Man

Patricio Abel Silva Andrades

Investigador Principal FONDEF

Universidad de Chile

Santiago, Chile

Líneas de Investigación


CELL MIGRATION; HYPOXIA; CELL SIGNALING

Educación

  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2009
  •  DOCTORADO EN CIENCIAS BIOMEDICAS, UNIVERSIDAD DE CHILE. Chile, 2016
  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2011

Experiencia Académica

  •   PROFESSOR Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2011 - 2019

Experiencia Profesional

  •   PROFESSOR Part Time

    UNIVERSIDAD CENTRAL DE CHILE

    Santiago, Chile

    2011 - 2019


 

Article (19)

Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling

Silva, Patricio; Flores, Tania; Herrera, Daniela; Torres, Vicente A.

Article ISI
FASEB JOURNAL  (2024)

The salivary peptide histatin-1 enhances bone repair<i> in</i><i> vivo</i>

Flores, Tania; Silva, Patricio; Gonzalez, Luis; Torres, Vicente A.

Article ISI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2023)

Identification of VEGFR2 as the Histatin-1 receptor in endothelial cells

Silva, Patricio; Criollo, Alfredo; Torres, Vicente A.

Article ISI
BIOCHEMICAL PHARMACOLOGY  (2022)

Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation

Hernandez, Nadia; Mateluna, Carlos; Silva, Patricio; Criollo, Alfredo; Nazmi, Kamran; Bikker, Floris J.; Bolscher, Jan G. M.; Garrido, Mauricio; Torres, Vicente A.

Article ISI
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE  (2021)

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Mayarling Francisca Troncoso; Mario Pavez; Carlos Wilson; Daniel Lagos; Javier Duran; Sebastián Ramos; Genaro Barrientos; Patricio Silva; Paola Llanos; Carla Basualto-Alarcón; et al.

Article SCIELO
BIOLOGICAL RESEARCH  (2021)

Nuclear accumulation of beta-catenin is associated with endosomal sequestration of the destruction complex and increased activation of Rab5 in oral dysplasia

Peña-Oyarzún D.; Venegas S.; Torres, VA

Article ISI SCOPUS
FASEB JOURNAL  (2020)

Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

Li, Ying; Silva, Patricio; Criollo, Alfredo

Article ISI
Molecular and Cellular Oncology  (2020)

The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

Rivas, Solange; Silva, Patricio; Montecino, Martin; Torres, Vicente A.

Article ISI
SCIENTIFIC REPORTS  (2020)

Focal adhesion kinase-dependent activation of the early endocytic protein Rab5 is associated with cell migration

Arriagada, Cecilia; Silva, Patricio; Millet, Martial; Moraga, Carolina; Torres, Vicente A.

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2019)

Role of glycosylation in hypoxia-driven cell migration and invasion

Arriagada, Cecilia; Silva, Patricio; Torres, Vicente A.

Article ISI SCOPUS
CELL ADHESION & MIGRATION  (2019)

Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration

Mendoza, P. A.; Torres, VA

Article ISI SCOPUS
Cell Adhesion and Migration  (2018)

Hypoxia-induced caveolin-1 expression promotes migration and invasion of tumor cells

Torres, VA

Article ISI SCOPUS
 (2018)

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells

Diaz-Valdivia, NI; Diaz, JE; Maldonado, HJ

Article ISI SCOPUS
Oncotarget  (2017)

The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis



Article ISI SCOPUS
FASEB Journal  (2017)

Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis.

Silva, Patricio; Mendoza, Pablo; Rivas, Solange; Díaz, Jorge; Moraga, Carolina; Quest, Andrew F G; Torres, Vicente A

Article
Oncotarget  (2016)

Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation.

Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F G; Torres, Vicente A

Article
Biochemical and biophysical research communications  (2015)

A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion.

Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew Fg; Torres, Vicente A

Article
Communicative & integrative biology  (2014)

Rab5 activation as a tumor cell migration switch

Mendoza, Pablo Alexis; Silva, Patricio; Torres, Vicente A.

Article
 (2014)

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway.

Altamirano, Francisco; Oyarce, César; Silva, Patricio; Toyos, Marcela; Wilson, Carlos; Lavandero, Sergio; Uhlén, Per; Estrada, Manuel

Article
The Journal of endocrinology  (2009)

1
Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

1
PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Verónica Palma

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

13
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Núcleo Interdisciplinario Biología y Genética

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

1
Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Alfredo Criollo

Associated Professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

1
Eugenia Morselli

Profesor Asociado de Planta Ordinaria

Fisiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago de Chile, Chile

15
Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

1
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Pablo Lois

Asistente de Investigación

Biología

Universidad de Chile

Santiago, Chile

1
Claudio Perez

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Cristina Bertocchi

Assistant Professor

Department of Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Pedro Torres

Ayudante laboratorio

Universidad de Chile

Santiago, Chile

1
Daniel Peña

Profesor Asociado

Universidad San Sebastián

Santiago, Chile

1
Maria Hernandez

Investigador Post Doctoral

Universidad de Chile

Santiago, Chile

3
Luis Solano

Asistente de investigación

Universidad de Chile

Santiago, Chile

3
CECILIA ARRIAGADA

Postdoctoral Fellow

Rutgers University

Newark, Estados Unidos

4
Montserrat Reyes

Profesor Asistente

Patología y Medicina Oral

Universidad de Chile

Santiago, Chile

1
Daniela Herrera

1
Douglas Matthies

Químico Farmacéutico

Salcobrand

Santiago, Chile