Man

Héctor Alejandro Venegas Esparza

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

Líneas de Investigación


Desarrollo de prototipos de vacuna contra H. pylori con bacteria atenuada y un probiótico. Evaluación de la porina PorA como adyuvant. Búsqueda de antimicrobianos de origen vegetal contra H. pylori. Desarrollo de fagoterapia para control de H.pylori

Educación

  •  Genética molecular/biotecnología, UNIVERSIDAD DE CHILE. Chile, 1976
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1971

Experiencia Académica

  •   Profesor Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    1973 - 1975

  •   Profesor Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    1975 - 2008

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2008 - 2012

  •   Profesor Asociado Full Time

    Universidad Diego Portales

    Medicina

    Santiago, Chile

    2013 - 2014

  •   PROFESOR TITULAR Full Time

    UNIVERSIDAD DIEGO PORTALES

    MEDICINA

    Santiago, Chile

    2015 - 2016

  •   Profesor titular asociado al CENTRO (CIB) Part Time

    UNIVERSIDAD DIEGO PORTALES

    MEDICINA

    Santiago, Chile

    2017 - A la fecha

  •   Profesor Asociado Full Time

    Pontificia Universidad Catolica de Chile

    Ciencias Biológicas

    Santiago, Chile

    2008 - 2012

Experiencia Profesional

  •   Asesor Científico Part Time

    BIOS CHILE

    Santiago, Chile

    1984 - 1989

  •   Asesor Part Time

    Bios Chile

    Santiago, Chile

    1984 - 1989


 

Article (35)

Progress in use of natural productsand their active components against Helicobacter pylori
Oral administration of recombinant Neisseria meningitidis PorA genetically fused to H. pylori HpaA antigen increases antibody levels in mouse serum, suggesting that PorA behaves as a putative adjuvant
Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children
Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism
Helicobacter pylori HopE and HopV porins present scarce expression among clinical isolates
Pex3p-Dependent Peroxisomal Biogenesis Initiates in the Endoplasmic Reticulum of Human Fibroblasts
Evaluation of the role of the Endoplasmic Reticulum-Golgi transit in the biogenesis of peroxisomal membrane proteins in wild type and peroxisome biogenesis mutant CHO cells
Gastric cancer is related to early Helicobacter pylori infection in a high-prevalence country
Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome
Helicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution
Congenital lipoid adrenal hyperplasia caused by a novel splicing mutation in the gene for the steroidogenic acute regulatory protein
Cloning and comparison of ten gene sequences of a Chilean H. pylori strain with other H. pylori strains revealed higher variability for VacA and CagA virulence factors
In vivo expression of ß-galactosidase by rat oviduct exposed to naked DNA or messenger RNA
Subset of hybrid eukaryotic proteins is exported by the type I secretion system of Erwinia chrysanthemi
Chromogenic plate assay distinguishing bacteriolytic from bacteriostatic activity of an antibiotic agent
Expression of the chicken lysozyme gene in potato enhances resistance to infection by Erwinia carotovora subsp, Atroseptica
Serological response to Helicobacter pylori recombinant antigens in Chilean infected patients with duodenal ulcer, non-ulcer dispepsia and gastric cancer
Construction of a gene encoding the bactericidal protein attacin. Studies on its expression in Escherichia coli
Rotavirus detectionby dot blot hybridization. Assay using a nonradiactive synthetic oligo deoxynucleotide probe
Characterization of transcription prometers from Thibacillus genus and its use in genetic transfer studies
Sequen ribosomal operonce of two tRNAs genes from Thiobacillus ferrooxidans
Sequence of two tRNAs genes from a Thiobacillus ferrooxidans ribosomal operon
The nucleotide sequence of the Salmonella typhi ompC porin gene
The yeast tRNA Phe gene family. Structures and transcription activities reveal member differences not explained by intragenic promoters
A Yeast tRNA leu gene is transcribed and spliced in a HeLa cell extract
Conditions affecting DNA cleavage by TthI at a TthI endonuclease-dam methylase overlapping sequence
Molecular cloning and physical map of bacteriophage PM2 DNA
A rapid precedure for purifying a restriction endonuclease from Thermus termophilus (TthI)
Isolation of yeast tRNA leu genes. DNA sequences of a cloned tRNA leu3 gene.
The ribosomal RNA genes of Sacharomyces cerevisiae II
Inactivation of rat liver RNA polymerases I and II and yeast RNA polymerase I by pyridoxal 5´phosphate. Evidence for the participation of lysyl residues at the active site.
Active site-directed inhibition of E. coli RNA polymerase
Effect of manganese on the quaternary structure of human liver arginase
NMDA-NR1 receptor subunit mRNA expression in rat brain after 6-OH-Dopamine induced lessions. A non-isotopic in situ hybridization study.
Subunits of yeast RNA polymerase I involved in the interactions with DNA and nucleotides

Abstract (3)

Reduced Gastric Th17 Response In Children Is Associated with Decreased Helicobacter pylori-induced Gastritis
Cloning and Expression of H. pylori Type IV Secretion System in Escherichia coli Cells by Detection of the Hummingbird Phenotype in Cultured Infected AGS Cells
Number and Sequences of CagA EPIYA Motifs in H. pylori Strains Isolated from Patients Descending from Indigenous Chilean Population are Conserved

JournalWhole (1)

H. pylori VacA virulence factor in uncultered Helicobacter heilmannii sensu lato from an infected child

Patent (2)

Procedure for expression of a tBTB protein on the bacterial surface of an attenuated oral live vaccine as prototype of a meningitis B vaccine
Metodo para la obtencion de vacunasdel tipo oral viva por atenuación en genes de la via de síntesis y reciclaje del metabolito nicotinamida dinucleotido (NAD)
42
Héctor Venegas

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

9
Paul Harris

Full Professor

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
jose palacios

Coordinador I+D

Vicerrectoría de Investigación Desarrollo e Innovación

Universidad de Santiago de Chile

Santiago, Chile

3
Carolina Serrano

Profesor Asistente Adjunto

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Augusto Manubens

Director

Tecnical Support

BIOSONDA S.A.

Santiago, Chile

2
GONZALO MARDONES

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Alex Godoy

Director

Facultad de Ingeniería

Universidad del Desarrollo

Santiago, Chile

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fabian Salazar

Postdoctoral Research Fellow

Biosciences

MRC Centre for Medical Mycology, University of Exeter

Exeter, Reino Unido

1
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

1
paula margozzini

Académico investigador y profesor Asistente

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Manuel Gidekel

GERENTE OPERACIONES Y PRESIDENTE

CONSORCIO DE TECNOLOGIA E INNOVACION PARA LA SALUD

SANTIAGO, Chile

1
Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
María Becker

Scientific Director, President

Research and Development

FUNDACIÓN CIENCIA Y TECNOLOGÍA PARA EL DESARROLLLO

Santiago, Chile

1
Jorge Touma

Candidato a Doctor y Asistente de investigacion

Universidad de Santiago de Chile

santiago, Chile

1
Maria Holuigue

Profesor Titular

Departamento de Genética Molecular y Microbiología

FACULTAD DE CIENCIAS BIOLÓGICAS, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Jorge Cancino

Assistant Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Alejandro Jara

Associate Professor

Statistics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

1
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

1
RICARDO MANZO

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO SALUD PUBLICA DE CHILE

SANTIAGO, Chile

1
Denise Haussmann

Profesora Titular

Departamento de Ciencias Básicas

Universidad Santo Tomás

Valdivia, Chile

1
Marlene Gebauer

Profesor Asistente

Departamento de Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (PUC)

Santiago, Chile