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PAMELA ALEJANDRA LEAL ROJAS

Profesor Asociado

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1) Caracterización molecular de tumores tracto biliar. 2) Estudio de vesículas extracelulares como fuente de marcadores moleculares. 3) Evaluación de extractos naturales en modelos preclínicos.

Biología Celular y Molecular Aplicada, UNIVERSIDAD DE LA FRONTERA. Chile, 2005
Ingeniero Agrónomo, UNIVERSIDAD DE LA FRONTERA. Chile, 2001
Posdoctorado, JOHNS HOPKINS UNIVERSITY. Estados Unidos, 2015

PROFESOR ASOCIADO Full Time

UNIVERSIDAD DE LA FRONTERA

Facultad de Ciencias Agropecuarias y Medioambiente

Temuco, Chile

2006 - A la fecha

Profesora Asociada Full Time

Universidad de La Frontera

Temuco, Chile

2006 - A la fecha
Directora de Cooperación Internacional Part Time

Universidad de La Frontera

Temuco, Chile

2017 - 2019
Directora de Calidad Part Time

Universidad de La Frontera

Temuco, Chile

2020 - A la fecha

2019
Joaquín Sepúlveda Hafemann. Efecto del inhibidor Surmanina en lineas celulares de cáncer de vesícula Biliar. Trabajo para optar al título de Bioquímico. Universidad de La Frontera. Temuco-Chile.
Profesor Guía. Terminada

2019
Ramón Silva Pezoa. Validación de potenciales blancos terapéuticos en cáncer avanzado de vesícula biliar identificados mediante proteómica cuantitativa. Tesis Doctoral. Programa de
Doctorado en Ciencias mención Biología Celular y Molecular Aplicada. Universidad de La Frontera. Terminada
Profesor Tutor.

2020
Luis Vergara Gómez. Caracterización del perfil proteómico de organoides derivados de pacientes con cáncer de vesícula biliar y su asociación con respuesta a gemcitabina
Tesis Doctoral. Programa de Doctorado en Ciencias mención Biología Celular y Molecular Aplicada. Universidad de La Frontera.
Profesor Tutor. En proceso

2007
Gidekel M, Gutiérrez A, Destefano-Beltrán L, Leal P, Dinamarca J, Guerra E. Low temperature responsive nucleotide sequences and used thereof (2007). USPTO Application #: 20070118922.

2005
Gidekel M, Gutiérrez A, Leal P, Destefano-Beltrán L, Dinamarca J, Guerra E. Novel Plant promoter transgenic plants expressing a Deschampsia antarctica modified gene transcript and
uses thereof (2005). Patent N° US7273931B2.

Artículo más citado

UNIVERSIDAD DE LA FRONTERA

Chile, 2021

McCall MN, Kim MS, Adil M, Patil AH, Lu Y, Mitchell CJ, Leal-Rojas P, Xu J, Kumar M, Dawson VL, Dawson TM, Baras AS, Rosenberg AZ, Arking DE, Burns KH, Pandey A, Halushka MK. Toward the human cellular microRNAome. Genome Res. 2017 Oct;27(10):1769-1781. doi: 10.1101/gr.222067.117. Epub 2017 Sep 6.
Artículo más citado

UNIVERSIDAD DE LA FRONTERA

Chile, 2016

Min-Sik Kim, Sneha M. Pinto, Derese Getnet, Raja Sekhar Nirujogi, Srikanth S. Manda, Raghothama Chaerkady, Anil K. Madugundu, Dhanashree S. Kelkar, Ruth Isserlin, Shobhit Jain, Joji K. Thomas, Babylakshmi Muthusamy, Pamela Leal-Rojas, Praveen Kumar, Nandini A. Sahasrabuddhe et al. A draft of the human proteome. Nature, May 2014, 509(7509): 575–581. (FI: 42.351)


Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity Guzman-Oyarzo, Dina; Hernandez-Montelongo, Jacobo; Rosas, Carlos; Leal, Pamela; Weber, Helga; Alvear, Marysol; Salazar, Luis A. Article ISI PHARMACEUTICS (2022)
Exosomes and cystic Echinococcosis. Systematic review Carlos Manterola; Pamela Leal Article International Journal of Morphology (2022)
CRISPR/Cas13-Based Platforms for a Potential Next-Generation Diagnosis of Colorectal Cancer through Exosomes Micro-RNA Detection: A Review Duran-Vinet, Benjamin; Araya-Castro, Karla; Calderon, Juan; Vergara, Luis; Weber, Helga; Retamales, Javier; Araya-Castro, Paulina; Leal-Rojas, Pamela Article ISI CANCERS (2021)
Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines Calderon-Reyes, Cristobal; Silva Pezoa, Ramon; Leal, Pamela; Ribera-Fonseca, Alejandra; Caceres, Cristina; Riquelme, Ismael; Zambrano, Tomas; Pena, Daniela; Alberdi, Miren; Reyes-Diaz, Marjorie Article ISI JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION (2020)
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor Garcia, Patricia; Bizama, Carolina; Rosa, Lorena; Espinoza, Jaime A.; Weber, Helga; Cerda-Infante, Javier; Sanchez, Marianela; Montecinos, Viviana P.; Lorenzo-Bermejo, Justo; Boekstegers, Felix; Davila-Lopez, Marcela; Alfaro, Francisca; Leiva-Acevedo, Claudia; Parra, Zasha; Romero, Diego; Kato, Sumie; Leal, Pamela; Lagos, Marcela; Carlos Roa, Juan Article ISI SCIELO BIOLOGICAL RESEARCH (2020)
Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer García, Patricia; Rosa, Lorena; Vargas, Sergio; Weber, Helga; Espinoza, Jaime A.; Suárez, Felipe; Romero-Calvo, Isabel; Elgueta, Nicole; Rivera, Vanessa; Nervi, Bruno; Obreque, Javiera; Leal, Pamela; Viñuela, Eduardo; Aguayo, Gloria; Muñiz, Sabrina; Sagredo, Alfredo; Roa, Juan C.; Bizama, Carolina Article ISI SCOPUS Cancers (2020)
The Anti-Proliferative and Anti-Invasive Effect of Leaf Extracts of Blueberry Plants Treated with Methyl Jasmonate on Human Gastric Cancer In Vitro Is Related to Their Antioxidant Properties Ribera-Fonseca, Alejandra; Jimenez, Danae; Leal, Pamela; Riquelme, Ismael; Carlos Roa, Juan; Alberdi, Miren; Peek, Richard M.; Reyes-Diaz, Marjorie Article ISI SCOPUS ANTIOXIDANTS (2020)
Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma Espinoza, Jaime A.; Riquelme, Ismael; Sagredo, Eduardo A.; Rosa, Lorena; Garcia, Patricia; Bizama, Carolina; Apud-Bell, Maria; Leal, Pamela; Weber, Helga; Benavente, Felipe; Vargas, Sergio; Romero, Diego; Kalergis, Alexis M; Carlos Roa, Juan Article ISI SCOPUS HISTOPATHOLOGY (2019)
PIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40Â kDa (PRAS40). Subbannayya, Tejaswini; Leal-Rojas, Pamela; Zhavoronkov, Alex; Ozerov, Ivan V; Korzinkin, Mikhail; Babu, Niraj; Radhakrishnan, Aneesha; Chavan, Sandip; Raja, Remya; Pinto, Sneha M; Patil, Arun H; Barbhuiya, Mustafa A; Kumar, Prashant; Guerrero-Preston, Rafael; Navani, Sanjay; Tiwari, Pramod K; Kumar, Rekha Vijay; Prasad, T S Keshava; Roa, Juan Carlos; Pandey, Akhilesh; Sidransky, David; Gowda, Harsha; Izumchenko, Evgeny; Chatterjee, Aditi Article Journal of cell communication and signaling (2019)
Effects of clopidogrel on inflammatory cytokines and adhesion molecules in human endothelial cells=> Role of nitric oxide mediating pleiotropic effects. Cerda, Alvaro; Pavez, Monica; Manriquez, Victor; Luchessi, Andre Ducati; Leal, Pamela; Benavente, Felipe; Fajardo, Cristina Moreno; Salazar, Luis; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo Article Cardiovascular therapeutics (2017)
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer Weber, H; Valbuena, JR; Barbhuiya, MA; Stein, S; Kunkel, H; García, P; Bizama, C; Riquelme, I; Espinoza, JA; Kurtz, SE; Tyner, J; Calderon, JF; Corvalán, AH; Grez, M; Pandey, A; Leal-Rojas, P; Roa, JC Article Oncotarget (2017)
The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer. Buchegger, Kurt; Silva, Ramón; López, Jaime; Ili, Carmen; Araya, Juan Carlos; Leal, Pamela; Brebi, Priscilla; Riquelme, Ismael; Roa, Juan Carlos Article Pathology, research and practice (2017)
The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer Wu, Xinyan; Zahari, Muhammad Saddiq; Renuse, Santosh; Kelkar, Dhanashree S.; Bharbuiya, Mustafa A.; Rojas, Pamela L.; Stearns, Vered; Gabrielson, Edward; Malla, Pavani; Sukumar, Saraswati; Mahajan, Nupam P.; Pandey, Akhilesh Article ISI ONCOTARGET (2017)
Toward the human cellular microRNAome McCall, MN; Kim, MS; Adil, M; Patil, AH; Lu, Y; Mitchell, CJ; Leal-Rojas, P; Xu, JC; Kumar, M; Dawson, VL; Dawson, TM; Baras, AS; Rosenberg, AZ; Arking, DE; Burns, KH; Pandey, A; Halushka, MK Article Genome Research (2017)
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway Riquelme I.; Tapia O.; Leal P.; Sandoval A.; Varga, MG; Letelier P; Buchegger, K; Bizama, C; Espinoza, JA; Peek, RM; Araya, JC; Roa, Jc Article ISI SCOPUS CELLULAR ONCOLOGY (2016)
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines Riquelme I.; Tapia O.; Espinoza, J.A; Leal P.; Buchegger, K; Sandoval A.; Bizama, C; Araya J.C.; Peek R.M.; Roa, J.C Article ISI SCOPUS PATHOLOGY & ONCOLOGY RESEARCH (2016)
Effects of c-FLIPL Knockdown in Cervical Uterine Carcinoma Cell Lines Ili CG; Brebi P.; Garcia P.; Leal P.; Lopez, J.; Tapia O.; Letelier P; Weber, H; Castillo J.; Roa, Jc Article ISI SCIELO INTERNATIONAL JOURNAL OF MORPHOLOGY (2015)
Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways Wu, XY; Zahari, MS; Ma, BY; Liu, R; Renuse, S; Sahasrabuddhe, NA; Chen L., Chaerkady; R, Kim MS; Zhong, J; Jelinek, C; Barbhuiya, MA; Leal-Rojas, P; Yang Y., Kashyap; MK, Marimuthu A.; Ling, M; Fackler, MJ; Merino, V; Zhang Z., Zahnow; CA, Gabrielson; E, Stearns; V, Roa; JC, Sukumar; S, Gill; PS, Pandey Article Oncotarget (2015)
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer Subbannayya T., Leal-Rojas; P, Barbhuiya; MA, Raja R.; Renuse, S; Sathe, G; Pinto, SM; Syed, N; Nanjappa, V; Patil, AH; Garcia P., Sahasrabuddhe; NA, Nair; B, Guerrero-Preston; R, Navani S.; Tiwari, PK; Santosh, V; Sidransky D., Prasad; TSK, Gowda H.; Roa, JC; Pandey, A; Chatterjee, A. Article BMC Cancer (2015)
Quantitative phosphoproteomic analysis of IL-33-mediated signaling Pinto S.M.; Nirujogi R.S.; Rojas P.L.; Patil A.H.; Manda S.S.; Subbannayya, Y; Roa, J.C; Chatterjee, A.; Prasad T.S.K.; Pandey, A Article ISI SCOPUS PROTEOMICS (2015)
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice Weber, H; Leal P.; Stein S; Kunkel H; Garcia P.; Bizama, C; Espinoza, JA; Riquelme I.; Nervi, B; Araya, JC; Grez, M; Roa, Jc Article ISI SCOPUS Oncotarget (2015)
A draft map of the human proteome. Kim, Min-Sik; Pinto, Sneha M; Getnet, Derese; Nirujogi, Raja Sekhar; Manda, Srikanth S; Chaerkady, Raghothama; Madugundu, Anil K; Kelkar, Dhanashree S; Isserlin, Ruth; Jain, Shobhit; Thomas, Joji K; Muthusamy, Babylakshmi; Leal-Rojas, Pamela; Kumar, Praveen; Sahasrabuddhe, Nandini A; Balakrishnan, Lavanya; Advani, Jayshree; George, Bijesh; Renuse, Santosh; Selvan, Lakshmi Dhevi N; Patil, Arun H; Nanjappa, Vishalakshi; Radhakrishnan, Aneesha; Prasad, Samarjeet; Subbannayya, Tejaswini; Raju, Rajesh; Kumar, Manish; Sreenivasamurthy, Sreelakshmi K; Marimuthu, Arivusudar; Sathe, Gajanan J; Chavan, Sandip; Datta, Keshava K; Subbannayya, Yashwanth; Sahu, Apeksha; Yelamanchi, Soujanya D; Jayaram, Savita; Rajagopalan, Pavithra; Sharma, Jyoti; Murthy, Krishna R; Syed, Nazia; Goel, Renu; Khan, Aafaque A; Ahmad, Sartaj; Dey, Gourav; Mudgal, Keshav; Chatterjee, Aditi; Huang, Tai-Chung; Zhong, Jun; Wu, Xinyan; Shaw, Patrick G; Freed, Donald; Zahari, Muhammad S; Mukherjee, Kanchan K; Shankar, Subramanian; Mahadevan, Anita Article Nature (2014)
Cytotoxic Effect of Double Emulsion (W/O/W) CuSO4 Loaded PLA Nanoparticles on MKN-45 Gastric Adenocarcinoma Cell Line Montiel-Eulefi, Enrique; Jara, Fernando; Toro, Claudio; Garcés, Marcelo; Leal, Pamela Article ISI SCIELO INTERNATIONAL JOURNAL OF MORPHOLOGY (2014)
Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population Brebi P.; Maldonado, L.; Noordhuis M.G.; Ili C.; Leal P.; Garcia P.; Brait M; Ribas, J; Michailidi C; Perez J.; Soudry E; Tapia O.; Guzman P.; Munoz S.; Van Neste L.; Van Criekinge W.; Irizarry R; Sidransky D.; Roa, J.C; Guerrero-Preston, R Article ISI SCOPUS EPIGENETICS (2014)
Identification of Prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics Sahasrabuddhe, NA; Barbhuiya, MA; Bhunia, S; Subbannayya T.; Gowda H.; Advani, J; Shrivastav, BR; Navani S.; Leal P.; Roa, Jc; Chaerkady, R; Gupta, S; Chatterjee, A.; Pandey, A; Tiwari, PK Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Immunohistochemical expression of vascular endothelial growth factor A in advanced gallbladder carcinoma. Letelier, Pablo; Garcia, Patricia; Leal, Pamela; Ili, Carmen; Buchegger, Kurt; Riquelme, Ismael; Sandoval, Alejandra; Tapia, Oscar; Roa, Juan C Article Applied immunohistochemistry & molecular morphology => AIMM (2014)
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance. Tapia, Oscar; Riquelme, Ismael; Leal, Pamela; Sandoval, Alejandra; Aedo, Susana; Weber, Helga; Letelier, Pablo; Bellolio, Enrique; Villaseca, Miguel; Garcia, Patricia; Roa, Juan Carlos Article Virchows Archiv => an international journal of pathology (2014)
AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines Leal P.; Garcia P.; Sandoval A.; Buchegger, K; Weber, H; Tapia O.; Roa, J.C Article ISI SCOPUS OncoTargets and Therapy (2013)
Cellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression Ili CG; Brebi P.; Tapia O.; Sandoval A.; Lopez, J.; Garcia P.; Leal P.; Sidransky D.; Guerrero-Preston, R; Roa, Jc Article ISI SCOPUS International Journal of Gynecological Pathology (2013)
Connective Tissue Growth Factor Immunohistochemical Expression Is Associated With Gallbladder Cancer Progression Garcia P.; Leal P.; Alvarez H.; Brebi P.; Ili C.; Tapia O.; Roa, Jc Article ISI SCOPUS Archives of Pathology and Laboratory Medicine (2013)
Immunohistochemical Expression of Phospho-mTOR Is Associated With Poor Prognosis in Patients With Gallbladder Adenocarcinoma Leal P.; Garcia P.; Sandoval A.; Letelier P; Brebi P.; Ili C.; Alvarez H.; Tapia O.; Roa, Jc Article ISI SCOPUS Archives of Pathology and Laboratory Medicine (2013)
In vitro Translocation Cytoplasm/nucleus of Embryonic Transcription Factor OCT-4 in Perivascular Cells Suggests that Aorta as a Niche of Quiescent Adult Stem Cells Herrera-Bravo, J; Montiel-Eulefi, E; Glaser, T; Garcés M.; Leal P.; Ulrich, AH Article ISI INTERNATIONAL JOURNAL OF MORPHOLOGY (2013)
Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro Garcia P.; Leal P.; Ili C.; Brebi P.; Alvarez H.; Roa, Jc Article ISI SCOPUS International Journal of Experimental Pathology (2013)
Clinical and public health research using methylated DNA Immunoprecipitation (MeDIP): A comparison of commercially available kits to examine differential DNA methylation across the genome Priscilla Brebi-‐Mieville, Carmen Ili-‐Gangas, Pamela Leal-‐Rojas, Ethan Soudry, Jimena Perez, Juan Carlos Roa, David Sidransky, and Rafael Guerrero-‐Preston. Article Epigenetics (2012)
Genotyping of Human Papillomavirus in Cervical Intraepithelial Neoplasia in a High-Risk Population Ili CG; Brebi P.; Lopez, J.; Garcia P.; Leal P.; Suarez, E; Roa, Jc Article ISI SCOPUS Journal of Medical Virology (2011)
Pericytes: New Approaches in Regenerative Therapy, Cerebrovascular Pathology and Cancer Montiel-Eulefi, E; Diaz, LB; Leal P.; Roa, Jc; Risopatrón J.; SALAZAR, LA; Romero F.; Sanchez R. Article ISI INTERNATIONAL JOURNAL OF MORPHOLOGY (2011)
[Promoter hypermethylation gene patterns in gynecological tumors]. Leal Rojas, Pamela; Anabalón Rodríguez, Leonardo; García Muñoz, Patricia; Tapia Escalona, Oscar; Guzmán González, Pablo; Araya Orostica, Juan Carlos; Villaseca Hernández, Miguel; Roa Strauch, Juan Carlos Article Medicina clinica (2009)
Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma Brebi P.; Ili CG; Lopez, J.; Garcia P.; Melo A.; Montenegro, S; Leal P.; Guzman P.; Roa, Jc Article ISI REVISTA MEDICA DE CHILE (2009)
Melanoma Hyperpigmentation Is Strongly Associated With KIT Alterations Wu, Julie M.; Alvarez, Hector; Garcia, Patricia; Rojas, Pamela L.; Wong, Grace; Maitra, Anirban; Antonescu, Cristina; Montgomery, Elizabeth A. Article ISI AMERICAN JOURNAL OF DERMATOPATHOLOGY (2009)
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target Koorstra, Jan-Bart M.; Karikari, Collins A.; Feldmann, Georg; Bisht, Savita; Rojas, Pamela Leal; Offerhaus, G. Johan A.; Alvarez, Hector; Maitra, Anirban Article ISI CANCER BIOLOGY THERAPY (2009)
Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy Alvarez, Hector; Rojas, Pamela Leal; Yong, Ken-Tye; Ding, Hong; Xu, Gaixia; Prasad, Paras N.; Wang, Jean; Canto, Marcia; Eshleman, James R.; Montgomery, Elizabeth A.; Maitra, Anirban Article ISI NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2008)
Identification and characterization of three novel cold acclimation-responsive genes from the extremophile hair grass Deschampsia antarctica Desv. Gidekel, M.; Destefano-Beltran, L; Garcia P.; Mujica, L; Leal P.; Cuba M.; Fuentes, L; Bravo, LA; CORCUERA, LJ; Alberdi M.; Concha, I; Gutierrez A. Article ISI SCOPUS EXTREMOPHILES (2003)


HSP90 Expression and Antitumoral Activity of Geldanamicin and Its Analog in Gallbladder Carcinoma Valbuena J.; Weber, H; Leal P.; Garcia P.; Bizama, C; Espinoza J.; Roa, J Abstract ISI MODERN PATHOLOGY (2015)
mTOR/P70S6K signaling pathway as a potential target for advanced gallbladder cancer therapy Roa, Jc; Leal P.; Weber, H; Garcia P.; Sandoval A.; Buchegger, K; Tapia O.; Nervi, B; Grez, M Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2014)
Expression Analysis of AKT/mTOR Signaling Pathway in Primary Tumors and Cell Lines Derived from Gallbladder Cancer Roa, Jc; Leal P.; Garcia P.; Tapia O.; Weber, H Abstract ISI MODERN PATHOLOGY (2013)
Level of miR-125B and miR-451 and Deregulated Expression of PI3K/AKT/mTOR Pathway in Gastric Cancer Tapia O.; Riquelme I.; Sandoval A.; Letelier P; Leal P.; Roa, Jc Abstract ISI MODERN PATHOLOGY (2013)
Heat Shock Protein (HSP)-90 Is Overexpressed in Gallbladder Carcinoma (GBC) Valbuena, JR; Roa, Jc; Leal P.; Garcia P.; Gonzalez S.; Oddo D.; Schnettler K.; Carrasco, G; Corvalan, AH Abstract ISI LABORATORY INVESTIGATION (2012)


Accessing untapped sources of natural products: An innovative transdisciplinary multi-omics approach for bioactive metabolites discovery in Actinobacteria and Cyanobacteria from extreme environments Leal, Pamela Alejandra; Weber, Helga; Nunez-Montero, Kattia Proyecto (2021)
Connecting molecular subtypes of colorectal cancer with extracellular vesicles heterogeneity in patient-derived organoids Roa, Juan Carlos; Bizama, Carolina; Weber, Helga; Garcia, Patricia Proyecto (2021)
Setting up de una plataforma de producción de anticuerpos monoclonales recombinantes, utilizando el biomarcador CDLN18 de cáncer de vesícula biliar Effer, Brian Proyecto (2021)
Circulating exoDNA as a next generation biospecimen for liquid biopsy of pancreatic-biliary cancers FONDECYT (1170893) Proyecto 2017-2020 Coinvestigador(a)
CARACTERIZACIÓN FENÓLICA DE EXTRACTOS DE FRUTOS DE CALAFATE Y SU POTENCIAL USO COMO AGENTE HIPOGLICEMIANTE y ANTICANCERíGENO DIUFRO (PIA16-0006) Proyecto 2016-2017 Coinvestigador(a)
Efecto del clopidogrel sobre mediadores de inflamación y adhesión celular en células endoteliales humanas DIUFRO (PIA15-0003) Proyecto 2015-2016 Coinvestigador(a)
Identificación de componentes diferenciales del microbioma intestinal entre individuos hipercolesterolémicos y controles. DIUFRO (PIA15-0001) Proyecto 2015-2016 Coinvestigador(a)
Proteomic signature of gallbladder cancer secreted exosomes=> a dynamic approach to delineate their potential role during malignant progression and their clinical relevance as novel reservoir of circulating biomarkers FONDECYT (1151008) Proyecto 2015-2018 Inv. Responsable
Identification and validation of early diagnostic gallbladder cancer biomarkers in Chilean patients by quantitative proteomics. A phase 1 and 2 Biomarker validation trial. FONDECYT (1130204) Proyecto 2013-2016 Coinvestigador(a)
Using a quantitative proteomic as a useful tool to identify potencial biomarkers in gallbladder cancer. PFCHA (3691) Proyecto 2013-2014 Inv. Responsable
Improving the production of phenylpropanoids with antioxidant activity in Highbush blueberry (Vaccinium corymbosum L.) using Methyl Jasmonate and UV-B radiation and its effect on gastric cancer chemoprevention. FONDECYT (1120917) Proyecto 2012-2015 Coinvestigador(a)
Rol de la activación de la vía AKT/mTOR en la patogénesis y progresión del cáncer de vesícula biliar=> estudio inmunohistoquímico en matrices de tejido (TMAs). DIRECCION DE INVESTIGACION UNIVERSIDAD DE LA FRONTERA (DIUFRO) (DI11-0039) Proyecto 2011-2012 Director(a)
Nanopartículas modificadas con cobre en el tratamiento del cáncer=> Evaluación in vitro, toxicología y biocompatibilidad. DIRECCION DE INVESTIGACION UNIVERSIDAD DE LA FRONTERA (DIUFRO) (PIA–Bioren) Proyecto 2010-2011 Coinvestigador(a)
Validation of MTOR metabolic pathway inactivation for gallbladder cancer targeted therapy. FONDECYT (1090171) Proyecto 2009-2012 Coinvestigador(a)
Rol de las proteínas SKP2 y FBW7, componentes del complejo SCF E3 ligasa, en cáncer de la vesícula biliar. DIRECCION DE INVESTIGACION UNIVERSIDAD DE LA FRONTERA (DIUFRO) (DI08-0077) Proyecto 2008-2009 Inv. Responsable
Centro de Excelencia en Biociencias de la Salud. PBCT–World Bank. PAI (PSD32) Proyecto 2006-2009 Postdoctorado
Deschampsia antarctica DESV.=> Prospección de genes y agentes fotoprotectores ultravioleta para su uso en la industria farmacéutica FONDEF (D0311079) Proyecto 2004-2005 Personal técnico y/o de apoyo


Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy Bizama, C; Garcia P.; Espinoza, JA; Weber, H; Leal P.; Nervi, B; Roa, Jc Review ISI SCOPUS Cancer Treatment Reviews (2015)

PAMELA LEAL

Profesor Asociado

Departamento de Ciencias Agronómicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

Patricia García

Profesor Asistente

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Helga Weber

Investigador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

Carolina Bizama

Assistant professor

Department of Pathology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

Carmen Ili

Academico Asociado

Scientific and technological Bioresource Nucleus (BIOREN)

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Jaime Lopez

Asistente de Investigación

Anatomía Patologica

Universidad de La Frontera

Temuco, Chile

Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

Juan Araya

Pathologist

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

Lorena Rosa

PhD

Departamento de Patología

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Guzmán

Pathologist

Hospital Regional Dr. Hernán Henríquez Araven

Temuco, Chile

Luis Salazar

Profesor Titular

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Sergio Vargas

Investigador

Hematología-Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

marcelo Garcés

Kurt Buchegger

Investigador Postdoctoral

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Manuel Gidekel

GERENTE OPERACIONES Y PRESIDENTE

CONSORCIO DE TECNOLOGIA E INNOVACION PARA LA SALUD

SANTIAGO, Chile

Enrique Montiel

Profesor Asistente

Ciencias Básicas

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Eduardo Sagredo

jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

Jennie Risopatrón

Académico y Director del CEBIOR

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

Claudio Toro

EXECUTIVE DIRECTOR

CENTRO DE INVESTIGACIÓN DE POLÍMEROS AVANZADOS

CONCEPCIÓN, Chile

Leon Bravo

Profesor Titular

Ciencias Agronómicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Sergio Munoz

Profesor Titular

Salud Publica

Universidad de La Frontera

Temuco, Chile

Fernando Romero

Profesor JC, asociado

Ciencias Preclínicas

Universidad de La Frontera

Temuco, Chile

Juan Calderon

Investigador

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

Paulina Araya

COORDINADORA ACADEMICA

Facultad de Medicina

Universidad del Desarrollo

SANTIAGO, Chile

Lida Fuentes

Researcher

Centro Regional de Estudios en Alimentos Saludables

Valparaiso, Chile

Marely Cuba

Titular professor

Ciencia y Tecnología Vegetal

UNIVERSIDAD DE CONCEPCIÓN, CAMPUS LOS ÁNGELES

Los Ángeles, Chile

Javiera Obreque

Investigadora Postdoctoral

CECAN - PUC

Santiago, Chile

PAMELA ALEJANDRA LEAL ROJAS

Líneas de Investigación

Educación

Biología Celular y Molecular Aplicada, UNIVERSIDAD DE LA FRONTERA. Chile, 2005

Ingeniero Agrónomo, UNIVERSIDAD DE LA FRONTERA. Chile, 2001

Posdoctorado, JOHNS HOPKINS UNIVERSITY. Estados Unidos, 2015

Experiencia Académica

PROFESOR ASOCIADO Full Time

Experiencia Profesional

Profesora Asociada Full Time

Directora de Cooperación Internacional Part Time

Directora de Calidad Part Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Artículo más citado

Artículo más citado

Article (42)

Abstract (5)

Proyecto (17)

Circulating exoDNA as a next generation biospecimen for liquid biopsy of pancreatic-biliary cancers

CARACTERIZACIÓN FENÓLICA DE EXTRACTOS DE FRUTOS DE CALAFATE Y SU POTENCIAL USO COMO AGENTE HIPOGLICEMIANTE y ANTICANCERíGENO

Efecto del clopidogrel sobre mediadores de inflamación y adhesión celular en células endoteliales humanas

Identificación de componentes diferenciales del microbioma intestinal entre individuos hipercolesterolémicos y controles.

Proteomic signature of gallbladder cancer secreted exosomes=> a dynamic approach to delineate their potential role during malignant progression and their clinical relevance as novel reservoir of circulating biomarkers

Identification and validation of early diagnostic gallbladder cancer biomarkers in Chilean patients by quantitative proteomics. A phase 1 and 2 Biomarker validation trial.

Using a quantitative proteomic as a useful tool to identify potencial biomarkers in gallbladder cancer.

Improving the production of phenylpropanoids with antioxidant activity in Highbush blueberry (Vaccinium corymbosum L.) using Methyl Jasmonate and UV-­B radiation and its effect on gastric cancer chemoprevention.

Rol de la activación de la vía AKT/mTOR en la patogénesis y progresión del cáncer de vesícula biliar=> estudio inmunohistoquímico en matrices de tejido (TMAs).

Nanopartículas modificadas con cobre en el tratamiento del cáncer=> Evaluación in vitro, toxicología y biocompatibilidad.

Validation of MTOR metabolic pathway inactivation for gallbladder cancer targeted therapy.

Rol de las proteínas SKP2 y FBW7, componentes del complejo SCF E3 ligasa, en cáncer de la vesícula biliar.

Centro de Excelencia en Biociencias de la Salud. PBCT–World Bank.

Deschampsia antarctica DESV.=> Prospección de genes y agentes fotoprotectores ultravioleta para su uso en la industria farmacéutica

Review (1)

Improving the production of phenylpropanoids with antioxidant activity in Highbush blueberry (Vaccinium corymbosum L.) using Methyl Jasmonate and UV-B radiation and its effect on gastric cancer chemoprevention.