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Maria Isabel Niemeyer Marich

Research

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

Estructura funcion de canales ionicos; Sensores de pH; Fisio(pato)logÃa epitelial

Licenciatura en Ciencias, mención Biología, UNIVERSIDAD DE CHILE. Chile, 1972
Certificate in Education, Homerton College, University of Cambridge. Reino Unido, 1978
Philosophy, New Hall and Department of Zoology, University of Cambridge. Chile, 1989

Research Assistant Full Time

University of Cambridge

Cambridge, Reino Unido

1981 - 1986
Postdoctoral Fellow Full Time

MRC Medical Research Council

Cambridge, Reino Unido

1989 - 1992
Visiting Scientist Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1992 - 1993
Post-doctoral fellow Full Time

MRC Medical Research Council

Cambridge, Reino Unido

1993 - 1994
Assistant professor Other

UNIVERSIDAD DE SANTIAGO DE CHILE

Ciencias Biomédicas

Santiago, Chile

1994 - 1995
Investigador Asociado Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1995 - 1998
Assistant professor Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

1998 - 2000

Undergraduate Students:
* Javier Urra Delgado, "Effects of double mutation Y219F-H220M on the pH sensor of the potassium channel TASK2", Undergraduate Universidad Austral de Chile. Finished 2005.
* Carla Araya Paredes, “Estudio de la interacción de TASK-2 con proteínas renales mediante el ensayo de doble hibrido en membrana”. Undergraduate Medical Technologist. Universidad Austral de Chile. Finished 2011.
* Bárbara Arevalo Ramos, "Modelamiento molecular y análisis del gating por pH0 en el canal de potasio TASK-3". Undergraduate Engineer in Bioinformatics. Universidad de Talca. Finished 2013.

Visit abroad
* Collaborative scientific meeting with Dr. Dominique Eladari y Dra. Regine Chambrey, Institut national de la santé et de la recherche médicale, Paris, May 2013.
* Collaborative scientific meeting with Dr. Jacques Teulon, Institut national de la santé et de la recherche médicale, Paris, 19th May to 13th June 2014.
* Collaborative scientific meeting with Dra. Olga Andrini and Dr. Marc Paulais, Universidad Pierre et marie Curie, Paris, 19th May to 13th June 2014.
* Collaborative scientific meeting with Dr. Jacques Teulon, Universidad Pierre et marie Curie, Paris, 09th - 28th July 2015.
* Collaborative scientific meeting with Dr. Jacques Teulon, Universite Pierre et Marie CURIE, Paris, 31th August to 01st October 2016.

Visit in Chile
* Working meetings, Dr. Jacques Teulon, Universite Pierre et Marie Curie-Paris 6, Paris, 25th - 30th November 2013.
* Collaborative scientific meeting with Dr. Peter Brown, University of Manchester School of Medicine. He also gave a seminar entitled "The Choroid Plexuses-What they do?", 05th - 18th November 2016.
* Collaborative scientific meeting with Dr. Jacques Teulon, Universidad Pierre et marie Curie, Paris, 09th - 31th January 2017

NOTA: M.I.Sepúlveda, nombre de casada usado en publicaciones entre el año 1984 al 1994
M.I. Niemeyer usado en su tesis doctoral y en publicaciones posteriores al año 1994.


Phosphatidylinositol (4,5)bisphosphate dynamically regulates the K-2P background K+ channel TASK-2 Niemeyer, María Isabel; Cid, L. Pablo; Paulais, Marc; Teulon, Jacques; Sepúlveda, Francisco V. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Gating, Regulation, and Structure in K-2P K+ Channels: In Varietate Concordia? Niemeyer, M. I.; Cid, L. P.; Gonzalez, W.; Sepulveda, F. V. Article ISI SCOPUS Molecular Pharmacology (2016)
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes Sotelo-Hitschfeld, T; Niemeyer, MI; Machler, P; Ruminot, I; Lerchundi R.; Wyss, MT; Stobart J.; Fernandez-Moncada, I; Valdebenito, R; Garrido-Gerter, P; Contreras-Baeza, Y; Schneider, BL; Aebischer, P; Lengacher, S; San Martin, A; Le Douce, J; Bonvento, G; Magistretti, PJ; Sepulveda, FV; Weber, B.; Barros, LF Article ISI SCOPUS Journal of Neuroscience (2015)
Identification and Functional Expression of a Glutamate and Avermectin-Gated Chloride Channel from Caligus rogercresseyi, a Southern Hemisphere Sea Louse Affecting Farmed Fish Cornejo I, Andrini O, Niemeyer MI, Marabolí V, González-Nilo FD, Teulon J, Sepúlveda FV, Cid LP Article ISI SCOPUS PLOS PATHOGENS (2014)
Zebrafish and mouse TASK-2 K+ channels are inhibited by increased CO2 and intracellular acidification Pena-Munzenmayer, G; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)
An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K-2P K+ Channel by Extracellular pH Gonzalez, W; Zuniga, L.; Cid, LP; Arevalo, B.; Niemeyer, MI; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2013)
G protein modulation of K-2P potassium channel TASK-2 Añazco C.; Pena-Munzenmayer, G; Araya C.; Cid, LP; Sepulveda, FV; Niemeyer, MI Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2013)
Gating of a pH-Sensitive K-2P Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter Zuniga, L.; Cid, L. P.; Sepulveda, F. V.; Niemeyer M.I.; Marquez, V; Gonzalez-Nilo F.D.; Chipot, C Article ISI PLOS ONE (2011)
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+ Ruminot, I; Gutiérrez R.; Pena-Munzenmayer, G; Añazco C.; Sotelo-Hitschfeld, T; Lerchundi R.; Niemeyer, MI; Shull, GE; Barros, LF Article ISI SCOPUS Journal of Neuroscience (2011)
Separate Gating Mechanisms Mediate the Regulation of K-2P Potassium Channel TASK-2 by Intra- and Extracellular pH Niemeyer, MI; Cid, LP; Pena-Munzenmayer, G; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2010)
Rapid Recycling of ClC-2 Chloride Channels Between Plasma Membrane and Endosomes: Role of a Tyrosine Endocytosis Motif in Surface Retrieval Cornejo I.; Niemeyer, MI; Zuniga, L.; Yusef, YR; Sepulveda, FV; Cid, LP Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons Niemeyer, MI; Cid, LP; Yusef, YR; Briones, R; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2009)
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Gating of two-pore domain K+ channels by extracellular pH Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain Yusef, YR; Zuniga, L.; Catalán M.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2006)
Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl(-) channels Flores, CA; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2006)
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif Pena-Muzenmayer, G; Catalán M.; Cornejo I.; Figueroa, CD; Melvin, JE; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2005)
Basolateral ClC-2 chloride channels in surface colon epithelium: Regulation by a direct effect of intracellular chloride Catalán M.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS GASTROENTEROLOGY (2004)
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies Niemeyer, MI; Yusef, YR; Cornejo I.; Flores, CA; Sepulveda, FV; Cid, LP Article ISI PHYSIOLOGICAL GENOMICS (2004)
The voltage-dependent CIC-2 chloride channel has a dual gating mechanism Zuniga, L.; Niemeyer, MI; Varela D.; Catalán M.; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2004)
A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the CIC-2 chloride channel Niemeyer, MI; Cid, LP; Zuniga, L.; Catalán M.; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2003)
Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity Niemeyer, MI; Cid, LP; Valenzuela, X; Sepulveda, FV Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2003)
A voltage-independent K+ conductance activated by cell swelling in Ehrlich cells is modulated by a G-protein-mediated process Niemeyer, MI; Stutzin A.; Sepulveda, FV Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization Catalán M.; Cornejo I.; Figueroa, CD; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel Varela D.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2002)
Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Greenfield LJ Jr.; Zaman SH; Sutherland ML; Lummis SC; Niemeyer, MI; Barnard EA; Macdonald RL Article NEUROPHARMACOLOGY (2002)
Cloning, cellular distribution and functional expression of small intestinal epithelium guinea pig C1C-5 chloride channel Cornejo I.; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)
K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2001)
Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume Niemeyer, MI; Cid, LP; Barros, LF; Sepulveda, FV Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The role of the agonist binding site in Ca2+ inhibition of the recombinant 5-HT3A receptor Niemeyer, MI; Lummis, SCR Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Characterisation of a cell swelling-activated K+-selective conductance of Ehrlich mouse ascites tumour cells Niemeyer, MI; Hougaard, C; Hoffmann, EK; Jorgensen, F; Stutzin A.; Sepulveda, FV Article ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
K+ currents activated by leukotriene D-4 or osmotic swelling in Ehrlich ascites tumour cells Hougaard, C; Niemeyer, MI; Hoffmann, EK; Sepulveda, FV Article ISI PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2000)
Splice variants of a ClC-2 chloride channel with differing functional characteristics Cid, LP; Niemeyer, MI; Ramirez A.; Sepulveda, FV Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)
Different efficacy of specific agonists at 5-HT 3 receptor splice variants: the role of the extra six amino acid segment Niemeyer, M-I.; Lummis, S C R. Article ISI British Journal of Pharmacology (1998)
Voltage control of calcium transients elicited by caffeine and tetracaine in cultured rat muscle cells. Hidalgo J.; Niemeyer, MI; Jaimovich E. Article ISI CELL CALCIUM (1995)
Actions of acromelic acid on nervous system l-glutamate receptors Sattelle, David B.; Sepúlveda, Maria-Isabel; Shinozaki, Haruhiko; Ishida, Michiko Article ISI Archives of Insect Biochemistry and Physiology (1994)
Chlorpromazine and QX222 block 5-HT3 receptors in N1E-115 neuroblastoma cells. Sepúlveda MI; Baker J.; Lummis SC Article ISI NEUROPHARMACOLOGY (1994)
Characterization of [3H]meta-chlorophenylbiguanide binding to 5-HT3 receptors in N1E-115 neuroblastoma cells. Lummis, SC; Sepúlveda, MI; Kilpatrick, GJ; Baker, J. Article ISI Eur J Pharmacol. (1993)
5-HT3 receptors in NG108-15 neuroblastoma x glioma cells: effect of the novel agonist 1-(m-chlorophenyl)-biguanide. Boess FG; Sepúlveda MI; Lummis SC; Martin IL Article ISI NEUROPHARMACOLOGY (1992)
Pharmacologically separable [(3)H]glutamate binding sites on insect muscle membranes. Sepúlveda MI; Sattelle DB Article ISI NEUROCHEMISTRY INTERNATIONAL (1991)
The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Sepúlveda MI; Lummis SC; Martin IL Article ISI Br J Pharmacology (1991)
Molecular target size of an L-glutamate receptor from the cockroach central nervous system. Sepúlveda MI; Sattelle DB Article ISI Neurosci Lett. (1989)
Pharmacology of an insect central nervous system [(3)H]l-glutamate binding site. Sepúlveda MI; Sattelle DB Article ISI NEUROCHEMISTRY INTERNATIONAL (1989)
Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles. Lew VL; Hockaday A,; Sepúlveda MI; Somlyo AV,; Somlyo AP; Ortiz OE; Bookchin RM Article ISI NATURE (1985)


Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2. Niemeyer, Maria Isabel; Cid, Luis P.; Paulais, Marc; TEULON , JACQUES; Sepulveda, Francisco V. ConferencePoster Physiology 2016 (2016)


Direct interactions of TASK- 2 potassium channel with components of the HCO3 - transport machinery Niemeyer, MI; Toledo, Camilo ConferenceProceedingWhole Ion Channels in the Valley III. (2015)


B lymphocytes taken to task: a role for a background conductance K-2P K+ channel in B cells. Focus on "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells" Flores, CA; Cid, LP; Niemeyer, MI; Sepulveda, FV EditorialMaterial ISI SCOPUS American Journal of Physiology - Cell Physiology (2011)
ClC-2 channels get new partners. Focus on Association between Hsp90 and the ClC-2 chloride channel upregulates channel function" Cid, LP; Niemeyer, MI; Sepulveda, FV EditorialMaterial ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)


No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy Niemeyer, MI; Cid, LP; Sepulveda, FV; Blanz, J; Auberson, M; Jentsch, TJ Letter ISI SCOPUS Nature Genetics (2010)


CANALES DE CLORURO ACTIVADOS POR CALCIO EN EL EPITELIO INTESTINAL COMO MEDIADORES DE LA SECRECION DE FLUIDO: POTENCIALES MEDIADORES DE LA DIARREA ROTAVIRAL Y MODIFICADORES DEL DEFECTO INTESTINAL EN LA FIBROSIS QUISTICA Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
ESTUDIO CELULAR Y MOLECULAR D LA VIA BASOLATERAL DE SALIDA DE CLORURO EN EL EPITELIO INTESTINAL Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
EXPLORING THE POSSIBLE ROLE OF THE INWARDLY RECTIFYING K+ CHANNEL KIR7.1 IN THE CILIATED EPITHELIA OF THE CHOROID PLEXUS AND THE CILIARY BODY OF THE EYE Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
EXTRACELLULAR AND INTRACELLULAR SENSORS IN THE GATING OF TASK-2, A TWO-PORE-DOMAIN POTASSIUM CHANNEL Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
MODULACION DE LA ACTIVIDAD DEL CANAL DE POTASIO DE DOS POROS EN TANDEM TASK-2 POR SUBUNIDADES DE PROTEINAS G HETEROTRIMERICAS. Anazco, Carolina; Niemeyer, Maria Isabel Proyecto (0)
MOLECULAR DISSECTION TO STUDY THE CONTRIBUTION OF THE INTRA AND EXTRACELLULAR PH SENSORS OF TASK-2 CHANNELS ON ITS RENAL FUNCTION. AN EXPERIMENTAL APPROACH USING TRANSGENIC MICE TO RESCUE THE TASK-2-NULL PHENOTYPE. Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
Molecular identification and functional characterisation of the volume regulated epithelial potassium channel. STUTZIN SCHOTTLANDER, ANDRES JOAQUIN; Cid, Luis P.; Niemeyer, Maria Isabel; Riquelme, Gloria H.; Sepulveda, Francisco V. Proyecto (0)
Necrotic liver cell death: dissection of molecular effector mechanisms. Barros, Luis F.; Niemeyer, Maria Isabel Proyecto (0)
Participation of TASK-2, a pH-sensitive K+ channel in volume regulation and apoptosis. Niemeyer, Maria Isabel; Barros, Luis F.; Sepulveda, Francisco V. Proyecto (0)
Regulation mechanism and oligomeric structure of a chloride channel expressed in epithelia. Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
REGULATION OF TASK-2 A K2P POTASSIUM CHANNEL, BY PHOSPHOINOSIDES. Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V.; Brown, Peter Proyecto (0)
Role of an intracellular segment in the modulation of the 5-HT3: receptor structure-function relationship studied by site directed mutagenesis. Niemeyer, Maria Isabel; LUMMIS, SARAH CATHERINE R. Proyecto (0)


MOLECULAR ASPECTS OF STRUCTURE, GATING, AND PHYSIOLOGY OF pH-SENSITIVE BACKGROUND K-2P AND Kir K+-TRANSPORT CHANNELS Sepulveda, F. V.; Cid, L. P.; Teulon, J; Niemeyer M.I. Review ISI SCOPUS PHYSIOLOGICAL REVIEWS (2015)
TASK-2 K-2P K+ channel: thoughts about gating and its fitness to physiological function Lopez-Cayuqueo, KI; Pena-Munzenmayer, G; Niemeyer, MI; Sepulveda, FV; Cid, LP Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
TASK-2: a K-2p K+ channel with complex regulation and diverse physiological functions Cid, L. Pablo; Roa-Rojas, Hugo A.; Niemeyer, María I.; González, Wendy; Araki, Masatake; Araki, Kimi; Sepúlveda, Francisco V. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2013)
TMEM16 proteins: the long awaited calcium-activated chloride channels? Flores, CA; Cid, LP; Sepulveda, FV; Niemeyer, MI Review ISI SCOPUS Brazilian Journal of Medical and Biological Research (2009)