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Nestor Antonio Lagos Wilson

Full Professor

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

Líneas de Investigación


Biochemistry; Physiology; Toxicology; BIOLOGY MARINE; BIOTECHNOLOGY;

Educación

  •  Bioquímica, UNIVERSIDAD DE CHILE. Chile, 1987

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1976 - A la fecha

Experiencia Profesional

  •   Full Professor Full Time

    Universidad de Chile

    Santiago, Chile

    1976 - A la fecha

Formación de Capital Humano


Son Muchas, No las anoto. ¡¡¡¡Disculpas!!!!



 

Article (56)

In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats
Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages
Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine
Evaluation of Neosaxitoxin as a local anesthetic during piglet castration=> A potential alternative for Lidocaine.
Phycobilisome isolation and C-phycocyanin purification from the cyanobacterium Aphanizomenon gracile
Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin
Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model
Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells=> Negative health consequences.
Gonyautoxins: First evidence in pain management in total knee arthroplasty
First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome
Seasonal variability of Dinophysis spp. and Protoceratium reticulatum associated to lipophilic shellfish toxins in a strongly stratified Chilean fjord
Determination of the variability of both hydrophilic and lipophilic toxins in endemic wild bivalves and carnivorous gastropods from the Southern part of Chile
Okadaic Acid Toxin at Sublethal Dose Produced Cell Proliferation in Gastric and Colon Epithelial Cell Lines
Exhaled Breath Condensate Analysis after Long Distance Races
FIRST REPORT OF DIARRHEIC SHELLFISH TOXINS IN MOLLUSKS FROM BUENOS AIRES PROVINCE (ARGENTINA) ASSOCIATED WITH DINOPHYSIS SPP.: EVIDENCE OF OKADAIC ACID, DINOPHYSISTOXIN-1 AND THEIR ACYL-DERIVATIVES
First report of diarrheic shellfish toxins in mollusks from buenos aires province (argentina) associated with dinophysis spp.: Evidence of okadaic acid, dinophysistoxin-1 and their acylderivatives
Lipophilic toxin profiles detected in farmed and benthic mussels populations from the most relevant production zones in Southern Chile
Highly Toxic Microcystis aeruginosa Strain, Isolated from So Paulo-Brazil, Produce Hepatotoxins and Paralytic Shellfish Poison Neurotoxins
Highly toxic microcystis aeruginosa strain, isolated from São Paulo-Brazil, produce hepatotoxins and paralytic shellfish poison neurotoxins
Route of metabolization and detoxication of paralytic shellfish toxins in humans
Evidence of in vitro glucuronidation and enzymatic transformation of paralytic shellfish toxins by healthy human liver microsomes fraction
Local infiltration of gonyautoxin is safe and effective in treatment of chronic tension-type headache
Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker
Effects of the toxic dinoflagellate Gymnodinium catenatum on uptake and fate of paralytic shellfish poisons in the Pacific giant lions-paw scallop Nodipecten subnodosus
GTX 2/3 epimers permeate the intestine through a paracellular pathway
Neosaxitoxin as a local anesthetic
Treatment of chronic anal fissure by gonyautoxin
High amount of dinophysistoxin-3 in Mytilus chilensis collected in Seno de Reloncaví, Chile, during massive human intoxication associated with outbreak of Vibrio parahaemolyticus
Gonyautoxin: New treatment for healing acute and chronic anal fissures
Human intoxication with paralytic shellfish toxins: Clinical parameters and toxin analysis in plasma and urine
Lung oxidative stress as related to exercise and altitude. Lipid peroxidation evidence in exhaled breath condensate: a possible predictor of acute mountain sickness
Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish
First evidence of Dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords
Paralytic shellfish poisoning: post-mortem analysis of tissue and body fluid samples from human victims in the Patagonia fjords
Permeability of human jejunal segments to gonyautoxins measured by the Ussing chamber technique
Simultaneous presence of Paralytic and Diarrheic Shellfish Poisoning toxins in Mytilus chilensis samples collected in the Chiloe Island, Austral Chilean fjords
The effect of temperature on growth and production of paralytic shellfish poisoning toxins by the cyanobacterium Cylindrospermopsis raciborskii C10
The Gonyautoxin 2/3 epimers reduces anal tone when injected in the anal sphincter of healthy adults
The gonyautoxin 2/3 epimers reduces anal tone when injected in the anal sphincter of healty adults
Quantitation of diarrhetic shellfish poisoning toxins in Chilean Mussel using pyrenyldiazomethane as fluorescent labeling reagent
Dynamics of intracellular calcium induced by lactate and glucose in rat pachytene spermatocytes and round spermatids
Toxicokinetics and toxicodynamics of gonyautoxins after an oral toxin dose in cats
Toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii (Cyanophyceae) isolated from Tabocas reservoir in Caruaru, Brazil, including demonstration of a new saxitoxin analogue
Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliums
First report of diarrhetic shellfish toxins in magellanic fjords, southern Chile
Temperature dependence of intracellular Ca2+ homeostasis in rat meiotic and postmeiotic spermatogenic cells
Biochemical characterization and inhibitory effects of dinophysistoxin-1, okadaic acid and microcystine 1-r on protein phosphatase 2a purified from the mussel Mytilus chilensis
Biochemical characterization and inhibitory effects of dinophysistoxin-1, okadaic acid and microcystine l-r on protein phosphatase 2a purified from the mussel Mytilus chilensis.
Effect of casein-derived peptides on D-xylose absorption assessed by H-2 breath test in normal volunteers
Energy metabolism and its linkage to intracellular Ca2+ and pH regulation in rat spermatogenic cells
Paralytic shellfish toxins in the freshwater cyanobacterium Aphanizomenon flos-aquae, isolated from Montargil reservoir, Portugal
Paralytic shellfish toxins in mussels and Alexandrium tamarense at Valdes Peninsula, Chubut, Patagonia, Argentina: Kinetics of a natural depuration
The first evidence of paralytic shellfish toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii, isolated from Brazil
Toxic effects, pharmacokinetics and clearance of saxitoxin, a component of paralytic shellfish poison (PSP), in cats
Accumulation of paralytic shellfish poisoning toxins in the bivalve Aulacomya ater and two carnivorous gastropods concholepas concholepas and Argobuccinum ranelliformes during an Alexandrium catenella bloom in Southern Chile
Microalgal blooms: A global issue with negative impact in Chile

Abstract (1)

Absorption of paralyzing toxins from the dinoflagellate Gymnodinium catenatum in giant lions-paw scallop Nodipecten subnodosus

BookWhole (1)

Life and interaction of hydrobiological organisms (Mytilus Sp.) with harmful algal blooms: Composition, distribution and metabolism of hydrophilic and hydrophobic toxins in the Austral Pacific Region

Letter (1)

Intrasphincteric neosaxitoxin injection: Evidence of lower esophageal sphincter relaxation in achalasia

Proyecto (10)

APLICACION DE TECNOLOGIAS PARA LA DETOXIFICACION DE MOLUSCOS CONTAMINADOS CON MAREA ROJA EN LAS REGIONES XI Y XII.
Detección y Cuantificación de DINOFISISTOXINA-3, una nueva toxina componente del Veneno Diarreico de Molusco (VDM) en mariscos del sur de Chile: Relación con intoxicaciones masivas asociadas al consumo de mariscos cocidos y síndrome diarreico.
Diarrheic Shellfish Toxins: biochemical and toxicological mechanism as tumor promoters
Investigación y Desarrollo de un proceso de producción industrial de toxinas marinas para uso farmacológico en patologías humanas.
PARTICIPACION DE LIPIDOS Y PROTEINAS INTRINSECAS DE MEMBRANA EN LA COMUNICACION INTERCELULAR EN EL CRISTALINO.
PRODUCCION DE ESTANDARES CERTIFICADOS PARA LA DETECCION Y CUANTIFICACION DE LAS TOXINAS PRESENTES EN EL VENENO DIARREICO DE MARISCO (VDM): PURIFICACION A PARTIR DE MARISCO CONTAMINADO.
PRODUCCION DE ESTANDARES CERTIFICADOS PARA LA DETECCION Y CUANTIFICACION DE VENENO PARALIZANTE DE MARISCO (VPM): PURIFICACION A PARTIR DE MARISCOS ALTAMENTE CONTAMINADOS.
Produccion y transformacion de toxinas bloqueadoras de canales de sodio por bacterias marinas aisladas desde moluscos bivalvos contaminados con veneno paralizante de molusco (Marea Roja)
Production of antisera which would have protection actions against paralytic shellfish poisoning toxins.
REGULACION DE LA COMUNICACION INTERCELULAR EN EL CRISTALINO.
64
Nestor Lagos

Full Professor

Fisiología y Biofísica

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

4
Mariella Rivas

Profesor Asistente

Biotecnología

Universidad de Antofagasta

Antofagasta, Chile

3
Tamara Bustamante

Asistente de Investigación

Fisiología y Biofísica

Facultad de Medicina Universidad de Chile

Santiago, Chile

3
Eric Tapia

Investigador

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

3
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

3
Robin Piron

Investigador postdoctoral

Facultad de Medicina

Universidad de Chile

Santiago, Chile

2
Oscar Araneda

Docente de Fisiologia -Profesor Investigador

Escuela de Kinesiología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Cristian Torres

Profesor Asistente

Ciencias Clínicas

Universidad de Chile

Santiago, Chile

1
Catharina Alves-de-Souza

Research Professot

MARBIONC Program

University of North Carolina Wilmington

Wilmington, Estados Unidos

1
Ramon Jorquera

Assistant Professor

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

1
Matias Guerra

Investigador

Banco de recursos Genéticos Microbianos

INIA Quilamapu

Chillan, Chile

1
Pamela Fernandez

Postdoc researcher

Centro i-mar, Universidad de Los Lagos

Puerto Montt, Chile

1
Eduardo Tapia

Investigador Protección Vegetal

Sanidad Vegetal

Instituto de Investigaciones Agropecuarias

Santiago, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Daniel Varela

Investigador

Universidad de Los Lagos

Puerto Montt, Chile

1
carolina valenzuela

profesor asistente

fomento de la produccion animal

universidad de chile

santiago, Chile

1
Cristian Torres

Profesor Asistente

Ciencias Clínicas

Universidad de Chile

Santiago, Chile

1
Verónica Iglesias

Académico

Epidemiología

ESCUELA DE SALUD PÚBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pedro Labarca

Principal Research

Biology

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
FRANCISCO BERRAL

Catedrático

Deporte

Universidad Pablo de Olavide

Sevilla, España

1
Jaime Hinzpeter

Staff Departamento

Ortopedia y Traumatología

Hospital Clínico U. de Chile

Santiago, Chile