Man

Helga Lorena Weber Rascheya

Investigador

Universidad de la Frontera

Temuco, Chile

Líneas de Investigación


Gallbladder Cancer Stem Cells, Metabolic pathways involved in gallbladder cancer; Cancer-specific therapies for gallbladder cancer; Oncolytic Viruses in pancreatic cancer

Educación

  •  Doctor Biología Celular y Molecular Aplicada, UNIVERSIDAD DE LA FRONTERA. Chile, 2010
  •  Ingeniero Agrónomo, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2001

Experiencia Académica

  •   Investigador Post Doctoral Other

    UNIVERSIDAD DE LA FRONTERA

    Vicerrectoría de Investigación y Post Grado

    Temuco, Chile

    2012 - 2016

  •   Investigador Full Time

    UNIVERSIDAD DE LA FRONTERA

    Vicerrectoría de Investigación y Postgrado

    Temuco, Chile

    2017 - A la fecha

Experiencia Profesional

  •   Becario Doctoral Full Time

    Fundación Instituto Leloir

    Buenos Aires, Argentina

    2010 - 2010

  •   Investigador Post Doctoral Full Time

    Universidad Adolfo Ibáñez

    Santiago, Chile

    2011 - 2011

  •   Becario Post Doctoral Full Time

    Institute for Biomedical Research Georg Speyer Haus

    Frankfurt, Alemania

    2012 - 2013

  •   Investigador Post Doctoral Full Time

    Universidad de La Frontera

    Temuco, Chile

    2012 - 2016

  •   Investigador Full Time

    Universidad de La Frontera

    Temuco, Chile

    2017 - A la fecha

Formación de Capital Humano


Comités de Tesis de Pre- Grado

2020 Isabela Antonia Navarra Pérez Núñez. Silenciamiento del gen glipican 1 (gpc1) en las líneas celulares de cáncer de vesícula biliar Clon 1 y TGBC-2. Work to apply for the Biotechnology degree. Universidad de La Frontera. Temuco-Chile. Tutor.

2019 Joaquin Ignacio Sepúlveda Hafemann. Effect of the inhibitor surmanin in cell lines of gallbladder cancer. Work to apply for the Biotechnology degree. Universidad de La Frontera. Temuco-Chile. Internal evaluator.

2015 Natalia Paz Badilla Vidal. Determination of tumor markers in samples of bovine ovarian tissue for potential determination in patients of fertility preservation programs. Work to apply for the Biochemistry degree. Universidad de La Frontera. Temuco-Chile. Internal evaluator.

Comités de Tesis de Post- Grado

2019 Rodrigo Antonio Salazar Celedón. Determination of photoprotective activity of melanin from Antarctic bacteria Streptomyces fildesensis on human epidermal cells. Doctoral thesis. Doctoral Program in Science in Applied Molecular and Cell Biology. Universidad de La Frontera. Temuco, Chile. Internal evaluator.

2019 María Elena De Lourdes Reyes Rebolledo. Role of chemokines of the CC subfamily in the promotion of resistance to cisplatin mediated by paracrine / autocrine regulation in gastric cancer cell lines. Doctoral thesis. Doctoral Program in Science in Applied Molecular and Cell Biology. Universidad de La Frontera. Temuco, Chile. Internal evaluator.

2019 Katterin Pamela Bobadilla Fernández. Effect of stabilized copper nanoparticles on the release of proangiogen factors in human keratinocits and their role in angiogenesis. Doctoral Program in Science in Applied Molecular and Cell Biology. Universidad de La Frontera. Temuco, Chile. Internal evaluator.



 

Article (13)

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor
Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer
Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naïve pT2 gallbladder adenocarcinoma patients
A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models
Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+hematopoietic progenitors
Effects of c-FLIPL Knockdown in Cervical Uterine Carcinoma Cell Lines
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance
AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines

Abstract (4)

HSP90 Expression and Antitumoral Activity of Geldanamicin and Its Analog in Gallbladder Carcinoma
mTOR/P70S6K signaling pathway as a potential target for advanced gallbladder cancer therapy
New Insights Into the Therapeutic Efficacy of the Pancreatic Cancer-Targeted AV25CDC Oncolytic Adenovirus
Expression Analysis of AKT/mTOR Signaling Pathway in Primary Tumors and Cell Lines Derived from Gallbladder Cancer

Patent (2)

Pharmaceutical kit and method for treating cancer
Extracts of Deschampsia antarctica Desv. with antineoplastic activity

Proyecto (6)

Connecting molecular subtypes of colorectal cancer with extracellular vesicles heterogeneity in patient-derived organoids
Immunotherapy targeting cancer stem-like cells=> A promising new approach for gallbladder cancer treatment. (año término 2021)
PROTEOMIC SIGNATURE OF GALLBLADDER CANCER SECRETED EXOSOMES=> A DYNAMIC APPROACH TO DELINEATE THEIR POTENTIAL ROLE DURING MALIGNANT PROGRESSION AND THEIR CLINICAL RELEVANCE AS NOVEL RESERVOIR OF CIRCULATING BIOMARKERS.
In vivo evaluation of the therapeutic efficacy of AZD8055 and Rapamycin in a subcutaneous tumor model in nude mice gallbladder cancer (NIH Swiss mice Athymic Nude).
Validation of mTOR metabolic pathway inactivation for gallbladder cancer targeted therapy
EL FACTOR GM-CSF GATILLA UN AUMENTO DEL TRANSPORTE DE HEXOSAS Y DE VITAMINA C MEDIADO POR LOS TRANSPORTADORES FACILITATIVOS DE HEXOSAS (GLUTS) EN ESPERMATOZOIDES DE MAMIFEROS.

Review (1)

Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy
20
Helga Weber

Investigador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

12
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

8
Patricia García

Profesor Asistente Adjunto

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

8
PAMELA LEAL

Investigador

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

8
Carolina Bizama

Profesor Asistente

Anatomía Patológica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

6
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

3
Lorena Rosa

PhD

Departamento de Patología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Manuel Gidekel

GERENTE OPERACIONES Y PRESIDENTE

CONSORCIO DE TECNOLOGIA E INNOVACION PARA LA SALUD

SANTIAGO, Chile

2
Sergio Vargas

Investigador

Hematología-Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Lopez

Asistente de Investigación

Anatomía Patologica

Universidad de La Frontera

Temuco, Chile

1
Kurt Buchegger

Investigador Postdoctoral

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Juan Araya

Pathologist

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

1
Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

1
Patricia Macanas

Profesor Asistente Adjunto

Hematology Oncology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

223543432, Chile

1
Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Juan Calderon

Investigador

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

1
jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile