Man

Roberto Aquiles Zúñiga Olate

Investigador Asociado a Proyectos

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

Líneas de Investigación


Desarrollo de Anticuerpos Terapéuticos para uso en cancer y enfermedades autoinmunes. Desarrollo de promotores de la transcripción para mejorar la expresión y producción de anticuerpos monoclonales recombinantes en células CHO.

Educación

  •  Biologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2003

 

Article (17)

Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells
Optimization of culture conditions for the expression of three different insoluble proteins in Escherichia coli
Transcription factor engineering in CHO cells for recombinant protein production
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNF alpha production in CHO cells
STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients
An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles
Interleukin 10 decreases MICA expression on melanoma cell surface
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells
Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic cells into tolerogenic phenotype
Yeast system as a model to study Moloney murine leukemia virus integrase: expression, mutagenesis and search for eukaryotic partners
Expression of the C-terminus of HIV-1 reverse transcriptase p66 and p51 subunits as a single polypeptide with RNase H activity
Lysine directed cross-linking of viral DNA-RNA : DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase
A dispensable peptide from Acidithiobacillus ferrooxidans tryptophanyl-tRNA synthetase affects tRNA binding
A dual-specific Glu-tRNA(Gln) and Asp-tRNA(Asn) amidotransferase is involved in decoding glutamine and asparagine codons in Acidithiobacillus ferrooxidans
Conserved amino acids near the carboxy terminus of bacterial tyrosyl-tRNA synthetase are involved in tRNA and Tyr-AMP binding

Patent (1)

Promoter with a region rich in cytosine-guanine dinucleotides, vectors, cellular lines, method for producing recombinant protein
18
Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

11
MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

8
JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

6
Diego Catalán

Profesor Asistente

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

5
Matias Gutiérrez

Investigador

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

4
Norberto Collazo

Business Developer

Center for Sustainable Biotechnology

Fraunhofer Chile Research

Santiago, Chile

3
OCTAVIO ARAVENA

Director Científico

I+D+i

MEDICEL SA

Santiago, Chile

2
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

2
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

2
Claudia Altamirano

Profesor Titular

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

2
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

1
Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

1
Jorge Vera

Docente de planta

Universidad Santo Tomás

Puerto Montt, Chile

1
Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

1
Julio Berrios

Académico Full-time

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Marcela Gatica

Coordinadora

Decanatura Facultad de Ciencias

Universidad de La Serena

La Serena, Chile

1
Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Valenzuela

Bioquímico

Hematologia

Hospital del Salvador

Santiago, Chile

1
Yesenia Latorre

Investigador

Laboratorio cultivo células animales

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Luis Mercado

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Antonio Serrano

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile