PDI - Resultado de Búsqueda

SarvaJit Chakravarty

Manager

Praxis Biotech LLC

San Francisco, Estados Unidos

Medicinal Chemistry, Drug discovery and development in multiple therapeutic areas (Including oncology and cancer inmunotherapy) in the biotech and pharma industry

Chemistry, St. Stephen’s College, Delhi University. India, 1987
Chemistry, New York University. Estados Unidos, 1992

Scientific Full Time

Scios Inc

Fremont, Estados Unidos

1992 - 2006
Director, Medicinal Chemistry, Full Time

Scios Inc

Fremont, Chile

2005 - 2006
Vice President, Chemistry Full Time

Sai Advantium

Montain view, Chile

2006 - 2007
Vice President, Medicinal Chemistry Full Time

Medivation Inc

San Francisco, Chile

2007 - 2015
Senior Vice President, Discovery & Preclinical Development Full Time

Medivation Inc

San Francisco, Chile

2015 - 2016
Manager Full Time

Praxis Biotech LLC

San Francico, Chile

2016 - A la fecha


Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; et al. Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2017)
Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110 delta as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignanciess Acuña, Claudia; Gaete, Diana; Pujala, Brahmam; Barde, Anup; Nayak, Anjan K.; Upendra, T. V. R.; Patel, Dhananjay; Chauhan, Shailender; Kanno, Stacy; Almirez, Ramona G.; et al. Article ISI JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)
Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR Ansari, Amantullah; Satalkar, Sharad; Patil, Varshavekumar; Shete, Amit S.; Kaur, Simranjeet; Gupta, Ashu; Singh, Siddhartha; Severance, Daniel L.; Hung, David T.; Pham, Son M.; et al. Article Bioorganic and Medicinal Chemistry Letters (2017)
Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3K delta Pujala, Brahmam; Middya, Sandip; Banerjee, Monali; Surya, Arjun; Nayak, Anjan K.; Gupta, Ashu; Khare, Sweta; Guguloth, Rambabu; Randive, Nitin A.; Shinde, Bharat U.; et al. Article ISI SCOPUS ACS MEDICINAL CHEMISTRY LETTERS (2016)
MDV3100: Tritium labeling at high specific activity Byon, Chang; Filer, Crist N.; Jain, Rajendra; Maniscalco, Mario P. Article Applied Radiation and Isotopes (2016)
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors Jadhavar, Pradeep S. Ramachandran, Sreekanth A. Riquelme, Eduardo. Gupta, Ashu. Quinn, Kevin P. Shivakumar, Devleena. Ray, Soumya. Zende, Dnyaneshwar. Nayak, Anjan K. Miglani, Sandeep K. Sathe, Balaji D. Raja, Mohd. Farias, Olivia. Alfaro, Iva Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2016)
Temozolomide analogs with improved brain/plasma ratios - Exploring the possibility of enhancing the therapeutic index of temozolomide Rai, Roopa; Banerjee, Monali; Wong, Darren H.; Gupta, Ashu; Tripathi, Shailendra; Jangir, Ramnivas; Yadav, Shyamraj; Melkani, Pankaj; Dixit, Vikas; Patil, Umesh; et al. Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2016)
Design and synthesis of piperazine-indole p38α MAP kinase inhibitors with improved pharmacokinetic profiles Tan, Xuefei; Tester, Richland W.; Luedtke, Gregory R.; Mavunkel, Babu J.; Perumattam, John J.; Lu, Qing; Nashashibi, Imad; Jung, Joon; Hu, Jie; Liclican, Albert; et al. Article Bioorganic and Medicinal Chemistry Letters (2010)
Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors Mavunkel, Babu J.; Perumattam, John J.; Tan, Xuefei; Luedtke, Gregory R.; Lu, Qing; Lim, Don; Kizer, Darin; Dugar, Sundeep; Xu, Yong-jin; Jung, Joon; et al. Article Bioorganic and Medicinal Chemistry Letters (2010)
p38 MAPK inhibition reduces diabetes-induced impairment of wound healing. Medicherla S, Wadsworth S, Cullen B, Silcock D, Ma JY, Mangadu R, Kerr I, Chakravarty S, Luedtke GL, Dugar S, Protter AA, Higgins LS. Article Diabetes Metab Syndr Obes (2009)
Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase Koppelman, Bruce; Webb, Heather K.; Medicherla, Satyanarayana; Almirez, Ramona; Feng, Ying; Chavez, Jose Carlos; Mao, Cheng Ping; Nguyen, Aaron; Liu, Yu-Wang; Kapoun, Ann M.; et al. Article Pharmacology (2008)
Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain MALKMUS, S; BRAININMATTOS, J; POWELL, H; CHAKRAVARTY, S Article Pharmacology Biochemistry and Behavior (2008)
Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension Zaiman, Ari L.; Podowski, Megan; Medicherla, Satya; Gordy, Kimberley; Xu, Fang; Zhen, Lijie; Shimoda, Larissa A.; Neptune, Enid; Higgins, Linda; Murphy, Alison; et al. Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors Raboisson, Pierre; Lenz, Oliver; Lin, Tse-I; Surleraux, Dominique; Scholliers, Annick; Vermeiren, Katrien; Delouvroy, Frederic; Verbinnen, Thierry; Simmen, Kenneth Article Bioorganic and Medicinal Chemistry Letters (2007)
Inhibiting TGF- signaling restores immune surveillance in the SMA-560 glioma model Ma, J. Y.; Janssen, L.; Sriram, V.; Aulwurm, S.; Kerr, I.; Webb, H. K.; Kapoun, A. M.; Kizer, D. E.; McEnroe, G.; Hart, B.; et al. Article Neuro-Oncology (2007)
Inhibition of Transforming Growth Factor beta Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness Gaspar, N. J.; Kapoun, A. M.; O'Young, G.; Quon, D.; Henson, M.; Damm, D. L.; Muiru, G. T.; Higgins, L. S.; Wong, D. H. Article Molecular Pharmacology (2007)
p38 -Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation Fitzgerald, M. F.; Spicer, D.; Woodman, P.; Ma, J. Y.; Kapoun, A. M.; Dugar, S.; Protter, A. A.; Higgins, L. S. Article Journal of Pharmacology and Experimental Therapeutics (2007)
A p38 Selective Mitogen-Activated Protein Kinase Inhibitor Prevents Periodontal Bone Loss Kirkwood, K. L.; Rogers, J. E.; Otremba, J.; Coatney, D. D.; Kreider, J. M.; D'Silva, N. J.; Dugar, S.; Higgins, L. S.; Protter, A. A. Article Journal of Pharmacology and Experimental Therapeutics (2006)
Indole-based heterocyclic inhibitors of p38alpha MAP kinase: designing a conformationally restricted analogue. Mavunkel BJ, Chakravarty S, Perumattam JJ, Luedtke GR, Liang X, Lim D, Xu YJ, Laney M, Liu DY, Schreiner GF, Lewicki JA, Dugar S. Article Bioorg Med Chem Lett (2003)
Synthesis and Characterization of Pseudopeptide Bradykinin B2 Receptor Antagonists Containing the 1,3,8-Triazaspiro[4.5]decan-4-one Ring System Mavunkel, Babu J.; Lu, Zhijian; Goehring, R. Richard; Lu, Songfeng; Perumattam, John; Novotny, Elizabeth A.; Connolly, Maureen; Valentine, Heather; Kyle, Donald J. Article JOURNAL OF MEDICINAL CHEMISTRY (1996)
A proposed model of bradykinin bound to the rat B2 receptor and its utility for drug design. Kyle DJ, Chakravarty S, Sinsko JA, Stormann TM. Article J Med Chem (1994)
Design of potent, cyclic peptide bradykinin receptor antagonists from conformationally constrained linear peptides. Chakravarty S, Wilkins D, Kyle DJ. Article J Med Chem (1993)


Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use Chakravarty, Jit Patent (2015)
N,N'-BIS-arylurea compounds Chakravarty, Jit Patent (2015)
Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use Chakravarty, Jit Patent (2015)
Compounds and methods of treating diabetes Chakravarty, Jit Patent (2014)
Substituted di-arylhydantoin and di-arylthiohydantoin compounds and methods of use thereof Chakravarty, Jit Patent (2014)
Fused bicyclic inhibitors of HCV Chakravarty, Jit Patent (2011)
2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof Chakravarty, Jit Patent
Azepino[4,5-B]indoles and methods of use Patent
Bridged heterocyclic compounds and methods of use Chakravarty, Jit Patent
Compounds and methods for treating diabetes Chakravarty, Jit Patent
Compounds and methods for treatment of hypertension Chakravarty, Jit Patent
Fused pyrimidine compounds and use thereof Patent
Methods of treating diabetes Patent
Pyrido[3,4-b] indoles and methods of use Chakravarty, Jit Patent
Pyrido[3,4-B]indoles and methods of use Patent
Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use Chakravarty, Jit Patent
Pyrido[4,3-B]indoles and methods of use Chakravarty, Jit Patent
Pyrido[4,3-b]indoles containing rigid moieties Chakravarty, Jit Patent
Substituted phenylcarbamoyl alkylamino arene compounds and N,N′-BIS-arylurea compounds Chakravarty, Jit Patent
Tetracyclic compounds Chakravarty, Jit Patent