Man

Fernando C. Ortiz

profesor asistente

Universidad Autónoma de Chile

Santiago, Chile

Líneas de Investigación


Demyelinating diseases; Neuroinflammation; Myelin synthesis and repair; Glia-neuron and glia-glia interaction, Pathophysiology of astrocytes and oligodendrocytes precursor cells.

Educación

  •  Licenciatura en Cs Mn Biologia, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Magister en Cs Fisiologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Doctorado en Cs Biologicas Mn Cs Fisiologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011

Experiencia Académica

  •   profesor asistente Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2017 - A la fecha

  •   profesor encargado, curso Morfofisiología Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Educación

    Santiago, Chile

    2011 - 2011

  •   Instructor, curso Fisiologia Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2011 - 2011

  •   profesor, curso fisiologia oral Part Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Santiago, Chile

    2011 - 2011

  •   profesor, curso Neurobiología Full Time

    UNIVERSIDAD ANDRES BELLO

    Santiago, Chile

    2009 - 2011

  •   Instructor, curso Fisiologia Part Time

    UNIVERSIDAD DEL DESARROLLO

    Santiago, Chile

    2009 - 2010

  •   Instructor, curso Biofisica y fisiologia general Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2008 - 2008

  •   Instructor, curso Fisiologia de sistemas Other

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2005 - 2009

  •   Investigador Postdoctoral Full Time

    Universidad Paris Sorbona, Paris-V

    Medicina

    Paris, Francia

    2014 - 2016

  •   Investigador Part Time

    NATIONAL INSTITUTE OF HEALTH

    Bethesda, Estados Unidos

    2013 - 2013

  •   Becario Postdoctoral Full Time

    Universidad Paris Sorbona, Paris-V

    Medicina

    Paris, Francia

    2011 - 2014

  •   Estudiante doctorado Other

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2006 - 2011

  •   Asistente tecnico, proyecto FONDECYT 1090157 Part Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2010 - 2011

  •   Asistente tecnico, proyecto FONDECYT 1040638 Part Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2006 - 2007

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad Autonoma de Chile

    Chile

    2017 - A la fecha

Formación de Capital Humano


THESIS AND INTERNSHIP DIRECTION

2019- To date. PhD Thesis Direction. PhD program on Biomedical Sciences, Universidad Autónoma de Chile.
Student: Coram Guevara.
Subject: Role of astrocytic cytokines on remyelination.

2018- To date. PhD Thesis Direction. PhD program on Biomedical Sciences, Universidad Autónoma de Chile.
Student: Sebastian Vejar.
Subject: Astrocyte-oligodendrocyte interaction on myelin metabolic supply to axon under demyelinated conditions.

2019- To date. Internship. School of Medicine, Universidad Autónoma de Chile.
Student: Andres Munoz.
Subject: Setting a new model of multiple sclerosis: demyelinated lesions in cerebellum,
Funded by ‘UA-Scientific Initiation Fellowship’.

2018 Internship. María García- Blanes Martínez, Biochemist, Universidad Autónoma de Madrid.
Subject: Immunohistochemistry and confocal imaging of glial in demyelinated lesions.

2018 Profesional Practice. Pontificia Universidad Católica de Valparaíso.
Student: Sebastian Vejar, Biochemist.
Subject: Setting a station for electrophysiological recordings, electrophysiological characterization of glial cells.

2017-2018 Internship. School of Medicine, Universidad Autónoma de Chile.
Student: Benjamin Suarez Camus.
Subject: Immunohistochemistry and electrophysiological characterization of demyelinated lesions
Funded by ‘UA-Scientific Initiation Fellowship’.

2014-2015 M. Sc . Thesis Co-Direction.
Student: Pierre-Yves Houry.
Thesis: Role of the Neuronal Activity on the oligodendroglia during the remyelination of corpus callosum.
Master Biologie et Santé-signalisation cellulaire-neuroscience, Paris Sud University.

2013-2014 M. Sc . Thesis Co-Direction.
Student: Nour Barça.
Thesis: Expression of NMDA receptor-mediated currents of oligodendrocyte precursor cells during early postnatal development and following demyelination of the mouse corpus callosum.
Master II recherche de science et technologie Mention Biologie intégrative et physiologie, Spécialité neurosciences. Paris Descartes University.

PARTICIPATION IN EXAMINING COMMITTEES

-2019. Undergraduate thesis. External examiner.
Student: Felipe Alvarez
Thesis: Estudio de efectos de trauma agudo sobre astrocitos del hipocampo en ratones de 2 meses de edad
Biochemistry. P. Universidad Catolica de Chile (in progress)

-2019. PhD thesis. External examiner.
Student: Amber Philp,
Tthesis: The Role of Platelets in Remyelination of the Central Nervous System.
PhD in Medical Sciences program. Universidad Austral de Chile (in progress)

-2018. MSc thesis. External examiner.
Student: Diego Becerra,
Thesis: Olfactory pattern separation in behaving mice.
Master in Biological Sciences program. Universidad de Chile (graduate in December 2019)

-2018. PhD thesis. Internal Member.
Student: Carola Tapia,
Thesis: Contribución del poro de transición de permeabilidad mitocondrial al daño mitocondrial y alteraciones sinápticas inducidas por la proteína tau clivada por caspasa 3.
PhD in Biomedical Sciences program. Universidad Autonoma de Chile (in progress)

-2018. PhD thesis. Internal Member.
Student: Camilo Toledo
Thesis: Rol del nucleo retrotrapezoide en el Desarrollo de alteraciones cardiorespiratorias en insuficiencia cardiaca.
PhD in Biomedical Sciences program. Universidad Autónoma de Chile (graduate in July 2018)


Difusión y Transferencia


OUTREACH ACTIVITIES

-Scientific content creator developing audovisual products for scientific divulgation. Associated with Samuel Restucci (cartoonist-cinema director) we are creating short-animated movies and virtual reality educational environments for divulgation.
https://www.youtube.com/watch?v=0nV_Ck7k-8U&feature=emb_title

-Scientific content creator developing books for scientific divulgation to adolescents. Associated with the center of scientific communication, Universidad Autónoma de Chile.
https://ciencias.uautonoma.cl/relatos-de-tu-conciencia/
.
-Internships in the Myelin Laboratory. We have created a program for short-internships of high school students in our laboratory. The associated schools belong to the metropolitan area.
https://myelin-lab.cl/divulgacion/

- Member of “Fundación Chile Hace Ciencia”. Nonprofit organization aiming to scientific divulgation. I participate as a scientific content collaborator, presenting seminars and organizing products for divulgation (i.e. currently we are preparing a book for high school students)
https://chilehaceciencia.wordpress.com/


Premios y Distinciones

  •   Travel Award

    CONICYT

    Chile, 2008

    It cover the expenses to attend the ISAC international meeting at Valladolid, Spain

  •   Travel Award

    CONICYT

    Chile, 2009

    It cover the expenses to attend the SfN meeting at Chicago, USA

  •   Travel Award

    VRAID-PUC

    Chile, 2010

    It cover the expenses to attend the SfN meeting at San Diego, USA

  •   Best Oral Communication

    ARSEP (French Society for Multiple Sclerosis)

    Francia, 2015

    Best Oral Communication in the Annual Meeting on Multiple Sclerosis, ARSEP Foundation, Paris.

  •   Best Poster presentation

    ARSEP (French Society for Multiple Sclerosis)

    Chile, 2014

    Best poster presentation in the Annual Meeting on Multiple Sclerosis, ARSEP Foundation, Paris.


 

Article (31)

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways
Potential Role of the Retrotrapezoid Nucleus in Mediating Cardio-Respiratory Dysfunction in Heart Failure With Preserved Ejection Fraction.
Sleep dysregulation in sympathetic-mediated diseases: implications for disease progression
Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive
Exercise training reduces brainstem oxidative stress and restores normal breathing function in heart failure
Heart rate and cardiac autonomic responses to concomitant deep breathing, hand grip exercise, and circulatory occlusion in healthy young adult men and women
Paraquat herbicide diminishes chemoreflex sensitivity, induces cardiac autonomic imbalance and impair cardiac function in rats
Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression
Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species
Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
Neuronal activity in vivo enhances functional myelin repair
Carotid Body Type-I Cells Under Chronic Sustained Hypoxia: Focus on Metabolism and Membrane Excitability
Carotid Body Type-I Cells Under Chronic Sustained Hypoxia=> Focus on Metabolism and Membrane Excitability.
In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups
In vivo optogenetic approach to study neuron-oligodendroglia interactions in mouse pups
Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
A commentary on: "Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair"
Alteration of synaptic connectivity of Oligodendrocyte Precursor Cells Following Demyelination
Alteration of synaptic connectivity of oligodendrocyte precursor cells following demyelination
Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons
Micromolar copper modifies electrical properties and spontaneous discharges of nodose ganglion neurons in vitro.
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Contribution of TASK-Like Potassium Channels to the Enhanced Rat Carotid Body Responsiveness to Hypoxia
Functional expression of the alpha 7 and alpha 4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body
Muscarinic modulation of TASK-like background potassium channel in rat carotid body chemoreceptor cells
Responses induced by acetylcholine and ATP in the rabbit petrosal ganglion.
Sustained hypoxia enhances TASK-like current inhibition by acute hypoxia in rat carotid body type-I cells.
Carotid body transmitters actions on rabbit petrosal ganglion in vitro
Glial-derived transforming growth factor β1 (TGF-β1): a key factor in multiple sclerosis neuroinflammation
Paraquat herbicide diminishes chemoreflex sensitivity, induces cardiac autonomic imbalance and impair cardiac function in rats.

ConferencePaper (1)

Contribution of TASK-like potassium channels to the enhanced rat carotid body responsiveness to hypoxia

ConferencePoster (48)

Caracterización de las vías colinérgicas del troncoencéfalo en las etapas desmielinizantes de un modelo murino de esclerosis múltiple
Impact of Vagal Nerve Stimulation on the progression of demyelinated lesions in a murine model of Multiple sclerosis
Efecto de la estimulación vagal sobre la remielinización en un modelo murino de EM
Rol de los canales formados por panexina-1 en la progression de lesiones desmielinizantes
Contribution of Reactive Astrocytes to Myelin Repair
Dissecting the Contribution of Reactive Astrocytes to Myelin Repair
Effect of Astrocytes Photo-activation on Remyelination in Freely Moving Mice
Exploring the Contribution of Reactive Astrocytes to Myelin Repair
Focal Demyelination in the Cerebellum: a Preclinical Model for the Study of Multiple Sclerosis
Alpha–linolenic acid decreases the myogenic differentiation of c2c12 cells
An in vivo optogenetic approach to study neuron-oligodendroglia interactions in mouse pups
Dissecting astrocyte- activity contribution to myelin repair
Effect of astrocyte activity on axon-oligodendroglia glutamatergic transmission
Effects of astrocyte activity on axon-OPC glutamatergic transmission,
Effects of astrocyte activity on myelin regeneration
Increased neuronal activity on remyelination
Effect of increased neuronal activity on remyelination in freely moving mice
Improved remyelination by increasing neuronal activity in freely moving mice
Improved remyelination by increasing neuronal activity in freely moving mice
Increased neuronal activity on remyelination in freely moving mice
An optogenetic approach to evaluate activity-dependent remyelination
An optogenetic approach to evaluate the effect of neuronal activity on remyelination
Impact of Gabaergic activity on cortical oligodendrogenesis
Is remyelination dependent on neuronal activity?
Alterations of synaptic connectivity of oligodendrocyte progenitor cells following central nervous system demyelination
Non-synaptic junctions on myelinating glia promote preferential myelination of electrically-active axons
Regulation of glutamatergic transmission in myelin repair
Alterations of NG2 cell synaptic connectivity following demyelination of corpus callosum
Influences of Neuronal-NG2 cell synapses on myelin
Chronic intermittent hypoxia increases the inhibition of TASK-like current and the depolarization evoked by acute hypoxia in rat CB type-I cells
Contribution of the Carotid Body to the Cardiorespiratory alterations induced by intermittent hypoxia
Electrophysiological evidence of two hyperpolarization- activated inward currents in petrosal ganglion neurons
Activation of α7 and α4β2 nicotinic acetylcholine receptor regulates catecholamine release in the rat carotid body
Functional expression of a hypoxia sensitive TASK-like potassium channel in adult rat carotid body type-1 cells
Functional expression of an oxygen-sensitive TASK-like background K+ channel in the adult rat carotid body type-I cells
The role of the TASK-like background potassium channel in carotid body function
Muscarinic acetylcholine receptor activation inhibits TASK-likeK+ current in rat carotid body chemoreceptor cells
Chronic hypoxia enhanced the TASK-like current inhibition evoked by acute hypoxia in rat carotid body
Evidences for regulation by external acidosis of nicotinic acetylcholine receptors in rat chemoreceptor cells
Sustained hypoxia potentiates the inhibitory effect of acute hypoxia on TASK-like potassium current in carotid body chemoreceptor cells
La hipoxia crónica potencia la inhibicion de la corriente tipo TASK evocada por hipoxia aguda
Efecto del cobre sobre las propiedades eléctricas de neuronas nodosas de conejo
El cobre modifica la excitabilidad de neuronas del ganglio nodoso de conejo
Electrophysiological characterization of rabbit petrosal and nodose ganglion neurons
Carotid body transmitters actions on rabbit petrosal ganglion in vitro
Propiedades eléctricas de neuronas de ganglios petrosos y nodosos de conejo, poster session
Serotonin induced responses in the rabbit petrosal ganlion in vitro, poster session
Efecto de serotonina sobre la frecuencia de descarga del nervio carotideo de conejo

Editorial (1)

Editorial: Physiology of Myelin Forming Cells, From Myelination to Neural Modulators

Proyecto (17)

ASTROCYTIC CYTOKINE SIGNALING IN MULTIPLE SCLEROSIS: A NOVEL TARGET TO REDUCE DISEASE PROGRESSION
Astrocytic cytokine signaling in multiple sclerosis: implications in disease progression
Vagal nerve stimulation: a new approach to treat MS
Multi-Target Drug Design Against Neurodegenerative Diseases
Role of myelination and oligodendroglia development on chronic social defeat stress
CENTRAL ROLE OF ASTROCYTES IN NEURONAL-DRIVEN REMYELINATION
Cortical myelination in a murine autistic model
Efecto de la foto-activación de astrocitos sobre la diferenciación de oligodendrocitos en lesiones desmielinizadas.
Role of reactive astrocytes at the different stages of remyelination in an in vivo model of multiple sclerosis
Manipulación de la reactividad de astrocitos en lesiones desmielinizantes
ROLE OF ASTROCYTES IN THE REMYELINATION OF THE CORPUS CALLOSUM IN A MODEL OF MULTIPLE SCLEROSIS-LESIONS
Regulation of myelin repair by glutamatergic transmission between axons and NG2 cells
Synaptic control of NG2 cell fate during myelination and myelin repair in white matter
CONTRIBUTION OF THE CAROTID BODY TO THE HYPERTENSION INDUCED BY INTERMITTENT HYPOXIA IN A RAT MODEL OF SLEEP APNEA=> ROLE OF THE SYMPATHETIC SYSTEM, OXIDATIVE STRESS AND PRO-INFLAMMATORY CYTOKINES.
PARTICIPATION OF PETROSAL GANGLION NEURONS IN THE INCREASED CHEMOREFLEX SENSIBILTY DURING HYPOXIC VENTILATORY ACCLIMATIZATION.
CONSECUENCIAS FISIOPATOLOGICAS DE LA HIPOXIA INTERMITENTE CRONICA SOBRE LA QUIMIORRECEPCION CAROTIDEA Y LA REGULACION CARDIORESPIRATORIA.
CARACTERIZACION ELECTROFISIOLOGICA Y FARMACOLOGICA DE LOS RECEPTORES INVOLUCRADOS EN LA GENERACION DE LA ACTIVIDAD AFERENTE QUIMIOSENSORIAL ARTERIAL EN NEURONAS PETROSAS.

Review (1)

Neuroinflammation in Demyelinating Diseases: Oxidative Stress as a Modulator of Glial Cross-Talk
79
Fernando Ortiz

profesor asistente

Universidad Autónoma de Chile

Santiago, Chile

5
David Andrade

Associate Professor

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

3
Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

1
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Paula Muñoz

Clinical Research Center Director

Universidad del Desarrollo

Santiago, Chile

1
Domiziana Ortolani

Postdoc

Fisiologia

Pontificia Universidad Católica de Chile

santiago, Chile

1
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
Eduardo Bravo

University of Iowa

Iowa City, Estados Unidos

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Paloma Maldonado

Investigador afiliado

Netherlands Institute for Neuroscience

Amsterdam, Holanda