Man

Héctor Alejandro Venegas Esparza

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

Líneas de Investigación


Desarrollo de prototipos de vacuna contra H. pylori con bacteria atenuada y un probiótico. Evaluación de la porina PorA como adyuvant. Búsqueda de antimicrobianos de origen vegetal contra H. pylori. Desarrollo de fagoterapia para control de H.pylori

Educación

  •  Genética molecular/biotecnología, UNIVERSIDAD DE CHILE. Chile, 1976
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1971

Experiencia Académica

  •   Profesor Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    1973 - 1975

  •   Profesor Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    1975 - 2008

  •   Profesor Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2008 - 2012

  •   Profesor Asociado Full Time

    Universidad Diego Portales

    Medicina

    Santiago, Chile

    2013 - 2014

  •   PROFESOR TITULAR Full Time

    UNIVERSIDAD DIEGO PORTALES

    MEDICINA

    Santiago, Chile

    2015 - 2016

  •   Profesor titular asociado al CENTRO (CIB) Part Time

    UNIVERSIDAD DIEGO PORTALES

    MEDICINA

    Santiago, Chile

    2017 - A la fecha

  •   Profesor Asociado Full Time

    Pontificia Universidad Catolica de Chile

    Ciencias Biológicas

    Santiago, Chile

    2008 - 2012

Experiencia Profesional

  •   Asesor Científico Part Time

    BIOS CHILE

    Santiago, Chile

    1984 - 1989

  •   Asesor Part Time

    Bios Chile

    Santiago, Chile

    1984 - 1989


 

Article (35)

Progress in use of natural productsand their active components against Helicobacter pylori

Venegas, A; Touma, JH; Bravo, J; Perez-Perez G

Article
Advances in Microbiology  (2016)

Oral administration of recombinant Neisseria meningitidis PorA genetically fused to H. pylori HpaA antigen increases antibody levels in mouse serum, suggesting that PorA behaves as a putative adjuvant

Manzo RA; Barrientos MJ; Maldonado, AE; Mosqueira, M; AVILA, A; Touma J.; Bruce E.; Venegas A.

Article ISI SCOPUS
Human Vaccines and Immunotherapeutics  (2015)

Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children

Serrano, C; Wright, SW; Bimczok, D; Shaffer, CL; Cover, TL; Venegas A.; Salazar, MG; Smythies, LE; Smith, PD

Article ISI SCOPUS
Mucosal Immunology  (2013)

Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism

Manubens, A; Salazar, F; Haussmann, D.; Figueroa, J; del Campo, M; Huaquin, L; Venegas A.

Article ISI SCOPUS
Cell and Tissue Research  (2010)

Helicobacter pylori HopE and HopV porins present scarce expression among clinical isolates

Lienlaf M.; Morales, JP; Diaz, MI; Diaz, R; Bruce E.; Siegel, F.; Leon, G; Venegas A.

Article ISI SCOPUS
World Journal of Gastroenterology  (2010)

Pex3p-Dependent Peroxisomal Biogenesis Initiates in the Endoplasmic Reticulum of Human Fibroblasts

Venegas A.; Koenig, CS; Cancino J.; González, A.

Article ISI SCOPUS
JOURNAL OF CELLULAR BIOCHEMISTRY  (2009)

Evaluation of the role of the Endoplasmic Reticulum-Golgi transit in the biogenesis of peroxisomal membrane proteins in wild type and peroxisome biogenesis mutant CHO cells

Toro, A.; Arredondo, C; Córdova G.; Araya, C; Palacios JL; Venegas A.; Morita, M; Imanaka, T

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2007)

Gastric cancer is related to early Helicobacter pylori infection in a high-prevalence country

Ferreccio, C; Rollan, A; Serrano, C; Gederlini, A; Margozzini P.; González, C; Aguilera X.; Venegas A.; Jara, A

Article ISI SCOPUS
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION  (2007)

Relationship between Helicobacter pylori virulence factors and regulatory cytokines as predictors of clinical outcome

Serrano, C; Diaz, MI; Valdivia, A; Godoy, A; Peña, A; Rollan, A; Kirberg, A.; Hebel, E.; Fierro, J; Klapp, G.; et al.

Article ISI SCOPUS
MICROBES AND INFECTION  (2007)

Helicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution

Diaz, MI; Valdivia, A; Martinez, P; Palacios JL; Harris, P; Novales, J.; Garrido, E.; Valderrama, D.; Shilling, C.; Kirberg, A.; et al.

Article ISI SCOPUS
WORLD JOURNAL OF GASTROENTEROLOGY  (2005)

Congenital lipoid adrenal hyperplasia caused by a novel splicing mutation in the gene for the steroidogenic acute regulatory protein

Reyes, ML; Carvajal, CA; Mosso, LM; Baquedano, P; Solar A.; Venegas A.

Article ISI SCOPUS
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM  (2004)

Cloning and comparison of ten gene sequences of a Chilean H. pylori strain with other H. pylori strains revealed higher variability for VacA and CagA virulence factors

Muller, I; Medina-Selby, A; Palacios JL; Martinez, P; Opazo, P; Bruce E.; Mancilla, M; Valenzuela, P; YUDELEVICH, A; Venegas A.

Article ISI SCIELO SCOPUS
BIOLOGICAL RESEARCH  (2002)

In vivo expression of ß-galactosidase by rat oviduct exposed to naked DNA or messenger RNA

Rios, Mariana; Venegas, Alejandro; Croxatto, Horacio B.

Article SCIELO
BIOLOGICAL RESEARCH  (2002)

Subset of hybrid eukaryotic proteins is exported by the type I secretion system of Erwinia chrysanthemi

Palacios JL; Zaror, I; Martinez, P; Uribe F.; Opazo, P; Socias, T; Gidekel, M.; Venegas A.

Article ISI SCOPUS
JOURNAL OF BACTERIOLOGY  (2001)

Chromogenic plate assay distinguishing bacteriolytic from bacteriostatic activity of an antibiotic agent

Mardones, G; Venegas A.

Article ISI SCOPUS
JOURNAL OF MICROBIOLOGICAL METHODS  (2000)

Expression of the chicken lysozyme gene in potato enhances resistance to infection by Erwinia carotovora subsp, Atroseptica

Serrano, C; Arce Johnson P.; Torres, H; Gebauer, M; Gutierrez, M; Moreno, M.; JORDANA, X; Venegas A.; Kalazich J.; Holuigue, L

Article ISI SCOPUS
AMERICAN JOURNAL OF POTATO RESEARCH  (2000)

Serological response to Helicobacter pylori recombinant antigens in Chilean infected patients with duodenal ulcer, non-ulcer dispepsia and gastric cancer

Opazo, P; Muller, I; Rollán, P; Valenzuela, P; Yudelevich, A; Garcia-de la Guarda, R; Urra, S; Venegas, A

Article ISI
Acta Pathologica Microbiologica immunologica Scandinavica  (1999)

Construction of a gene encoding the bactericidal protein attacin. Studies on its expression in Escherichia coli

Santibañez, E; Gomez,I; Martínez MT; Bruce, E; Venegas, A

Article
BIOLOGICAL RESEARCH  (1997)

Rotavirus detectionby dot blot hybridization. Assay using a nonradiactive synthetic oligo deoxynucleotide probe

Fernandez, J; Sandino, AM; Yudelevich, A; Avendaño, LF; Venegas, A; Hinrichsen, V; Spencer, E.

Article ISI
EPIDEMIOLOGY AND INFECTION  (1996)

Characterization of transcription prometers from Thibacillus genus and its use in genetic transfer studies

Metz, C; Sanchez, H; Venegas, A

Article SCIELO o equivalente
Archivos de Biologia y Medicina Experimental  (1990)

Sequen ribosomal operonce of two tRNAs genes from Thiobacillus ferrooxidans

Venegas, A; Hevia, E; Sanchez, H.

Article ISI
NUCLEIC ACIDS RESEARCH  (1988)

Sequence of two tRNAs genes from a Thiobacillus ferrooxidans ribosomal operon

Venegas, A; Hevia, E; Sanchez, H.

Article ISI
NUCLEIC ACIDS RESEARCH  (1988)

The nucleotide sequence of the Salmonella typhi ompC porin gene

Venegas, A; Gomez, I; Zaror, I; Yudelevich, A

Article ISI
NUCLEIC ACIDS RESEARCH  (1988)

The yeast tRNA Phe gene family. Structures and transcription activities reveal member differences not explained by intragenic promoters

Bull, P; Thorikay, M; Moenne, A; Wilkens, M; Sanchez, H; Valenzuela P; Venegas, A

Article ISI
DNA  (1987)

A Yeast tRNA leu gene is transcribed and spliced in a HeLa cell extract

Standring, DN; Venegas, A; Rutter, WJ

Article ISI
Proceeding of the National Academic of Sciences USA (PNAS)  (1981)

Conditions affecting DNA cleavage by TthI at a TthI endonuclease-dam methylase overlapping sequence

Venegas, A; Motles, M; Vasquez, C; Vicuña R.

Article ISI
FEBS LETTERS  (1981)

Molecular cloning and physical map of bacteriophage PM2 DNA

Alonso, A; Medina, A; Vicuña R; Venegas, A; Valenzuela, P; Yudelevich, A.

Article ISI
GENE  (1981)

A rapid precedure for purifying a restriction endonuclease from Thermus termophilus (TthI)

Venegas, A; Vicuña, R; Alonso, A; Valdes, F; Yudelevich A.

Article ISI
FEBS LETTERS  (1980)

Isolation of yeast tRNA leu genes. DNA sequences of a cloned tRNA leu3 gene.

Venegas, A: Quiroga, M; Zaldivar J; Rutter, WJ; Valenzuela, P.

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (1979)

The ribosomal RNA genes of Sacharomyces cerevisiae II

Valenzuela, P: Bell, GI, Venegas, A; Sewell, ET; Masiarz, FR; de Gennaro, LJ; Weinberg, F; Rutter, WJ.

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (1977)

Inactivation of rat liver RNA polymerases I and II and yeast RNA polymerase I by pyridoxal 5´phosphate. Evidence for the participation of lysyl residues at the active site.

Martial, J; Zaldivar, J: Bull, P; Venegas, A: Valenzuela, P.

Article ISI
BIOCHEMISTRY  (1975)

Active site-directed inhibition of E. coli RNA polymerase

Venegas, A; Martial, J; Valenzuela, P.

Article ISI
Biochemical Biophysical Research Communications  (1973)

Effect of manganese on the quaternary structure of human liver arginase

Carvajal, N; Venegas, A; Oestreicher, G; Plaza, M.

Article ISI
BIOCHIMICA ET BIOPHYSICA ACTA  (1971)

NMDA-NR1 receptor subunit mRNA expression in rat brain after 6-OH-Dopamine induced lessions. A non-isotopic in situ hybridization study.

Andres, ME; Gysling, K; Araneda, S; Venegas, A; Bustos, G.

Article ISI
JOURNAL OF NEUROSCIENCE RESEARCH  

Subunits of yeast RNA polymerase I involved in the interactions with DNA and nucleotides

Valenzuela, P; Bull, P; Zaldivar, J; Venegas, A; Martial, J.

Article ISI
Biochemical Biophysical Research Communications  

Abstract (3)

Reduced Gastric Th17 Response In Children Is Associated with Decreased Helicobacter pylori-induced Gastritis

Serrano, CA; Wright, S; Birrczok, D; Oover, TL; Venegas A.; Smythios, LE; Smith, PD; Haris, PR

Abstract
GASTROENTEROLOGY  (2011)

Cloning and Expression of H. pylori Type IV Secretion System in Escherichia coli Cells by Detection of the Hummingbird Phenotype in Cultured Infected AGS Cells

Contreras O.; Palacios JL; Bruce E.; Mansilla, I; Venegas A.

Abstract
HELICOBACTER  (2009)

Number and Sequences of CagA EPIYA Motifs in H. pylori Strains Isolated from Patients Descending from Indigenous Chilean Population are Conserved

Diaz, R; Mansilla, I; Lienlaf M.; Bruce E.; Catrileo C.; Villagrán A.; Harris, P; Venegas A.

Abstract
HELICOBACTER  (2009)

JournalWhole (1)

H. pylori VacA virulence factor in uncultered Helicobacter heilmannii sensu lato from an infected child

Hernandez, C ;Serrano, CA; Villagran; Torres, J; , Venegas, A;

JournalWhole
 (2016)

Patent (2)

Procedure for expression of a tBTB protein on the bacterial surface of an attenuated oral live vaccine as prototype of a meningitis B vaccine



Patent Approved via PCT in Canada N° Ref 30000624CA
 (2012)

Metodo para la obtencion de vacunasdel tipo oral viva por atenuación en genes de la via de síntesis y reciclaje del metabolito nicotinamida dinucleotido (NAD)



Patent Presentada en Chile al INAPI
 (2008)

1
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Marlene Gebauer

Profesor Asistente

Departamento de Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (PUC)

Santiago, Chile

1
fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

2
GONZALO MARDONES

Associate Professor

Medicine

Universidad San Sebastián

Valdivia, Chile

1
Maria Holuigue

Fundadora

Fundación Cienciarte

Santiago, Chile

9
Paul Harris

Full Professor

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
María Becker

Scientific Director, President

Research and Development

FUNDACIÓN CIENCIA Y TECNOLOGÍA PARA EL DESARROLLLO

Santiago, Chile

1
Alejandro Jara

Full Professor

Statistics

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
jose palacios

Coordinador I+D

Vicerrectoría de Investigación Desarrollo e Innovación

Universidad de Santiago de Chile

Santiago, Chile

2
Augusto Manubens

Director

Tecnical Support

BIOSONDA S.A.

Santiago, Chile

42
Héctor Venegas

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Carolina Serrano

Profesor Asistente Ordinario

Pediatric Gastroenterology and Nutrition

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alex Godoy

Director

Facultad de Ingeniería

Universidad del Desarrollo

Santiago, Chile

1
Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

1
Lorena Mosso

profesor titular

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Manuel Gidekel

GERENTE OPERACIONES Y PRESIDENTE

CONSORCIO DE TECNOLOGIA E INNOVACION PARA LA SALUD

SANTIAGO, Chile

1
paula margozzini

Associate Professor

Public Health

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

1
Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

1
Fabian Salazar

Postdoctoral Research Fellow

Biosciences

MRC Centre for Medical Mycology, University of Exeter

Exeter, Reino Unido

1
RICARDO MANZO

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO SALUD PUBLICA DE CHILE

SANTIAGO, Chile

1
Jorge Touma

Candidato a Doctor y Asistente de investigacion

Universidad de Santiago de Chile

santiago, Chile

1
Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Denise Haussmann

Profesora Titular

Departamento de Ciencias Básicas

Universidad Santo Tomás

Valdivia, Chile

1
Julio Kalazich

Académico

Acuicultura y Recursos Agroalimentarios

Universidad de Los Lagos

Osorno, Chile

2
Patricio Martinez

Director Biominería

Centro de Biotecnología de Sistemas

UNAB

Santiago, Chile