Man

Jorge Emilio Jalil Milad

FULL PROFESSOR

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

Líneas de Investigación


REMODELADO CARDIOVASCULAR FISIOPATOLOGIA CARDIOVASCULAR VIA RHO A /RHO KINASA EN HIPERTENSION ARTERIAL E INSUFICIENCIA CARDIACA INSUFICIENCIA CARDIACA HIPERTENSION ARTERIAL SISTEMA RENINA ANGIOTENSINA ALDOSTERONA

Educación

  •  MD, UNIVERSIDAD DE CHILE. Chile, 1980
  •  MD, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1980

Experiencia Académica

  •   RESIDENT FELLOW INTERNAL MEDICINE DE MEDICINA Full Time

    UNIVERSIDAD DE CHILE

    MEDICINA

    SANTIAGO, Chile

    1981 - 1984

  •   RESIDENT FELLOW IN CARDIOLOGY Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    MEDICINA

    SANTIAGO, Chile

    1984 - 1986

  •   POSTDOCTORAL RESEARCH FELLOW Full Time

    MICHAEL REESE HOSPITAL AFFILIATED TO THE UNIVERSITY OF CHICAGO

    CHICAGO, Estados Unidos

    1986 - 1989

Experiencia Profesional

  •   FULL PROFESSOR Full Time

    PUC, SCHOOL OF MEDICINE

    SANTIAGO, Chile

    2008 - A la fecha


 

Article (77)

Cantin C, Jalil JE, Bulnes JF, Novoa U, MacNab P, Godoy I, Córdova S, Gabrielli L, Ocaranza MP.
Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions
Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension.
Potential adverse cardiac remodelling in highly trained athletes: still unknown clinical significance.
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT(2)R and Akt-dependent mechanism.
Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling.
Does Good Aerobic Capacity Attenuate the Effects of Aging on Cardiovascular Risk Factors? Results from a Cross-Sectional Study in a Latino Population.
Diuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall.
Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat
On Endogenous Angiotensin II Antagonism in Hypertension
Simultaneous Rho kinase inhibition in circulating leukocytes and in cardiovascular tissue in rats with high angiotensin converting enzyme levels
ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension.
Estrogens and myocardial chymase: new insights into pathological hypertrophy and remodeling.
Gaps and Resemblances in Current Heart Failure Guidelines: A Clinical Perspective.
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis.
Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study
Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system.
Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure.
Rapid aspirin desensitization in patients with a history of aspirin hypersensitivity requiring coronary angioplasty. Report of four cases
[Cardiovascular risk factors in a group of health care workers]. [Agregación de factores de riesgo cardiovascular y conciencia de enfermedad en trabajadores de un hospital universitario.]
Agregación de factores de riesgo cardiovascular y conciencia de enfermedad en trabajadores de un hospital universitario
Cardiovascular risk factors in a group of health care workers
Cardiovascular risk factors in a group of health care workers Agregación de factores de riesgo cardiovascular y conciencia de enfermedad en trabajadores de un hospital universitario
Mayores niveles de ECA y Angiotensina II determinados genéticamente, se asocian a menor actividad del eje ECA2/angiotensina-(1-9) y mayor remodelamiento de la pared aórtica de ratas hipertensas
Protective role of the ACE2/Ang-(19) axis in cardiovascular remodeling
Hidroclorotiazida y espironolactona reducen la hipertrofia de la pared aórtica en la hipertensión arterial experimental
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure
Mayor actividad de rho kinasa en leucocitos circulantes se asocia a estrés oxidativo y rigidez arterial en hipertensos diabéticos
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
Efectividad del uso combinado de un inhibidor de Rho Kinasa y de un antagonista del receptor de angiotensina II en la prevención de hipertrofia ventricular en ratas hipertensas
Heart energy metabolism and its role in the treatment of heart failure Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients
La sobreexpresión del gen de enzima convertidora de angiotensina homóloga (ECA2) revierte la hipertensión arterial y el remodelado cardíaco experimental
La sobrexpresión génica vascular de NADPH oxidasa en la hipertensión arterial experimental se reduce solamente con inhibición directa de Rho kinasa
Menores niveles tisulares de la enzima convertidora de angiotensina I homologa (ECA-2) y angiotensina-(1-9) están asociados a mayor remodelamiento de la pared aórtica de ratas hipertensas
Cardiotrofina-1 circulante puede diferenciar la hipertrofia ventricular fisiológica del atleta de la hipertrofia patológica del paciente hipertenso
La vía de señalización Rho A/ Rho Kinasa se encuentra activada en el miocardio en ratas con fibrosis cardíaca inducida por isoprotenerol
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism
Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
Interactions between beta(1) and beta(2) adrenergic receptor polymorphisms as risk factors for chronic heart failure
Interactions between ß 1 and ß 2 adrenergic receptor polymorphisms as risk factors for chronic heart failure Interacción entre los polimorfismos del receptor ß 1 y ß 2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
MAYOR EXPRESION DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA I HOMOLOGA (ECA2) EN LA PARED ARTERIAL DE RATAS CON NIVELES GENETICAMENTE ELEVADOS DE ANGIOTENSINA II: EFECTOS DECANDESARTAN Y FASUDIL
MENOR EXPRESION DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA I HOMOLOGA (ECA2) SE ASOCIA A MAYOR REMODELAMIENTO DE LA PARED AORTICA DE RATAS CON NIVELES GENETICAMENTE ELEVADOS DE ANGIOTENSINA II
Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
FASUDIL PREVIENE LA SOBREXPRESION DE GENES PROCOAGULANTES, PROINFLAMATORIOS Y PROFIBROTICOS EN LA PARED ARTERIAL DE RATAS HIPERTENSAS
Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I-converting enzyme levels
Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism
Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
Usefulness of sublingual isosorbide to assess the reversibility of pulmonary hypertension in cardiac transplant candidates
DISMINUCION DE LA ACTIVIDAD DE LA ECA-2 (ENZIMA CONVERTIDORA DE ANGIOTENSINA I HOMOLOGA) EN LA DIFUNCION VENTRICULAR IZQUIERDA POST INFARTO AL MIOCARDIO EN LA RATA
Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels
MAYOR ACTIVIDAD DE NADPH OXIDASA VASCULAR EN RATAS CON NIVELES ELEVADOS DE ECA
Perindopril regulates ?-agonist-induced cardiac apoptosis
Effects of tilt test and beta-adrenergic stimulation on the QT interval in normal children and pediatric patients with unexplained syncope Efectos de la prueba de la mesa basculante y de la estimulación betaadrenérgica sobre el intervalo QT en niños sanos y en pacientes pediátricos con síncope de etiología no precisada
Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans
Administration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status
Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting enzyme deletion/deletion genotype
Long-term automated peritoneal dialysis in patients with refractory congestive heart failure.
Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
A 36 years experience with implantable pacemakers
Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
Angiotensin I-converting enzyme insertion/deletion polymorphism and adrenergic response to exercise in hypertensive patients
Persistence of oxidative stress after heart tranplantation: A comparative study of patients with heart transplant versus chronic stable heart failure
Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart transplant versus chronic stable heart failure
Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat
Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin II levels
Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene
Hyperuricemia as a marker for anaerobic threshold in chronic cardiac failure
Selective training of respiratory muscles in patients with chronic heart failure
D/d polymorphism of the ace gene might be a risk factor for in-stent restenosis El genotipo D/D del gen de la enzima conversiva de la angiotensina como factor de riesgo de reestenosis post-stent coronario
Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat
Enalapril restores depressed circulating insulin-like growth factor 1 in patients with chronic heart failure
Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy
Cyclic AMP dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction
Regression of left ventricular hypertrophy in experimental renovascular hypertension: Diastolic dysfunction depends more on myocardial collagen than it does on myocardial mass
Valor pronóstico de la monitoría ambulatoria de presión arterial en pacientes hipertensos: Observaciones en la literatura

Abstract (15)

Angiotensin-(1-9) Decreases Hypertension and Vascular Damage by Inhibiting Rhoa/rock Activity in Doca Hypertensive Rats
NON TRADITIONAL RISK FACTORS AND MORTALITY: DO THEY ADD INFORMATION BEYOND TRADITIONAL RISK FACTORS?
Angiotensin-(1-9) Prevents Cardiomyocyte Hypertrophy Through Calcium Influx Dependent Pathway
Angiotensin-(1-9) Prevents the Cardiovascular Pathological Remodeling Induced by Angiotensin II In Vivo
CARDIOVASCULAR RISK FACTORS AMONG A UNIVERSITY HOSPITAL HEALTH WORKERS POPULATION IN SANTIAGO, CHILE: HIGH BURDEN AND LOW AWARENESS
INCREASED RHO KINASE ACTIVITY AND OXIDATIVE STRESS LEVELS IN DIABETIC HYPERTENSIVE PATIENTS
Atorvastatin inhibits the Rho A/Rho kinase pathway and, reduces blood pressure and the expression of vascular remodeling genes in rats with genetically high levels of angiotensin II
Cardiotrophin-I plasma levels are increased in hypertensive patients with cardiac hypertrophy and diastolic dysfunction
Increased angiotensin converting enzyme 2 activity (ACE2) during prevention of left ventricular hypertrophy with an ACE inhibitor
The Arg389Arg adrenergic receptor variant interacts with the Arg16Arg and Gly27Gly beta 2 adrenergic receptor variants decreasing the risk for chronic heart failure
beta(2)-adrenergic receptor polymorphisms are not associated with heart failure
Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in normotensive and hypertensive subjects
A clinical indication for natriuretic peptide CDD/ANP-95-126 in patients with heart and renal failure.
Comparison of oxidative stress status between heart transplant and advanced chronic heart failure patients
Myocardial angiotensin II generation and the angiotensin I - converting enzyme gene polymorphism in the rat

EditorialMaterial (6)

Estrogens and Myocardial Chymase New Insights Into Pathological Hypertrophy and Remodeling
Combined rho kinase and renin-angiotensin system inhibition: a new therapeutic perspective for renal and cardiovascular remodeling
Large Left Segmental Pulmonary Artery Pseudoaneurysm After Right Heart Catheterization Successful Percutaneous Closure Combined With Balloon Mitral Valvotomy
Mitogen-Activated Protein Kinases as Biomarkers of Hypertension or Cardiac Pressure Overload
Blood pressure reduction, potassium channels, and the endothelium - Insights from L-serine
Effects of tilt test and beta-adrenergic stimulation on the QT interval in normal children and pediatric patients with unexplained syncope

Review (9)

ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension
Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system
Exercise and cardiac rehabilitation in secondary cardiovascular prevention
Rehabilitación cardiovascular y ejercicio en prevención secundaria
Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Cardiac hypertrophy: Molecular and cellular events
Prognostic value of ambulatory blood pressure monitoring in hypertensive patients. A review [Valor pronóstico de la monitoría ambulatoria de presión arterial en pacientes hipertensos: Observaciones en la literatura]
Prognostic value of ambulatory blood pressure monitoring in hypertensive patients. A review Valor pronóstico de la monitoría ambulatoria de presión arterial en pacientes hipertensos: Observaciones en la literatura
Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling
108
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

39
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

32
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

20
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

17
Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

9
Monica Acevedo

Associate Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

9
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Samuel Cordova

ESCUELA DE MEDICINA, PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

5
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

5
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

4
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

3
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

3
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

3
Roberto Ebensperger

Associate Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Juan Carlos Quintana

Médico nuclear

Radiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carolina Nazzal

Profesor Asociado

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

2
Leticia Gonzalez

Profesional Apoyo a la Investigacion

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Pedro Pérez

Profesor Asociado

Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Dante Lindefjeld

Staff, Assistant Professor

Cardiology

Clinical Hospital of the Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

1
Juan Ossa

Profesor asistente

Pediatria y Cirugia Oriente

Universidad De Chile, Hospital Luis Calvo Mackenna

Santiago, Chile

1
Patricio Araos

Estudiante Doctorado

Fisiología

University of Chile

Santiago, Chile

1
Pablo Sepúlveda

Cardiólogo Intervencionista

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Mauricio Garrido

Profesor Asistente

Odontología Conservadora

UNIVERSIDAD DE CHILE, FACULTAD DE ODONTOLOGÍA

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Orlando Diaz

Profesor Asociado

Enfermedades Respiratorias

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

1
Macarena Valdes

Académica

Escuela de Salud Pública

Universidad de Chile

Santiago, Chile

1
Gonzalo Martínez

Cardiólogo Intervencional

Cardiología

Hospital Clínico Universidad Católica

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile