Man

Cristian Adrián Sandoval Acuña

Profesor

I can IB

Praga, Chile

Líneas de Investigación


Farmacología del Cancer, Metabolismo mitocondrial, Metabolismo intracelular de Hierro, Resistencia tumoral

Educación

  •  Farmacología, UNIVERSIDAD DE CHILE. Chile, 2016
  •  Bioquímica, mención Toxicología y Diagnóstico Molecular, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

  •   Profesor Encargado de Biotecnología Other

    Universidad Central de Chile

    Facultad de Medicina y Ciencias de la Salud

    Santiago, Chile

    2015 - 2016

Experiencia Profesional

  •   Investigador Asociado Full Time

    Instituto de Biotecnología, Academia Checa de Ciencias

    Praga, Rep. Checa

    2021 - 2024

  •   Investigador Postdoctoral Full Time

    Instituto de Biotecnología, Academia Checa de Ciencias

    Praga, Rep. Checa

    2016 - 2021

Premios y Distinciones

  •   Young Investigator Award

    Society for Free Radical Research-Europe

    Portugal, 2018

    Premio a la mejor presentación de poster durante el 19th SFRR?I Biennial Meeting 2018

  •   Support of Perspective Human Sources: Financial support of Postdoctoral Fellows

    Academica Checa de Ciencias

    Rep. Checa, 2017

    Distinción a Investigadores Postdoctorales de Excelencia dentro de la Academia Checa de Ciencias


 

Article (11)

NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation

Jadhav, Sukanya B.; Vondrackova, Michaela; Potomova, Petra; Sandoval-Acuna, Cristian; Smigova, Jana; Klanicova, Kristyna; Rosel, Daniel; Brabek, Jan; Stursa, Jan; Werner, Lukas; et al.

Article ISI
FRONTIERS IN PHARMACOLOGY  (2024)

Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma

Sychra, Tomas; Spalenkova, Alzbeta; Balatka, Stepan; Vaclavikova, Radka; Seborova, Karolina; Ehrlichova, Marie; Truksa, Jaroslav; Sandoval-Acuna, Cristian; Nemcova, Vlasta; Szabo, Arpad; et al.

Article ISI
ISCIENCE  (2024)

Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model

Seborova, Karolina; Koucka, Kamila; Spalenkova, Alzbeta; Holy, Petr; Ehrlichova, Marie; Sychra, Tomas; Chen, Lei; Bendale, Hersh; Ojima, Iwao; Sandoval-Acuna, Cristian; et al.

Article ISI
FRONTIERS IN PHARMACOLOGY  (2022)

Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene

Novakova, Zora; Milosevic, Mirko; Kutil, Zsofia; Ondrakova, Marketa; Havlinova, Barbora; Kasparek, Petr; Sandoval-Acuna, Cristian; Korandova, Zuzana; Truksa, Jaroslav; Vrbacky, Marek; et al.

Article ISI
SCIENTIFIC REPORTS  (2022)

Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy

Sandoval-Acuna, Cristian; Torrealba, Natalia; Tomkova, Veronika; Jadhav, Sukanya B.; Blazkova, Kristyna; Merta, Ladislav; Lettlova, Sandra; Adamcova, Miroslava K.; Rosel, Daniel; Brabek, Jan; et al.

Article ISI
CANCER RESEARCH  (2021)

Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Truksa J.; Urra F.A.

Article ISI SCOPUS
Cells  (2020)

Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines

Rojas, Diego; Pavani, Mario

Article ISI SCOPUS
Toxicology in Vitro  (2020)

Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells

Tomkova, Veronika; Sandoval-Acuna, Cristian; Torrealba, Natalia; Truksa, Jaroslav

Article ISI
FREE RADICAL BIOLOGY AND MEDICINE  (2019)

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R.; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; Hubackova, Sona; Endaya, Berwini; Judasova, Kristyna; et al.

Article ISI
CELL METABOLISM  (2019)

Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma

Peredo-Silva, Liliana; Fuentes-Retamal, Sebasti?n; Sandoval-Acu?a, Cristian; Madrid-Rojas, Mat?as; Rebolledo, Solange

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2017)

Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates

Sandoval-Acuna, Cristian; Fuentes-Retamal, Sebastián; Guzmán-Rivera, Daniela; Peredo-Silva, Liliana; Madrid-Rojas, Matías; Rebolledo, Solange

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2016)

Review (1)

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions

Sandoval-Acuna C; Ferreira J.; Speisky H.

Review ISI SCOPUS
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS  (2014)

2
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

3
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1
HERNAN SPEISKY

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

2
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

2
José Jara

Assistant Professor

Research Institute of Dental Sciences

Universidad de Chile

Santiago, Chile

1
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
Gloria Calaf

Jefe Laboratorio Biología del Cáncer

Universidad de Tarapacá

Arica, Chile

4
Sebastián Fuentes

Investigador Postdoctoral

Institulo de Ciencias Biomédicas - Instituto de investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

12
Cristian Sandoval

Profesor

I can IB

Praga, Chile

1
Daniela Guzmán

Docente

Escuela de Química y Farmacia

Universidad Andrés Bello

Santiago, Chile