Aging and Regeneration (CARE)

    Santiago, Chile

    2010 - 2012

Formación de Capital Humano


Thesis Students:

PhD:
2021: Muriel D. Mardones, PhD in Molecular Biosciences, Universidad Andrés Bello
2021: Miguel Guerra, PhD in Molecular Biosciences, Universidad Andrés Bello
2021: Nur Jury, PhD in Molecular Biosciences, Universidad Andrés Bello (co-tutor)
2020: Sebastián B. Arredondo, PhD in Molecular Biosciences, Universidad Andrés Bello

PhD, In Progress:
2021-present: Camila Huerta, PhD in Molecular Biosciences, Universidad Andrés Bello
2019-present: Sebastián Santibañez, PhD in Biomedicine, Universidad Andrés Bello
2018-present: Daniela Valenzuela, PhD in Molecular Biosciences, Universidad Andrés Bello

Undergraduate:
2021: Camila Galvez: “Caracterización de RNF43 en progenitores hipocampales adultos”. Biochemist. Universidad Andrés Bello. Tutor.
2021: Sonia López: “Estudio del módulo de señalización RSPO-LGR en la regulación de la proliferación de progenitores neurales adultos”. Engineer in Biotechnology. Universidad Andrés Bello. Tutor.
2020: Pilar González-Farret: “Análisis de la modificación epigenética H3k9me2 en el hipocampo de un modelo de la enfermedad de Alzheimer”. Biologist. Universidad Andrés Bello. Tutor.
2016: Valentina Jorquera: “Función de PSD-95 en el desarrollo de nuevas neuronas generadas en el hipocampo de cerebro adulto”. Master in Biotechnology. Universidad Andrés Bello. Tutor.
2016: Muriel Mardones: “Análisis in vivo de la función del receptor Frizzled-1 en la neurogénesis hipocampal adulta”. Master in Biotechnology. Universidad Andrés Bello. Tutor.
2016: Joaquín Jensen: “Rol de la vía no canónica de Wnt 5a en la neurogénesis hipocampal adulta”. Biochemistry, P. Universidad Católica de Valparaíso. Tutor
2016: Miguel Guerra: “Función de PSD-95 en la neurogénesis hipocampal adulta”. Biochemistry, P. Universidad Católica de Valparaíso. Tutor
2015: Gabriela Andaur Andrade: “Estudio de la función del receptor Wnt Frizzled-1 en prognitores neuronales del hipocampo adulto”. Master in Biotechnology. Universidad Andrés Bello. Tutor.
2015: Daniel Bustamante: “Estudio del papel de Wnt-5a sobre la neurogénesis hipocampal adulta”. Engineer in Biotechnology. Universidad Andrés Bello. Tutor.
2015: Sebastián Arredondo: “ Estudio del efecto de andrografolido sobre la neurogénesis en el hipocampo adulto”. Biochemist. P. Universidad Católica de Chile. Co-tutor.

Regular courses:
2013-present: "Cell Biology" course for undergraduate students. Universidad Andres Bello.


Premios y Distinciones

  •   Doctoral Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2002

    Doctoral Fellowship CONICYT 2002-2005

  •   Doctoral Thesis Fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2003

    Doctoral Thesis Fellowship from CONICYT 2003-2004

  •   Award for the Young Neuroscientists Symposium

    Chilean Society for Neuroscience

    Chile, 2011

    Awarded for the Symposium "Young Neuroscientists" in the VII Annual Meeting . Chilean Society for Neuroscience. Santa Cruz, 27-29 September, 2011.


 

Article (44)

Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala
H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus
Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1 Delta E9 mouse model of Alzheimer's disease
Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling.
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer?s disease mice
NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons
Wnt signalling in neuronal differentiation and development
Chronic hypoxia induces the activation of the Wnt/beta-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1 Delta E9 transgenic mice in vivo
PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors
Wnt signalling in neuronal differentiation and development
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons
Tetrahydrohyperforin Increases Adult Hippocampal Neurogenesis in Wild-Type and APPswe/PS1 Delta E9 Mice
Frizzled Receptors in Neurons: From Growth Cones to the Synapse
SIRT1 Regulates Dendritic Development in Hippocampal Neurons
Wnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against A beta Toxicity
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease: a possible effect on APP processing
The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2 X4 Receptors
The cellular prion protein prevents copper-induced inhibition of P2X 4 receptors
Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
THE ROLE OF WNT SIGNALING IN NEUROPROTECTION
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against a beta oligomers
Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target
Induction of cellular prion protein gene expression by copper in neurons
The functional links between prion protein and copper
Fas ligand in the uterus of the non-pregnant mouse induces apoptosis of CD4+T cells
Is there a role for copper in neurodegenerative diseases
Expression of intercellular adhesion molecule 1 (ICAM-1) on the human oviductal epithelium and mediation lymphoid cell adherence

BookSection (2)

Wnt Signaling Roles on the Structure and Function of the Central Synapses: Involvement in Alzheimer’s Disease
Role of Alzheimer’s β-amyloid on Wnt Signaling

EditorialMaterial (1)

IgA in the lumen of the human oviduct is not related to the menstrual cycle but increases during local inflammation

Proyecto (14)

Epigenetic changes in the pathogenesis of dementia: contribution of environmental stressors
Epigenetic changes in the pathogenesis of dementia=> contribution of environmental stressors
Adult neurogenesis, hippocampal plasticity and memory: Regulation by Wnt signaling
Adult neurogenesis, hippocampal plasticity and memory=> Regulation by Wnt signaling
Astrocyte-to-neuron communication in plasticity, learning and memory
ROLE OF PSD95 IN NMDAR-MEDIATED REFINEMENT OF THE NEURONAL STRUCTURE AND CONSOLIDATION OF FEAR MEMORIES
A new platform to derive astrocytes from induced pluripotent stem cells (iPSCs) from ALS patients and from ALS mouse transgenic models: evaluatng if the toxic factors released by human and mouse astrocytes kill motoneurons trhrough a common pathogenic pathway
A new platform to derive astrocytes from induced pluripotent stem cells (iPSCs) from ALS patients and from ALS mouse transgenic models=>..."
WNT RECEPTORS INVOLVED IN THE REGULATION OF NEUROGENESIS IN THE ADULT HIPPOCAMPUS - SEARCHING FOR THE ROLES OF WNT SIGNALING CASCADES
Wnt receptors involved in the regulation of neurogenesis in the adult hippocampus - Searching for the roles of Wnt signaling cascades
Mejoramiento de la formación académica y científica en biología y fisiología celular=> función de células madres en regeneración tisular
Droga semi-sintética IDN5706 para el Tratamiento de la Enfermedad de Alzheimer y Trastornos Cognitivos
EFECTO DE LA VIA WNT NO CANONICA SOBRE EL ENSAMBLAJE Y DIFERENCIACION DEL APARATO POSTSINAPTICO EN NEURONAS HIPOCAMPALES; POSIBLE CONEXION CON LA QUINASA C-ABL.
Efecto de la vía wnt no canónica sobre el ensamblaje y diferenciación del aparato postsináptico en neuronas hipocampales; posible conexión con la quinasa c-Abl

Review (8)

Wnt signaling in the nervous system and in Alzheimers disease
Wnt signaling in the regulation of adult hippocampal neurogenesis
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease
Neurobiological effects of hyperforin and its potential in Alzheimer's disease therapy
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations
Role of copper in prion diseases: Deleterious or beneficial?
Copper brain homeostasis: Role of amyloid precursor protein and prion protein
Is there a role for copper in neurodegenerative diseases?
57
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

33
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

7
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

4
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

3
estibaliz ampuero

Profesor Asistente

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

2
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

2
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

2
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

2
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

2
Matias Campos

Business Developer

Fundación LEITAT Chile

Santiago, Chile

1
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudio Allard

PROFESOR ASISTENTE

Química y Biología

Universidad de Atacama

Copiapó, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Marcia Manterola

Profesor Asistente

Genetica Humana Block C

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Orrego

Ayudante

Ciencias

Universidad de Arica

Santiago, Chile

1
Macarena Rojas

Directora Ejecutiva

Centro de Gerociencia, Salud Mental y Metabolismo, GERO

Santiago, Chile

1
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Servet Martinez

Full professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

1
Mario Rosemblatt

Executive Director

-

Fundacion Ciencia & Vida

Santiago, Chile

1
Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

1
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

1
Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

1
Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

1
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

1
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

1
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Paulina Salazar

CTO

Desarrollo de productos y servicios biotecnológicos SpA

Valparaíso, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Jorge Escobar

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Alejandro Maass

Director

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

1
Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

1
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Pablo Ruiz

Associate Professor

Instituto de Salud Poblacional

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile