Man

Patricio Abel Silva Andrades

Investigador Principal FONDEF

Universidad de Chile

Santiago, Chile

Líneas de Investigación


CELL MIGRATION; HYPOXIA; CELL SIGNALING

Educación

  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2009
  •  DOCTORADO EN CIENCIAS BIOMEDICAS, UNIVERSIDAD DE CHILE. Chile, 2016
  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

  •   PROFESSOR Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2011 - 2019

Experiencia Profesional

  •   PROFESSOR Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Santiago, Chile

    2011 - 2019


 

Article (19)

Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling
The salivary peptide histatin-1 enhances bone repair<i> in</i><i> vivo</i>
Identification of VEGFR2 as the Histatin-1 receptor in endothelial cells
Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation
Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration
Role of glycosylation in hypoxia-driven cell migration and invasion
Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration
Hypoxia-induced caveolin-1 expression promotes migration and invasion of tumor cells
Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells
The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis.
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation.
A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion.
Rab5 activation as a tumor cell migration switch
Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.
15
Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

13
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

4
Montserrat Reyes

Profesor Asistente

Universidad de Chile

Santiago, Chile

3
CECILIA ARRIAGADA

Postdoctoral Fellow

Rutgers University

Newark, Estados Unidos

3
Luis Solano

Asistente de investigación

Universidad de Chile

Santiago, Chile

2
Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

2
Pedro Torres

Ayudante laboratorio

Universidad de Chile

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Daniel Peña

Investigador postdoctoral

Departamento de Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
Pablo Lois

Asistente de Investigación

Biología

Universidad de Chile

Santiago, Chile

1
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile