SarvaJit Chakravarty


Praxis Biotech LLC

San Francisco, Estados Unidos

Líneas de Investigación

Medicinal Chemistry, Drug discovery and development in multiple therapeutic areas (Including oncology and cancer inmunotherapy) in the biotech and pharma industry


  •  Chemistry, St. Stephen’s College, Delhi University. India, 1987
  •  Chemistry, New York University. Estados Unidos, 1992

Experiencia Profesional

  •   Scientific Full Time

    Scios Inc

    Fremont, Estados Unidos

    1992 - 2006

  •   Director, Medicinal Chemistry, Full Time

    Scios Inc

    Fremont, Chile

    2005 - 2006

  •   Vice President, Chemistry Full Time

    Sai Advantium

    Montain view, Chile

    2006 - 2007

  •   Vice President, Medicinal Chemistry Full Time

    Medivation Inc

    San Francisco, Chile

    2007 - 2015

  •   Senior Vice President, Discovery & Preclinical Development Full Time

    Medivation Inc

    San Francisco, Chile

    2015 - 2016

  •   Manager Full Time

    Praxis Biotech LLC

    San Francico, Chile

    2016 - A la fecha


Article (22)

Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors
Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110 delta as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignanciess
Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR
Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ
MDV3100: Tritium labeling at high specific activity
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors
Temozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide
Design and synthesis of piperazine-indole p38α MAP kinase inhibitors with improved pharmacokinetic profiles
Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors
p38 MAPK inhibition reduces diabetes-induced impairment of wound healing.
Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase
Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain
Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension
Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors
Inhibiting TGF-  signaling restores immune surveillance in the SMA-560 glioma model
Inhibition of Transforming Growth Factor beta Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness
p38 -Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation
A p38  Selective Mitogen-Activated Protein Kinase Inhibitor Prevents Periodontal Bone Loss
Indole-based heterocyclic inhibitors of p38alpha MAP kinase: designing a conformationally restricted analogue.
Synthesis and Characterization of Pseudopeptide Bradykinin B2 Receptor Antagonists Containing the 1,3,8-Triazaspiro[4.5]decan-4-one Ring System
A proposed model of bradykinin bound to the rat B2 receptor and its utility for drug design.
Design of potent, cyclic peptide bradykinin receptor antagonists from conformationally constrained linear peptides.

Patent (20)

Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
N,N'-BIS-arylurea compounds
Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
Compounds and methods of treating diabetes
Substituted di-arylhydantoin and di-arylthiohydantoin compounds and methods of use thereof
Fused bicyclic inhibitors of HCV
2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof
Azepino[4,5-B]indoles and methods of use
Bridged heterocyclic compounds and methods of use
Compounds and methods for treating diabetes
Compounds and methods for treatment of hypertension
Fused pyrimidine compounds and use thereof
Methods of treating diabetes
Pyrido[3,4-b] indoles and methods of use
Pyrido[3,4-B]indoles and methods of use
Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use
Pyrido[4,3-B]indoles and methods of use
Pyrido[4,3-b]indoles containing rigid moieties
Substituted phenylcarbamoyl alkylamino arene compounds and N,N′-BIS-arylurea compounds
Tetracyclic compounds
SarvaJit Chakravarty


Praxis Biotech LLC

San Francisco, Estados Unidos

Sebastian Bernales


Merken Biotech

Santiago, Chile

Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

Felipe Olivares




Santiago, Chile