Man

Patricio Abel Silva Andrades

Investigados Postdoctoral

Universidad de Chile

Santiago, Chile

Líneas de Investigación


CELL MIGRATION; HYPOXIA; CELL SIGNALING

Educación

  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2009
  •  DOCTORADO EN CIENCIAS BIOMEDICAS, UNIVERSIDAD DE CHILE. Chile, 2016
  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

  •   PROFESSOR Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2011 - 2019

Experiencia Profesional

  •   PROFESSOR Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Santiago, Chile

    2011 - 2019


 

Article (19)

Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling

Silva, Patricio; Hernandez, Nadia; Tapia, Hector; Gaete-Ramirez, Belen; Torres, Pedro; Flores, Tania; Herrera, Daniela; Caceres-Verschae, Albano; Acuna, Rodrigo A.; Varas-Godoy, Manuel; Torres, Vicente A.

Article ISI
FASEB JOURNAL  (2024)

The salivary peptide histatin-1 enhances bone repair<i> in</i><i> vivo</i>

Torres, Pedro; Flores, Victor; Flores, Tania; Silva, Patricio; Gonzalez, Luis; Cordova, Luis A.; Reyes, Montserrat; Torres, Vicente A.

Article ISI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2023)

Identification of VEGFR2 as the Histatin-1 receptor in endothelial cells

Mateluna, Carlos; Torres, Pedro; Rodriguez-Pena, Marcelo; Silva, Patricio; Matthies, Douglas J.; Criollo, Alfredo; Bikker, Floris J.; Bolscher, Jan G. M.; Wilson, Christian A. M.; Zapata-Torres, Gerald; Torres, Vicente A.

Article ISI
BIOCHEMICAL PHARMACOLOGY  (2022)

Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation

Torres, Pedro; Hernandez, Nadia; Mateluna, Carlos; Silva, Patricio; Reyes, Montserrat; Solano, Luis; Venegas, Sebastian; Criollo, Alfredo; Nazmi, Kamran; Bikker, Floris J.; Bolscher, Jan G. M.; Garrido, Mauricio; Caceres, Monica; Torres, Vicente A.

Article ISI
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE  (2021)

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Mayarling Francisca Troncoso; Mario Pavez; Carlos Wilson; Daniel Lagos; Javier Duran; Sebastián Ramos; Genaro Barrientos; Patricio Silva; Paola Llanos; Carla Basualto-Alarcón; B. Daan Westenbrink; Sergio Lavandero; Manuel Estrada

Article SCIELO
BIOLOGICAL RESEARCH  (2021)

Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia

Reyes M.; Peña-Oyarzún D.; Silva P.; Venegas S.; Criollo A.; Torres, V.A.

Article ISI SCOPUS
FASEB JOURNAL  (2020)

Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

Paz Hernandez-Caceres, Maria; Cereceda, Karina; Hernandez, Sergio; Li, Ying; Narro, Carla; Rivera, Patricia; Silva, Patricio; Avalos, Yenniffer; Jara, Claudia; Burgos, Paulina; Toledo-Valenzuela, Lilian; Lagos, Pablo; Cifuentes Araneda, Flavia; Perez-Leighton, Claudio; Bertocchi, Cristina; Clegg, Deborah J.; Criollo, Alfredo; Tapia-Rojas, Cheril; Burgos, Patricia, V; Morselli, Eugenia

Article ISI
Molecular and Cellular Oncology  (2020)

The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

Rivas, Solange; Silva, Patricio; Reyes, Montserrat; Sepulveda, Hugo; Solano, Luis; Acuna, Juan; Guerrero, Marisol; Varas-Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martin; Torres, Vicente A.

Article ISI
SCIENTIFIC REPORTS  (2020)

Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration

Arriagada, Cecilia; Silva, Patricio; Millet, Martial; Solano, Luis; Moraga, Carolina; Torres, Vicente A.

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2019)

Role of glycosylation in hypoxia-driven cell migration and invasion

Arriagada, Cecilia; Silva, Patricio; Torres, Vicente A.

Article ISI SCOPUS
CELL ADHESION & MIGRATION  (2019)

Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration

Mendoza, P. A.; Silva P.; Díaz J.; Arriagada C.; Canales J.; Cerda O.; Torres, V.A.

Article ISI SCOPUS
Cell Adhesion and Migration  (2018)

Hypoxia-induced caveolin-1 expression promotes migration and invasion of tumor cells

Bennett J.C.; Silva P.; Martinez S.; Torres, V.A.; Quest, A.F.G.

Article ISI SCOPUS
 (2018)

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells

Diaz-Valdivia, NI; Calderon, CC; Diaz, JE; Lobos-Gonzalez, L; Sepulveda, H; Ortiz, RJ; Martinez, S; Silva, V; Maldonado, HJ; Silva, P; Wehinger, S; Burzio, VA; Torres, VA; Montecino, M; Leyton, L; Quest, AFG

Article ISI SCOPUS
Oncotarget  (2017)

The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis

Torres, P; Diaz, J; Arce, M; Silva, P; Mendoza, P; Lois, P; Molina-Berrios, A; Owen, GI; Palma, V; Torres, VA

Article ISI SCOPUS
FASEB Journal  (2017)

Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis.

Silva, Patricio; Mendoza, Pablo; Rivas, Solange; Díaz, Jorge; Moraga, Carolina; Quest, Andrew F G; Torres, Vicente A

Article
Oncotarget  (2016)

Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation.

Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F G; Torres, Vicente A

Article
Biochemical and biophysical research communications  (2015)

A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion.

Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew Fg; Torres, Vicente A

Article
Communicative & integrative biology  (2014)

Rab5 activation as a tumor cell migration switch

Mendoza, Pablo Alexis; Diaz, Jorge; Silva, Patricio; Torres, Vicente A.

Article
 (2014)

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.

Altamirano, Francisco; Oyarce, César; Silva, Patricio; Toyos, Marcela; Wilson, Carlos; Lavandero, Sergio; Uhlén, Per; Estrada, Manuel

Article
The Journal of endocrinology  (2009)

15
Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

11
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

4
Montserrat Reyes

Profesor Asistente

Universidad de Chile

Santiago, Chile

3
CECILIA ARRIAGADA

Postdoctoral Fellow

Rutgers University

Newark, Estados Unidos

3
Luis Solano

Asistente de investigación

Universidad de Chile

Santiago, Chile

2
Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

2
Pedro Torres

Ayudante laboratorio

Universidad de Chile

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Daniel Peña

Investigador postdoctoral

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
Pablo Lois

Asistente de Investigación

Biología

Universidad de Chile

Santiago, Chile

1
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile