Man

Pedro Julio Labarca Prado

Principal Research

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Líneas de Investigación


Biophysics, Ecology and Evolution

Educación

  •  Biology , UNIVERSIDAD DE CHILE. Chile, 1975
  •  Biophysics, School of Arts and Sciences, Brandeis University. Estados Unidos, 1980

Experiencia Académica

  •   Research Associate Full Time

    Harvard Medical School.

    Boston, Estados Unidos

    1975 - 1976

  •   Visiting Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    1985 - 1987

  •   Assistant Professor Full Time

    DUKE UNIVERSITY

    Carolina del Norte, Estados Unidos

    1987 - 1989

  •   Associate Professor Part Time

    UNIVERSIDAD DE CHILE

    Sciences

    Santiago, Chile

    1991 - 2000

  •   Post-Doctoral Full Time

    University of California

    San Diego, Estados Unidos

    1980 - 1984

Formación de Capital Humano


Undergraduates Students:
* Orlando Jorquera, Chile
* Carolina Oliva, "Transmisión sináptica alterada en mutantes de Drosophila deficientes en inositol polifosphato 1-fosfatasa (*Carlos Maureira, colaborador)", Licenciada en Ciencias, Pontificia Universidad Católica de Santiago. Finished
*Timoty Warren (USA)
* Juan Pablo Sandoval, Chile
* Hugo Silva, Universidad Austral de Chile
* Pamela Santibañez, Universidad Austral de Chile. Finished
* Alejandra Urra Gallardo, "Caracterización Molecular de Microalgas de Nieve". Universidad Austral de Chile. Finished 2012.
* Editha Elías, Universidad Austral de Chile. Finished 2011

Postgrade Students:
* Ricardo Delgado, Chile
* Patricia Hidalgo, Chile
* Claudia Basso, Chile
* Carlos Maureira, "Registros electrofisiológicos de los Mushroom Bodies de Drosophila melanogaster" Universidad de Chile, Finished
* Ramón Jorquera Araya, "Poblaciones de Vesículas y Plasticidad SIináptica de Corta Duración en la Unión Neuromuscular de la Larva de Drosophila melanogaster". Universidad Austral de Chile. Finished 2007.
* Felipe Espinoza, México
* Carlos Muñoz -Garay, Méxicohttps://investigadores.conicyt.cl/en/profile/publications?u=1
* Gabriel Gasque, México
* Rodrigo Scheihing Aguila, "Selección Fenotípica y Variabilidad Genética Espacio-Temporal en Poblaciones de Limnocythere atacamae (OSTRACODA: LIMNOCYTHERE)”. Universidad Austral de Chile. Finished 2011.

Postdoctoral:
* Christopher Falhke, Alemania
* Sofía La Vista-Llano, Argentina


Difusión y Transferencia


Visiting Professor:
* Biotecnology Institute.
* Universidad Autónoma de México.
* Department of Neurobiology, The Rockeffeller University.
* Department of Neurobiology, Harvard Medical School.
* Max Planck Institute for Biophysical Chemistry, Göttingen.
* Invited Professor, School of Medicine, Gunma University and Japanese Physiological Soc. (Japón).
* Invited Professor, Faculté de Medicine, L’Université Paris Rene Descartes, France.

Membership:
* Member Latinoamerican Academy of Sciences. 2002
* Chairman Latinoamerican Biophtsical Soc. 1997
* Presidential Chair in Science. 1996 - 2002

Fellowship:
* Postdoctoral fellow, Muscular Distrophy Association of America. 1982 - 1984
* Fellowship from the School of Arts and Sciences, Brandeis University. 1976 - 1979

Committees:
* Member of the Directory,“Fundación Imagen de Chile”. 2009
* Member of the Presidential Fellowships Program Committee. 2007
* Director of the course “Imaging in Neuroscience” organized by Centro de Estudios Científicos, The National Academy of Sciences, USA and the Howard Hughes Medical Institute. 2002
* Member organizing committee of International Symposia “From Ion Channels to Behavior”. 1993
* Organizer of Internatinal course "Molecular Approaches to Ion Channel Structure and Function". 1991
* Member Organizing Committee of the International Symposia "Ionic Channels in Cells and Model Systems. Centro de Estudios Científicos de Santiago, Santiago, Chile. 1984


Premios y Distinciones

  •   International Scholar

    Howard Hughes Medical Institute.

    Estados Unidos, 1996

    .

  •   Rectoral Medal

    UNIVERSIDAD DE CHILE

    Chile, 2005

    .

  •   National Science Award

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2004

    .

  •   Rectoral Medal

    UNIVERSIDAD DE CHILE

    Chile, 1999

    .

  •   John Simon Guggenheim Memorial Foundation Fellowship

    JOHN SIMON GUGGENHEIM MEMORIAL FOUNDATION

    Estados Unidos, 1996

    .

  •   Patrimonial Chair of Excelence

    CONACYT

    México, 1996

    .


 

Article (63)

First Record of Testate Amoebae on Glaciers and Description of a New Species Puytoracia jenswendti nov sp (Rhizaria, Euglyphida)
Viability selection on body size in a non-marine ostracod
A quantitative survey of the aquatic invertebrate community in the "Monumento natural Salar de Surire" on the Chilean Altiplano
Morphological and molecular analysis of centropagids from the high Andean plateau (Copepoda: Calanoidea)
Glacier mass balance interpreted from biological analysis of firn cores in the Chilean lake district
A new species of Cletocamptus (Copepoda : Harpacticoida) firom Chile and some notes on Cletocamptus axi Mielke, 2000
Sp-tetraKCNG: A novel cyclic nucleotide gated K+ channel
Bridging behavior and physiology: Ion-channel perspective on mushroom body-dependent olfactory learning and memory in Drosophila
Drosophila melanogaster Scramblases modulate synaptic transmission
Oviduct contraction in Drosophila is modulated by a neural network that is both, octopaminergic and glutamatergic
Cholesterol-depleting compounds modulate K+-currents in Drosophila kenyon cells
Shal and Shaker differential contribution to the K+ currents in the Drosophila mushroom body neurons
Signaling through Gs alpha is required for the growth and function of neuromuscular synapses in Drosophila
Synaptic vesicle pools and plasticity of synaptic transmission at the Drosophila synapse
Dynamics of intracellular calcium induced by lactate and glucose in rat pachytene spermatocytes and round spermatids
Inwardly rectifying K+ channels in spermatogenic cells: Functional expression and implication in sperm capacitation
Sea urchin sperm cation-selective channels directly modulated by cAMP
Size of vesicle pools, rates of mobilization, and recycling at neuromuscular synapses of a Drosophila mutant, shibire
Ion channels in sperm physiology.
Mouse sperm patch-clamp recording reveals Cl- channels sensitive to niflumic acid, a blocker of the sperm acrosome reaction.
Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component downregulated by cAMP.
Pore accessibility during C-type inactivation in Shaker K+ channels.
Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants.
A cAMP regulated K+-selective channel from the sea urchin sperm plasma membrane.
A ciliary K+ conductance sensitive to charibdotoxin underlies inhibitory responses in toad olfactory receptor neurons.
Ion channel classes in purified olfactory cilia membranes: planar lipid bilayer studies.
Ion channels from the mouse sperm plasma membrane in planar lipid bilayers.
Molecular determinants of ion conduction and inactivation in K+ channels.
Selectivity and gating properties of a cAMP-modulated, K(+)-selective channel from Drosophila larval muscle.
A high-conductance voltage-dependent multistate Ca2+ channel found in sea urchin and mouse spermatozoa.
Inhibitory KFormula Current Activated by Odorants in Toad Olfactory Neurons
Sea urchin sperm: an ion channel reconstitution study case
Shaker mutants lack post-tetanic potentiation at motor end-plates.
Insertion of ion channels into planar lipid bilayers by vesicle fusion.
K(+)-channel blockers restore synaptic plasticity in the neuromuscular junction of dunce, a Drosophila learning and memory mutant.
Surface charge effects on ion conduction in ion channels.
Voltage-gated currents in isolated olfactory neurons from the frog Caudiverbera caudiverbera.
A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.
Four cases of direct ion channel gating by cyclic nucleotides.
Activation by saccharides of a cation-selective pathway on canine lingual epithelium.
L-glutamate activates excitatory and inhibitory channels in Drosophila larval muscle.
Varieties of Calcium-Activated Potassium Channels
Activation by odorants of a multistate cation channel from olfactory cilia.
Ion channels from chemosensory olfactory neurons.
Voltage gating of conductance in lipid bilayers induced by porin from outer membrane of Neisseria gonorrhoeae.
Large cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayers.
Native and chemically modified porin channels from Salmonella typhi Ty2 in planar lipid bilayers.
Acetylcholine Receptor Channel Open States and Agonist Occupancy
Kinetic analysis of channel gating. Application to the cholinergic receptor channel and the chloride channel from Torpedo californica.
The occurrence of long openings in the purified cholinergic receptor channel increases with acetylcholine concentration
Acetylcholine receptor in planar lipid bilayers. Characterization of the channel properties of the purified nicotinic acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayers.
Channel properties of the purified acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayer membranes
Reconstitution of Single Ion Channel Molecules
The acetylcholine receptor channel from Torpedo californica has two open states.
A K+-selective, three-state channel from fragmented sarcoplasmic reticulum of frog leg muscle.
A potassium Selective, Three-State Channel from the Sarcoplasmic Reticulum of Frog Muscle
What can we learn from bilayers?
Thermodynamic and kinetic studies of the gating behavior of a K+-selective channel from the sarcoplasmic reticulum membrane.
Energetics of sodium transport in toad urinary bladder.
Metabolic Cost of Transport and the Degree of Coupling between Transport and Metabolism
Metabolic cost of sodium transport in toad urinary bladder.
Metabolic evidence that serosal sodium does not recycle through the active transepithelial transport pathway of toad bladder.
Channel Properties of the Purified Acetylcholine Receptor

BookSection (15)

Diálogo abierto desde el mundo de la ciencia
La Biología no Existe
Gating and selectivity properties of a cAMP-activated K+ channel from Drosophila larval muscle.
Inhibitory responses to odorants in vertebrate olfactory neurons.
Possible participation of a cAMP regulated K+ channel from the sea urchin sperm in the speract response
Transducción Química en las neuronas olfatorias de los vertebrados
Molecular Biology of K+ channels. Potassium Channels and their Modulators
Transducción Química en el Gusto
Transducción Química en el Olfato
Ion channels: key elements in sea urchin sperm physiology.
Joaquín Luco: Dos Historias de una Vida
The reconstituted acetylcholine receptor
Conduction and Gating in the Cholinergic Receptor
Studies on the potassium and chloride conductances drived from the fragmentes sarcoplasmic reticulum of vertebrates skeletal muscle
Amiloride as a Probe in the Study of Sodium Transport.

Proyecto (11)

MECANISMOS DE REGULACION DE LA DISPONIBILIDAD DE LAS VESICULAS SINAPTICAS.
DINAMICA DE LAS VESICULAS SINAPTICAS Y SECRECION DE NEUROTRANSMISOR EN LA SINAPSIS NEUROMUSCULAR DE LA DROSOPHILA MELANOGASTER.
APRENDIZAJE Y RETENCION EN LA DROSOPHILA: ESTUDIOS ELECTROFISIOLOGICOS EN INDIVIDUOS NORMALES Y EN MUTANTES NEUROLOGICOS
ESTUDIO DE CANALES IONICOS EN MEMBRANAS EXCITABLES DE POR NEUROTRANSMISORES Y SEGUNDOS MENSAJEROS EN LA CEPA NORMAL Y EN MUTANTES NEUROLOGICOS.
ESTUDIO DE LAS CONDUCTANCIAS DE MEMBRANA Y DE LA ADAPTACION EN NEURONAS OLFATORIAS DE VERTEBRADOS
ESTUDIOS DE LA PLASTICIDAD SINAPTICA Y DE LA ADQUISICION Y RETENCISON DE LA INFORMACION OLFATIVA EN IPP. UN MUTANTE DE LA DROSOPHILA DEFICIENTE EN EL METABOLISMO DEL FOSFOINOSITOL
ESTUDIOS ELECTROFISIOLOGICOS DE LOS MECANISMOS DE QUIMIOTRANSDUCCION Y REGULACION DE LA ACTIVIDAD ELECTRICA EN NEURONAS OLFATORIAS DE VERTEBRADOS.
ESTUDIOS ELECTROFISIOLOGICOS EN MEMBRANAS EXCITABLES DE LA CEPA SILVESTRE Y EN MUTANTES NEUROLOGICOS DE LA DROSOPHILA
MOVILIZACION DE VESICULAS SINAPTICAS EN LA JUNTURA NEUROMUSCULAR DE LA LARVA DE LA DROSOPHILA MELANOGASTER Y SU ROL EN LAS ALTERACIONES DE LA PLASTICIDAD SINAPTICA EN TRES MUTANTES NEUROLOGICOS
RECEPTORES DE GLUTAMATO EN FIBRAS MUSCULARES DE LA LARVA DE DROSOPHILA MALANOGASTER.
The Human Frontier in Science Program
89
Pedro Labarca

Principal Research

Biology

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

7
Roberto Nespolo

Titular Professor

Instituto de Ciencias Ambientales y Evolutivas

Universidad Austral de Chile

Valdivia, Chile

5
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

3
Ramon Jorquera

Assistant Professor

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

2
Leyla Cardenas

full professor

Instituto de ciencias ambientales y evolutivas

Universidad Austral de Chile

valdivia, Chile

2
Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

2
Carlos Maureira

Investigador Associated

Biology

Universidad de Chile

Santiago, Chile

2
Gino Casassa

Associate Professor

Vicerrectoría de Investigación y Postgrado

UNIVERSIDAD DE MAGALLANES

Punta Arenas, Chile

1
GLADYS ASENCIO

Investigadora Asociada

CENTRO I-MAR, UNIV. DE LOS LAGOS

Pto Montt, Chile

1
Paola Krall

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

1
Nestor Lagos

Full Professor

Fisiología y Biofísica

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

1
Hugo Silva

Asistente Científico

Cargill Innovation Centre

Cargill

Calbuco, Chile

1
Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

1
Jorge Jaramillo

Docente

Universidad Austral de Chile

Valdivia, Chile