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Carolina Carolina Llanos Muñoz

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects young women. In our group we are interested in understanding the immunological mechanisms leading to the emergence and development of this disease.

Medical, Universidad de Chile. Chile, 2000
Internal Medicine, Universidad de Chile. Chile, 2005
Clinical Immunology and Rheumatology, Pontificia Universidad Católica de Chile. Chile, 2012

Assistant Professor Full Time

Pontificia Universidad Católica de Chile

Facultad de Medicina

Santiago, Chile

2012 - 2014
Associate Research Full Time

New York University

Medicine

New York, Estados Unidos

2009 - 2010
Investigador Adjunto Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2009 - 2010
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Chile

2014 - A la fecha

Chair Full Time

Departamento Inmunología Clínica y Reumatología, Escuela de Medicina; P. Universidad Católica de Chile

Santiago, Chile

2014 - 2019

Biochemistry Thesis, student Fabián Vega Tapia Pontificia Universidad Católica de Valparaíso, Advisor
Research Seminar of Biochemistry student Cristian Figueroa Parada, Pontificia Universidad Católica de Chile, Advisor.

Basic Science Award

S.L.E. Foundation Inc, New York

Estados Unidos, 2006

Basic Science Award for the Project: "Impaired clearence of apoptotic cardiocytes and pathogenesis of Congenital Heart Block: link to SSA/Ro-SSB/La antibodies". Mentor: Jill Buyon, MD.


Heme-Oxygenase-1 Is Decreased in Circulating Monocytes and Is Associated With Impaired Phagocytosis and ROS Production in Lupus Nephritis Obreque, Javiera; Villarroel, Alejandra; San Francisco, Ignacio F.; Valenzuela, Rodrigo; Llanos, Carolina Article ISI SCOPUS Frontiers in Immunology (2019)
Innate Immune Cells' Contribution to Systemic Lupus Erythematosus Herrada, Andres A.; Escobedo, Noelia; Iruretagoyena, Mirentxu; Valenzuela, Rodrigo A.; Burgos, Paula, I; Llanos, Carolina Article ISI SCOPUS Frontiers in Immunology (2019)
The Prevalence of Rheumatoid Arthritis in Chile: A Nationwide Study Performed as Part of the National Health Survey Massardo, Loreto; Llanos, Carolina; Iacobelli, Sergio; Burgos, Paula; Cisternas, Marcela; Iruretagoyena, Mirentxu; Armstrong, Macarena; Aguilera, Raquel.; Radrigán, Francisco; Passi-Solar, Alvaro; et al. Article JOURNAL OF RHEUMATOLOGY (2019)
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)-Pan-American League of Associations of Rheumatology (PANLAR) Bonfa, E; Espada, G; Acevedo Vásquez E.M.; Iglesias Gamarra A.J.; Silva, CA; Vargas Peña A.; Ugolini-Lopes M.R.; Savio V.; Drenkard, C; Babini A.; et al. Article ISI SCOPUS Annals of the Rheumatic Diseases (2018)
Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype Article ISI SCOPUS Immunology (2017)
Modulating the function of the immune system by thyroid hormones and thyrotropin Muñoz-Durango, Natalia Article ISI SCOPUS IMMUNOLOGY LETTERS (2017)
Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus Mackern-Oberti, JP; Obreque, J; Llanos, C Article ISI SCOPUS Clinical and Experimental Immunology (2015)
Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases Riquelme, S. A.; Llanos, C; Schmidt, C. B.; Simon, T; Anegon, I; Jara, E; Riedel, C. A.; Bueno, S. M.; Kalergis, AM Article SCOPUS Current Gene Therapy (2014)
Carbon monoxide exposure improves immune function in lupus-prone mice Mackern-Oberti, JP; Llanos, C; Riquelme, SA; Jacobelli, SH; Anegon, I Article ISI SCOPUS Immunology (2013)
Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus Llanos, C; Saxena, A; Dische R.; Halushka M. Article ISI SCOPUS Rheumatology (2012)
Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus Llanos, C; Carreño, LJ; Henríquez, C; Gutiérrez, MA; Anegon, I; Kalergis, AM Article ISI SCOPUS Immunology (2012)
Heme oxygenase-1 expression were decreased in monocytes from Systemic Lupus Erithematosus patients Mackern, J; Llanos, C; Herrada, A; Leandro, C; Gomez, R; Anegon, I; Jacobelli, S.; Kalergis, A Article JOURNAL OF IMMUNOLOGY (2012)
Maternal Use of Hydroxychloroquine Is Associated With a Reduced Risk of Recurrent Anti-SSA/Ro-Antibody-Associated Cardiac Manifestations of Neonatal Lupus Costedoat-Chalumeau, N; Pisoni, CN; Khamashta M.A.; Saxena, A; Friedman, D; Llanos, C; Piette J.-C. Article ISI SCOPUS Circulation (2012)
Association of the Idiotype: Antiidiotype Antibody Ratio With the Efficacy of Intravenous Immunoglobulin Treatment for the Prevention of Recurrent Autoimmune-Associated Congenital Heart Block Routsias, JG; Kyriakidis, NC; Friedman, DM; Llanos, C; Clancy, R; Moutsopoulos, HM; Buyon J.; Tzioufas, AG Article ISI SCOPUS Arthritis and Rheumatism (2011)
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity Llanos, C Article ISI SCIELO SCOPUS Biological Research (2011)
Maternal and Fetal Factors Associated With Mortality and Morbidity in a Multi-Racial/Ethnic Registry of Anti-SSA/Ro-Associated Cardiac Neonatal Lupus Izmirly, PM; Saxena, A; Kim, MY; Wang, D; Sahl, SK; Llanos, C; Friedman, D; Buyon, JP Article ISI SCOPUS Circulation (2011)
Cutaneous manifestations of neonatal lupus and risk of subsequent congenital heart block. Izmirly PM, Llanos C, Lee LA, Askanase A, Kim MY, Buyon JP. Article Arthritis Rheumatism (2010)
Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial Friedman DM, Llanos C, Izmirly PM, Brock B, Byron J, Copel J, Cummiskey K, Dooley MA, Foley J, Graves C, Hendershott C, Kates R, Komissarova EV, Miller M, Paré E, Phoon CK, Prosen T, Reisner D, Ruderman E, Samuels P, Yu JK, Kim MY, Buyon JP. Article Arthritis Rheumatism (2010)
Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine. Izmirly PM, Kim MY, Llanos C, Le PU, Guerra MM, Askanase AD, Salmon JE, Buyon JP. Article ANNALS OF THE RHEUMATIC DISEASES (2010)
Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors. Llanos C, Izmirly PM, Katholi M, Clancy RM, Friedman DM, Kim MY, Buyon JP. Article Arthritis Rheumatism (2010)
Antibody reactivity to alpha-enolase in mothers of children with congenital heart block. Llanos C, Chan EK, Li S, Abadal GX, Izmirly P, Byrne C, Clancy RM, Buyon JP. Article JOURNAL OF RHEUMATOLOGY (2009)
Prospective evaluation of fetuses with autoimmune-associated congenital heart block followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study. Friedman DM, Kim MY, Copel JA, Llanos C, Davis C, Buyon JP. Article American Journal of Cardiology (2009)
Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum Gonzalez-Gronow, M; Cuchacovich M.; Llanos, C; Urzua, C; Gawdi, G; Pizzo, SV Article ISI SCOPUS CANCER RESEARCH (2006)
Systemic vasculitis associated with Fasciola hepatica infection Llanos, C; Soto, L; Sabugo, F; Gallegos, I; Valenzuela, O; Verdaguer J.; Cuchacovich M. Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2006)
Tumour necrosis factor (TNF)alpha-308 G/G promoter polymorphism and TNF alpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto, L; Edwardes, M; Gutiérrez, M; Llanos, C; Pacheco, D.; Sabugo, F; Alamo, M; Fuentealba, C; Villanueva, L; et al. Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2006)
Anti-tumor necrosis factor-? therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis Gonzalez-Gronow, M; Cuchacovich M.; Gatica H.; Aguillón, JC; Llanos, C Article JOURNAL OF RHEUMATOLOGY (2005)
Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis Mavropoulos, JC; Cuchacovich M.; Llanos, C; Gatica H.; Pizzo, SV; Gonzalez-Gronow, M Article ISI JOURNAL OF RHEUMATOLOGY (2005)
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy Schiattino, I; Villegas, R; Cruzat, A; Cuenca J.; Salazar, L; Aravena, O; Pesce B,; Catalán, D; Llanos, C; Cuchacovich M. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2005)
Rituximab (anti-CD20 monoclonal antibody) for refractory systemic lupus erythematosus. Report of one case Sabugo, F; Llanos, C; Soto, L; Gutierrez, J; Cuchacovich M. Article ISI REVISTA MEDICA DE CHILE (2005)
THE INFLUENCE OF -238 AND -308 TNF ALPHA POLYMORPHISMS ON THE PATHOGENESIS AND RESPONSE TO TREATMENT IN RHEUMATOID ARTHRITIS Llanos, Carolina; Soto, Lilian; Sabugo, Francisca; Bastias, Jose; Salazar,Lorena; Aguillon, Juan; Cuchacovich, Miguel Article REVISTA MEDICA DE CHILE (2005)


Anatomic and Pathologic Findings in Hearts from Fetuses and Infants with Cardiac Manifestations of Neonatal Lupus Llanos, C; Clancy, RM; Abellar, R; Buyon, JP; Friedman, DM Abstract SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2010)
Tumor necrosis factor-alpha levels gurrelate with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto, L; Gutiérrez, M; Llanos, C; Sabugo, F; Pacheco, D.; Alamos, M.; Fuentealba, C; Villanueva, L; Gatica H.; et al. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2006)
Dendritic cells pulsed with type II bovine collagen modulate the murine collagen induced arthritis. Salazar, LE; Aravena, OA; Abello P; Aguirre A.; Catalán, D; Llanos, C; Sabugo, F; González, F; González, C; Cuchacovich M. Abstract CLINICAL IMMUNOLOGY (2005)
TNF-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto, L; Edwardes, M; Suissa, S; Gutiérrez, M; Llanos, C; Sabugo, F; Pacheco, D.; Alamo, M; Fuentealba, C; et al. Abstract ANNALS OF THE RHEUMATIC DISEASES (2005)
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis. Cuchacovich M.; Soto, L; Edwardes, M; Gutiérrez, M; Llanos, C; Pacheco, D.; Sabugo, F; Alamo, M; Fuentealba, C; Villanueva, L; et al. Abstract ARTHRITIS AND RHEUMATISM (2005)
Interaction between REM sleep homeostasis, wakefulness and non-REM sleep, in sleep deprivation protocols Rodriguez, A; Llanos, C; Molina, E; Ocampo-Garces, A; Vivaldi, E Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)
Length of REM sleep episodes during selective intermittent deprivation of REM sleep Llanos, C; Molina, E; Rodriguez, A; Ocampo-Garces, A Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


Flagellate Erythema in a Case of Paraneoplastic Dermatomyositis Acle, R EditorialMaterial ISI SCOPUS JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2016)


Letter to the Editor in response to the article Preventing congenital neonatal heart block in offspring of mothers with anti-SSA/Ro and SSB/La antibodies: A review of published literature and registered clinical trials. by Gleicher N, Elkayam U, Autoimmun Rev. 2013 Sep;12(11):1039-45 Costedoat-Chalumeau, N; Lzmirly, P; Clancy, R; Saxena, A; Wahren-Herlenius, M; Silverman, E; Brucato, A; Boutjdir, M; Khamashta, M; Llanos, C; et al. Letter ISI AUTOIMMUNITY REVIEWS (2014)


Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus Mackern-Oberti, JP; Llanos, C; Riedel, CA; Bueno, SM Review ISI SCOPUS Immunology (2015)
Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases Mackern-Oberti, JP; Llanos, C; Vega, F; SALAZAR ONFRAY F; Riedel, CA; Bueno, SM Review ISI SCOPUS Autoimmunity Reviews (2015)
Targeting Dendritic Cell Function during Systemic Autoimmunity to Restore Tolerance Mackern-Oberti, JP; Vega, F; Llanos, C; Bueno, SM Review ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Tolerogenic dendritic cells as a therapy for treating lupus Llanos, C; Mackern-Oberti, JP; Vega, F; Jacobelli, SH Review ISI SCOPUS Clinical Immunology (2013)
Genetic and Pharmacological Modulation of Dendritic Cell-T Cell Interactions as a Therapeutic Strategy for Systemic Lupus Erythematosus Llanos, C; Riedel, CA; Jacobelli, SH Review ISI CURRENT GENE THERAPY (2011)
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? Cruzat, A; Aravena, O; Salazar, L; Llanos, C; Cuchacovich M. Review ISI IMMUNOBIOLOGY (2006)
Emergent therapies for rheumatoid arthritis Cruzat, A; Contreras-Levicoy, J; Dotte, A; Pesce B,; Aravena, O; Salazar, L; Catalán, D; Abello P; Aguirre A.; Llanos, C; et al. Review REVISTA MEDICA DE CHILE (2005)

Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

OCTAVIO ARAVENA

Gestión I+D

I+D+i

Comisión Chilena de Energía Nuclear

Santiago, Chile

Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Evelyn Jara

Docente/Investigador

Ciencias Básicas

Universidad Santo Tomás

Temuco, Chile

Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Paula Abello

Docente Adjunto

Ciencias Biológicas

Universidad San Sebastián

Santiago, Chile

Rodrigo Villegas

Académico

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

Natalia Muñoz

Estudiante de Doctorado y Jefe Alterno_Proyecto COPEC-UC R772

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

María Villarroel

Médico Anátomo-Patólogo

Anatomía Patológica

Red de Salud UC Christus / Pontificia Universidad Católica de Chile

Santiago, Chile

Fabián Vega

Investigador postdoctoral

Oftalmología

Universidad de Chile

Santiago, Chile

Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

Javiera Obreque

Investigadora Postdoctoral

CECAN - PUC

Santiago, Chile

Carolina Carolina Llanos Muñoz

Líneas de Investigación

Educación

Medical, Universidad de Chile. Chile, 2000

Internal Medicine, Universidad de Chile. Chile, 2005

Clinical Immunology and Rheumatology, Pontificia Universidad Católica de Chile. Chile, 2012

Experiencia Académica

Assistant Professor Full Time

Associate Research Full Time

Investigador Adjunto Full Time

Associate Professor Full Time

Experiencia Profesional

Chair Full Time

Formación de Capital Humano

Premios y Distinciones

Basic Science Award

Article (30)

Abstract (7)

EditorialMaterial (1)

Letter (1)

Review (7)