Man

Julio Andrés Alcayaga Urbina

Profesor Titular

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

Líneas de Investigación


Arterial chemoreceptors; Peripheral control of ventilation; Properties of visceral sensory neurons; Physiological and pathophysiological responses to hypoxic challenges; Neuron-glia interaction

Educación

  •  Fisiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1988

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2015 - A la fecha

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2001 - 2015

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    1992 - 2001

  •   Instructor Full Time

    UNIV.COLUMBUS

    Ciencias

    Santiago, Chile

    1988 - 1991

  •   Resarch associate Full Time

    University of Utah

    Salt Lake City, Estados Unidos

    1988 - 1991

Experiencia Profesional

  •   Scientific Assessor Part Time

    Topical Testing Inc

    Salt Lake City, Estados Unidos

    1991 - 1991

  •   Visiting professor Full Time

    Victor Segalen Bordeaux II, Bordeaux, France. INSERM. Unité 194

    Bordeaux, Francia

    1998 - 1999

Formación de Capital Humano


DIRECCION O CODIRECCION DE TESIS
2019-2021 “Participación de la proteína quinasa Cdk5 en funciones fisiológicas y patológicas del ganglio nodoso”. Pedro Pablo Piquer Alliende. Doctorado en Ciencias, Mención Biología Molecular, Celular y Neurociencias. Facultad de Ciencias, Universidad de Chile. Codirector.
2016-2019 “Interacción célula glial-neurona: efectos en las propiedades eléctricas de neuronas del ganglio nodoso”. Memoria de Ingeniería en Biotecnología. Lorena Meneses Sepúlveda. Facultad de Ciencias Naturales, Matemática y del Medio Ambiente, Universidad Tecnológica Metropolitana.
2016-2018 “Efectos neurotóxicos del fungicida triadimefón sobre el sistema dopaminérgico de las larvas de pez cebra”. Tesis Magíster. Susana Paredes Zúñiga, Magíster en Ciencias Biológicas. Facultad de Ciencias, Universidad de Chile. Codirector.

Post doctoral fellow
2014-2016 "Caracterización del efecto agudo y crónico de la droga antiepiléptica fenitoína (difenilhidantoina) sobre la excitabilidad neuronal: estudio de su impacto a nivel de célula individual y el escalamiento a nivel de redes neuronales." Jorge Vera Buschmann. Patrocinador.


Difusión y Transferencia


SOCIEDADES CIENTIFICAS
2015-2016 director, Sociedad Chilena de Ciencias Fisiológicas.
2013- Miembro American Physiological Society.
2013-2014 Past-presidente, Sociedad Chilena de Ciencias Fisiológicas.
2011-2012 presidente, Sociedad Chilena de Ciencias Fisiológicas.
2009-2010 vicepresidente, Sociedad Chilena de Ciencias Fisiológicas.
2007-2008 director, Sociedad Chilena de Ciencias Fisiológicas.
2005-2006 Past-presidente, Sociedad Chilena de Ciencias Fisiológicas.
2005- Miembro Sociedad Chilena de Neurociencia.
2003-2004 presidente, Sociedad Chilena de Ciencias Fisiológicas.
2001-2002 vicepresidente, Sociedad Chilena de Ciencias Fisiológicas.
1995-2001 director, Sociedad Chilena de Ciencias Fisiológicas.
1995- Miembro International Society of Arterial Chemoreception (ISAC).
1990 Miembro Society for Neuroscience.
1988 Miembro Sociedad de Biología de Chile.
1987 Miembro Sociedad Chilena de Ciencias Fisiológicas.

COMUNICACIONES
Piquer P, Sandoval R, Duran C, Alcayaga J, Utreras E (2019) Sensory neurons from nodose ganglia express Cyclin-dependent kinase 5, its activators and its targets involved in pain signaling. XIII Reunión Anual Sociedad Chilena de Neurociencia. La Serena, Chile. Noviembre 5-7.
Alcayaga J, Del Rio R, Vera J, Retamal MA (2018) P2X7 receptors in the rat nodose ganglion neurons and their role in sensory modulation. LXI Reunión Anual Sociedad de Biología de Chile, XIV Reunión Anual Sociedad Chilena de Neurociencia, LI Reunión Anual Sociedad de Genética de Chile y la XII Reunión Anual Sociedad Chilena de Evolución. Puerto Varas, Chile. Noviembre 20-22.
Alcayaga, J (2017) Petrosal ganglion neuron modifications induced by chronic phenytoin treatment: implication in anticonvulsant treatment hypoventilation. Simposio: Neural control of the cardiorespiratory function: a view from the central and peripheral nervous system. XIII Reunión Anual Sociedad Chilena de Neurociencia. Castro, Chile. Octubre 1-3.
Vera J, Lippmann K, Alcayaga, J (2017) Characterization of intrinsic oscillatory behavior of CA1 pyramidal neurons in a rat model of blood-brain barrier dysfunction-induced epileptogenesis. XIII Reunión Anual Sociedad Chilena de Neurociencia. Castro, Chile. Octubre 1-3.
Alcayaga, J (2017) Transmitters involved in the receptor cell-nerve terminal communication in the carotid body. 1st Symposium on Cardiovascular and Respiratory Regulation: A Multidisciplinary Perspective. Santiago, Chile. Septiembre 29.
Alcayaga, J (2016) Ventilatory and cardiovascular adjustments following chronic phenytoin treatment: role of chemoreflexes. Simposio: Chemoreflexes in health and disease: a view from the central and peripheral. LIX Reunión Anual Sociedad de Biología de Chile y X Reunión Anual Sociedad Chilena de Evolución y XXVII Reunión Anual Sociedad Botánica de Chile. Concón, Chile. Noviembre 8-10.
Pino GN, Alcayaga J (2016) Efectos cardiovasculares del tratamiento agudo con fenitoína en ratas en normoxia e hipoxia aguda. LIX Reunión Anual Sociedad de Biología de Chile y X Reunión Anual Sociedad Chilena de Evolución y XXVII Reunión Anual Sociedad Botánica de Chile. Concón, Chile. Noviembre 8-10.
Ortiz IL, Oyarce, MP, Vera JA, Del Rio R, Alcayaga J (2016) Carotid nerve sinus and identified petrosal chemosensory neurons responses are modified by chronic phenytoin treatment in the rat. II Congreso FALAN. Buenos Aires, Argentina. Octubre 17-20.
Pino GN, Alcayaga J (2016) Efectos ventilatorios y cardiovasculares del tratamiento agudo y crónico con fenitoína en ratas. XXXI Reunión Anual Sociedad Chilena de Ciencias Fisiológicas, Reserva Biológica Huilo-Huilo, Región de Los Ríos.
Navarrete-Opazo A, Alcayaga J (2016) intermittent hypoxia enhances walking endurance in incomplete spinal cord injury patients. 10th International Society for Physical and Rehabilation Medicine Worl Congress. Kuala Lampur, Malasia. Mayo 29-junio 2.


Premios y Distinciones

  •   OEA -Fellow

    Organización de Estados Americanos (OEA)

    Estados Unidos, 1990

    Post-doctoral fellow

  •   Ferdinando Data Foundation Incentive Award

    International Society for Arterial Chemoreception

    Italia, 1996

    Award to scientific presentation to ISAC congreess from researchers outside USA, Canada and Europe

  •   Premio mejor docente

    UNIVERSIDAD DE CHILE

    Chile, 2006

    Best teacher award from the University to a teacher elected by the students


 

Article (53)

Carotid Body Chemoreceptors: Physiology, Pathology, and Implications for Health and Disease
Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure
Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways
Acute effects of systemic erythropoietin injections on carotid body chemosensory activity following hypoxic and hypercapnic stimulation
Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
Imbalance in renal vasoactive enzymes induced by mild hypoxia=> Angiotensin-converting enzyme increases while neutral endopeptidase decreases
Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats
Competition between persistent Na+ and muscarine-sensitive K+ currents shapes perithreshold resonance and spike tuning in CA1 pyramidal neurons
Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?
Intermittent hypoxia and locomotor training enhances dynamic but not standing balance in incomplete spinal cord injury patients
Chronic phenytoin treatment reduces rat carotid body chemosensory responses to acute hypoxia
Intermittent hypoxia does not elicit memory impairment in spinal cord injury patients
Repetitive intermittent hypoxia and locomotor training enhances walking function in incomplete spinal cord injury subjects: a randomized, triple-blind, placebo-controlled clinical trial
Micromolar copper modifies electrical properties and spontaneous discharges of nodose ganglion neurons in vitro
Micromolar copper modifies electrical properties and spontaneous discharges of nodose ganglion neurons in vitro
Opening of pannexin- and con nexin-based channels increases the excitability of nodose ganglion sensory neurons
Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons.
Petrosal Ganglion: a more complex role than originally imagined
Petrosal ganglion: a more complex role than originally imagined
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Petrosal ganglion responses to acetylcholine and ATP are enhanced by chronic normobaric hypoxia in the rabbit
Petrosal ganglion responses to acetylcholine and ATP are enhanced by chronic normobaric hypoxia in the rabbit
NO modulation of carotid body chemoreception in health and disease
Rabbit ventilatory responses to peripheral chemoexcitators: effects of chronic hypoxia
Responses induced by acetylcholine and ATP in the rabbit petrosal ganglion
Cardioventilatory Acclimatization Induced by Chronic Intermittent Hypoxia
Evidence for Histamine as a New Modulator of Carotid Body Chemoreception
Neurotransmitters in Carotid Body Function: The Case of Dopamine - Invited Article
Modulatory effects of histamine on cat carotid body chemoreception
Root to leaf electrical signaling in avocado in response to light and soil water content
ATP- and ACh-induced responses in isolated cat petrosal ganglion neurons
Effects of intermittent hypoxia on cat petrosal ganglion responses induced by acetylcholine, adenosine 5 '-triphosphate and NaCN
Electrical and pharmacological properties of petrosal ganglion neurons that innervate the carotid body
Are there interactions between acetylcholine- and ATP-induced responses at the level of a visceral sensory ganglion?
Chronic intermittent hypoxia enhances carotid body chemosensory responses to acute hypoxia
Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: Effects of cytisine and its bromo derivatives
Endothelins in the cat petrosal ganglion and carotid body: Effects and immunolocalization
Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals
ACh and ATP mediate excitatory transmission in cat carotid identified chemoreceptor units in vitro
Carotid chemosensory neurons in the petrosal ganglia are excited by ACh and ATP
Catecholamine release from isolated sensory neurons of cat petrosal ganglia in tissue culture
Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro
Effects of bicarbonate buffer on acetylcholine-, adenosine 5 ' triphosphate-, and cyanide-induced responses in the cat petrosal ganglion in vitro
Effects of bicarbonate buffer on acetylcholine-, adenosine 5´triphosphate-, and cyanide-induced responses in the cat petrosal ganglion in vitro
Acetylcholine sensitivity in sensory neurons dissociated from the cat petrosal ganglion
Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro
Interactions between acetylcholine and dopamine in chemoreception
Lack of correlation between cholinergic-induced changes in chemosensory activity and dopamine release from the cat carotid body in vitro
Nitric oxide modulation of carotid chemoreception
Responses of petrosal ganglion neurons in vitro to hypoxic stimuli and putative transmitters

Abstract (3)

Chronic Phenytoin Treatment Reduces Hypoxic Ventilatory Responses in Rats
Acetylcholine sensitivity in dissociated neurones of the cat petrosal ganglion
Petrosal ganglion responses to arterial chemoreceptor putative transmitters

ConferencePaper (2)

Rabbit ventilatory responses to peripheral chemoexcitators: Effects of chronic hypoxia
Electrical Signal Measurements in Avocado Trees: a Potential Tool for Monitoring Physiological Responses to Soil Water Content?

Errata (1)

Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro (vol 966, pg 283, 2003)

Proyecto (8)

Physiological rôle of neuron-neuron and neuron-glia interactions within a visceral sensory ganglion.
Neuron-neuron and neuron-glia interactions within a visceral sensory ganglion=> physiological relevance.
Biofísica de transporte de iones en las familias de proteínas ClC y Na/K ATPasas=> Investigación y Docencia
Broadening and strengthening international network collaborations=> expanding the horizon on the neurobiology of chemosensation research.
CARACTERIZACIÓN DEL EFECTO AGUDO Y CRÓNICO DE LA DROGA ANTIEPILÉPTICA FENITOINA (DIFENILHIDANTOINA) SOBRE LA EXCITABILIDAD NEURONAL=> ESTUDIO DE SU IMPACTO A NIVEL DE CÉLULA INDIVIDUAL Y EL ESCALAMIENTO A NIVEL DE REDES NEURONALES.
Long term effects of phenytoin (diphenylhydantoin) on peripheral ventilatory control=> studies in humans and an animal model.
Red Iberoamericana de Medicina y Fisiología de Altura (ALTMEDFIS)
Contribution of the carotid body to the hypertension induced by intermittent hypoxia in a rat model of sleep apnea=> role of the sympathetic system, oxidative stress and pro-inflammatory cytokines

Review (1)

NO modulation of carotid body chemoreception in health and disease
50
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

41
Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

13
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

6
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
Luis Leon

Director of Bioinformatics

R&D

Genoma Mayor SpA

Santiago, Chile

1
Cecilia Vergara

Profesor Asociado

Biología

DEPARTAMENTO BIOLOGIA, FACULTAD DE CIENCIAS, U. DE CHILE

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

1
Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
German Ebensperger

PROFESOR ASISTENTE

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Pilar Gil

Profesor asistente

Fruticultura y enología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile