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Christian Raul Castillo Rivas

Líneas de Investigación


Estudio de la respuesta inmune innata antiparasitaria en modelos de transplacentaria y modelo endoteliales in vitro.

Educación

  •  Medico Veterinario, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Ciencias Silvoagropecuarias y Veterinarias, UNIVERSIDAD DE CHILE. Chile, 2017

Experiencia Académica

  •   Investigador Postdoctoral Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2018 - A la fecha

  •   Profesor Adjunto Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2018 - A la fecha

Formación de Capital Humano


Tesis de pregrado:
1. Christian Alfredo Gallardo Arce. “Determinación del perfil de citoquinas mediadas por receptores tipo NOD en el trofoblasto humano en respuesta a la infección con Trypanosoma cruzi” Titulo de Tecnólogo Medico, Universidad de Chile. 2016.
2. Alexandra Mackarena Sandoval Vilches. “Evaluación del efecto de fármacos antichagásicos sobre la función endotelial en modelo ex vivo de infección por Trypanosoma cruzi.”. Título de Tecnólogo Medico, Universidad de Chile. 2014.
3. Marta Fajardo Godoy, Macarena Rojas González. «Identificación mediante método de PCR de presencia de Trypanosoma cruzi en Rhipicephalus sanguineus en cánidos domésticos del sector Cerro Grande en la ciudad de La Serena ». Tesis para optar al título de Médico Veterinario. Facultad de ciencias agropecuarias, Escuela de Medicina Veterinaria, Universidad Pedro de Valdivia, sede La Serena. En curso.



 

Article (37)

Statins change the cytokine profile in Trypanosoma cruzi-infected U937 macrophages and murine cardiac tissue through Rho-associated kinases inhibition
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis
Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue
Endogenous overexpression of an active phosphorylated form of DNA polymerase beta under oxidative stress in Trypanosoma cruzi
Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi
Old Yellow Enzyme from Trypanosoma cruzi Exhibits In Vivo Prostaglandin F-2 alpha Synthase Activity and Has a Key Role in Parasite Infection and Drug Susceptibility
Erratum for González-Herrera et al., "Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy".
Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor expression and cytokine/chemokine profiles
Ex vivo infection of human placental chorionic villi explants with Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor expression and cytokine/chemokine profiles.
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Toll-like receptor-2 mediates local innate immune response against Trypanosoma cruzi in ex vivo infected human placental chorionic villi explants
Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo.
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection
A local innate immune response against Trypanosoma cruzi in the human placenta=> The epithelial turnover of the trophoblast.
A local innate immune response against Trypanosoma cruzi in the human placenta=> The epithelial turnover of the trophoblast.
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection.
Role of placental barrier integrity in infection by Trypanosoma cruzi
Role of placental barrier integrity in infection by Trypanosoma cruzi.
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma.
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma.
Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting.
IFPA Meeting 2013 Workshop Report III=> Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta
IFPA Meeting 2013 Workshop Report III=> maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants
Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants
Trypanosoma cruzi induces trophoblast differentiation: A potential local antiparasitic mechanism of the human placenta?
Phospholipase C gamma and ERK1/2 Mitogen Activated Kinase Pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta
Phospholipase C gamma and ERK1/2 mitogen activated kinase pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta
Phospholipase C gamma and ERK1/2 mitogen activated kinase pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta.
Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection=> evidence of a 15-epi-lipoxin A4-mediated effect
The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta
The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta
The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta.
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi.
Reorganization of extracellular matrix in placentas from women with asymptomatic chagas disease=> mechanism of parasite invasion or local placental defense?

Proyecto (11)

Mechanism of Congenital Chagas disease: Effective placental Trypanosoma cruzi infection depends on parasite-derived exovesicles
Modulation of the receptor for advanced glycation end products (RAGE) in a Host-pathogen model: an immunobiological approach to improve placental barrier integrity
Congenital Chagas Disease Consortium: Identification and validation of biomarkers to improve the control of congenital Chagas disease
Mechanism of Congenital Chagas disease: Effective Trypanosoma cruzi placental infection depends on specific host-derived microRNAs
Cardiopatía chagásica crónica: Evaluación preclínica del rol de la alarmina HMGB1 como blanco terapéutico
Cardiopatía chagásica crónica=> Evaluación preclínica del rol de la alarmina HMGB1 como blanco terapéutico
Congenital Chagas disease research Consortium
Red de Colaboración Internacional entre Chile y Uruguay para el Estudio de la Expresión Génica en Enfermedades Infecciosas y Cancer
Mechanism of congenital Chagas disease=> Effective infection depends on the interplay between T. cruzi and the trophoblast in the human placenta
Advanced Center for Traning and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplasic Aggressions
CONGENITAL CHAGAS" DISEASE=> MECHANISMS OF TRYPANOSOMA CRUZI INFECTION AND INVASION IN HUMAN PLACENTA
9
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

7
Ana Liempi

Investigador

Instituto de Ciencia Biomedica

Universidad de Chile, Facultad de Medicina

Santiago, Chile

5
Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Fabiola González

Investigadora Postdoctoral

Universidad de Chile

Santiago, Chile

2
Daniel Droguett

Profesor Conferenciante

Estomatología

Universidad de Talca

Talca, Chile

2
juan duaso

Academico

Universidad Vina del Mar

Viña del Mar, Chile

1
Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gemma Rojo

Profesor asistente/Investigador Postdoctoral UChile/UOH

Instituto de Ciencias Agroalimentarias, Animales y Ambientales (ICA3)

Universidad de O'Higgins (UOH)

San Fernando, Chile

1
Michel Lapier

Académico

Química y Farmacia

Universidad de Valparaíso

Valparaíso, Chile

1
Carolina Campos

Associate Professor

School of Chemistry and Pharmacy

Universidad de Valparaiso

Valparaíso, Chile

1
Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

1
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile