Man

Fabian Alberto Salazar Lizama

Postdoctoral Research Fellow

MRC Centre for Medical Mycology, University of Exeter

Exeter, Reino Unido

Líneas de Investigación


Role of C-type lectin receptors in innate and adaptive immunity to fungi. Role of C-type lectin receptos in dendritic cell phenotype and function.

Educación

  •  PhD in Immunology, UNIVERSITY OF NOTTINGHAM. Reino Unido, 2016
  •  Magister en Bioquimica, mencion Proteinas y Biotecnologia, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Bioquimico, UNIVERSIDAD DE CHILE. Chile, 2010
  •  Licenciatura en Bioquimica, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Profesional

  •   Postdoctoral Research Fellow Full Time

    MRC Centre for Medical Mycology at the University of Aberdeen

    Aberdeen, Reino Unido

    2016 - 2019

  •   Research Associate Part Time

    University of Nottingham, School of Life Sciences, Immunology

    Nottingham, Reino Unido

    2014 - 2016

  •   Research Associate Full Time

    Fundacion Ciencia y Tecnologia para el Desarrollo

    Santiago, Chile

    2010 - 2012

  •   Postdoctoral Research Fellow Full Time

    MRC Centre for Medical Mycology at the University of Exeter

    Exeter, Reino Unido

    2019 - A la fecha

Formación de Capital Humano


- Co-supervisor of PhD students (University of Exeter, 2019 to date).
- Co-Supervisor of intern students (Hons and MSc) (University of Aberdeen, 2016-2019).
- Bench supervisor of intern students (BMedSci and MSc) (University of Nottingham, 2012-2016).
- Lecture about innate immunity as part of the UG course ‘Immunology’ at the University of Chile (2010-2011).
- Made tutorial, marked exam/reports of the UG course ‘Immunology’ at the University of Chile (2009).
- Teaching skill courses: Demonstrating in laboratory practicals, Introduction to teaching and Small groups teaching.


Difusión y Transferencia


CONFERENCE ATTENDANCE:
- Salazar, F., Dambuza, I., Speakman, E. & Brown, G. D. (2019). Novel dendritic cell-expressed C-type lectin receptors modulate adaptive immune responses during Candida infection. Gordon Research Conference and Seminar Immunology of Fungal Infections. 12-18 January 2019, Galveston, Texas, USA.
- Salazar, F., Hall, L., Negm, O.H., Tighe, P.J., Shakib, F. & Ghaemmaghami, A.M. (2015). Mannose receptor negatively regulates the TLR4-AhR-IDO axis in DCs with implication in allergic responses. 4th European Congress of Immunology. 6-9 September 2015, Vienna, Austria.
- Salazar, F., Hall, L., Negm, O.H., Tighe, P.J., Shakib, F. & Ghaemmaghami, A.M. (2015). The role of mannose receptor in modulating the TLR4-IDO axis in allergy. MACS Allergy Day. 19th May 2015, London, UK. (PRIZE BEST ORAL PRESENTATION).
- Salazar, F., Hall, L., Shakib, F. & Ghaemmaghami, A.M. (2014). Differential regulation of indoleamine 2,3-dioxygenase by TLRs and CLRs in human DCs, the role of aryl-hydrocarbon receptor. 13th International Symposium on Dendritic Cells. 14-18 September 2014, Tours, France.
- Salazar, F., Shakib, F. & Ghaemmaghami, A.M. (2013). Differential regulation of IDO by TLRs and CLRs in human DCs. 27th Annual Conference of the European Macrophage and Dendritic Cell Society. 10-12 October 2013, Erlangen, Germany.
- Salazar, F., Shakib, F. & Ghaemmaghami, A.M. (2013). Differential regulation of indoleamine 2,3-dioxygenase in human airway epithelial cells and dendritic cells. Joint Respiratory Research Day. 4th September 2013, Loughborough, UK.
- Salazar, F., Nova, E., Manubens, A., Cachicas, V., De Ioannes, A. & Becker, M. I. (2009). Innate immunity of marine invertebrates: search of antimicrobial peptides with potential biotechnological applications. 9th Latin American Congress of Immunology. 3-7 November 2009, Valparaiso, Chile.


Premios y Distinciones

  •   Early Researcher of Excellence Award

    UNIVERSITY OF NOTTINGHAM

    Reino Unido, 2015

    Awarded by the School of Life Sciences Postgraduate Research Committee in recognition for outstanding research contributions.

  •   Becas Chile Doctorado en el Extranjero

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2010

    Beca que financia estudios de doctorado en el extranjero.

  •   Beca de Magister Facultad de Ciencias Quimicas y Farmeceuticas

    UNIVERSIDAD DE CHILE

    Chile, 2008

    Beca que financia estudios de Magister

  •   Becas Chile Post-doctorado en el Extranjero

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2017

    Beca que financia estudios de post-doctorado en el extranjero.


 

Article (24)

T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors
The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function
TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals
A friendly danger Immune cell receptor DNGR-1 limits inflammatory tissue damage
Antifungal Innate Immunity: A Perspective from the Last 10 Years
Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation
The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs
Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation
The impact of surface chemistry modification on macrophage polarisation
The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization
Immunocompetence of breeding females is sensitive to cortisol levels but not to communal rearing in the degu (Octodon degus)
Immunocompetence of breeding females is sensitive to cortisol levels but not to communal rearing in the degu (Octodon degus)
A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma
A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma
Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation
Allergen recognition by innate immune cells=> critical role of dendritic and epithelial cells
The role of lectins in allergic sensitization and allergic disease
Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects
Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects
Hemocyanins as immunostimulants
Hemocyanins as immunostimulants
Hemocyanins as immunostimulants Hemocianinas, una herramienta inmunológica de la biomedicina actual
Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism
Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism

Abstract (2)

Novel hemocyanin from the Fissurella latimarginata exhibits an outstanding immunogenicity and non-specific immunomodulatory effects in a melanoma model
Exceptional Immunological and Anticancer Properties of a New Hemocyanin from Fissurella Latimarginata (FLH)

BookSection (2)

Mollusk hemocyanins as natural immunostimulants in biomedical applications
Hemocyanins in the Immunotherapy of Superficial Bladder Cancer.

Patent (1)

Extracto de hemocitos de Loco -Concholepas concholepas- con actividad antimicrobiana, composición, procedimiento de preparación y sus usos

Proyecto (6)

C-type lectins in anti Fungal Immunity
Mollusk hemocyanins as immunomodulatory proteins with beneficial clinical outcomes=> Elucidating the role of C-type lectin receptors in these effects
Pilot Study to Assess the Use of an Immunocompetent 3D Model of Human Upper Airway for Comparing the Impact of Different Proteins in Different Matrices
Local immunomodulation around implants by innovative auxiliary hydrogel-based systems encapsulating autologous and phenotype controlled macrophages
Immunological basis involved in the immunomodulatory effects of mollusk hemocyanins in the immune system of mammals
Identificación y caracterización de péptidos bioactivos de hemocianina de Loco y Lapas chilenas, con aplicaciones biotecnológicas.

Review (1)

Hemocianinas, una herramienta inmunológica de la biomedicina actual
20
Fabian Salazar

Postdoctoral Research Fellow

Biosciences

MRC Centre for Medical Mycology, University of Exeter

Exeter, Reino Unido

9
María Becker

Scientific Director, President

Research and Development

FUNDACIÓN CIENCIA Y TECNOLOGÍA PARA EL DESARROLLLO

Santiago, Chile

8
Augusto Manubens

Director

Tecnical Support

BIOSONDA S.A.

Santiago, Chile

8
Sergio Arancibia

Medical Science Liaison

Medical Affairs

Johnson & Johnson (Janssen Pharmaceutical)

Santiago, Chile

7
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

4
Pablo De Ioannes

Associate research scientist

Structural Biology

NYU Medical Center

NEW YORK, Estados Unidos

1
Luis Ebensperger

Full Professor

Ecology

PUC, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE ECOLOGÍA

Santiago, Chile

1
Michelle Salazar

Asistente de Investigación

Fundación Ciencia y Tecnología para el Desarrollo (FUCITED)

Santiago, Chile

1
Sebastián Abades

Profesor Asociado

Universidad Mayor

Santiago, Chile

1
Andrea González

Investigadora Asociada

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

Santiago, Chile

1
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

1
Héctor Venegas

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

1
José Jiménez

Postdoc

Investigación

Fundacion Ciencia y Vida

Santiago, Chile

1
Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Denise Haussmann

Profesora Titular

Departamento de Ciencias Básicas

Universidad Santo Tomás

Valdivia, Chile