Img_9501.jpg_thumb90

Nicolás René Saavedra Cuevas

Profesor Asociado

Universidad de La Frontera

Temuco, Chile

Líneas de Investigación


Role of microbiome in cardiovascular diseases; Identification of active compounds in natural products with pharmacological potential; Genetic and epigenetic basis of priority diseases for Precision Medicine

Educación

  •  Laboratorio Clínico, Hematología y Banco de Sangre, UNIVERSIDAD DE LA FRONTERA. Chile, 2009
  •  Biología Celular y Molecular Aplicada, UNIVERSIDAD DE LA FRONTERA. Chile, 2013

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE LA FRONTERA

    Medicina

    Temuco, Chile

    2016 - 2021

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE LA FRONTERA

    Medicina

    Temuco, Chile

    2022 - A la fecha

Experiencia Profesional

  •   Profesor Guia de Tesis

    Universidad de La Frontera

    Chile

    2009 - 2009

  •   Profesor Guia de Tesis

    Universidad de La Frontera

    Chile

    2009 - 2009

  •   Profesor Guia de Tesis

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Profesor Guia de Tesis

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Apoyo Tecnico

    Universidad de La Frontera

    Chile

    2008 - 2008

  •   Apoyo Técnico

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Profesor Invitado

    Universidad San Sebastian

    Chile

    2010 - 2010

  •   Profesor

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Profesor

    Universidad de La Frontera

    Chile

    2010 - 2010

  •   Profesor

    Universidad de La Frontera

    Chile

    2009 - 2009

  •   Docente Bioquímica Clínica

    Universidad Santo Tomás

    Chile

    2013 - 2013

  •   Docente carrera de Tecnología Medica

    Universidad de La Frontera

    Chile

    2011 - 2011

  •   Investigador Postdoctoral

    Universidad de La Frontera

    Chile

    2014 - 2015

Premios y Distinciones

  •   Mejor Egresado Programas de Doctorado

    UNIVERSIDAD DE LA FRONTERA

    Chile, 2014

    Distinción al mejor egresado de la generación entre los programas de Doctorado de la Universidad de La Frontera.


 

Article (58)

Genome Sequences of 408 SARS-CoV-2 Strains Obtained from Nasopharyngeal Swabs in La Araucanía Region, Southern Chile.
MicroRNA-20a-5p Downregulation by Atorvastatin: A Potential Mechanism Involved in Lipid-Lowering Therapy
Novel molecular biomarkers of cancer therapy-induced cardiotoxicity in adult population: a scoping review
Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review
Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update
MicroRNA-33b is a Potential Non-Invasive Biomarker for Response to Atorvastatin Treatment in Chilean Subjects With Hypercholesterolemia: A Pilot Study
Protective effect of Pinot noir pomace extract against the cytotoxicity induced by polycyclic aromatic hydrocarbons on endothelial cells
Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field
Circulating miRNA-23b and miRNA-143 Are Potential Biomarkers for In-Stent Restenosis
Drimenol, isodrimeninol and polygodial isolated from Drimys winteri reduce monocyte adhesion to stimulated human endothelial cells
Drimys winteri and isodrimeninol decreased foam cell formation in THP-1 derived macrophages
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia
Histological Evaluation and Gene Expression Profiling of Autophagy-Related Genes for Cartilage of Young and Senescent Rats
Prodigiosin Modulates the Immune Response and Could Promote a Stable Atherosclerotic Lession in C57bl/6Ldlr-/- Mice
Hybrid cardiac rehabilitation trial (HYCARET): protocol of a randomised, multicentre, non-inferiority trial in South America
Propolis Reduces the Expression of Autophagy-Related Proteins in Chondrocytes under Interleukin-1 beta Stimulus
Polymorphisms in Genes Involved in the Leptin-Melanocortin Pathway are Associated with Obesity-Related Cardiometabolic Alterations in a Southern Chilean Population
Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls
Bacterial Community Profile of the Gut Microbiota Differs between Hypercholesterolemic Subjects and Controls.
CYP2C19*2 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls
Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects.
Epigenetic Modifications of Major Depressive Disorder.
HMGCR rs17671591 SNP Determines Lower Plasma LDL-C after Atorvastatin Therapy in Chilean Individuals.
HMGCR rs17671591 SNP Determines Lower Plasma LDL-C after Atorvastatin Therapy in Chilean Individuals.
Polyphenol-rich extract from propolis reduces the expression and activity of Streptococcus mutans glucosyltransferases at subinhibitory concentrations
Polyphenols from Chilean Propolis and Pinocembrin Reduce MMP-9 Gene Expression and Activity in Activated Macrophages.
Polyphenols from Chilean Propolis and Pinocembrin Reduce MMP-9 Gene Expression and Activity in Activated Macrophages.
Reference gene selection for quantitative real-time PCR in Solanum lycopersicum L. inoculated with the mycorrhizal fungus Rhizophagus irregularis
Antibiofilm Activity of Chilean Propolis on Streptococcus mutans Is Influenced by the Year of Collection
Efficacy of Ezetimibe Is Not Related to NPC1L1 Gene Polymorphisms in a Pilot Study of Chilean Hypercholesterolemic Subjects
ERK1/2 and HIF1 alpha Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis
Frequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients
Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects
SLCO1B1 c.388A > G Polymorphism Is Associated with HDL-C Levels in Response to Atorvastatin in Chilean Individuals
Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis
Chemical and botanical characterization of Chilean propolis and biological activity on cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus
Phytate addition to soil induces changes in the abundance and expression of Bacillus beta-propeller phytase genes in the rhizosphere
Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia
La Respuesta Terapéutica a Ezetimiba en Ratones C57BL/6 es Mediada por Cambios en la Expresión de NPC1L1, ABCG5 y ABCG8 en el Enterocito
Therapeutic response to ezetimibe in C57BL/6 mice is mediated by changes in NPC1L1, ABCG5 and ABCG8 expression in the enterocyte
Therapeutic response to ezetimibe in C57BL/6 mice is mediated by changes in NPC1L1, ABCG5 and ABCG8 expression in the enterocyte La Respuesta Terapéutica a Ezetimiba en Ratones C57BL/6 es Mediada por Cambios en la Expresión de NPC1L1, ABCG5 y ABCG8 en el Enterocito
Efecto del Propóleos Chileno sobre el Metabolismo de Glucosa en Ratones Diabéticos
Effect of Chilean propolis on cariogenic bacteria Lactobacillus fermentum
Effect of Chilean propolis on cariogenic bacteria Lactobacillus fermentum Efecto de propóleos chilenos sobre la bacteria cariogénica Lactobacillus fermentum
Effect of Chilean Propolis on Glucose Metabolism in Diabetic Mice
Effect of chilean propolis on glucose metabolism in diabetic mice Efecto del propóleos chileno sobre el metabolismo de glucosa en ratones diabéticos
Frequency of Common Variants in Genes Involved in Lipid-Lowering Response to Statins in Chilean Subjects with Hypercholesterolemia
Frequency of common variants in genes involved in lipid-lowering response to statins in Chilean subjects with hypercholesterolemia Frecuencia de polimorfismos en genes relacionados a la respuesta terapéutica a estatinas en individuos Chilenos con hipercolesterolemia
Polimorfismo rs3091244 del gen de la proteína C reactiva influencia los niveles séricos de CRP-hs en individuos de la región de La Araucanía
TP53 Codon 72 Polymorphism Is Associated with Coronary Artery Disease in Chilean Subjects.
TP53 codon 72 polymorphism is associated with coronary artery disease in Chilean subjects.
Asociación del polimorfismo rs2241766 del gen de la adiponectina y enfermedad arterial coronaria en individuos del sur de Chile
Polimorfismo SNP-43 del gen de Calpaína-10 en individuos con enfermedad coronaria y controles
Polimorfismos genéticos de APOA5 se asocian a hipertrigliceridemia e hiperglicemia en individuos chilenos con enfermedad coronaria y controles
Presencia del alelo T para el polimorfismo rs2781666 G>T del gen arginasa 1 constituye un factor protector contra enfermedad arterial coronaria
TP53 Codon 72 Polymorphism Is Associated with Coronary Artery Disease in Chilean Subjects
Polimorfismo Pro72Arg del gen TP53 se asocia a enfermedad coronaria en individuos Chilenos

Abstract (14)

REPRESSION OF NOVEL GENES IMPLICATED IN AUTOPHAGY - RELATED MECHANISMS IN THE CARTILAGE OF SENESCENT RAT
ASSOCIATION OF POLYMORPHISMS IN TUMOR NECROSIS FACTOR ALPHA GENE WITH CORONARY POST-ANGIOPLASTY RESTENOSIS
NOS3 GENE POLYMORPHISMS IN CHILEAN PATIENTS WITH POST-ANGIOPLASTY RESTENOSIS
POLYPHENOLS INHIBIT IN VITRO ANGIOGENESIS THROUGH MODULATION OF MICRORNAS EXPRESSION
Association Between Single Nucleotide Polymorphism of Adiponectin Gene and Coronary Artery Disease in Southern Chilean Subjects
Influence of ABCG5/G8 Polymorphisms on Serum Lipid Levels and Response to Ezetimibe Therapy in Chilean Subjects
Single Nucleotide Polymorphism of CRP Gene Affects the Plasma CRP-hs Levels in Chilean Subjects
A148g Variant of Pon2 Gene in Chilean Individuals with Coronary Disease Confirmed by Angiography and Controls
Capn10 Ucsnp-43 Gene Polymorphism in Chilean Individuals with Coronary Artery Disease and Controls
GENE POLYMORPHISMS AND SUSCEPTIBILITY TO CORONARY ARTERY DISEASE IN CHILEAN SUBJECTS
GENETIC POLYMORPHISMS OF APOA5 ARE ASSOCIATED WITH HYPERTRIGLYCERIDEMIA AND HYPERGLYCEMIA IN CHILEAN SUBJECTS WITH CAD
Genetic Variant of Ampk Affect the Metabolism of Lipids and Glucose in Chilean Women with Polycystic Ovary Syndrome
The Presence of Deletion Allele for SNP-19 Polymorphism of CALPAIN-10 Gene Constitutes a Protector Factor Against Coronary Artery Disease
Frequency of common variants of ABCB1, CYP3A4 and CYP3A5 genes in Chilean subjects with primary hypercholesteromia

ConferencePaper (1)

PCSK9 polymorphism rs505151 affects lipid-lowering response to atorvastatin but does not influence ezetimibe therapy in Chilean subjects

Proyecto (9)

Circulating miRNAs as predictor biomarkers of atorvastatin therapy effectiveness=> Validation in a cohort of hypercholesterolemic individuals and a putative mechanistic insight
Increased acute coronary events incidence induced by air pollution is mediated by epigenetic mechanisms
CONTRIBUTION OF ALTERATIONS IN GUT MICROBIOME COMPOSITION AND ITS RELATED CIRCULATING-RNAS IN THE DEVELOPMENT OF HYPERCHOLESTEROLEMIA IN CHILEAN SUBJECTS
Identificación de componentes diferenciales del microbioma intestinal entre individuos hipercolesterolémicos y controles
CLINICAL, ANGIOGRAPHIC, GENETIC AND EPIGENETIC DETERMINANTS OF CORONARY ARTERY RESTENOSIS AFTER ANGIOPLASTY
Detección de polimorfismos genéticos asociados a factores de riesgo cardiovascular en población VIH de la Región de La Araucanía.
Identificação de microRNAs na modulação da angiogênese por polifenóis.
MicroRNAs exosomales en plasma como potenciales biomarcadores de Enfermedad Arterial Coronaria en pacientes Chilenos
Exploration of rhizobacterial diversity and phytase genes in plants grown in extreme Chilean environments

Review (1)

Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors
65
Nicolás Saavedra

Profesor Asociado

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

39
Luis Salazar

Profesor Titular

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

27
Fernando Lanas

Profesor titular

Medicina Interna

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

17
Luis Salazar

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

14
Alejandro Cuevas

Profesor Asistente

Departamento de Ciencias Preclínicas

Universidad de la Frontera

Temuco, Chile

9
Jose Caamaño

Académico a contrata

Medicina Interna

Universidad de La Frontera

Temuco, Chile

6
Marysol Alvear

Académico e Investigador

Departamento de Ciencias Químicas y Recursos Naturales.

Universidad de La Frontera

Temuco, Chile

6
Alejandro Pacheco

Académico

Kinesiología

Universidad Católica del Maule

Talca, Chile

4
Leticia Barrientos

Academicoj/c

Ciencias Báscias

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

4
Pamela Seron

Profesora Titular

Medicina Interna

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

3
Jorge Veloz

Profesor Asistente

Ciencias Biológicas y Químicas

Universidad San Sebastián

Santiago, Chile

3
Jenny Ruedlinger

INVESTIGADOR POSTDOCTORAL EN PROYECTO MAUCO

SALUD PÚBLICA

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

3
Gloria Montenegro

Profesor Titular

Departamento Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
CONSUELO ARIAS

Docente

Ciencias Preclínicas

Universidad de La Frontera

Temuco, Chile

2
Milko Jorquera

PROFESOR TITULAR

CIENCIAS QUIMICA Y RECURSOS NATURALES

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

2
Cristian Paz

Académico

Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

1
Jacquelinne Acuña

Asistant professor

Universidad de La Frontera

Temuco, Chile

1
MARIA JOSE OLIVEROS

DOCENTE KINESIOLOGIA

DEPARTAMENTO DE MEDICINA INTERNA

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

1
Fumito MARUYAMA

Professor

Hiroshima University

Higashi-Hiroshima, Japón

1
Alvaro Cerda

Académico

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Gladys Morales

Profesor Asociado

Salud Pública

Universidad de La Frontera

Temuco, Chile

1
Javier Ortiz

Investigador Postdoctoral

Ciencias Agropecuarias y Forestales

Universidad de La Frontera

Temuco, Chile

1
Danis Fuentes

Investigador Postdoctoral

Ciencias Forestales

Universidad de La Frontera

Temuco, Chile

1
Fumito Maruyama

Associate Professor

Department of Microbiology

University of Kyoto

Kyoto, Japón

1
Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cesar Arriagada

Profesor Titular

Ciencias Forestales

Universidad de La Frontera

Temuco, Chile

1
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

1
Gabriel Marzuca

Profesor Asociado

Departamento de Medicina Interna

Universidad de La Frontera

TEMUCO, Chile

1
NEFTALI GUZMAN

Assistant Professor

Universidad Catolica de Temuco

Temuco, Chile

1
Cesar Arriagada

Profesor Titular

Ciencias Forestales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Claudio Meneses

Profesor Asociado

Facultad de Agronomía e Ingeniería Forestal/ Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carolina Bizama

Profesor Asistente

Anatomía Patológica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Patricia García

Profesor Asistente Adjunto

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Sergio Munoz

Profesor Titular

Salud Publica

Universidad de La Frontera

Temuco, Chile

1
Andrés Ávila

Full professor

Ingeniería Matemática

Universidad de La Frontera

Temuco, Chile

1
Christian Herrera

Director de Departamento

Ciencias Preclínicas

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
José Márquez

Académico

Universidad de Santiago de Chile

Santiago de Chile, Chile