Man

Sebastián Andrés Fuentes Retamal

Investigador Postdoctoral

Universidad de Chile

Santiago, Chile

Líneas de Investigación


metabolismo del cáncer, terapias dirigidas hacia la mitocondria, plasticidad mitocondrial

Educación

  •  Farmacología, UNIVERSIDAD DE CHILE. Chile, 2020
  •  Químico farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2015

Experiencia Académica

  •   Docente Part Time

    UNIVERSIDAD DIEGO PORTALES

    Facultad de Salud y odontología

    Santiago, Chile

    2017 - 2017

  •   Docente Part Time

    UNIVERSIDAD ANDRES BELLO

    Facultad de Medicina

    Santiago, Chile

    2018 - A la fecha

  •   Docente Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2018 - 2019

  •   Docente Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias veterinarias y pecuarias

    Santiago, Chile

    2020 - A la fecha

  •   Docente Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Chile

    2021 - A la fecha

Experiencia Profesional

  •   Docente Part Time

    Universidad Andrés Bello

    Chile

    2018 - A la fecha

  •   Docente Part Time

    Universidad de Chile

    Chile

    2018 - A la fecha

  •   Docente Part Time

    Universidad Diego Portales

    Chile

    2017 - 2017

Formación de Capital Humano


Dirección de tesis y seminarios de tílulo



 

Article (16)

Antimigratory Effect of Lipophilic Cations Derived from Gallic and Gentisic Acid and Synergistic Effect with 5-Fluorouracil on Metastatic Colorectal Cancer Cells: A New Synthesis Route

Suárez-Rozas, Cristian; Jara, Jose Antonio; Cortes, Gonzalo; Rojas, Diego; Araya-Valdes, Gabriel; Molina-Berrios, Alfredo; Gonzalez-Herrera, Fabiola; Fuentes-Retamal, Sebastián; Aranguiz-Urroz, Pablo; Campodonico, Paola Rossana; et al.

Article ISI SCOPUS
Cancers  (2024)

Mitochondrial bioenergetics as a cell fate rheostat for responsive to Bcl-2 drugs: New cues for cancer chemotherapy

Palominos, Charlotte; Fuentes-Retamal, S; Salazar, Juan Pablo; Guzmán-Rivera, Daniela; Correa, Pablo; Mellado, Mathias; Araya-Maturana, Ramiro; URRA-FAUNDEZ, FELIX ARIEL

Article ISI SCOPUS
Cancer Letters  (2024)

A paraguayan toad <i>Rhinella schneideri</i> preparation based on Mbya tradition increases mitochondrial bioenergetics with migrastatic effects dependent on AMPK in breast cancer cells

Rojas-De-Arias, Antonieta

Article ISI SCOPUS
 (2022)

Functional, immunological characterization, and anticancer activity of BaMtx: A new Lys49-PLA<sub>2</sub> homologue isolated from the venom of Peruvian <i>Bothrops atrox</i> snake (Serpentes: Viperidae)

Proleón, Álex; Torrejón, Daniel; Quispe, Edwin; Bautista, Lorgio

Article ISI SCOPUS
 (2022)

Shedding Light on the Dentition and Venom Delivery System of the Rear-Fanged Snake, Galvarinus chilensis chilensis (Serpentes: Dipsadidae: Tachymenini) from Chile

Herrera, Yarela; Peichoto, Maria Elisa

Article ISI SCOPUS
 (2022)

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease

Rabelo, Rayane Aparecida Nonato; Barbosa, Cesar; Rates, Mariana; Fuentes-Retamal, Sebastian S.; Guzman-Rivera, Daniela D.; Quintero, Helena; Machado, Fabiana; Maya, Juan

Article ISI
PLOS NEGLECTED TROPICAL DISEASES  (2021)

Extracellular Matrix Signals as Drivers of Mitochondrial Bioenergetics and Metabolic Plasticity of Cancer Cells During Metastasis

URRA-FAUNDEZ, FELIX ARIEL; Rodríguez-Lucart, Yarcely A.; López-Torres, Camila; ARAYA-MATURANA, RAMIRO JUAN

Article ISI SCOPUS
Frontiers in Cell and Developmental Biology  (2021)

FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells

RAMIREZ-RODRIGUEZ, ONEY OSCAR

Article ISI SCOPUS
Antioxidants  (2021)

An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells

Pablo Millas-Vargas, Juan; Correa, Pablo; Miranda, Dante; Pulgar, Rodrigo

Article ISI
BIOORGANIC CHEMISTRY  (2020)

Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Truksa, J; Urra, FA

Article ISI
CELLS  (2020)

Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines

Rojas, Diego; Pavani, Mario

Article ISI SCOPUS
TOXICOLOGY IN VITRO  (2020)

Simvastatin Improves Cardiac Function through Notch 1 Activation in BALB/c Mice with Chronic Chagas Cardiomyopathy

Diego Maya, Juan

Article ISI
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY  (2020)

The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells

Correa, Pablo

Article ISI
TOXINS  (2020)

Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs



Article ISI SCOPUS
TOXICOLOGY IN VITRO  (2019)

Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma

Peredo-Silva, Liliana; Fuentes-Retamal, Sebasti?n; Sandoval-Acu?a, Cristian; Madrid-Rojas, Mat?as; Rebolledo, Solange

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2017)

Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates

Sandoval-Acuna, Cristian; Fuentes-Retamal, Sebastián; Guzmán-Rivera, Daniela; Peredo-Silva, Liliana; Madrid-Rojas, Matías; Rebolledo, Solange

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2016)

Abstract (2)

CYTOTOXIC EFFECT OF GENTISIC ACID AND PROTOCATECHUIC ACID TRIPHENYLPHOSPHONIUM DERIVATIVES IN HUMAN BREAST CANCER CELLS: POSSIBLE MECHANISM AND BIOENERGETIC IMPLICATIONS

Sandoval-Acuna C; Fuentes-Retamal, S; Guzmán-Rivera, D.; Speisky, H; Castro-Castillo, V.; Madrid-Rojas, M; Ferreira, J

Abstract ISI
Anticancer research.  (2014)

LIPOPHILIC CATION-DERIVED POLIHIDROXY-BENZOATES AS NEW CYTOTOXIC MOLECULES IN HUMAN BREAST CANCER CELLS

Catalán, M; Fuentes-Retamal, S; Jara, JA; Castro-Castillo, V.; Madrid-Rojas, M; Pavani, M.; Ferreira, J

Abstract ISI
Anticancer research.  (2014)

BookSection (1)

Chapter 1 - Recent advances in molecular mechanisms of anticancer natural products that target mitochondrial bioenergetics

Prof. Atta-Ur-Rahman, FRS

BookSection
 (2021)

Proyecto (1)

α-KGDH inhibition prevents triple-negative breast cancer cell migration by mitophagy induction: a potential anti-cancer target.



Proyecto
 (2021)

1
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

3
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

4
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Ramiro Araya Maturana

Profesor Titular

Universidad de Talca

SantiaTalcago, Chile

1
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

1
HERNAN SPEISKY

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

1
Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

2
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

3
José Jara

Assistant Professor

Research Institute of Dental Sciences

Universidad de Chile

Santiago, Chile

1
Alfredo Molina

Profesor Asistente

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

santiago, Chile

1
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

3
Félix Urra

Profesor asistente

Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y Clínica

University of Chile

Santiago, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Gloria Calaf

Jefe Laboratorio Biología del Cáncer

Universidad de Tarapacá

Arica, Chile

1
JEAN DE ANDRADE

Académico Docente

Departamento de Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

1
Cristian Suárez

Investigador Postdoctoral Fondecyt Postdoctorado 2022 N° 3220509

Universidad del Desarrollo

Santiago, Chile

21
Sebastián Fuentes

Investigador Postdoctoral

Institulo de Ciencias Biomédicas - Instituto de investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
catherin donoso

Postdoctorado

de Ciencias Exactas

Univesidad Andres Bello

Santiago, Chile

1
Helena Quintero

2
Fabiola González

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

4
Cristian Sandoval

Profesor

I can IB

Praga, Chile

4
Daniela Guzmán

Docente

Escuela de Química y Farmacia

Universidad Andrés Bello

Santiago, Chile

1
David Cabezas

Investigador

Centro de Investigaciones Nucleares para Aplicaciones en Salud y Biomedicina

Comisión Chilena de Energía Nuclear

Santiago, Chile