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Gonzalo Ignacio Cancino Lobos

Assistant Professor

Universidad Mayor

Santiago, Chile

Líneas de Investigación


Our main research interest is to understand how the brain cortex develops. Using animal models and iPSCs, we are trying to understand how autism-associated genes and environmental factors disrupt neurogenesis, gliogenesis and neuronal migration

Educación

  •  BS in Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Master in Biological Sciences mention Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  PhD in Biological Sciences mention Cellular and Molecular Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009

Experiencia Académica

  •   Postdoctoral Research Fellow Full Time

    THE HOSPITAL FOR SICK CHILDREN

    Toronto, Canada

    2009 - 2016

  •   Postdoctoral research fellow Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Ciencias Biologicas

    Santiago, Chile

    2016 - 2017

  •   Assistant Professor Full Time

    UNIVERSIDAD MAYOR

    Facultad de Ciencias

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Teaching Assistant Part Time

    Pontificia Universidad Catolica de Chile

    Chile

    2005 - 2009

  •   Research Assistant Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2004 - 2005

  •   PhD student Full Time

    Pontificia Universidad Catolica de Chile

    Chile

    2005 - 2009

  •   Research Associate Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2016 - 2017

Premios y Distinciones

  •   IBRO Return Home Fellowship

    IBRO-International Brain Research Organization

    Estados Unidos, 2016

    The objective of the IBRO Return Home Program is to coordinate efforts with other research organizations to improve the opportunities for productive neuroscience research within regions of the world and to provide more support to those researchers trained overseas who wish to return to their home countries.

  •   Postdoctoral research fellowship

    Heart and Stroke Foundation of Canada

    Canada, 2011

    The Personnel Award program of the Heart and Stroke Foundation of Canada (HSFC) provides salary support for Canada's best young researchers. These individuals are pursuing research at universities, hospitals and institutes across Canada and abroad.

  •   SfN Chapters Graduate Student Travel Award

    Society for Neuroscience

    Estados Unidos, 2007

    Chapter Travel Awards enable outstanding graduate students and postdoctoral trainees nominated by their local SfN chapter to attend the SfN annual meeting. The awards provide complimentary registration and a stipend to help defray travel expenses.

  •   Becas Chile Postdoctorado en el extranjero

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    La Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) llama a concurso con el fin de otorgar becas a chilenos/as y extranjeros/as con permanencia definitiva en Chile, para iniciar o continuar la realización de programas postdoctorales en instituciones de excelencia en el exterior. El presente concurso busca fomentar la productividad y el futuro posicionamiento científico de investigadores/as con el grado académico de Doctor, en el ámbito académico y productivo, a través de su incorporación en prestigiosos y consolidados grupos de investigación en el extranjero, de tal forma que, a su regreso al país contribuyan a la consolidación de las universidades y centros científicos nacionales

  •   Excellence Award

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2009

    Premio otorgado por a Vicerrectoria de investigacion y doctorado de la Pontificia Universidad Catolica de Chile a la mejor tesis de doctorado


 

Article (21)

The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis
MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content
A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring
Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks
The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner
Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice
Ankrd11 Is a Chromatin Regulator Involved in Autism that Is Essential for Neural Development
Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response
Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system
Neurog1 and Neurog2 Control Two Waves of Neuronal Differentiation in the Piriform Cortex
p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells
The Snail Transcription Factor Regulates the Numbers of Neural Precursor Cells and Newborn Neurons throughout Mammalian Life
p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease
Transient Maternal IL-6 Mediates Long-Lasting Changes in Neural Stem Cell Pools by Deregulating an Endogenous Self-Renewal Pathway
Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation
c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease
TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors
Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease
STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits

ConferencePaper (2)

Alzheimer's beta-amyloid deposits induce the c-Abl/p73 signaling in AD models.
Amyloid-beta-peptide activates the neuronal c-Abl tyrosine kinase/p73 signaling pathway

Proyecto (10)

ABL kinases at the crossroads of healthy synaptic remodeling and synaptic dysfunction in in vitro excitotoxiciy and in vivo temporal lobe Epilepsy.
Maternal Multiple Sclerosis effect on offspring neural development in the murine model of experimental autoimmune encephalomyelitis
El gen asociado al autismo PTPRD regula la expresión de genes asociados a proliferación y diferenciación de precursores neurales
La neurogénesis adulta hipocampal se encuentra disminuida en ratones nulos para el gen receptor tirosina fosfatasa delta PTPRD asociado al trastorno del espectro autista
The role of the ASD-associated gene PTPRD in gliogenesis during cortical brain development
Comprendiendo las funciones de la tirosina fosfatasa PTPRD en la neurogénesis adulta, sinapsis, y sus implicancias en la etiología del autismo
Modelling human brain disorders using iPSCs and brain organoids
The impact of the tyrosine phosphatase Ptprd on neural stem cell biology and its contribution to autism spectrum disorder etiology
AUTISM-ASSOCIATED GENETIC AND ENVIRONMENTAL FACTORS IMPACTING BRAIN DEVELOPMENT
p63-mediated adult neural stem cell maintenance in ischemic repair
28
Gonzalo Cancino

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

6
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

6
Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

2
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Andrea Gómez

Investigador Postdoctoral

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Julio Amigo

Assistant Professor

Physiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile