PDI - Resultado de Búsqueda

Mabel Elizabeth Catalán Díaz

Profesora Asistente

Universidad de Chile

Santiago, Chile

Química farmacológica del cáncer y la obesidad; Farmacología mitocondrial; Cáncer de colorrectal; Obesidad

Licenciatura en Farmacia, UNIVERSIDAD DE CHILE. Chile, 2007
Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2014
Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2007

Profesora Asistente Full Time

UNIVERSIDAD DE CHILE

de Medicina

Santiago, Chile

2018 - A la fecha
Profesora por proyecto de inserción Other

UNIVERSIDAD DE CHILE

de Medicina

Santiago, Chile

2014 - 2017

Academico con proyecto de inserción

Universidad de Chile

Chile

2014 - A la fecha
Profesora Asistente Full Time

Universidad de Chile

Chile

2018 - A la fecha

Medalla Doctoral

UNIVERSIDAD DE CHILE

Chile, 2014

Distinción al grado de doctor otorgado por la Universidad de Chile


Boldine prevents the inflammatory response of cardiac fibroblasts induced by SGK1-NFκB signaling pathway activation Article CELLULAR SIGNALLING (2024)
Gallic acid triphenylphosphonium derivatives TPP+-C10 and TPP+-C12 inhibit mitochondrial function in Candida albicans exerting antifungal and antibiofilm effects Article JOURNAL OF APPLIED MICROBIOLOGY (2024)
Lipoxin A4 prevents high glucose-induced inflammatory response in cardiac fibroblast through FOXO1 inhibition Catalan, Mabel; Vivar, Raul Article ISI CELLULAR SIGNALLING (2023)
SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF-β1 Catalan, Mabel; Vivar, Raill Article ISI CELLULAR SIGNALLING (2023)
Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition Clayton, Natasha S.; Catalan, Mabel; Ridley, Anne J.; Vivar, Raul; Diego Maya, Juan Article ISI FRONTIERS IN IMMUNOLOGY (2023)
FoxO1 is required for high glucose-dependent cardiac fibroblasts into myofibroblast phenoconversion Contreras, Alejandra Article CELLULAR SIGNALLING (2021)
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells Pavani, Mario; Torrealba, Natalia Article CELLS (2020)
Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines Article RSC MEDICINAL CHEMISTRY (2020)
Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity Article INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines Rojas, Diego; Pavani, Mario Article TOXICOLOGY IN VITRO (2020)
Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1 Hill, Joseph Article BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines Carrasco-Pozo, Catalina Article MOLECULES (2020)
Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs Mella, Jaime; Cassels, Bruce K.; Yañez, Claudi Article TOXICOLOGY IN VITRO (2019)
TGF‑β1 induced up‑regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts Ayala, Pedro Article MOLECULAR BIOLOGY REPORTS (2019)
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP(+)-linked-polyhydroxybenzoates Pavani, Mario; Speisky, Hernan E. Article TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)


Targeting decyl polyOH benzoate esters coupled to triphenylphosphonium towards mitochondrial respiratory chain is an efficient approach for cancer treatment. Antitumor activity against several human lung cancer cell types. Basic and Preclinical studies Catalan, Mabel Proyecto (2017)
In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer Proyecto (2016)
In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer. Universidad de Chile Proyecto (2016)
Estudio de mecanismos de acción de Cationes Lipofilicos deslocalizados derivados de Alquil- Polihidroxibenzoatos unidos al grupo Trifenilfosfonio como Antineoplasicos de acción mitocondrial Proyecto (2014)

Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Renatto Anfossi

Coordinador de Investigación

Unidad de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

Christian Castillo

Profesor Asistente

Instituto Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Fabiola González

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

Mabel Elizabeth Catalán Díaz

Líneas de Investigación

Educación

Licenciatura en Farmacia, UNIVERSIDAD DE CHILE. Chile, 2007

Doctorado en Farmacología, UNIVERSIDAD DE CHILE. Chile, 2014

Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

Profesora Asistente Full Time

Profesora por proyecto de inserción Other

Experiencia Profesional

Academico con proyecto de inserción

Profesora Asistente Full Time

Premios y Distinciones

Medalla Doctoral

Article (15)

Boldine prevents the inflammatory response of cardiac fibroblasts induced by SGK1-NFκB signaling pathway activation

Gallic acid triphenylphosphonium derivatives TPP+-C10 and TPP+-C12 inhibit mitochondrial function in Candida albicans exerting antifungal and antibiofilm effects

Lipoxin A4 prevents high glucose-induced inflammatory response in cardiac fibroblast through FOXO1 inhibition

SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF-β1

Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition

FoxO1 is required for high glucose-dependent cardiac fibroblasts into myofibroblast phenoconversion

Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines

Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity

Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1

The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines

Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs

TGF‑β1 induced up‑regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts

Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP(+)-linked-polyhydroxybenzoates

Proyecto (4)

Targeting decyl polyOH benzoate esters coupled to triphenylphosphonium towards mitochondrial respiratory chain is an efficient approach for cancer treatment. Antitumor activity against several human lung cancer cell types. Basic and Preclinical studies

In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer

In vitro and in vivo pre-clinical antineoplastic evaluation of new delocalized lipophilic cation derivatives in metastatic colorectal cancer.

Estudio de mecanismos de acción de Cationes Lipofilicos deslocalizados derivados de Alquil- Polihidroxibenzoatos unidos al grupo Trifenilfosfonio como Antineoplasicos de acción mitocondrial

Mabel Catalán

Renatto Anfossi

Christian Castillo

Fabiola González