Man

Alan Neely Delgueil

Pofesor

Universidad de Valparaíso

Valparaiso, Estados Unidos

Líneas de Investigación


Estudio de la relación estructura y función de canales de iones combinando técnicas electrofisiologicas, de fluorescencia, biología molecular y modelado cinético.

Educación

  •  Biologia, FLORIDA STATE UNIVERSITY. Estados Unidos, 1991

Experiencia Académica

  •   Postdoctoral Fellow Full Time

    WASHINGTON UNIVERSITY IN ST. LOUIS

    Saint Louis, Estados Unidos

    1991 - 1991

  •   Assistant Professor Full Time

    Texas Tec University Health Science Center

    Lubbock, Estados Unidos

    1994 - 1999

  •   Postdoctoral Fellow Full Time

    BAYLOR COLLEGE OF MEDICINE

    Houston, Estados Unidos

    1991 - 1994

  •   Visiting Professor Other

    University of California at Los Angeles

    Los Angeles, Estados Unidos

    2014 - A la fecha

  •   Profesor Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaiso, Chile

    1999 - A la fecha

Formación de Capital Humano


Programa Magíster en Ciencias Biológicas mención Neurociencia. Fac de Ciencias U Valparaíso. Tutor Tesis
2002, Delany Torres Salazar. Detección en tiempo real del reclutamiento de canales de K+ tipo Shaker hacia la membrana plasmática de ovocitos de Xenopus laevis y sus sensibilidad a Ca2+ intracelular.
2003 Jennie García. Contribución de receptores ionotrópicos glutamatérgicos al desarrollo en retina de pez cebra (Danio rerio).
2009 Christian Tapia Mecanismos moleculares de activación asociados a un canal de potasio en C. elegans
2015 Daniela De Giorgis. REGULATION OF VOLTAGE SENSING STRUCTURES OF CaV1.2 CALCIUM CHANNEL BY THE AUXILIATRY B-SUBINT (b3)

Programa de Magíster en Ciencias Médicas, mención en Biología Celular y Molecular
2017 Nieves Navarro Efecto de la subunidad Cav?3Xo de los canales de calcio activados por voltaje sobre la endocitosis en ovocitos de Xenopus Leavis

Programa de Doctorado en Ciencias mención Neurociencia. Fac de Ciencias U Valparaíso.
2007 Giovanni Gonzalez Gutierrez. Modulación de la Activación de los Canales de Calcio Dependientes de Voltaje mediada por la subunidad reguladora ?.
2012 Gustavo Contreras MODULACION DE LOS SENSORES DE VOLTAJE DEL CANAL DE K+ ACTIVADO POR Ca+2 MEDIADA POR SUBUNIDADES BETA

Programa de Doctorado en Ciencias mención Biología Celular Molecualr y Neurociencia. Fac de Ciencias U de Chile
2009. Rodrigo Astete Altamirano. Regulación del tráfico e incorporación a la membrana plasmática de la subunidad CaV1.2 del canal de calcio dependiente de voltaje tipo L.



 

Article (56)

The Ca2+ channel subunit CaV?2a-subunit down-regulates voltage-activated ion current densities by disrupting actin-dependent traffic in chromaffin cells
Gating charge displacement in a monomeric voltage-gated proton (H(v)1) channel
The α 2 δ-1 subunit remodels Ca V 1.2 voltage sensors and allows Ca 2+ influx at physiological membrane potentials
Molecular mechanism underlying beta 1 regulation in voltage- and calcium-activated potassium (BK) channels
Voltage-gated proton (H(v)1) channels, a singular voltage sensing domain
Functional heterogeneity of the four voltage sensors of a human L-type calcium channel
Structure-function of proteins interacting with the alpha(1) pore-forming subunit of high-voltage-activated calcium channels
A BK (Slo1) channel journey from molecule to physiology
Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells
Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells
A Short Polybasic Segment between the Two Conserved Domains of the beta(2a)-Subunit Modulates the Rate of Inactivation of R-type Calcium Channel
A Short Polybasic Segment between the Two Conserved Domains of the beta(2a)-Subunit Modulates the Rate of Inactivation of R-type Calcium Channel
Modulation of BK channel voltage gating by different auxiliary beta subunits
Modulation of BK channel voltage gating by different auxiliary beta subunits
Homodimerization of the Src Homology 3 Domain of the Calcium Channel beta-Subunit Drives Dynamin-dependent Endocytosis
Homodimerization of the Src Homology 3 Domain of the Calcium Channel beta-Subunit Drives Dynamin-dependent Endocytosis
Swapping the I-II intracellular linker between L-type Ca(V)1.2 and R-type Ca(V)2.3 high-voltage gated calcium channels exchanges activation attributes
Swapping the I-II intracellular linker between L-type Ca(V)1.2 and R-type Ca(V)2.3 high-voltage gated calcium channels exchanges activation attributes
Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes
Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.
The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells
The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells
Mutations of nonconserved residues within the calcium channel alpha(1)-interaction domain inhibit beta-subunit potentiation
Mutations of nonconserved residues within the calcium channel alpha(1)-interaction domain inhibit beta-subunit potentiation
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium
The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating
The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating
The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating
Multiplicity of protein interactions and functions of the voltage-gated calcium channel beta-subunit
Multiplicity of protein interactions and functions of the voltage-gated calcium channel beta-subunit
Multiplicity of protein interactions and functions of the voltage-gated calcium channel beta-subunit
The Src homology 3 domain of the beta-subunit of voltage-gated calcium channels promotes endocytosis via dynamin interaction
The Src homology 3 domain of the beta-subunit of voltage-gated calcium channels promotes endocytosis via dynamin interaction
The Src homology 3 domain of the beta-subunit of voltage-gated calcium channels promotes endocytosis via dynamin interaction
The alpha(1)-beta-subunit interaction that modulates calcium channel activity is reversible and requires a competent alpha-interaction domain
The alpha(1)-beta-subunit interaction that modulates calcium channel activity is reversible and requires a competent alpha-interaction domain
The alpha(1)-beta-subunit interaction that modulates calcium channel activity is reversible and requires a competent alpha-interaction domain
Folding of active calcium channel beta(1b)-subunit by size-exclusion chromatography and its role on channel function
Folding of active calcium channel beta(1b)-subunit by size-exclusion chromatography and its role on channel function
Differential modulation of cardiac Ca2+ channel gating by ?-subunits
Differential modulation of cardiac Ca2+ channel gating by beta-subunits
Role of potassium channels in amyloid-induced cell death.
Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac alpha 1C subunit.
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.
The suppression of Ca(2+)- and voltage-dependent outward K+ current during mAChR activation in rat adrenal chromaffin cells.
Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes.
Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit.
Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.
The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation.
Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.
Effects of muscarine on single rat adrenal chromaffin cells.
Two components of calcium-activated potassium current in rat adrenal chromaffin cells.
Trapping of an open-channel blocker at the frog neuromuscular acetylcholine channel.
Voltage-Gated Proton (HV1) Channels,a Singular Voltage Sensing Domain

Abstract (12)

beta 2A and beta 3 Differentially Modulate Time- and Voltage-Dependent Properties of Individual Voltage Sensors in the Human Ca(v)1.2 Channel
The alpha 2 delta Subunit Efficiently Couples VSDs Activation to Pore Opening in Human Ca(v)1.2 Channels
The alpha(2)delta Subunit Facilitates Ca(V)1.2 Channel Activation by Remodeling Its Four Voltage Sensor Domains
The Functional Heterogeneity of the Human CaV1.2 Voltage Sensors
Global Fit to Model Modulation of Voltage and Calcium Activated K-Channels by Auxiliary beta Subunits
Optically-Resolved Conformational Rearrangements of the Voltage-Sensing Domains of the Human Ca(V)1.2 Channel
A Short Basic Segment within a Non-Conserved Region of the Beta-Subunit Modulates the Rate of Inactivation of the R-Type Calcium Channel
Differential Effects of Beta Subunits on the Voltage Sensor of Ca2+ and Voltage-Activated K+ Channels
The C Terminus is Responsible of the Thermo Sensitivity in TRPM8 Channels
Ca(v)2.3 Calcium Channels Inactivate from the Open State with Partial Charge Immobilization and Altered Deactivation Kinetic
The SH-3 domain of voltage gated calcium channel beta-subunit promotes endocytosis via dynamin interaction.
S5-S6 interaction during gating transitions in a K+ channel.

Proyecto (27)

DIFFERENTIAL REGULATION OF VOLTAGE-SENSORS IN HIGH VOLTAGE ACTIVATED CALCIUM CHANNELS
Voltage-driven Structural Transitions in Voltage-Gated Calcium Channels
Sensor de Voltaje de Canales de iones=> Desde la Estructura a la Función
COUPLING OF VOLTAGE-SENSORS TO THE GATE IN CALCIUM CHANNELS
COUPLING OF VOLTAGE-SENSORS TO THE GATE IN CALCIUM CHANNELS
MOLECULAR DETERMINANTS OF ARCHITECTURE AND DYNAMICS OF VOLTAGE-SENSITIVE PROTON CHANNEL (HV)
MOLECULAR DETERMINANTS OF ARCHITECTURE AND DYNAMICS OF VOLTAGE-SENSITIVE PROTON CHANNEL (HV)
CONTRIBUTION OF SRC KINASES, N-WASP AND CORTACTIN TO CORTICAL ACTIN REARRANGEMENT AND EXOCITOSIS DYNAMICS IN CHROMAFFIN CELLS.
Centro Interdisciplinario de Neurociencia de Valparaíso (CINV)
Centro Interdisciplinario de Neurosciencia de Valparaíso
REGULATION OF CALCIUM CHANNEL INACTIVATION BY ITS BETA-SUBUNIT
MECANISMOS MOLECULARES QUE GOBIERNAN EL KISS-AND-RUN DINAMINA-DEPENDIENTE=> PARTICIPACION DE SINAPTOFISINA Y PROTEINAS CON DOMINIO SH3.
Modularidad Funcional de la subunidad beta de los canales de calcio activados por voltaje
Superficies de interacción en el plegamiento y oligomerización de proteínas formadoras de canales iónicos
MECANISMOS MOLECULARES DE LA EXPRESION Y FUNCION DEL CANAL DE CALCIO POR LA SUBUNIDAD ACCESORIA BETA
Mecanismos moleculares de la expresión y función del canal de calcio por la subunidad accesoria beta
DETERMINANTES ESTRUCTURALES DE LA CONDUCCION Y LA SELECTIVIDAD EN CANALES DE NA+ DEPENDIENTES DE POTENCIAL.
MECANISMOS MOLECULARES DE LA MODULACION FUNCIONAL DEL CANAL DE CALCIO POR SUS SUBUNIDADES ACCESORIAS.
Molecular mechanisms of calcium channel function
Molecular mechanisms of cardiac caclium channel function
Centro de Neurociencia Celular y Molecular de Valparaíso
Fortalecimiento de los programas de Postgrado en Neurociencia de la Facultad de Ciencia de la Universidad de Valparaíso
Mecanismos moleculares de la modulación funcional del canal de calcio por subunidades accesorias
MECANISMOS MOLECULARES QUE GOBIERNAN EL KISS-AND-RUN DINAMINA-DEPENDIENTE: PARTICIPACION DE SINAPTOFISINA Y PROTEINAS CON DOMINIO SH3
Regulation of calcium channel inactivation by its beta-subunit
Superficies de interacción en el plegamiento y oligomerización de proteínas formadoras de canales iónicos
Voltage sensor: Structure to Function

Review (1)

Voltage sensor of ion channels and enzymes
53
Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Estados Unidos

6
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

6
GUSTAVO CONTRERAS

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

3
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

2
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

2
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
christian tapia

ACADEMICO

QUIMICA Y FARMACIA

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

1
Arlek Gonzalez

INVESTIGADOR POST-DOCTORAL

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIA, UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile