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Alan Neely Delgueil

Pofesor

Universidad de Valparaíso

Valparaiso, Chile

Estudio de la relación estructura y función de canales de iones combinando técnicas electrofisiologicas, de fluorescencia, biología molecular y modelado cinético.

Biologia, FLORIDA STATE UNIVERSITY. Estados Unidos, 1991

Postdoctoral Fellow Full Time

WASHINGTON UNIVERSITY IN ST. LOUIS

Saint Louis, Estados Unidos

1991 - 1991
Assistant Professor Full Time

Texas Tec University Health Science Center

Lubbock, Estados Unidos

1994 - 1999
Postdoctoral Fellow Full Time

BAYLOR COLLEGE OF MEDICINE

Houston, Estados Unidos

1991 - 1994
Visiting Professor Other

University of California at Los Angeles

Los Angeles, Estados Unidos

2014 - A la fecha
Profesor Full Time

UNIVERSIDAD DE VALPARAISO

Ciencias

Valparaiso, Chile

1999 - A la fecha

Programa Magíster en Ciencias Biológicas mención Neurociencia. Fac de Ciencias U Valparaíso. Tutor Tesis
2002, Delany Torres Salazar. Detección en tiempo real del reclutamiento de canales de K+ tipo Shaker hacia la membrana plasmática de ovocitos de Xenopus laevis y sus sensibilidad a Ca2+ intracelular.
2003 Jennie García. Contribución de receptores ionotrópicos glutamatérgicos al desarrollo en retina de pez cebra (Danio rerio).
2009 Christian Tapia Mecanismos moleculares de activación asociados a un canal de potasio en C. elegans
2015 Daniela De Giorgis. REGULATION OF VOLTAGE SENSING STRUCTURES OF CaV1.2 CALCIUM CHANNEL BY THE AUXILIATRY B-SUBINT (b3)

Programa de Magíster en Ciencias Médicas, mención en Biología Celular y Molecular
2017 Nieves Navarro Efecto de la subunidad Cav?3Xo de los canales de calcio activados por voltaje sobre la endocitosis en ovocitos de Xenopus Leavis

Programa de Doctorado en Ciencias mención Neurociencia. Fac de Ciencias U Valparaíso.
2007 Giovanni Gonzalez Gutierrez. Modulación de la Activación de los Canales de Calcio Dependientes de Voltaje mediada por la subunidad reguladora ?.
2012 Gustavo Contreras MODULACION DE LOS SENSORES DE VOLTAJE DEL CANAL DE K+ ACTIVADO POR Ca+2 MEDIADA POR SUBUNIDADES BETA

Programa de Doctorado en Ciencias mención Biología Celular Molecualr y Neurociencia. Fac de Ciencias U de Chile
2009. Rodrigo Astete Altamirano. Regulación del tráfico e incorporación a la membrana plasmática de la subunidad CaV1.2 del canal de calcio dependiente de voltaje tipo L.


Trapping Charge Mechanism in Hv1 Channels (CiHv1) Carrillo, Christian; Pena-Pichicoi, Antonio; Hernandez-Ochoa, Erick O.; Neely, Alan; Alvarez, Osvaldo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2024)
Unnexin is a protein subunit of a large- pore channel expressed by unicellular organisms Solis, Francisco; Zamorano, Pedro; Neely, Alan; Martinez, Agustin D. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2023)
Direct inhibition of Ca(V)2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction Contreras, Gustavo F.; Navarro-Quezada, Nieves; Mellado, Guido; Neely, Alan Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)
Expression of Hv1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation Paz Villar, Javiera; Fernandez, Audry; Pupo, Amaury; Neely, Alan; Alvarez, Osvaldo; Garate, Jose; Barajas-Martinez, Hector; Peter Larsson, H.; Lopez-Rodriguez, Angelica Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
Spider Toxin SNX-482 Gating Modifier Spontaneously Partitions in the Membrane Guided by Electrostatic Interactions Antonio Garate, Jose; Neely, Alan Article ISI MEMBRANES (2022)
The distinct role of the four voltage sensors of the skeletal Ca(V)1.1 channel in voltage-dependent activation Quinonez, Marbella; Neely, Alan; Olcese, Riccardo Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2021)
The voltage sensor is responsible for ApH dependence in Hv1 channels Alvear-Arias, Juan J.; Neely, Alan; Larsson, H. Peter; Alvarez, Osvaldo; Garate, Jose Antonio Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures Neely, Alan; Marabol, Vanessa; Rojas, Maximiliano Article ISI SCIENTIFIC REPORTS (2020)
The Ca2+ channel subunit CaV?2a-subunit down-regulates voltage-activated ion current densities by disrupting actin-dependent traffic in chromaffin cells Article ISI SCOPUS Journal of Neurochemistry (2019)
Gating charge displacement in a monomeric voltage-gated proton (H(v)1) channel Larsson, HP Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The alpha(2)delta-1 subunit remodels Ca(V)1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials Savalli, Nicoletta; Pantazis, Antonios; Weiss, James N. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2016)
Molecular mechanism underlying beta 1 regulation in voltage- and calcium-activated potassium (BK) channels Castillo, K; Pupo, A; Torres, YP; Neely, A; González, C; Latorre, R Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2015)
Voltage-gated proton (H(v)1) channels, a singular voltage sensing domain Castillo,Karen; Pupo, Amaury; Baez-Nieto, David; Contreras, Gustavo F.; Morera, Francisco J.; Neely, Alan; Latorre, Ramon; Gonzalez, Carlos Article ISI SCOPUS FEBS Letters (2015)
Functional heterogeneity of the four voltage sensors of a human L-type calcium channel Pantazisa A.; Savalli, N; Sigg, D; Neely, A; Olcese, R Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Structure-function of proteins interacting with the alpha(1) pore-forming subunit of high-voltage-activated calcium channels Neely, Alan; Hidalgo, Patricia Article ISI SCOPUS Frontiers in Physiology (2014)
A BK (Slo1) channel journey from molecule to physiology Castillo, K; Enrique, N; Carrasquel-Ursulaez, W; Castillo JP; Milesi, V; Neely, A; Alvarez, O; Ferreira, G; González, C; Latorre, R Article ISI SCOPUS Channels (2013)
Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells Gonzalez-Jamett AM; Momboisse F.; Guerra MJ; Ory S; Baez-Matus X; Barraza, N; Calco V; Houy S; Couve, E.; Neely, A; et al. Article ISI SCOPUS PLOS ONE (2013)
A Short Polybasic Segment between the Two Conserved Domains of the beta(2a)-Subunit Modulates the Rate of Inactivation of R-type Calcium Channel Miranda-Laferte E.; Schmidt, S; Jara, AC; Neely, A; Hidalgo, P Article ISI SCOPUS Journal of Biological Chemistry (2012)
Modulation of BK channel voltage gating by different auxiliary beta subunits Contreras, GF; Neely, A; Alvarez, O; González, C; Latorre, R Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Homodimerization of the Src Homology 3 Domain of the Calcium Channel beta-Subunit Drives Dynamin-dependent Endocytosis Miranda-Laferte E.; Gonzalez-Gutierrez G.; Schmidt, S; Zeug, A; Ponimaskin, EG; Neely, A; Hidalgo, P Article ISI SCOPUS Journal of Biological Chemistry (2011)
Swapping the I-II intracellular linker between L-type Ca(V)1.2 and R-type Ca(V)2.3 high-voltage gated calcium channels exchanges activation attributes Gonzalez-Gutierrez G.; Miranda-Laferte E.; Contreras, G; Neely, A; Hidalgo, P Article ISI CHANNELS (2010)
Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes Gonzalez-Gutierrez G.; Miranda-Laferte E.; Hidalgo, P; Contreras, G; Neely, A Article SCOPUS CHANNELS (2010)
Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes. Gonzalez-Gutierrez G.; Miranda-Laferte E.; Contreras, G; Neely, A; Hidalgo, P Article SCOPUS Channels (Austin, Tex.) (2010)
The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells Gonzalez-Jamett AM; Baez-Matus X; Hevia, MA; Guerra MJ; Olivares, MJ; Neely, A Article ISI SCOPUS Journal of Neuroscience (2010)
Mutations of nonconserved residues within the calcium channel alpha(1)-interaction domain inhibit beta-subunit potentiation Gonzalez-Gutierrez G.; Miranda-Laferte E.; Naranjo, D; Hidalgo, P; Neely, A Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2008)
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium Gonzalez-Perez, V; Neely, A; Tapia, C; Gonzalez-Gutierrez G.; Contreras, G; Orio, P; Lagos, V; Rojas, G; Estevez, T.; Stack K.; et al. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2008)
The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating Gonzalez-Gutierrez G.; Miranda-Laferte E.; Nothmann, D; Schmidt, S; Neely, A; Hidalgo, P Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Multiplicity of protein interactions and functions of the voltage-gated calcium channel beta-subunit Hidalgo, P; Neely, A Article ISI SCOPUS CELL CALCIUM (2007)
The Src homology 3 domain of the beta-subunit of voltage-gated calcium channels promotes endocytosis via dynamin interaction Gonzalez-Gutierrez G.; Miranda-Laferte E.; Neely, A; Hidalgo, P Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The alpha(1)-beta-subunit interaction that modulates calcium channel activity is reversible and requires a competent alpha-interaction domain Hidalgo, P; Gonzalez-Gutierrez G.; Garcia-Olivares, J; Neely, A Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Folding of active calcium channel beta(1b)-subunit by size-exclusion chromatography and its role on channel function Neely, A; Garcia-Olivares, J; Voswinkel, S; Horstkott, H; Hidalgo, P Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Differential modulation of cardiac Ca2+ channel gating by ?-subunits Dzhura I.; Neely, A Article SCOPUS BIOPHYSICAL JOURNAL (2003)
Differential modulation of cardiac Ca2+ channel gating by beta-subunits Dzhura I.; Neely, A Article ISI BIOPHYSICAL JOURNAL (2003)
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation Angelini, Marina; Steccanella, Federica; Wier, Julian; Wu, FenFen; Quinonez,Marbella; Difranco, Marino; Neely, Alan; Cannon, Stephen C.; Olcese, Riccardo Article ISI JOURNAL OF GENERAL PHYSIOLOGY


beta 2A and beta 3 Differentially Modulate Time- and Voltage-Dependent Properties of Individual Voltage Sensors in the Human Ca(v)1.2 Channel Savalli, N; Sigg, D; Neely, A; Olcese, R Abstract ISI BIOPHYSICAL JOURNAL (2015)
The alpha 2 delta Subunit Efficiently Couples VSDs Activation to Pore Opening in Human Ca(v)1.2 Channels Savalli, N; Pantazis, A; Sigg, D; Neely, A; Olcese, R Abstract ISI BIOPHYSICAL JOURNAL (2015)
The alpha(2)delta Subunit Facilitates Ca(V)1.2 Channel Activation by Remodeling Its Four Voltage Sensor Domains Savalli, N; Pantazis, A; Sigg, D; Neely, A; Olcese, R Abstract ISI BIOPHYSICAL JOURNAL (2014)
The Functional Heterogeneity of the Human CaV1.2 Voltage Sensors Pantazis, A; Savalli, N; Sigg, D; Neely, A; Olcese, R Abstract ISI BIOPHYSICAL JOURNAL (2014)
Global Fit to Model Modulation of Voltage and Calcium Activated K-Channels by Auxiliary beta Subunits Neely, A; Alvarez, O; González, CL; Ramon, L Abstract ISI BIOPHYSICAL JOURNAL (2013)
Optically-Resolved Conformational Rearrangements of the Voltage-Sensing Domains of the Human Ca(V)1.2 Channel Pantazis, A; Savalli, N; Neely, A; Olcese, R Abstract ISI BIOPHYSICAL JOURNAL (2013)
A Short Basic Segment within a Non-Conserved Region of the Beta-Subunit Modulates the Rate of Inactivation of the R-Type Calcium Channel Erick, ML; Schmidt, S; Neely, A; Hidalgo, P Abstract ISI BIOPHYSICAL JOURNAL (2012)
Differential Effects of Beta Subunits on the Voltage Sensor of Ca2+ and Voltage-Activated K+ Channels Neely, A; Alvarez, O; González, C; Latorre, R Abstract ISI BIOPHYSICAL JOURNAL (2012)
The C Terminus is Responsible of the Thermo Sensitivity in TRPM8 Channels Raddatz, N; Baez-Nieto, D; Rosenmann, E; Neely, A; González, C; Alvarez, O; Latorre, R Abstract ISI BIOPHYSICAL JOURNAL (2012)
Ca(v)2.3 Calcium Channels Inactivate from the Open State with Partial Charge Immobilization and Altered Deactivation Kinetic Contreras, G; Neely, A Abstract ISI BIOPHYSICAL JOURNAL (2010)
The SH-3 domain of voltage gated calcium channel beta-subunit promotes endocytosis via dynamin interaction. Gonzalez-Gutierrez G.; Miranda-Laferte E.; Neely, A; Hidalgo, P Abstract ISI BIOPHYSICAL JOURNAL (2007)
S5-S6 interaction during gating transitions in a K+ channel. Joho, RH; Espinosa, F; Fleischhauer, R; McMahon, A; Neely, A Abstract ISI BIOPHYSICAL JOURNAL (2001)


DIFFERENTIAL REGULATION OF VOLTAGE-SENSORS IN HIGH VOLTAGE ACTIVATED CALCIUM CHANNELS Alan Neely Proyecto (2016)
COUPLING OF VOLTAGE-SENSORS TO THE GATE IN CALCIUM CHANNELS Alan Neely Proyecto (2012)
MOLECULAR DETERMINANTS OF ARCHITECTURE AND DYNAMICS OF VOLTAGE-SENSITIVE PROTON CHANNEL (HV) Alan Neely Proyecto (2012)
Centro Interdisciplinario de Neurosciencia de Valparaíso Ramon Latorre; Alan Neely Proyecto El Instituto Milenio Centro Interdisciplinario de Neurociencia de Valparaíso (CINV) es un centro de investigación albergado en la Universidad de Valparaíso. Su principal preocupación es el funcionamiento del sistema nervioso desde un punto de vista interdisciplinario y con este objetivo reúne a biofísicos, fisiólogos, neurobiólogos y expertos en genómica, bioinformática y simulación molecular, que desarrollan ciencia y extensión en un ambiente académico de estándar mundial. Las áreas actualmente mejor representadas en el CINV corresponden a aquellas que estudian las bases moleculares de la excitación neuronal, la transmisión sináptica (entre neuronas u otras células), diferenciación neuronal y los mecanismos neuronales de la percepción (auditiva, visual). Durante sus primeros cinco años, el CINV ha logrado no sólo acrecentar la productividad de su ciencia aumentando de 18 artículos el 2011 a 54 artículos ISI el año 2015, sino también la calidad de la misma. Esto incluye publicaciones en revistas de alto impacto como Nature, Nature Communications, Neuron y Proceeding of the National Academy of Sciences (USA). El CINV trata distintos aspectos de una pregunta científica fundamental: ¿Cómo responde el sistema nervioso a los estímulos sensoriales en salud y enfermedad? Esta pregunta se aborda a través de las diferentes líneas de investigación que engloba este Instituto Milenio, estudiandodesde el funcionamiento íntimo de las proteínas que captan las señales del mundo externo hasta el comportamiento de las redes neuronales. (2010)
Modularidad Funcional de la subunidad beta de los canales de calcio activados por voltaje Alan Neely; Patricia Hidalgo Proyecto (2007)
Mecanismos moleculares de la expresión y función del canal de calcio por la subunidad accesoria beta Alan Neely Proyecto (2002)
Molecular mechanisms of calcium channel function Alan Neely Proyecto (1996)
Molecular mechanisms of cardiac caclium channel function Alan Neely Proyecto (1994)
Centro de Neurociencia Celular y Molecular de Valparaíso Alan Neely; Adrian Palacios; Patricio Velez; Ana Maria Cardenas Proyecto (0)
Fortalecimiento de los programas de Postgrado en Neurociencia de la Facultad de Ciencia de la Universidad de Valparaíso Alan Neely Proyecto (0)
Mecanismos moleculares de la modulación funcional del canal de calcio por subunidades accesorias Alan Neely; Patricio Velez Proyecto (0)
MECANISMOS MOLECULARES QUE GOBIERNAN EL KISS-AND-RUN DINAMINA-DEPENDIENTE: PARTICIPACION DE SINAPTOFISINA Y PROTEINAS CON DOMINIO SH3 Ana Maria Cardenas; Alan Neely Proyecto (0)
Regulation of calcium channel inactivation by its beta-subunit Alan Neely Proyecto (0)
Superficies de interacción en el plegamiento y oligomerización de proteínas formadoras de canales iónicos Alan Neely; David Naranjo Proyecto (0)
Voltage sensor: Structure to Function Carlos González; Alan Neely Proyecto (0)