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Macarena Soledad Arrázola Tello

Profesor Asistente

Universidad Mayor

Santiago, Chile

- Neurodegeneración en envejecimiento, neuroinflamación y deterioro cognitivo. Implicancias terapéuticas - Degeneración de la retina y nervio óptico en atrofia óptica dominante - Función y estructura mitocondrial

Biología Celular y Molecular, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2014
Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
Químico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Docente Part Time

Universidad Bernardo O'Higgins

Facultad de Salud, Deporte y Recreación

Santiago, Chile

2011 - 2015
Profesor Asistente Full Time

Universidad Mayor

Facultad de Ciencias

Santiago, Chile

2022 - A la fecha

Postdoctorado Full Time

Université Paul Sabatier

Toulouse, Chile

2015 - 2017
Doctorado (tesista) Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2009 - 2014
Asistente de Investigación Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2008 - 2009
Tesista Pregrado Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2006 - 2007
Postdoctorado Full Time

Universidad Mayor

Santiago, Chile

2017 - 2021
Investigador Principal Full Time

Centro de Biología Integrativa /Universidad Mayor

Santiago, Chile

2022 - A la fecha

1. Felipe Veliz Valverde (2021- a la fecha), co-directora, Programa de Doctorado en Neurobiología, Universidad Mayor
Titulo tesis: "Impact of voluntary exercise on necroptotic-dependent axona degeneration and cognitive performance along aging"

2. Alexandra Iribarren / Javiera Paz Oporto (2022), Directora, Pregrado Tecnología Médica, Universidad Mayor
Título Tesis: "Estudio de la expresión de PGAM5 durante la progresión de la degeneración de la retina y nervio óptico en atrofia óptica dominante"

3. Iván Avendaño / Sofía Jiménez Le-Fort (2023), Directora, Pregrado Tecnología Médica, Universidad Mayor
Título Tesis: "Implementación de un equipo no invasivo para la evaluación de la agudeza visual en modelos de ratón"

2º lugar a la presentación de “Tesis en 3 minutos, UC"

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2014

Concurso enfocado a alumnos de doctorado que fomenta la difusión de los trabajos de tesis en 3 minutos a un publico general. Título de la presentación: Alzheimer´s disease and mitochondrial dysfunction: How Wnt signaling protects neurons?
Premio a la mejor presentación oral de Estudiantes de Doctorado

Sociedad de Biología Celular de Chile, Congreso Anual XXVII

Chile, 2013

Presentación oral realizada durante las conferencias del congreso anual de la Sociedad de Biología Celular de Chile, premiada como la mejor presentación de Doctorado, titulada "Wnt3a ligand prevents mitochondrial permeability transition pore opening induced by A? oligomers"


Commentary on "PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons" Arrazola, Macarena S.; Court, Felipe A. Article ISI NEURAL REGENERATION RESEARCH (2023)
Genetic background modulates phenotypic expressivity in OPA1 mutated mice, relevance to DOA pathogenesis Atamena, Djamaa; Gurram, Venu; Petsophonsakul, Petnoi; Khosrobakhsh, Farnoosh; Arrazola, Macarena S.; Botella, Marlene; Wissinger, Bernd; Szelechowski, Marion; Belenguer, Pascale Article ISI FRONTIERS IN MOLECULAR NEUROSCIENCE (2023)
Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice Andraini, Trinovita; Mouledous, Lionel; Petsophonsakul, Petnoi; Florian, Cedrick; Gauzin, Sebastien; Botella-Daloyau, Marlene; Arrazola, Macarena; Nikolla, Kamela; Philip, Adam; Leydier, Alice; Marque, Manon; Arnaune-Pelloquin, Laetitia; Belenguer, Pascale; Rampon, Claire; Miquel, Marie -Christine Article ISI ENEURO (2023)
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation Arrazola, Macarena S.; Lira, Matias; Veliz-Valverde, Felipe; Quiroz, Gabriel; Iqbal, Somya; Eaton, Samantha L.; Lamont, Douglas J.; Huerta, Hernan; Ureta, Gonzalo; Bernales, Sebastian; Cardenas, J. Cesar; Cerpa, Waldo; Wishart, Thomas M.; Court, Felipe A. Article ISI AGING CELL (2023)
Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance Santos, Nicolas; Valenzuela, Santiago; Segura, Camilo; Osorio-Roman, Igor; Arrazola, Macarena S.; Panadero-Medianero, Concepcion; Santana, Paula A.; Ahumada, Manuel Article ISI DISCOVER NANO (2023)
Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase Ramos-Fernandez, Eva; Arrazola, Macarena S.; Oliva, Carolina A; Arredondo, Sebastian B.; Varela-Nallar, Lorena; Inestrosa, Nibaldo C. Article ISI SCIENTIFIC REPORTS (2021)
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation. Montecinos-Oliva C, Arrázola MS, Jara C, Tapia-Rojas C, Inestrosa NC. Article ISI SCOPUS PHARMACEUTICALS (2020)
Axonal Degeneration Is Mediated by Necroptosis Activation ArrÃ¡zola M.S.; Saquel C.; CatalÃ¡n R.J.; Barrientos S.A.; Hernandez D.E.; MartÃnez N.W.; Catenaccio A.; Court F.A. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2019)
Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology Arrazola, Macarena S.; Court, Felipe A. Article ISI SCOPUS NEURAL REGENERATION RESEARCH (2019)
Mitochondria in Developmental and Adult Neurogenesis Arrazola, MS; Andraini, T; Szelechowski, M; Mouledous, L; Arnaune-Pelloquin, L; Davezac, N; Belenguer, P; Rampon, C; Miquel, MC Article ISI NEUROTOXICITY RESEARCH (2019)
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling Chao de la Barca J.M.; ArrÃ¡zola M.S.; Bocca C.; ArnaunÃ©-Pelloquin L.; Iuliano O.; Tcherkez G.; Lenaers G.; Simard, G; Belenguer P.; Reynier P. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease. Richetin, Kevin; Moulis, Manon; Millet, Aurélie; Arràzola, Macarena S; Andraini, Trinovita; Hua, Jennifer; Davezac, Noélie; Roybon, Laurent; Belenguer, Pascale; Miquel, Marie-Christine; Rampon, Claire Article Neurobiology of disease (2017)
Wnt Signaling Prevents the AÎ² Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons. Arrázola, Macarena S; Ramos-Fernández, Eva; Cisternas, Pedro; Ordenes, Daniela; Inestrosa, Nibaldo C Article PloS one (2017)
How the Wnt signaling pathway protects from neurodegeneration=> the mitochondrial scenario. Arrázola, Macarena S; Silva-Alvarez, Carmen; Inestrosa, Nibaldo C Article Frontiers in cellular neuroscience (2015)
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?=> Changes in A beta oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice Tapia-Rojas, C; Lindsay, CB; Montecinos-Oliva, C; Arrazola MS, Retamales; RM, Bunout D.; Hirsch S., Inestrosa Article Molecular Neurodegeneration (2015)
The Protein Oxidation Repair Enzyme Methionine Sulfoxide Reductase A Modulates A beta Aggregation and Toxicity In Vivo Minniti A.N., Arrázola M.S.; Bravo-Zehnder, M; Ramos F., Inestrosa N.C. Article ANTIOXIDANTS & REDOX SIGNALING (2015)
WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by AÎ² oligomers. Vargas, Jessica Y; Ahumada, Juan; Arrázola, Macarena S; Fuenzalida, Marco; Inestrosa, Nibaldo C Article Experimental neurology (2015)
Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons Godoy J.A., Arrázola M.S.; Ordenes D., Silva-Alvarez; C, Braidy N Article Journal of Biological Chemistry (2014)
Canonical Wnt signaling protects hippocampal neurons from A beta oligomers=> role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics Silva-Alvarez, C; Arrazola MS, Godoy; JA, Ordenes D.; Inestrosa, NC Article Frontiers in Cellular Neuroscience (2013)
Nicotine Prevents Synaptic Impairment Induced by Amyloid-beta Oligomers Through alpha 7-Nicotinic Acetylcholine Receptor Activation Inestrosa, NC; Godoy, JA; Vargas JY, Arrazola MS; rios ja, Carvajal FJ; Serrano FG, Farias GG. Article NEUROMOLECULAR MEDICINE (2013)
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease Dinamarca MC, Sagal JP; Quintanilla RA, Godoy; JA, Arrazola MS; Inestrosa, NC Article MOLECULAR NEURODEGENERATION (2010)
Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway Arrazola MS, Varela-Nallar; L, Colombres M; Toledo EM, Cruzat F.; Pavez L, Assar R.; Aravena A, Gonzalez M; Montecino M., Maass A; Martínez, S.; Inestrosa, NC Article Journal of Cellular Physiology (2009)
Release of acetylcholinesterase (ACH) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice Dinamarca MC, Arrázola M.; Toledo E, Cerpa; WF, Hancke J; Inestrosa, NC Article CHEMICO-BIOLOGICAL INTERACTIONS (2008)


Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis Arrázola M.S.; Inestrosa, N. C. BookWhole SCOPUS Neuronal Cell Death: Methods and Protocols (2014)
Role of Alzheimer's ?-Amyloid on Wnt signaling Inestrosa, N. C.; Grabowski C.; Arrazola M; Varela-Nallar L.; Toledo E.M. BookWhole SCOPUS Protein Misfolding Disorders: A Trip into the ER (2009)


Targeting RIPK3 to inhibit axonal degeneration and brain inflammation in Parkinson´s disease Court, Felipe A.; Arrazola, MS Proyecto Accelerating biological undestanding and therapeutic translation for Parkinson's disease Program (2023)
From proof of principle to nvel therapeutic targets in Dominant Optic Atrophy: The role of necroptosis/Pgam5 signaling in optic nerve degeneration Arrázola, Macarena S. Proyecto Fondecyt Iniciación (2022)
Contribution of chronic inflammation in neurodegeneration along aging: Role of necroptosis in the vulnerability of different neuronal populations Arrázola, Macarena S. Proyecto Fondecyt Postdoctorado (2018)
Cellular basis of OPA1 function in the neuronal physiology and pathology. A study for the upcoming development of therapeutic strategies for Dominant Optic Atrophy Arrázola, Macarena S. Proyecto (2015)
Centro de Gerociencia, Salud Mental y Metabolismo Gonzalez-Billault, C Proyecto Investigador Adjunto desde Enero 2023 a la fecha (2015)
CARACTERIZACION DEL PROCESO DE CORROSION MEDIADA POR BIOFILMS EN CAÑERIAS DE COBRE MEDIANTE LA INTEGRACION DE MODELACION MATEMATICA DE AUTOMATAS CELULARES, MICROSCOPIA Y ESPECTROSCOPIA. FONDECYT (1040607) Proyecto 2004-2007 Personal técnico y/o de apoyo
DISENO Y SINTESIS DE NUEVAS BASES DE SCHIFF QUIRALES MEDIANTE ACTIVACION DE ENLACES C-H Y M-C EN COMPLEJOS ORGANOMETALICOS DE ELEMENTOS DEL GRUPO DEL PLATINO. FONDECYT (1030520) Proyecto 2003-2007 Personal técnico y/o de apoyo