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Alexies Alberto Dagnino Subiabre

Full Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Líneas de Investigación


1) Neurobiology of stress resilience 2) Neuroendocrinology 3) Behavioral Neuroscience

Educación

  •  Doctor en Ciencias Biomédicas, UNIVERSIDAD DE CHILE. Chile, 2003
  •  Bioquímico, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1999

Experiencia Académica

  •   Full Professor Full Time

    UNIVERSIDAD DE VALPARAISO

    Sciences

    Valparaíso, Chile

    2011 - A la fecha

  •   Associate Professor Full Time

    UNIVERSIDAD CATOLICA DEL NORTE

    Medicine

    Coquimbo, Chile

    2006 - 2011

Experiencia Profesional

  •   Full Professor Full Time

    Universidad de Valparaíso

    Valparaíso, Chile

    2011 - A la fecha

  •   Associate Professor Full Time

    Universidad Católica del Norte

    Coquimbo, Chile

    2003 - Sin Información

Formación de Capital Humano


Tutorial (from 2018):
Graduate:
Ongoing:
- Andrew Justin Taylor. 2023. Thesis project: The effect of maternal stress during early lactation on oxytocinergic system and social behavior of prepuberty offspring. PhD program in neuroscience, Universidad de Valparaíso.
- Rodrigo Unda. 2023. Thesis project: Detection of biomarkers of stress resilience in the human voice. PhD program in Health Sciences and Engineering, Universidad de Valparaíso.
- Lorena Mercado. 2023. Thesis project: Role n-6/n-3 PUFA balance on neuroinflammation in the limbic system. PhD program in Nutrition and Food, Universidad de Chile.

Finished:
PhD (4 Finished):
- Mauricio Ramirez. 2021. Thesis title: Effect of chronic stress on brain oscillations of fear memory in the rat prefrontal cortex. PhD program in neuroscience, Universidad de Valparaíso.
- Felipe Rojas. 2021. Human sensory processing under acute psychosocial stress: neurophysiological correlates. Human sensory processing under acute psychosocial stress: neurophysiological correlates. PhD program in neuroscience, Pontificia Universidad Católica de Chile. (Alexies Dagnino was co-tutor).
- Ann Mary Iturra. 2019. Effect of social defeat stress on gamma oscillatory activity in the nucleus accumbens of rats during social interaction. PhD program in neuroscience, Universidad de Valparaíso.
- Catherine Pérez. 2018. Effects of stress and PUFA on emotional memory: brain oscillations and behavior. PhD program in neuroscience, Universidad de Valparaíso.

Master (12 Finished):
- Sandra Reyes. 2023. Thesis title: Effect of maternal stress during early lactation on anxiety and depression-like behaviors in prepubertal rats. Master program in neuroscience, Universidad de Valparaíso.
- Emmanuel Aranda. 2023. Maternal Behavior and Vulnerability to Social Stress. Master program in neuroscience, Universidad de Valparaíso.
- Luisa Montoya. 2023. Effects of stress and type 1 cannabinoid receptor modulators on brain oscillations of fear memory. Master program in neuroscience, Universidad de Valparaíso.
- Patricio Soto. 2022. Effect of Transcranial Alternating Current Electrical Stimulation (tACS) on Working Memory; Systematic Review and Meta-analysis. Master program in neuroscience, Universidad de Valparaíso.
- Ariane Luttecke. 2021. Development of a Chronic Stress Model for Social Defeat in Female Rats: Assessment of Behaviors Similar to Depression and Anxiety. Master program in neuroscience, Universidad de Valparaíso.
- Andrew Justin Taylor. 2020. Study of memory consolidated in a social context. Master program in neuroscience. Universidad de Valparaíso.
- Valentín Peñaloza. 2020. Infusion in the hippocampus of modulators of the cannabinoid receptor type 1: effects on memory in stressed rats. Universidad de Valparaíso.
- Vicente Ruiz. 2020. Effect of distress on Nurr1 and Prss12 immunostaining in the claustrum, morphometric analysis, and association with behavioral alterations. Universidad de Valparaíso.
- Vicente Ruiz. 2020. Effect of distress on Nurr1 and Prss12 immunostaining in the claustrum, morphometric analysis, and association with behavioral alterations. Universidad de Valparaíso.
- Maria Teresa Salas. 2019. Effect of prenatal stress on learning and memory in prepuberty rats. Universidad de Valparaíso.
- Marcia Arriagada. 2019. Role of glucocorticoid receptors in a model of postpartum depression in rats. Universidad de Valparaíso.
- Hernán Alvarez. 2018. Effects of AM251 and n-6 polyunsturated fatty acids on decision-making, impulsiveness, and attention in stressed rats. Universidad de Valparaíso.

Undergraduate (7 Finished):
- Valentina Mariángel Lobos, Tomás Ortiz Ponce. 2023. Effect of stress due to social defeat on intraocular pressure in rats. Medical Technology. Pontificia Unversidad Católica de Valparaíso.
- Luis Tabilo. 2022. Transgenerational Effect of Vulnerability and Resilience to Stress. Pontificia Universidad Católica de Valparaíso.
- Arabia Olea y Robinson Carrasco. 2021. Effect of chronic stress on the number of PV+ - GAD 65 and 67 + neurons located in the basolateral amygdala of adult male Sprague Dawley rats. Medical Technology, Universidad de Valparaíso.
- Antonia Cavieres. 2020. Adapting chronic social defeat stress to female Sprague Dawley rats. Bachelor of Science, Universidad de Valparaíso.
- Valentina Gaete. 2019. Study on the memory of social fear in experimental animals. Psychology, Universidad de Valparaíso.
- Valentina Gaete. 2019. Study on the memory of social fear in experimental animals. Psychology, Universidad de Valparaíso.
- German JUJIHARA. 2019. Effects of chronic stress and n-3 PUFAs on the levels of cannabinoid receptor type 1 and the memory, Universidad de Valparaíso.


Difusión y Transferencia


Google Scholar:
https://scholar.google.es/citations?hl=es&user=8x6ub_8AAAAJ&view_op=list_works&sortby=pubdate

Lab website:
www.stress.cl

ORCID: 0000-0002-9909-9826

https://www.researchgate.net/profile/Alexies_Dagnino-Subiabre


Premios y Distinciones

  •   Best Researcher in the UCN

    UNIVERSIDAD CATOLICA DEL NORTE

    Chile, 2011

    Best Researcher in the UCN

  •   Fellowship for research stay in USA

    UNIVERSIDAD DE CHILE

    Chile, 2002

    Department of Pharmacology, East Tennessee State University, USA.

  •   Chile, CONICYT

    UNIVERSIDAD DE CHILE

    Chile, 2001

    Ph.D. fellowship

  •   Fellowship for assistance to the Symposium "Young Researchers in Neurosciences" in the II Annual meeting chilean society of neuroscience. September 27-29, 2006, Valdivia, Chile.

    Sociendad de Neurociencia de Chile

    Chile, 2006

    Fellowship for

  •   IBRO Travel Grant

    International Brain Research Organization

    Francia, 2019

    To attend 10th IBRO World Congress, Daegu, Korea.

  •   Global Fellowships Scheme 2022-23

    UNIVERSITY OF BRIGHTON

    Reino Unido, 2023

    The Global Fellowship Scheme provides prestigious awards to enable world-leading researchers and scholars from around the globe to spend between one and three months at the University of Brighton. During this time, you will be able to engage in productive research and build lasting collaborations.


 

Article (47)

The Neuroprotective Role of Quinoa (<i>Chenopodium quinoa</i>, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats
Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies
Impact of acute psychosocial stress on attentional control in humans. A study of evoked potentials and pupillary response
Editorial: Early life stress and its impact on physiological fitness
Effect of Confinement on Anxiety Symptoms and Sleep Quality during the COVID-19 Pandemic
Resilience to stress and social touch
Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats.
Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats
C-low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress
Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats
Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia
Impact of Stress on Gamma Oscillations in the Rat Nucleus Accumbens During Spontaneous Social Interaction
Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats
Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats.
n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats
Difference in Perseverative Errors during a Visual Attention Task with Auditory Distractors in Alpha-9 Nicotinic Receptor Subunit Wild Type and Knock-Out Mice.
Music Training and Education Slow the Deterioration of Music Perception Produced by Presbycusis in the Elderly.
Music Training and Education Slow the Deterioration of Music Perception Produced by Presbycusis in the Elderly.
Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats
Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats
Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats
Synaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood
Synaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood
Synaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood.
Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex
Neonatal Exposure to Estradiol Valerate Increases Dopamine Content in Nigrostriatal Pathway During Adulthood in the Rat
Effects of chronic stress on the auditory system and fear learning: an evolutionary approach
Long-term omega-3 fatty acid supplementation induces anti-stress effects and improves learning in rats
REPEATED RESTRAINT STRESS IMPAIRS AUDITORY ATTENTION AND GABAERGIC SYNAPTIC EFFICACY IN THE RAT AUDITORY CORTEX
Corticosterone treatment impairs auditory fear learning and the dendritic morphology of the rat inferior colliculus
Mathematical Modeling of Convective Air Drying of Quinoa-Supplemented Feed for Laboratory Rats
CHRONIC FLUOXETINE TREATMENT INDUCES STRUCTURAL PLASTICITY AND SELECTIVE CHANGES IN GLUTAMATE RECEPTOR SUBUNITS IN THE RAT CEREBRAL CORTEX
Effect of the Environment on the Dendritic Morphology of the Rat Auditory Cortex
Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism
Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) rnRNA and integrin alpha 5 expression in the rat pineal gland
Chronic stress impairs acoustic conditioning more than visual conditioning in rats: Morphological and behavioural evidence
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome
NEUROTOXICITY OF SOME MAO INHIBITORS IN ADULT RAT HYPOTHALAMIC CELL CULTURE
Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line
Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival
Study of GH sensitivity in Chilean patients with idiopathic short stature
Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission?

Abstract (1)

The possible role of one-electron reduction of aminochrome in the neurodegeneration of the dopaminergic systems and the neuroprotective role of DT-diaphorase

Proyecto (9)

Impact of the high n-6 polyunsaturated fatty acid intake and/or maternal obesity on neurodevelopment. Is there an essential contribution of dietary n-3 fatty acids?
Hyperandrogenism during prenatal and pubertal development alters functional brain networks compromising social cognition in daughters of women with polycystic ovary syndrome: a doble hit hypothesis
Role of the glucocorticoid receptors on the long-term effects of stress resilience
From presbycusis to dementia=> a basic and clinical approach (Anillo de Ciencia y Tecnologia)
EFFECTS OF -3 FATTY ACIDS AND ENDOCANNABINOIDS ON LEARNING AND AUDITORY ATTENTION OF CHRONICALLY STRESSED RATS
REGULATION OF LONG-TERM PLASTICITY AT INHIBITORY CIRCUITS BY ACETYLCHOLINE=> NEW ROLE OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE HIPPOCAMPAL FUNCTION AND MEMORY
EFFECTS OF ANTIDEPRESSANT AND ENRICHED ENVIRONMENT TREATMENTS ON THE STRESS-INDUCED IMPAIRMENT IN THE RAT AUDITORY SYSTEM
Center for Stress and Antidepressant (Anillo de Ciencia y Tecnologia)
Centro de biotecnología BIOTECZA

Review (2)

Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism
Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: Implication for the action of acylpeptide hydrolase
44
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

10
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

9
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

8
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

7
Gonzalo Terreros

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

5
MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile

3
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

3
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Catherine Pérez

Postdoctoral

Centro de Investigación de Clínica Avanzada, CICA.

Hospital Clínico de la Universidad de Chile

Santiago, Chile

2
Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

2
Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

2
Pablo Fuentealba

Assistant Professor

Psychiatry

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
estibaliz ampuero

Profesor Asistente

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile

1
Marcela Sjoberg

Assistant professor

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Antonio Vega

Full Professor

Department of Food Engineering

UNIVERSIDAD DE LA SERENA

La Serena, Chile

1
WAEL EL-DEREDY

Profesor Titular

Ingenieria Biomedica

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Katherine Saud

Lab Manager

Terapia Celular

Bioscell S.A.

Santiago, Chile

1
Paulina Bustos

Investigadora Postdoctoral

Facultad de Ciencias

Universidad de Valparaíso

Valparaíso, Chile

1
Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Moya

Full Professor

Instituto de Fisiología

Universidad de Valparaiso

Valparaiso, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Pablo Muñoz

Profesor titular

Patología y Fisiología

UNIVERSIDAD DE VALPARAÍSO

Valparaiso, Chile

1
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

1
Karem Arriaza

Académico

Universidad Arturo Prat

Iquique, Chile

1
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

1
Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Cristian Núñez

Profesor de Fisiología

Escuela de Medicina

Universidad de Magallanes

Punta Arenas, Chile

1
Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile

1
Angélica Escobar

Profesora Auxiliar

Fisiología

valp

Valparaiso, Chile

1
Amanda D'Espessailles

Investigadora Postdoctoral

Instituto de Ciencias de a Salud

Universidad de O'Higgins

Rancagua, Chile

1
Jaime Silva

Director

Psicología

Universidad del Desarrollo

Santiago, Chile

1
Karen Flores

académico investigador

Universidad Arturo Prat

Iquique, Chile