Cv1.jpg_thumb90

Hugo Sebastián Diaz Alvarado

PhD

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Heart Failure pathophysiology, neural control of cardiac function, neuroinflammation and cardiovascular disease

Educación

  •  Biomedical Sciences, UNIVERSIDAD AUTONOMA DE CHILE. Chile, 2020
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2015
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 2015

Experiencia Académica

  •   Ayudante Part Time

    Universidad Autónoma de Chile

    Medicine

    Santiago, Chile

    2016 - 2018

  •   Aydante alumno Part Time

    UNIVERSIDAD DE CHILE

    Chemical and Pharmaceutical Sciences

    Santiago, Chile

    2011 - 2012

  •   THESIS CO-ADVISOR Full Time

    UNIVERSIDAD DE CHILE

    CIENCIAS QUIMICAS Y FARMACÉUTICAS

    Santiago, Chile

    2014 - 2016

Experiencia Profesional

  •   PhD student Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2017 - 2019

  •   Postdoctoral research fellow Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


Undergraduate students:
1. Ceballos, Gabriel. Participación de la lipoproteína de baja densidad oxidada (oxLDL) en la inducción de la autofagia y sobrevida en miofibroblastos cardiacos. Universidad de Chile, 2016


Difusión y Transferencia


1. Free communications:
1.1. International Scientific Meetings:
- Hugo S. Díaz, David C. Andrade; Camilo Toledo; Claudia Lucero; Alexis Arce-Álvarez; Katherin V. Pereyra; Harold D. Schultz; Josiane N. Silva; Ana C. Takakura; Thiago S. Moreira; Noah J. Marcus, Rodrigo Del Rio, Episodic stimulation of central chemoreflex elicits long-term breathing disorders and autonomic imbalance in heart failure rats. European Respiratory Society Congress, Madrid, Spain, 2019
- Hugo S. Díaz, Rodrigo Del Rio, Brainstem pre-sympathetic neuron controls oscillatory breathing in heart failure rats. European Respiratory Society Congress, Madrid, Spain, 2019
- H.S. Díaz, D. C. Andrade. C. Toledo. N. Silva, A.C. Takakura, T.S. Moreira, R. Del Rio EPISODIC HYPERCAPNIC STIMULATION OF CENTRAL CHEMORECEPTORS INDUCED RESPIRATORY PLASTICITY AND ELICITS LONG-TERM BREATHING DISORDERS IN HEART FAILURE RATS. 2nd Neural Control of Breathing Symposium, São Paulo, Brazil, 2019
- Esteban Diaz-Jara, David C. Andrade, Camilo Toledo, Hugo Díaz, Rodrigo Del Rio. EXERCISE TRAINING INTOLERANCE IN HIGH OUTPUT HEART FAILURE IS ASSOCIATED WITH ALTERED CHEMOREFLEX FUNCTION. 2nd Neural Control of Breathing Symposium, São Paulo, Brazil, 2019
- Rodrigo Del Rio, David C Andrade, Camilo Toledo, Hugo S Diaz, Claudia Lucero, Alexis Arce-Alvarez. Brainstem pre-sympathetic neuron controls oscillatory breathing in heart failure. Experimental Biology, San Diego, California, United States, 2018
- Díaz HS, Andrade DC, Toledo C, Lucero C, Arce-Álvarez A, Del Rio R. Selective ablation of central pre-sympathetic of C1 neurons from of the Rostral Ventrolateral Medulla prevents cardiac function impairment in heart failure rats with preserved ejection fraction. International Society of Autonomic Neuroscience. Nagoya, Japan, 2017.
- Andrade DC, Toledo C, Takakura AC, Moreira TS, Lucero C, Díaz HS, Arce-Álvarez A, Iturriaga R, Del Rio R. Selective ablation of brainstem pre-sympathetic neurons abolishes the progressive decline in cardiac function in HFpEF. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Toledo C, Andrade DC, Díaz HS, Arce-Álvarez A, Lucero C, Del Rio R. Purinergic signaling in the retrotrapezoid nucleus: a new mechanism involved in the development of breathing pattern irregularities in HFpEF rats. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Díaz HS, Andrade DC, Toledo C, Lucero C, Arce-Álvarez A, Del Rio R. Episodic stimulation of the central chemoreflex elicits ventilatory long-term facilitation and respiratory disorders in heart failure rats with preserved ejection fraction: Role of the Retrotrapezoid nucleus. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Lucero C, Andrade DC, Toledo C, Díaz HS, Arce-Álvarez A, Retamal M, Del Rio R. Chronic blockade of Connexin43 Hemichannels reduces Cardiac Arrhythmogenesis in Heart Failure with preserved Ejection Fraction. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Arce-Alvarez A, Andrade DC, Toledo C, Lucero C, Díaz H, Del Rio R. Role of Central Chemoreflex Exercise training is an effective non-pharmacological strategy for restore cardiac autonomic imbalance and cardiac function in heart failure with preserved ejection fraction rats. International Union of Physiological Sciences World Congress. Rio de Janeiro Brazil, 2017.
- Andrade DC, Arce-Alvarez A, Toledo C, Diaz H, Lucero C, Faundez M, Iturriaga R, Del Rio R. Exercise training intolerance in heart failure with preserved ejection fraction is associated with altered chemoreflex gain and sympathoexcitation in rats. Experimental Biology 2017, Chicago USA. FASEB Journal.
- Toledo C, Andrade DC, Lucero C, Diaz H, Arce A, Del Rio R. Decreased purinergic signaling in the RTN is associated with respiratory disorders in HFpEF rats. Experimental Biology 2017, Chicago USA. FASEB Journal
- Del Rio R, Diaz H, Toledo C, Andrade DC, Arce-Alvarez A, Lucero C. Endoplasmic Reticulum Stress and Neuroinflammation in the RVLM: A Novel Mechanism Related to Sympathoexcitation in Preserved Ejection Fraction Heart Failure. Experimental Biology 2017, Chicago USA. FASEB Journal

1.2. National Scientific Meetings:
- H, S. Díaz, D. C. Andrade, C. Toledo, R. Del Rio. Episodic hypercapnic stimulation of central chemoreceptors induced respiratory plasticity and elicits long-term breathing disorders in heart failure rats. XV Reunión Anual de la Sociedad Chilena de Neurociencia 2019, La Serena, Región de Coquimbo, Chile.
- Karla G. Schwarz, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Rodrigo Del Rio. Brainstem catecholaminergic neurons mediate sleep-dependent disordered breathing in heart failure rats. XV Reunión Anual de la Sociedad Chilena de Neurociencia 2019, La Serena, Región de Coquimbo, Chile.
- Camilo Toledo, David C. Andrade, Hugo S. Díaz, Karla G. Schwarz, Katherin V. Pereyra, Cristóbal Diaz, Esteban Diaz-Jara, Rodrigo Del Rio Altered Wnt signaling in the hippocampusis associated with cognitive impairment in heart failure rats. XV Reunión Anual de la Sociedad Chilena de Neurociencia 2019, La Serena, Región de Coquimbo, Chile.
- Diaz-Opazo C, Toledo C, Andrade DC, Diaz HS, Schwarz KG, Diaz-JaraE, Pereyra KV, Del Rio. Acute chemogenetic inhibition of RVLM astrocytes decreases cardiorespiratory chemoreflex response in healthy rats. XV Reunión Anual de la Sociedad Chilena de Neurociencia 2019, La Serena, Región de Coquimbo, Chile.
- Díaz HS, Andrade DC, Toledo C, Arce-Álvarez, LuceroC, Del RioR Brainstem Endoplasmic reticulum stress in the rostral ventrolateral medulla mediates cardiorespiratory disorders in heart failure: A new actor in cardiorespiratory pathophysiology. XXXIII Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2018. Huilo-Huilo, Región de los Ríos, Chile
- Camilo Toledo, Hugo S. Diaz, David C. Andrade, Rodrigo Del Rio Episodic stimulation of central chemoreceptors neurons elicits cardiorespiratory plasticity in heart failure: uncovering a new phenomenon in the progression of the disease. XIV Reunión Anual de la Sociedad Chilena de Neurociencia 2018, Puerto Varas, Región de Los Lagos, Chile.
- Toledo C, Andrade DC, Arce-ÁlvarezA, DíazHS, LuceroC, Del RioR Purinergicsignaling in brainstem chemosensitive astrocytes: implications for breathing disorders in heart failure. XXXIII Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2018. Huilo-Huilo, Región de los Ríos, Chile
- LuceroCM, AndradeDC, ToledoC, DíazH, Arce-ÁlvarezA, RetamalM,Del RioR,Ablation of pre-sympathetic neurons Sympathetic overstimulation from RVLM improvescardiac dysfunction and increased arrhythmogenesis in heart failure: role of cardiac ias associated with AR-?1 signaling. XXXIII Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2018. Huilo-Huilo, Región de los Ríos, Chile
- Ale FreneA, Andrade DC, ToledoC, Arce-ÁlvarezA, DíazHS, LuceroC, Del RioR. Role of carotid bodyfunctionon exercise capacity: are the peripheral chemoreceptors involved in normal rats? XXXIII Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2018. Huilo-Huilo, Región de los Ríos, Chile
- Arce-Álvarez A, MelipillanC, AndradeDC, ToledoC, Diaz H, Lucero CM, Rodrigo Del Rio. Cardiac autonomic failure in infants with spontaneous hypertoniaof the upper and lower limbs. XXXIII Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2018. Huilo-Huilo, Región de los Ríos, Chile
- AndradeDC, ToledoC, Arce-ÁlvarezA, DíazHS, LuceroC, RodríguezM, Del RioR Photostimulation of brainstem pre-sympathetic neurons triggerslong-term sympathoexcitation and irregular breathing. XXXIII Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2018. Huilo-Huilo, Región de los Ríos, Chile
- Andrade DC, Arce-Álvarez A, Toledo C, Díaz HS, Lucero C, Del Rio R. Role of exercise training on cardiac autonomic control in preserved ejection fraction heart failure. VII Congreso Internacional de Ciencias del Deporte”. 2017, Santiago, Chile.
- Andrade DC, Toledo C, Arce-Álvarez A, Díaz HS, Lucero C, Del Rio R. Exercise training and sympathetic activation in heart failure with preserved ejection fraction: observations in an experimental model. 1st Symposium in Cardiovascular and Respiratory Regulation: A Multidisciplinary Perspective. 2017, Santiago, Chile.
- Andrade DC, Toledo C, Lucero C, Díaz H, Arce-Alvarez A, Del Rio R (Oral Presentation). Selective RVLM C1 neuron ablation improves cardiac sympathetic control in heart failure rats. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Toledo C, Andrade DC, Díaz H, Arce-Alvarez A, Lucero C, Del Rio R. P2X7 receptor signaling in the retrotrapezoid nucleus contribute to breathing pattern irregularities in heart failure. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Díaz HS, Toledo C, Andrade DC, Arce-Álvarez A, Lucero C, Del Rio R. Endoplasmic reticulum stress and neuroinflammation in heart failure: A novel link to sympathoexcitation. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Arce-Álvarez A, Melipillan C, Andrade DC, Toledo C, Díaz H, Lucero C, Del Rio R. Autonomic nervous system impairment in children with pyramidal syndrome. XIII Reunión Anual de la Sociedad Chilena de Neurociencia 2017, Castro, Chiloe.
- Andrade DC, Arce-Alvarez A, Toledo C, Lucero C, Díaz H, Del Rio R. Exercise training and cardiac function deterioration in heart failure with preserved ejection fraction: to tolerate or not to tolerate, that is the question. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Toledo C, Andrade DC, Arce-Alvarez A, Lucero C, Díaz H, Del Rio R. Central sympathetic neuron activation is associated with increased production of O2- radical, expression of AT1R and NF-kB in rats with HFpEF. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Lucero CM, Andrade DC, Toledo C, Manríquez M, Díaz H., Chronic connexin 43 hemichannel blockade reduces cardiac arrhythmogenesis and improves cardiac function in heart failure. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Díaz H, Toledo C, Andrade DC, Arce-Alvarez A, Lucero C, Del Río R. Endoplasmic Reticulum stress in chronic heart failure: a link to sympatho-excitation. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Arce-Álvarez A, Andrade DC, Toledo C, Lucero C, Díaz H, Del Rio R. Effects of exercise training on cardiac function and autonomic balance in rats with HFpEF. XXXI Reunión Anual de la sociedad Chilena de Ciencias Fisiológicas. 2016. Huilo-Huilo, Región de los Ríos, Chile.
- Díaz, Hugo; Reyes, Javiera; Villa, Mónica; Toledo, Jorge; García, Lorena, Role of TNF-? and oxLDL/LOX-1 pathway on cardiac myofibroblast phenotype, XXXVIII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Puerto Varas, 2015
- Mónica Villa, Hugo Díaz, Sebastián Leiva, Diana Figueroa, Valentina Camus, Elias Inostroza, Eliseo Parra, Gabriel Ceballos, Lorena García, Receptor LOX-1 es esencial en el proceso de diferenciación y mantención del fenotipo pro-fibrótico de miofibroblastos cardíacos, XXV Congreso Interamericano de Cardiología y Cirugía Cardiovascular, Santiago, 2015
- Figueroa D, Díaz H, Peña M, Arancibia J, Delporte C, García L., Evaluation of inflammatory parameters of foliar extracts of two genotypes from murtilla (Ugni molinae Turcz.) in cardiac fibroblasts, XXXVIII Reunión Anual de la Sociedad de
Bioquímica y Biología Molecular, Puerto Varas, Chile 2015

4. Lectures and Plenary Lectures
4.1. National
- Potenciales efectos tóxicos de industrias de curtiembre sobre la salud de la población, Santiago, Chile, 2012


Premios y Distinciones

  •   Mejor presentación oral

    SOCIEDAD CHILENA DE NEUROCIRUGIA

    Chile, 2019

    Premio entregado por la Sociedad Chilena de Neurociencia a la Presentación Oral titulada "Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure"


 

Article (14)

Inhibition of Brainstem Endoplasmic Reticulum Stress Rescues Cardiorespiratory Dysfunction in High Output Heart Failure
Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats
Episodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure
Neuroinflammation in heart failure: new insights for an old disease
Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure
Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment
Rostral ventrolateral medullary catecholaminergic neurones mediate irregular breathing pattern in volume overload heart failure rats
Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?
Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats
Ventilatory and Autonomic Regulation in Sleep Apnea Syndrome: A Potential Protective Role for Erythropoietin?
Cardiac diastolic and autonomic dysfunction are aggravated by central chemoreflex activation in heart failure with preserved ejection fraction rats
Carotid Body-Mediated Chemoreflex Drive in The Setting of low and High Output Heart Failure
Exercise training improves cardiac autonomic control, cardiac function, and arrhythmogenesis in rats with preserved-ejection fraction heart failure

ConferencePaper (1)

Endoplasmic Reticulum Stress and Neuroinflammation in the RVLM: A Novel Mechanism Related to Sympathoexcitation in Preserved Ejection Fraction Heart Failure

Proyecto (6)

Valorización del brócoli y sus sub-productos mediante la optimización de su cultivo para producir un extracto rico en sulforafano y antioxidantes que sea aplicable como nutracéutico
Ox-LDL/LOX-1/NADPH oxidase signaling pathway in cardiac myofibroblast=> novel role in the regulation of autophagy, survival and profibrotic response
CENTRO DE ESTUDIOS AVANZADOS DE ENFERMEDADES CRÓNICAS (ACCDIS)
Ox-LDL/LOX-1/NADPH oxidase signaling pathway in cardiac myofibroblast=> novel role in the regulation of autophagy, survival and profibrotic response
Mejoramiento de Propiedades Funcionales de Aceites de Oliva como Estrategia para Incrementar su Valorización y Diferenciación en el Mercado Nacional e Internaciona
Desarrollo de Productos Nutra-Cosméticos con Acción Anti-Envejecimiento en Base a Nuevos Compuestos Bioactivos
18
Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

12
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

11
David Andrade

Associate Professor

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

3
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

3
Katherin Pereyra

Instructor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Camilo Toledo

Postdoctorado

Physiolgy

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile