Man

Mabel Elizabeth Catalán Díaz

Profesora Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Química farmacológica del cáncer y la obesidad; Farmacología mitocondrial; Cáncer de colorrectal; Obesidad

Educación

  •  Licenciatura en Farmacia, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2014
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesora Asistente Full Time

    UNIVERSIDAD DE CHILE

    de Medicina

    Santiago, Chile

    2018 - A la fecha

  •   Profesora por proyecto de inserción Other

    UNIVERSIDAD DE CHILE

    de Medicina

    Santiago, Chile

    2014 - 2017

Experiencia Profesional

  •   Academico con proyecto de inserción

    Universidad de Chile

    Chile

    2014 - A la fecha

  •   Profesora Asistente Full Time

    Universidad de Chile

    Chile

    2018 - A la fecha

Premios y Distinciones

  •   Medalla Doctoral

    UNIVERSIDAD DE CHILE

    Chile, 2014

    Distinción al grado de doctor otorgado por la Universidad de Chile


 

Article (11)

FoxO1 is required for high glucose-dependent cardiac fibroblasts into myofibroblast phenoconversion
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells
Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines
Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity
Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines
Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1
The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines
Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs
TGF‑β1 induced up‑regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP(+)-linked-polyhydroxybenzoates
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast.

Proyecto (3)

Targeting decyl polyOH benzoate esters coupled to triphenylphosphonium towards mitochondrial respiratory chain is an efficient approach for cancer treatment. Antitumor activity against several human lung cancer cell types. Basic and Preclinical studies
In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer.
Estudio de mecanismos de acción de Cationes Lipofilicos deslocalizados derivados de Alquil- Polihidroxibenzoatos unidos al grupo Trifenilfosfonio como Antineoplasicos de acción mitocondrial
13
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile