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Sebastián Andrés Fuentes Retamal

Investigador Postdoctoral

Universidad de Chile

Santiago, Chile

metabolismo del cáncer, terapias dirigidas hacia la mitocondria, plasticidad mitocondrial

Farmacología, UNIVERSIDAD DE CHILE. Chile, 2020
Químico farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2015

Docente Part Time

UNIVERSIDAD DIEGO PORTALES

Facultad de Salud y odontología

Santiago, Chile

2017 - 2017
Docente Part Time

UNIVERSIDAD ANDRES BELLO

Facultad de Medicina

Santiago, Chile

2018 - A la fecha
Docente Part Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2018 - 2019
Docente Part Time

UNIVERSIDAD DE CHILE

Facultad de Ciencias veterinarias y pecuarias

Santiago, Chile

2020 - A la fecha
Docente Part Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Chile

2021 - A la fecha

Docente Part Time

Universidad Andrés Bello

Chile

2018 - A la fecha
Docente Part Time

Universidad de Chile

Chile

2018 - A la fecha
Docente Part Time

Universidad Diego Portales

Chile

2017 - 2017

Dirección de tesis y seminarios de tílulo


Antimigratory Effect of Lipophilic Cations Derived from Gallic and Gentisic Acid and Synergistic Effect with 5-Fluorouracil on Metastatic Colorectal Cancer Cells: A New Synthesis Route Suárez-Rozas, Cristian; Jara, Jose Antonio; Cortes, Gonzalo; Rojas, Diego; Araya-Valdes, Gabriel; Molina-Berrios, Alfredo; Gonzalez-Herrera, Fabiola; Fuentes-Retamal, Sebastián; Aranguiz-Urroz, Pablo; Campodonico, Paola Rossana; et al. Article ISI CANCERS (2024)
Mitochondrial bioenergetics as a cell fate rheostat for responsive to Bcl-2 drugs: New cues for cancer chemotherapy Palominos, Charlotte; Fuentes-Retamal, S.; Salazar, Juan Pablo; Guzmán-Rivera, Daniela; Correa, Pablo; Mellado, Mathias; Araya-Maturana, Ramiro; URRA-FAUNDEZ, FELIX ARIEL Article ISI SCOPUS CANCER LETTERS (2024)
A paraguayan toad <i>Rhinella schneideri</i> preparation based on Mbya tradition increases mitochondrial bioenergetics with migrastatic effects dependent on AMPK in breast cancer cells Rojas-De-Arias, Antonieta Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2022)
Functional, immunological characterization, and anticancer activity of BaMtx: A new Lys49-PLA<sub>2</sub> homologue isolated from the venom of Peruvian <i>Bothrops atrox</i> snake (Serpentes: Viperidae) Proleón, Álex; Torrejón, Daniel; Quispe, Edwin; Bautista, Lorgio Article ISI SCOPUS INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)
Shedding Light on the Dentition and Venom Delivery System of the Rear-Fanged Snake, Galvarinus chilensis chilensis (Serpentes: Dipsadidae: Tachymenini) from Chile Herrera, Yarela; Peichoto, Maria Elisa Article ISI SCOPUS Biology (2022)
Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease Rabelo, Rayane Aparecida Nonato; Barbosa, Cesar; Rates, Mariana; Fuentes-Retamal, Sebastian S.; Guzman-Rivera, Daniela D.; Quintero, Helena; Machado, Fabiana; Maya, Juan Article ISI PLOS NEGLECTED TROPICAL DISEASES (2021)
Extracellular Matrix Signals as Drivers of Mitochondrial Bioenergetics and Metabolic Plasticity of Cancer Cells During Metastasis URRA-FAUNDEZ, FELIX ARIEL; Rodríguez-Lucart, Yarcely A.; López-Torres, Camila; ARAYA-MATURANA, RAMIRO JUAN Article ISI SCOPUS Frontiers in Cell and Developmental Biology (2021)
FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells RAMIREZ-RODRIGUEZ, ONEY OSCAR Article ISI SCOPUS Antioxidants (2021)
An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells Pablo Millas-Vargas, Juan; Correa, Pablo; Miranda, Dante; Pulgar, Rodrigo Article ISI BIOORGANIC CHEMISTRY (2020)
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells Truksa, J; Urra, FA Article ISI CELLS (2020)
Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines Rojas, Diego; Pavani, Mario Article ISI SCOPUS Toxicology in Vitro (2020)
Simvastatin Improves Cardiac Function through Notch 1 Activation in BALB/c Mice with Chronic Chagas Cardiomyopathy Diego Maya, Juan Article ISI ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)
The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition and Effect on the Proliferation and Migration of Lung Cancer Cells Correa, Pablo Article ISI TOXINS (2020)
Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs Article ISI SCOPUS TOXICOLOGY IN VITRO (2019)
Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma Peredo-Silva, Liliana; Fuentes-Retamal, Sebasti?n; Sandoval-Acu?a, Cristian; Madrid-Rojas, Mat?as; Rebolledo, Solange Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP+-linked-polyhydroxybenzoates Sandoval-Acuna, Cristian; Fuentes-Retamal, Sebastián; Guzmán-Rivera, Daniela; Peredo-Silva, Liliana; Madrid-Rojas, Matías; Rebolledo, Solange Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)


CYTOTOXIC EFFECT OF GENTISIC ACID AND PROTOCATECHUIC ACID TRIPHENYLPHOSPHONIUM DERIVATIVES IN HUMAN BREAST CANCER CELLS: POSSIBLE MECHANISM AND BIOENERGETIC IMPLICATIONS Sandoval-Acuna C; Fuentes-Retamal, S.; Guzmán-Rivera, D.; Speisky, H; Castro-Castillo, V.; Madrid-Rojas, M; Ferreira J. Abstract ISI Anticancer research. (2014)
LIPOPHILIC CATION-DERIVED POLIHIDROXY-BENZOATES AS NEW CYTOTOXIC MOLECULES IN HUMAN BREAST CANCER CELLS Catalán M.; Fuentes-Retamal, S.; Jara, JA; Castro-Castillo, V.; Madrid-Rojas, M; Pavani, M.; Ferreira J. Abstract ISI Anticancer research. (2014)


Chapter 1 - Recent advances in molecular mechanisms of anticancer natural products that target mitochondrial bioenergetics Prof. Atta-Ur-Rahman, FRS BookSection (2021)


α-KGDH inhibition prevents triple-negative breast cancer cell migration by mitophagy induction: a potential anti-cancer target. Proyecto (2021)
Lipophilic cations of esters of alkyltriphenylphosphonium polyhydroxybenzoates as mitochondriotropic antineoplastic agents. Antitumoral activity spectra on human tumour cells from different tissues FONDECYT (1130772) Proyecto 2013-2016 Tesista
Estudio de mecanismos de acción de cationes lipofílicos deslocalizados derivados de alquil-polihidroxibenzoatos unidos al grupo trifenilfosfonio como antineoplásicos de acción mitocondrial. PAI (791220004) Proyecto 2013-2016 Tesista
Lipophilic cations of esters of alkyltriphenylphosphonium polyhydroxybenzoates as mitochondriotropic antineoplastic agents. Antitumoral activity spectra on human tumour cells from different tissues. FONDECYT (1130772) Proyecto 2013-2016 Personal técnico y/o de apoyo
Regio- and stereo-selective Diels-Alder reactions in the synthesis of CDC25B fosfatase inhibitors. FONDECYT (1110176) Proyecto 2011-2014 Personal técnico y/o de apoyo
A rational synthetic approach to 3-indolealkyl(aryl)piperazine derivatives as new hetero and homobivalent ligands with potential serotonergic activity. FONDECYT (1090169) Proyecto 2009-2013 Personal técnico y/o de apoyo