Man

OCTAVIO ALEXIS ARAVENA MADARIAGA

INVESTIGADOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Autoinmunidad y tolerancia inmune, paricipacion de los linfocitos B reguladores y su interaccion con otros componentes de la regulacion inmune. Artritis reumatoide y células dendriticas e inmunoproteomica.

Educación

  •  Biotecnología , Universidad Andrés Bello . Chile, 2016

Experiencia Académica

  •   ASISTENTE Other

    UNIVERSIDAD DE CHILE

    FACULTAD DE MEDICINA

    SANTIAGO , Chile

    2014 - 2014

  •   ASISTENTE Other

    UNIVERSIDAD DE CHILE

    FACULTAD DE MEDICINA

    SANTIAGO , Chile

    2014 - 2014

  •   ASISTENTE Part Time

    UNIVERSIDAD ANDRES BELLO

    MEDICINA

    SANTIAGO , Chile

    2011 - 2011

  •   PROFESOR INSTRUCTOR Part Time

    UNIVERSIDAD AUTONOMA DE CHILE

    SALUD

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   EXAMINADOR ÁREA BIOTECNOLOGÍA Full Time

    INSTITUTO NACIONAL PROPIEDAD INDUSTRIAL

    SANTIAGO, Chile

    2009 - 2011

Premios y Distinciones

  •   Beca Doctorado Nacional

    CONSEJO NACIONAL PARA INVESTIGACIONES CIENTIFICAS Y TECNOLOGICAS

    Chile, 2012

    Becario Conicyt


 

Article (18)

Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC
Regulatory B cells: Development, phenotypes, functions, and role in transplantation
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response
Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation
Blocking of p38 and transforming growth factor ss receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis
Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-gamma-producing NK cell and regulatory T cell subsets
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells
Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis
Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic cells into tolerogenic phenotype
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-?) gene and ex vivo lipopolysaccharide-induced TNF-? expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus
The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus

Proyecto (7)

International research network on characterization of new therapeutic targets for rheumatoid arthritis
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas una terapia personalizada para reinstruir el sistema inmune de pacientes con artritis reumatoide
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas=> una terapia personalizada para reinstruir el sistema inmune de pacientes con artritis reumatoide
Regulatory B cells promote TIM-1 mediated tolerogenic dendritic cells function, a possible altered mechanism in autoimmunity
Development of an international research network focused on uncovering new molecular targets and evaluating novel cell-based strategies for the therapy of autoimmune diseases
EL FACTOR DE NECROSIS TUMORAL (TNF) EN EL BALANCE DE LOS EJES TH1/TH17=> LECCIONES DESDE LA TERAPIA ANTI-TNF EN ARTRITIS REUMATOIDE
INMUNOTERAPIA TOLEROGENICA MEDIADA POR CELULAS DENDRITICAS PARA EL TRATAMIENTO DE LA ARTRITIS MURINA INDUCIDA POR COLAGENO=> FASE INICIAL PARA UN POSIBLE TRATAMIENTO DE LA ARTRITIS REUMATOIDE

Abstract (5)

Identification of T-cell autoantigenic peptides in rheumatoid arthritis as new targets for an antigen-specific dendritic cell-based therapy
ANTI-TNF THERAPY INDUCES CHANGES ON T CELLS AND NK CELLS SUB-POPULATIONS IN RHEUMATOID ARTHRITIS PATIENTS
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients
Dexamethasone Pretreatment Followed by an Inoculation of Short-term Lipopolysaccharide-stimulated Dendritic Cells Improves the Response of Murine Collagen-induced Arthritis
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients

Review (2)

Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
Emergent therapies for rheumatoid arthritis

Article (1)

TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients.
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OCTAVIO ARAVENA

INVESTIGADOR

INSTITUTO CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE

Santiago, Chile

18
Juan Aguillón

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

9
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

9
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

8
Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

6
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

5
Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile

3
Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

3
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

3
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

2
Carolina Llanos

Profesor Asociado

Inmunología Clínica y Reumatología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

1
Fermín González

Profesor Asociado

universidad de chile

Santiago, Chile

1
Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Nicolás Dutzan

Assistant Professor

Facultad de Odontología, Departamento de Odontología Conservadora

Universidad de Chile

Santiago, Chile

1
Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Daniel Bueno

Médico

Servicio de Salud metropolitano Sur

Santiago, Chile

1
Patricia Pozo

Académico

Ciencias Farmacéuticas

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Estefania Nova

Assistant Professor

Clinical Biochemistry & Immunology

University of Concepcion

Concepción , Chile

1
Katina Schinnerling

Profesor Investigador

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

1
Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile