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Lorena Patricia Varela Nallar

Assistant Professor

Universidad Andres Bello

Santiago, Chile

Wnt signaling in adult neurogenesis Adult neurogenesis in Alzheimer's disease Epigenetics in Alzheimer's disease

Biochemist, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2000
Biological Sciences- Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Associate Professor Full Time

Universidad Andres Bello

Faculty of Biological Sciences

Santiago, Chile

2012 - A la fecha

Postdoctoral Researcher Full Time

Pontificia Universidad Católica de Chile, Center for Aging and Regeneration (CARE)

Santiago, Chile

2010 - 2012

Thesis Students:

PhD:
2021: Muriel D. Mardones, PhD in Molecular Biosciences, Universidad Andrés Bello
2021: Miguel Guerra, PhD in Molecular Biosciences, Universidad Andrés Bello
2021: Nur Jury, PhD in Molecular Biosciences, Universidad Andrés Bello (co-tutor)
2020: Sebastián B. Arredondo, PhD in Molecular Biosciences, Universidad Andrés Bello

PhD, In Progress:
2021-present: Camila Huerta, PhD in Molecular Biosciences, Universidad Andrés Bello
2019-present: Sebastián Santibañez, PhD in Biomedicine, Universidad Andrés Bello
2018-present: Daniela Valenzuela, PhD in Molecular Biosciences, Universidad Andrés Bello

Undergraduate:
2021: Camila Galvez: “Caracterización de RNF43 en progenitores hipocampales adultos”. Biochemist. Universidad Andrés Bello. Tutor.
2021: Sonia López: “Estudio del módulo de señalización RSPO-LGR en la regulación de la proliferación de progenitores neurales adultos”. Engineer in Biotechnology. Universidad Andrés Bello. Tutor.
2020: Pilar González-Farret: “Análisis de la modificación epigenética H3k9me2 en el hipocampo de un modelo de la enfermedad de Alzheimer”. Biologist. Universidad Andrés Bello. Tutor.
2016: Valentina Jorquera: “Función de PSD-95 en el desarrollo de nuevas neuronas generadas en el hipocampo de cerebro adulto”. Master in Biotechnology. Universidad Andrés Bello. Tutor.
2016: Muriel Mardones: “Análisis in vivo de la función del receptor Frizzled-1 en la neurogénesis hipocampal adulta”. Master in Biotechnology. Universidad Andrés Bello. Tutor.
2016: Joaquín Jensen: “Rol de la vía no canónica de Wnt 5a en la neurogénesis hipocampal adulta”. Biochemistry, P. Universidad Católica de Valparaíso. Tutor
2016: Miguel Guerra: “Función de PSD-95 en la neurogénesis hipocampal adulta”. Biochemistry, P. Universidad Católica de Valparaíso. Tutor
2015: Gabriela Andaur Andrade: “Estudio de la función del receptor Wnt Frizzled-1 en prognitores neuronales del hipocampo adulto”. Master in Biotechnology. Universidad Andrés Bello. Tutor.
2015: Daniel Bustamante: “Estudio del papel de Wnt-5a sobre la neurogénesis hipocampal adulta”. Engineer in Biotechnology. Universidad Andrés Bello. Tutor.
2015: Sebastián Arredondo: “ Estudio del efecto de andrografolido sobre la neurogénesis en el hipocampo adulto”. Biochemist. P. Universidad Católica de Chile. Co-tutor.

Regular courses:
2013-present: "Cell Biology" course for undergraduate students. Universidad Andres Bello.

Doctoral Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2002

Doctoral Fellowship CONICYT 2002-2005
Doctoral Thesis Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2003

Doctoral Thesis Fellowship from CONICYT 2003-2004
Award for the Young Neuroscientists Symposium

Chilean Society for Neuroscience

Chile, 2011

Awarded for the Symposium "Young Neuroscientists" in the VII Annual Meeting . Chilean Society for Neuroscience. Santa Cruz, 27-29 September, 2011.


Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala Linsambarth, Sergio; Carvajal, Francisco J.; Moraga-Amaro, Rodrigo; Mendez, Luis; Tamburini, Giovanni; Jimenez, Ivanka; Antonio Verdugo, Daniel; Gomez, Gonzalo, I; Jury, Nur; Martinez, Pablo; Van Zundert, Brigitte; Varela-Nallar, Lorena; Retamal, Mauricio A.; Martin, Claire; Altenberg, Guillermo A.; Fiori, Mariana C.; Cerpa, Waldo; Orellana, Juan A.; Stehberg, Jimmy Article ISI FASEB JOURNAL (2022)
H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus Guerra, Miguel V.; Caceres, Matias I.; Herrera-Soto, Andrea; Arredondo, Sebastian B.; Varas-Godoy, Manuel; Van Zundert, Brigitte; Varela-Nallar, Lorena Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1 Delta E9 mouse model of Alzheimer's disease Arredondo, Sebastian B.; Reyes, Daniel T.; Herrera-Soto, Andrea; Mardones, Muriel D.; Inestrosa, Nibaldo C.; Varela-Nallar, Lorena Article ISI SCIENTIFIC REPORTS (2021)
Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase Ramos-Fernandez, Eva; Arrazola, Macarena S.; Oliva, Carolina A; Arredondo, Sebastian B.; Varela-Nallar, Lorena; Inestrosa, Nibaldo C. Article ISI SCIENTIFIC REPORTS (2021)
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG Espinoza, Sofia; Arredondo, Sebastian B.; Barake, Francisca; Carvajal, Francisco; Guerrero, Fernanda G.; Segovia-Miranda, Fabian; Valenzuela, David M.; Wyneken, Ursula; Rojas-Fernandez, Alejandro; Cerpa, Waldo; Massardo, Loreto; Varela-Nallar, Lorena; Gonzalez, Alfonso Article ISI BMC BIOLOGY (2020)
Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution CalderÃ³n-GarcidueÃ±as L.; Herrera-Soto A.; Jury N.; Maher B.A.; GonzÃ¡lez-Maciel A.; Reynoso-Robles R.; Ruiz-Rudolph P.; van Zundert B.; Varela-Nallar L. Article ISI SCOPUS Environmental Research (2020)
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease Arredondo, Sebastian B.; Valenzuela-Bezanilla, Daniela; Mardones, Muriel D.; Varela-Nallar, Lorena Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice Jury N.; Abarzua S.; Diaz I.; Guerra M.V.; Ampuero E.; Cubillos P.; Martinez P.; Herrera-Soto A.; Arredondo C.; Rojas F.; Manterola M.; Rojas A.; Montecino M.; Varela-Nallar L.; Van Zundert B. Article ISI SCOPUS CLINICAL EPIGENETICS (2020)
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling. Article ISI SCOPUS STEM CELLS (2020)
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus Salech, Felipe; Varela-Nallar, Lorena; Arredondo, Sebastian B.; Bustamante, Daniel B.; Andaur, Gabriela A.; Cisneros, Rodrigo; Ponce, Daniela P.; Ayala, Patricia; Inestrosa, Nibaldo C.; Valdes, Jose L.; Behrens, Maria I.; Couve, Andres Article ISI SCOPUS JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)
PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus Mardones, Muriel D.; Jorquera, Patricia V.; Herrera-Soto, Andrea; Ampuero, Estibaliz; Bustos, Fernando J; Van Zundert, Brigitte; Varela-Nallar, Lorena Article ISI SCOPUS JOURNAL OF CHEMICAL NEUROANATOMY (2019)
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer?s disease mice Bustos, Fernando J; Ampuero, Estibaliz; Jury, Nur; Aguilar, Rodrigo; Falahi, Fahimeh; Toledo, Jorge; Ahumada, Juan; Lata, Jaclyn; Cubillos, Paula; Henríquez, Berta; Guerra, Miguel V; Stehberg, Jimmy; Neve, Rachael L; Inestrosa, Nibaldo C; Wyneken, Ursula; Fuenzalida, Marco; Härtel, Steffen; Sena-Esteves, Miguel; Varela-Nallar, Lorena; Rots, Marianne G; Montecino, Martin; van Zundert, Brigitte Article Brain (2017)
NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac Bustos, Fernando J; Jury, Nur; Martínez, Pablo; Ampuero, Estibaliz; Campos, Matias; Abarzúa, Sebastian; Jaramillo, Karen; Ibing, Susanne; Mardones, Muriel D.; Haensgen, Henny; Kzhyshkowska, Julia; Tevy, Maria Florencia; Neve, Rachael; Sanhueza, Magdalena; Varela-Nallar, Lorena; Montecino, Martín; Van Zundert, Brigitte Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Frizzled-1 receptor regulates adult hippocampal neurogenesis Mardones M.D., Andaur G.A.; Varas-Godoy M, Henriquez J.F.; Salech F, Behrens M.I.; Couve A, Inestrosa N.C. Article Molecular Brain (2016)
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease Tapia-Rojas, C; Aranguiz, F; Varela-Nallar, L; Inestrosa, NC Article ISI SCOPUS Brain Pathology (2016)
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus Varela-Nallar, L; Arredondo, SB; Tapia-Rojas, C; Hancke, J; Inestrosa, NC Article ISI SCOPUS Neural Plasticity (2015)
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells Flores-Santibez, Felipe; Fernndez, Dominique; Meza, Daniel; Tejn, Gabriela; Vargas, Leonardo; Varela-Nallar, Lorena; Arredondo, Sebastin; Guixé, Victoria; Rosemblatt, Mario; Bono, Mara Rosa; Sauma, Daniela Article ISI SCOPUS Immunology (2015)
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance Cisternas P.; salazar, P; Serrano, FG; Montecinos-Oliva, C; Arredondo, SB; Varela-Nallar, L; Barja S.; Vio, CP; Gomez-Pinilla, F; Inestrosa, NC Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2015)
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons alfaro ie; Varela-Nallar, L; Varas-Godoy, M; Inestrosa, NC Article ISI SCOPUS Molecular and Cellular Neuroscience (2015)
Wnt signalling in neuronal differentiation and development Inestrosa NC, Varela-Nallar L. Article Cell and Tissue Research (2015)
Chronic hypoxia induces the activation of the Wnt/beta-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1 Delta E9 transgenic mice in vivo Varela-Nallar, L; Rojas-Abalos, M; Abbott AC; Moya, EA; Iturriaga R.; Inestrosa, NC Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors Bustos, Fernando J.; Varela-Nallar, Lorena; Campos, Matias; Henriquez, Berta; Phillips, Marnie; Opazo, Carlos; Aguayo, Luis G.; Montecino, Martin; Constantine-Paton, Martha; Inestrosa, Nibaldo C.; van Zundert, Brigitte Article ISI SCOPUS PLOS ONE (2014)
Wnt signalling in neuronal differentiation and development Inestrosa, N. C.; Varela-Nallar L. Article ISI SCOPUS Cell and Tissue Research (2014)
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons Slater, Paula G.; Ramirez, Valerie T.; Gonzalez-Billault, Christian; Varela-Nallar, Lorena; Inestrosa, Nibaldo C; Katoh, Masaru Article ISI SCOPUS PLOS ONE (2013)
Tetrahydrohyperforin Increases Adult Hippocampal Neurogenesis in Wild-Type and APPswe/PS1 Delta E9 Mice Abbott AC; Toledo, CC; Aranguiz FC; Inestrosa, NC; Varela-Nallar, L Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Frizzled Receptors in Neurons: From Growth Cones to the Synapse Varela-Nallar, L; Ramirez V.T.; Gonzalez-Billault, C; Inestrosa, N. C. Article ISI SCOPUS Cytoskeleton (2012)
SIRT1 Regulates Dendritic Development in Hippocampal Neurons Codocedo, Juan F.; Allard, Claudio; Godoy, Juan A; Varela-Nallar, Lorena; Inestrosa, Nibaldo C; Allinquant, Bernadette Article ISI SCOPUS PLOS ONE (2012)
Wnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against A beta Toxicity Varela-Nallar, L; Parodi, J; Farias G.G.; Inestrosa, N. C. Article ISI SCOPUS Neurodegenerative Diseases (2012)
Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1 Delta E9 model of Alzheimer's disease: a possible effect on APP processing Inestrosa, NC; Tapia-Rojas, C; Griffith TN; Carvajal, FJ; Benito MJ; Rivera-Dictter, A; Alvarez, AR; Serrano, FG; Hancke, JL; Burgos, PV; Parodi, J; Varela-Nallar, L Article ISI SCOPUS Translational Psychiatry (2011)
The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2 X4 Receptors Lorca, Ramn A.; Varela-Nallar, Lorena; Inestrosa, Nibaldo C; Huidobro-Toro, J. Pablo Article SCOPUS International Journal of Alzheimer's Disease (2011)
The cellular prion protein prevents copper-induced inhibition of P2X 4 receptors Lorca R.A.; Huidobro-Toro J.P.; Varela-Nallar, L; Inestrosa, N. C. Article International Journal of Alzheimer's Disease (2011)
Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic Escobar, J; Varela-Nallar, L; Coddou, C.; Nelson, P.; Maisey, K; Valdes, D.; Aspée A.; Espinosa, V; Rozas C.; Montoya, M; Mandiola C.; Rodríguez FE; Acuna-Castillo, C; Escobar A.; Fernandez, R.; Diáz, H.; Sandoval M.; Imarai M.; Rios M. Article ISI SCOPUS Mediators of Inflammation (2010)
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation de Arce KP; Varela-Nallar, L; Farias O.; Cifuentes, A.; Bull, P; Couch BA; Koleske AJ; Inestrosa, NC; Alvarez, AR Article ISI SCOPUS Journal of Neuroscience (2010)
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses Varela-Nallar, L; alfaro ie; Serrano, FG; Parodi, J; Inestrosa, NC Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2010)
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway Arrazola, MS; Varela-Nallar, L; Colombres M.; Toledo EM; Cruzat F.; Pavez, L.; Assar, R; Aravena, A.; Gonzalez, M.; Montecino, M.; Maass A.; Martínez, S.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function Varela-Nallar, L; Grabowski CP; alfaro ie; Alvarez, AR; Inestrosa, NC Article ISI SCOPUS NEUROSCIENCE LETTERS (2009)
THE ROLE OF WNT SIGNALING IN NEUROPROTECTION Cerpa, W.; Toledo EM; Varela-Nallar, L; Inestrosa, NC Article ISI DRUG NEWS PERSPECTIVES (2009)
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against a beta oligomers Chacón MA; Varela-Nallar, L; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Synaptotoxicity in Alzheimer's disease: The Wnt signaling pathway as a molecular target Inestrosa, NC; Varela-Nallar, L; Grabowski CP; Colombres M. Article ISI IUBMB LIFE (2007)
Induction of cellular prion protein gene expression by copper in neurons Varela-Nallar, L; Toledo EM; Larrondo, LF; Cabral, ALB; Martins, VR; Inestrosa, NC Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
The functional links between prion protein and copper Varela-Nallar, L; Toledo EM; Chacón MA; Inestrosa, NC Article ISI SCIELO BIOLOGICAL RESEARCH (2006)
Fas ligand in the uterus of the non-pregnant mouse induces apoptosis of CD4+T cells Imarai M.; Varela-Nallar, L; Figueroa-Gaete, C; Gonzalez P.; Valdes, D.; Velasquez L.; Cardenas H.; Maisey, K Article ISI SCOPUS JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2005)
Is there a role for copper in neurodegenerative diseases Cerpa, W; Varela-Nallar, L; Reyes, AE; Minniti, AN; Inestrosa, NC. Article ISI MOLECULAR ASPECTS OF MEDICINE (2005)
Expression of intercellular adhesion molecule 1 (ICAM-1) on the human oviductal epithelium and mediation lymphoid cell adherence Utreras, E; Ossandon, P; Acuna-Castillo, C; Varela-Nallar, L; Muller C.; Arraztoa JA; Cardenas H.; Imarai M. Article ISI JOURNAL OF REPRODUCTION AND FERTILITY (2000)


Wnt Signaling Roles on the Structure and Function of the Central Synapses: Involvement in Alzheimer’s Disease Inestrosa, NC; Varela-Nallar, L; Sabine Wislet-Gendebien BookSection (2013)
Role of Alzheimer’s β-amyloid on Wnt Signaling Inestrosa, NC; Grabowski, C; Arrázola, M; Varela-Nallar, L; Toledo, EM.; Claudio Hetz BookSection (2008)


IgA in the lumen of the human oviduct is not related to the menstrual cycle but increases during local inflammation Arraztoa JA; Rocha, A; Varela-Nallar, L; Velasquez L.; Toro V.; Cardenas H.; Imarai M. EditorialMaterial ISI FERTILITY AND STERILITY (2002)


Epigenetic changes in the pathogenesis of dementia: contribution of environmental stressors van Zundert, Brigitte; Varela-Nallar, Lorena; Stehberg, Jimmy Proyecto (2017)
Epigenetic changes in the pathogenesis of dementia=> contribution of environmental stressors Universidad Andres Bello (DI-4-17/N) Proyecto 2017-2019 Inv. Responsable
Adult neurogenesis, hippocampal plasticity and memory: Regulation by Wnt signaling Varela-Nallar, Lorena Proyecto (2015)
Adult neurogenesis, hippocampal plasticity and memory=> Regulation by Wnt signaling FONDECYT (1150933) Proyecto 2015-2018 Inv. Principal
Astrocyte-to-neuron communication in plasticity, learning and memory Universidad Andres Bello (DI-603-14/N) Proyecto 2014-2016 Coinvestigador(a)
ROLE OF PSD95 IN NMDAR-MEDIATED REFINEMENT OF THE NEURONAL STRUCTURE AND CONSOLIDATION OF FEAR MEMORIES FONDECYT (1140301) Proyecto 2014-2018 Coinvestigador(a)
A new platform to derive astrocytes from induced pluripotent stem cells (iPSCs) from ALS patients and from ALS mouse transgenic models: evaluatng if the toxic factors released by human and mouse astrocytes kill motoneurons trhrough a common pathogenic pathway van Zundert, Brigitte; Varela-Nallar, Lorena; Montecino, Martin Proyecto (2013)
A new platform to derive astrocytes from induced pluripotent stem cells (iPSCs) from ALS patients and from ALS mouse transgenic models=>..." PCI (USA-2013-0) Proyecto 2013-2016 Coinvestigador(a)
WNT RECEPTORS INVOLVED IN THE REGULATION OF NEUROGENESIS IN THE ADULT HIPPOCAMPUS - SEARCHING FOR THE ROLES OF WNT SIGNALING CASCADES FONDECYT (11110012) Proyecto 2011-2014 Inv. Responsable
Wnt receptors involved in the regulation of neurogenesis in the adult hippocampus - Searching for the roles of Wnt signaling cascades Varela-Nallar, Lorena Proyecto (2011)
Mejoramiento de la formación académica y científica en biología y fisiología celular=> función de células madres en regeneración tisular PAI (79090027) Proyecto 2010-2012 Investigador(a)
Droga semi-sintética IDN5706 para el Tratamiento de la Enfermedad de Alzheimer y Trastornos Cognitivos FONDEF (D07I1052) Proyecto 2009-2010 Postdoctorado
EFECTO DE LA VIA WNT NO CANONICA SOBRE EL ENSAMBLAJE Y DIFERENCIACION DEL APARATO POSTSINAPTICO EN NEURONAS HIPOCAMPALES; POSIBLE CONEXION CON LA QUINASA C-ABL. FONDECYT (3070017) Proyecto 2007-2009 Inv. Responsable
Efecto de la vía wnt no canónica sobre el ensamblaje y diferenciación del aparato postsináptico en neuronas hipocampales; posible conexión con la quinasa c-Abl Varela-Nallar, Lorena Proyecto (2007)


Wnt signaling in the nervous system and in Alzheimers disease Inestrosa, NC; Varela-Nallar, L Review ISI JOURNAL OF MOLECULAR CELL BIOLOGY (2014)
Wnt signaling in the regulation of adult hippocampal neurogenesis Varela-Nallar, L; Inestrosa, NC Review ISI SCOPUS Frontiers in Cellular Neuroscience (2013)
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease Varela-Nallar, L; Aranguiz FC; Abbott AC; Slater PG; Inestrosa, NC Review ISI SCOPUS Birth Defects Research Part C - Embryo Today: Reviews (2010)
Neurobiological effects of hyperforin and its potential in Alzheimer's disease therapy Griffith T.N.; Varela-Nallar L.; Dinamarca M.C.; Inestrosa, N. C. Review ISI SCOPUS Current Medicinal Chemistry (2010)
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations Farias GG.; Godoy JA; Cerpa, W.; Varela-Nallar, L; Inestrosa, NC Review ISI SCOPUS Developmental Dynamics (2010)
Role of copper in prion diseases: Deleterious or beneficial? Varela-Nallar, L; González A; Inestrosa, NC Review ISI CURRENT PHARMACEUTICAL DESIGN (2006)
Copper brain homeostasis: Role of amyloid precursor protein and prion protein Inestrosa, NC; Cerpa, W.; Varela-Nallar, L Review ISI SCOPUS IUBMB LIFE (2005)
Is there a role for copper in neurodegenerative diseases? Cerpa, W.; Varela-Nallar, L; Minniti A.N.; Inestrosa, N. C.; Reyes A.E. Review SCOPUS MOLECULAR ASPECTS OF MEDICINE (2005)

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

estibaliz ampuero

Profesor Asistente

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

Matias Campos

Jefe Negocios

Centro Tecnológico para la innovación alimentaria

Santiago, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

Juan Godoy

Investigador

Centro de Oncologia dePrecision

Santiago, Chile

Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Macarena Rojas

Directora Ejecutiva

Centro de Gerociencia, Salud Mental y Metabolismo, GERO

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Paula Slater

Postdoctoral researcher

Biological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudio Allard

PROFESOR ASISTENTE

Química y Biología

Universidad de Atacama

Copiapó, Chile

Rodrigo Orrego

Ayudante

Ciencias

Universidad de Arica

Santiago, Chile

Marcia Manterola

Profesor Asistente

Genetica Humana Block C

UNIVERSIDAD DE CHILE

Santiago, Chile

Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Maria Tevy

investigadora invitada

INTA

Universidad de Chile

Santiago de Chile, Chile

Hernan Diaz

Fabián Segovia

Associate professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Servet Martinez

Full professor

Mathematical Engineering

Universidad de Chile

Santiago, Chile

Mario Rosemblatt

Executive Director

Fundacion Ciencia & Vida

Santiago, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

Luis Larrondo

Associate Professor

Genetica Molecular y Microbiologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Fernando Cruzat

Profesor Asociado

Oceanografia

Universidad de Concepción

Concepción, Chile

Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Paulina Salazar

CTO

Desarrollo de productos y servicios biotecnológicos SpA

Valparaíso, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Salesa Barja

Médico Nutrióloga pediátrica

Gastroenterología y Nutrición Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Carolina Oliva

Investigadora y Coordinadora Áreas STEM

Vicerrectoría de Investigación y Doctorados

Universidad Autónoma de Chile

Santiago, Chile

Pablo Ruiz

Associate Professor

Instituto de Salud Poblacional

UNIVERSIDAD DE CHILE

Santiago, Chile

Macarena Arrázola

Profesor Asistente

Centro de Biología Integrativa

Universidad Mayor

Santiago, Chile

Maria Magdalena Sanhueza

Profesora Asociada

Biología

Universidad de Chile

Santiago, Chile

Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Valerie Ramirez

Senior Associate Scientist

Inflammation Research

Amgen

Thousand Oaks, Estados Unidos

Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Jorge Escobar

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

Alejandro Maass

Main Researcher

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

Lorena Patricia Varela Nallar

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2000

Biological Sciences- Cell and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

Associate Professor Full Time

Experiencia Profesional

Postdoctoral Researcher Full Time

Formación de Capital Humano

Premios y Distinciones

Doctoral Fellowship

Doctoral Thesis Fellowship

Award for the Young Neuroscientists Symposium

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Proyecto (14)

Epigenetic changes in the pathogenesis of dementia=> contribution of environmental stressors

Adult neurogenesis, hippocampal plasticity and memory=> Regulation by Wnt signaling

Astrocyte-to-neuron communication in plasticity, learning and memory

ROLE OF PSD95 IN NMDAR-MEDIATED REFINEMENT OF THE NEURONAL STRUCTURE AND CONSOLIDATION OF FEAR MEMORIES

A new platform to derive astrocytes from induced pluripotent stem cells (iPSCs) from ALS patients and from ALS mouse transgenic models=>..."

WNT RECEPTORS INVOLVED IN THE REGULATION OF NEUROGENESIS IN THE ADULT HIPPOCAMPUS - SEARCHING FOR THE ROLES OF WNT SIGNALING CASCADES

Mejoramiento de la formación académica y científica en biología y fisiología celular=> función de células madres en regeneración tisular

Droga semi-sintética IDN5706 para el Tratamiento de la Enfermedad de Alzheimer y Trastornos Cognitivos

EFECTO DE LA VIA WNT NO CANONICA SOBRE EL ENSAMBLAJE Y DIFERENCIACION DEL APARATO POSTSINAPTICO EN NEURONAS HIPOCAMPALES; POSIBLE CONEXION CON LA QUINASA C-ABL.

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