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Arturo José Borzutzky Schachter

Chief; Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Atopic dermatitis; food allergy; vitamin D; pediatric rheumatologic diseases; primary immunodeficiency; Kawasaki disease

Educación

  •  Médico Cirujano (Medical Doctor), PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Specialist in Pediatrics, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Specialist in Pediatric Rheumatology, Allergy and Immunology, HARVARD UNIVERSITY. Estados Unidos, 2010

Experiencia Académica

  •   Instructor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2007 - 2012

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2012 - 2017

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Specialist in Pediatric Immunology, Allergy and Rheumatology Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2010 - A la fecha

Formación de Capital Humano


Undergraduate and graduate teaching of Immunology, Allergy, and Pediatric Rheumatology at the School of Medicine and School of Biological Sciences at Pontificia Universidad Católica de Chile. Research Program Coordinator of the Pediatrics Residency. Project tutor of 8 residents and 3 fellows. Thesis director of 1 PhD student, 1 Master of Medical Sciences student, 1 Master of Nutrition thesis, and 3 undergraduate biochemistry thesis.


Difusión y Transferencia


Medical and Scientific Advisor of the Fundación Creciendo con Alergias Alimentarias and Corporación de Ayuda al Niño con Artritis Crónica Juvenil.
Member of the Guidelines Committee of the Chilean Ministry of Health for Juvenile Idiopathic Arthritis and Cow's Milk Allergy.


Premios y Distinciones

  •   Clinical Excellence (Junior) Prize, School of Medicine

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2016

    Yearly prize to Clinical Excellence awarded by the School of Medicine, Pontificia Universidad Católica de Chile.

  •   2nd Best Original Article of the Year Revista Chilena de Pediatría

    SOCIEDAD CHILENA DE PEDIATRIA

    Chile, 2015

    2nd Best Original Article of the Year Revista Chilena de Pediatría

  •   Young Investigator Award, Division of Pediatrics

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2015

    Young Investigator Award, Division of Pediatrics, Pontificia Universidad Católica de Chile

  •   Best Research Article 2014, Division of Pediatrics, Pontificia Universidad Católica de Chile

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2014

    Best Research Article 2014, Division of Pediatrics, Pontificia Universidad Católica de Chile

  •   Peter Lehner Family Clinical Research Fellowship, Children’s Hospital Boston

    Boston Children's Hospital

    Estados Unidos, 2007

    Peter Lehner Family Clinical Research Fellowship, Children’s Hospital Boston

  •   Dr. Enrique Fanta Núñez Award to the best pediatric resident of class 2007, Department of Pediatrics, School of Medicine

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2007

    Dr. Enrique Fanta Núñez Award to the best pediatric resident of class 2007, Department of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile.


 

Article (58)

Clinical characterization of Chilean patients with food protein-induced enterocolitis syndrome
Refractory systemic juvenile idiopathic arthritis successfully treated with rapamycin
Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile
Hypersensitivity reactions to measles-mumps-rubella vaccine in patients with IgE-mediated cow's milk allergy
ICD-10 coded hospitalizations due to drug hypersensitivity: A nationwide study from Chile
Increasing food allergies in Chile, a developing country post-epidemiological transition
Severe respiratory disease caused by human respiratory syncytial virus impairs language learning during early infancy
Disseminated Mycobacterial Disease in a Patient with 22q11.2 Deletion Syndrome: Case Report and Review of the Literature
Is there an association between indoor allergens and the severity of atopic dermatitis?
Latin American consensus on the supportive management of patients with severe combined immunodeficiency
Severe Necrotic Reaction to 23-Valent Polysaccharide Pneumococcal Vaccine in a Patient with STAT3 Deficiency
Vitamin D modulates the allergic phenotype of dendritic cells in children with atopic dermatitis
Clinical characterization of Chilean patients with IgE-mediated food allergy.
Defective TLR9-driven STAT3 activation in B cells of patients with CVID
Diagnostic validity of fecal occult blood test in infants with food protein-induced allergic proctocolitis
Estudio de validez diagnóstica de la prueba de hemorragia oculta fecal en lactantes con proctocolitis alérgica inducida por proteína alimentaria
Hypomorphic CARD11 mutations associated with diverse immunologic phenotypes with or without atopic disease
Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease.
Immunohistochemical expression of vitamin D receptor in melanocytic naevi and cutaneous melanoma=> a case-control study.
Role of dendritic cells in peanut allergy.
Circulating vitamin D-binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma=> A case-control study.
Evolution of the skin manifestations of X-linked pigmentary reticulate disorder
Incidence and risk factors of food allergy after umbilical cord blood transplantation in children.
Primary immunodeficiencies in Chile evaluated through ICD-10 coded hospital admissions
Regional solar radiation is inversely correlated with incidence and severity of tuberculosis in Chile
Solar radiation is inversely associated with inflammatory bowel disease admissions
Distribución geográfica de la enfermedad de Kawasaki en Chile
Geographic distribution of Kawasaki disease throughout Chile
Humoral and Cellular Autoreactivity to Epidermal Proteins in Atopic Dermatitis
Incidence and risk factors of food allergy after umbilical cord blood transplantation in children
Parent-reported prevalence of food allergy in Mexican schoolchildren: A population-based study
Potenciales consecuencias neurocognitivas de infección por virus respiratorio sincicial humano
Vitamin D axis and its role in skin carcinogenesis: a comprehensive review
Association of Kawasaki disease with tropospheric winds in Central Chile: Is wind-borne desert dust a risk factor?
Deficiencia severa de vitamina D en niños de Punta Arenas, Chile: influencia de estado nutricional en la respuesta a suplementación
Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers
Latex allergy in the perioperative period [Alergia al látex en el período perioperatorio]
Severe vitamin D deficiency in children from Punta Arenas, Chile: Influence of nutritional status on the response to supplementation [Deficiencia severa de vitamina D en niños de Punta Arenas, Chile: Influencia de estado  nutricional en la respuesta a suplementación]
Agreement Between Dermatologic and Pediatric Researchers in Scoring of Atopic Dermatitis in Children
Higher latitude and lower solar radiation influence on anaphylaxis in Chilean children
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function
Prevalence of parent-reported immediate hypersensitivity food allergy in Chilean school-aged children
Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis
Clinical and genetic features of hereditary periodic fever syndromes in Hispanic patients: the Chilean experience
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
Pediatric Chronic Nonbacterial Osteomyelitis
Rising hospitalization rates of Kawasaki Disease in Chile between 2001 and 2007
A Novel Missense Mutation in MVK Associated With MK Deficiency and Dyserythropoietic Anemia
Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter
A Girl with Severe Hand Swelling and Abdominal Cramps
High sensitivity C-reactive protein and endothelial function in Chilean patients with history of Kawasaki disease
Cardiac tumors in children and adults: A retrospective study
Osteoporosis in children with severe congenital neutropenia: Bone mineral density and treatment with bisphosphonates
Nitric oxide in pulmonary arteriovenous malformations and Fontan procedure
Accidental clozapine intoxication in a ten-year-old child
Missed diagnosis of osteoporosis and failure to treat elderly adults with hip fracture in Chile
Osteoporosis in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Abstract (9)

Clusters of Autoimmune Diseases in Children and the Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity
Excellent Agreement Between Dermatology and Pediatric Researchers In Severity Scoring Of Atopic Dermatitis (SCORAD) Index In Children
Induction Of Remission Of Frequent Idiopathic Anaphylaxis With Rituximab
Pediatric Rheumatology Admissions in Chile, 2001-2010: Unavailability of a Pediatric Rheumatologist May Hinder a Correct Diagnosis
Immunologic and Rheumatologic Diseases Temporally Associated with Mycoplasma pneumoniae Infection in Children
Latitude Gradient of Anaphylaxis in Chile: A Potential Role of Vitamin D Status
Asthma and Anaphylaxis Mortality Trends in Chile Between 1991 and 2008
Clinical and Genetic Features of Autoinflammatory Syndromes in Hispanic Patients: The Chilean Experience
Osteoporosis in children with severe congenital neutropenia: Bone metabolism and treatment with bisphosphonates

EditorialMaterial (2)

Severe Spinal Neurofibromatosis in a Child
Accelerated carpal bone maturation in juvenile idiopathic arthritis: pitfall for bone age measurement

Letter (3)

Induction of remission of idiopathic anaphylaxis with rituximab
Spinal neurofibromatosis in children Reply
Paediatric hypertension-associated erythromelalgia responds to corticosteroids and is not associated with SCN9A mutations

Proyecto (30)

Activation of the CD200/CD200R pathway by Staphylococcus aureus in atopic dermatitis=> a potential therapeutic target.
Early origins of allergy and asthma
Non-invasive diagnostic panel of skin antimicrobial peptides
IDENTIFYING ENDOTYPES AND POTENTIAL THERAPEUTIC TARGETS IN ATOPIC DERMATITIS THROUGH AN INTEGRATED SYSTEMS BIOLOGY APPROACH
Identifying endotypes and potential therapeutic targets in atopic dermatitis through an integrated systems biology approach.
A Multicenter, Open-Label Trial of Intravenous Golimumab, a Human Anti- TNFα Antibody, in Pediatric Subjects With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy.
A Multicenter, Open-Label Trial of Intravenous Golimumab, a Human Anti-TNFα Antibody, in Pediatric Subjects With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy (GO-VIVA) Protocol CNTO148JIA3003; Phase 3.
Effects of Antarctic environment on vitamin D status and health risk biomarkers of its inhabitants.
Effects of Antarctic environment on vitamin D status and health risk biomarkers of its inhabitants.
Identification of non-invasive biomarkers of allergic proctocolitis
Identification of non-invasive biomarkers of allergic proctocolitis.
A Randomized, Double-blind, Controlled Trial of Vitamin D for the Prevention of Acute Respiratory Infections in Children Aged 18 to 36 Months in Santiago, Coyhaique and Punta Arenas, Chile.
Estudio prospectivo multicentrico, multinacional sobre la epidemiología, diagnóstico, tratamiento y publicaciones de la enfermedad de Kawasaki en niños de América Latina: REKAMLATINA-1
Estudio prospectivo multicéntrico multinacional sobre la epidemiología, diagnóstico, tratamiento y complicaciones de la Enfermedad de Kawasaki en niños de América Latina=> REKAMLATINA-1
Neurocognitive evaluation after severe infection by Respiratory Syncitial Virus in Infants
Vitamin D status, vitamin D receptor polymorphisms and tumoral expression in patients with sporadic and familial melanoma in Chilean population: a case control study
Vitamin D status, vitamin D receptor polymorphisms and tumoral expression in patients with sporadic and familial melanoma in Chilean population=> a case control study.
Effect of H. pylori infection in the development of a tolerogenic immune response in children with IgE-mediated allergy.
Impact of vitamin D supplementation on clinical severity and immunologic tolerance of pediatric atopic dermatitis
Neurocognitive evaluation after severe infection by Respiratory Syncitial Virus in Infants
Clusters de enfermedades autoinmunes en pacientes con autoinmunidad pediátrica.
Prevalence of food allergy in Chilean school children
Clinical and genetic features of autoinflammatory diseases in Hispanic patients=> the Chilean experience.
Epidemiology of immunologic and rheumatologic diseases in Chile.
The PRES European Network of Registries for Autoinflammatory Diseases in Childhood (EuroFever)." Co-Investigator. Funding=>
Clinical characteristics and treatment of pediatric patients with chronic recurrent multifocal osteomyelitis.
C1-Inhibitor OPEN LABEL Study for HAE.
Studies of Immunological Deficiency Syndromes
Marcadores de riesgo cardiovascular y funcion endotelial en pacientes con historia de enfermedad de Kawasaki.
A Randomized, Double-blind, Controlled Trial of Vitamin D for the Prevention of Acute Respiratory Infections in Children Aged 18 to 36 Months in Santiago, Coyhaique and Punta Arenas, Chile.

Review (3)

Orofacial granulomatosis and diet therapy
Role of vitamin D in the pathogenesis and treatment of atopic dermatitis
NOD2-associated diseases: Bridging innate immunity and autoinflammation
78
Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

21
Rodrigo Hoyos

Profesor Asistente

Enfermedades Infecciosas e Inmunología Pediátrica

Escuela de Medicina, Pontificia Universidad Católica de Chile

Santiago, Chile

6
carolina iturriaga

Jefa de proyectos y estudios Clínicos Laboratorio de inmunología y Alergia Traslacional UC

Pediatria

Pontificia Universidad Católica de Chile

santiago, Chile

5
Pamela Morales

Profesor asistente adjunto

Enfermedades infecciosas, inmunología y reumatología pediatrica

Pontificia Universidad Católica de Chile

santiago, Chile

4
Lorena Cifuentes

Académico

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA, DIVISIÓN DE PEDIATRÍA

Santiago, Chile

3
Maria Poli

Assistant Professor

Pediatrics

Universidad del Desarrollo

Santiago, Chile

2
Paul Harris

Full Professor

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Raquel Aguilera

PROFESOR ASISTENTE

INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Sara Concha

Residente

Departamento de Enfermedades Infecciosas e Inmunología Pediátrica

Pontificia Universidad Católica

Santiago, Chile

2
Monica Acevedo

Associate Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Javier Tinoco

Jefe Unidad de de IAAS

Medicina Interna

Clinica Universidad de Los Andes

Santiago, Chile

2
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

2
Juan Gana

Gastroenterólogo Pediatra

Departamento de Gastroenterología y Nutrición Pediátrica.

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Flores

Medico Pediatra

Centro de Responsabilidad del Niño

Complejo Asistencial Dr. Sotero del Rio

Santiago, Chile

1
Pamela Zúñiga

Profesor Asociado

Pediatria

Pontificia Universidad Católica de Chile

Santiago , Chile

1
María Jara

Profesor Asistente

Ciencias de la Salud, Fonoaudiología

Pontificia Universidad Católica de Chile

Macul, Chile

1
María Balcells

Associate Professor

Department of Infectious Diseases of the Adult

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Danisa Ivanovic-Zuvic

Fellowship en Investigación

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carolina Serrano

Profesor Asistente Adjunto

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Iris Espinoza

Associated Professor

Departament of Oral Patology and Medicine

Universidad de Chile

Santiago, Chile

1
Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Jonathan Kraus

ENDOCRINÓLOGO PEDIATRA

PEDIATRÍA

HOSPITAL LUIS CALVO MACKENNA

SANTIAGO, Chile

1
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

1
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Raul Escobar

Académico

Neurología Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Paul

Instructor Adjunto

Pediatría

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Hector Jorquera

Professor

Chemical and Bioprocess Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Caroll Hernández

Investigador Postdoctoral

Enfermedades Infecciosas e Inmunología Pediátrica

Pontificia Universidad Católica de Chile

Santiago , Chile

1
Marcela Peña

Profesor titular

Psicologia

PONTIFICIA UNIVERESIDAD CATOLICA DE CHILE

Santiago, Chile

1
jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

1
Samuel Cordova

ESCUELA DE MEDICINA, PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Cristián Vera

Profesor Asociado

Dermatología

Pontificia Universidad Católica de Chile

Santiago, Chile