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Marcelo Alejandro Navarrete Signorile

Profesor Titular

Universidad de Magallanes

Punta Arenas, Chile

Líneas de Investigación


Bioinformatics Lymphoma biology Tumor genetics and immunology

Educación

  •  Medicine, ALBERT-LUDWIGS-UNIVERSITAT FREIBURG. Alemania, 2009
  •  Hematology, UNIVERSIDAD DE BUENOS AIRES. Argentina, 2009
  •  Medico, UNIVERSIDAD NACIONAL DE ROSARIO. Chile, 2002

Experiencia Académica

  •   Researcher Full Time

    ALBERT-LUDWIGS-UNIVERSITAT FREIBURG

    Medicine

    Freiburg, Alemania

    2006 - 2009

  •   Postdoc Full Time

    ALBERT-LUDWIGS-UNIVERSITAT FREIBURG

    Medicine

    Freiburg, Alemania

    2009 - 2011

  •   Researcher Full Time

    LEIDEN UNIVERSITY MEDICAL CENTER

    Medicine

    Leiden, Holanda

    2011 - 2013

  •   Professor Full Time

    UNIVERSIDAD DE MAGALLANES

    Medicine

    Punta Arenas, Chile

    2013 - A la fecha

Experiencia Profesional

  •   Especialista en Formacion Full Time

    Hospital General de Agudos Dr. T. Alvarez

    Buenos Aires, Argentina

    2002 - 2007

  •   Especialista en Hematologia Other

    Clinica Red Salud Magallanes

    Punta Arenas, Chile

    2014 - A la fecha

  •   Coordinador Laboratorio Covid19 Other

    CADI UMAG

    Punta Arenas, Chile

    2020 - A la fecha

Formación de Capital Humano


Coordinator of the Immunology course at the School of Medicine, University of Magallanes.
PhD Thesis: Florian Scherer, University of Freiburg, Germany
PhD Thesis: Marvyn Koning, Leiden University, The Netherlands
PhD Thesis: Julieta Sepulveda, Leiden University & University of Magallanes
PhD Thesis: Jorge Gonzalez, University of Magallanes


Premios y Distinciones

  •   ASH Merit Award

    American Society of Hematology

    Estados Unidos, 2011

    Merit Award in the context of the ASH conference


 

Article (24)

AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms
Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile
Generalized Property-Based Encoders and Digital Signal Processing Facilitate Predictive Tasks in Protein Engineering
Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas
Tandem Substitutions in Somatic Hypermutation
TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression
AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics
Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes
LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
Physical and psychosocial development of Mapuche and nonindigenous Chilean toddlers: A modest role of ethnicity
Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response
The pathogenesis of follicular lymphoma, beyond apoptosis resistance
ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias.
Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation
Selection patterns of B-cell receptors and the natural history of follicular lymphoma
ELISpot and DC-ELISpot Assay to Measure Frequency of Antigen-Specific IFN gamma-Secreting Cells
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation.
Template-switching anchored polymerase chain reaction reliably amplifies functional lambda light chain transcripts of malignant lymphoma.
Usage of standardized antigen-presenting cells improves ELISpot performance for complex protein antigens
The use of rituximab therapy in patients with acquired factor v inhibitors
Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma
Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma
Nosology of Malignant Lymphomas - A Modern Pathobiological Approach

Abstract (2)

HIGH-THROUGHPUT ANALYSIS OF FULL-LENGTH IMMUNOGLOBULIN TRANSCRIPTS BY TEMPLATE-SWITCHING ANCHORED PCR AND MASSIVE PARALLEL SEQUENCING ON THE PACBIO PLATFORM
Massive Parallel Sequencing of Full-Length B-Cell Receptor Sequences Reveals HLA-Dependent Shaping of the B-Cell Immune Repertoire

ConferencePaper (1)

Identification of Immunoglobulin Gene Usage in Immune Repertoires Sequenced by Nanopore Technology

Letter (3)

ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation
Template-switching anchored polymerase chain reaction reliably amplifies functional lambda light chain transcripts of malignant lymphoma

Proyecto (12)

Caracterización funcional de mutaciones con potencial oncogénico inducidas por la enzima AID durante la progresión leucemica
Computational Oncology: Follicular lymphoma as a model for multidimensional analysis of tumor heterogeneity and subclonal evolution
Tratamiento con Plasma Hiperinmune para Pacientes Críticos con COVID-19
Assessment of AID-related somatic signatures and their role in tumor progression of class switched vs non-switched B-cell neoplasms
Oncogenic B-Cell Receptor Signalling in Aggressive B-Cell Lymphomas
ANALYSIS OF IMMUNOGLOBULIN-DERIVED EPITOPES DIVERSIFICATION FOR IMPROVING IDIOTYPE VACCINATION STRATEGIES
Developing an European American Next Generation Sequencing Network (DEANN)
DEVELOPMENT OF A NOVEL TOOL FOR B-CELL RECEPTOR SELECTION PATTERN ANALYSIS IN INDOLENT NON-HODGKIN LYMPHOMAS
High-throughput sequencing of the B-cell repertoire.
RED-IBEROAMERICANA DE LEUCEMIA LINFOIDE CRÓNICA=> HACIA EL DESARROLLO DE NUEVOS MARCADORES PRONÓSTICOS.
Role of B-Cell Receptor in Lymphoma Immunobiology
Immunotherapy of B-cell Lymphomas

Review (1)

Mortality in Critically Ill Elderly Individuals Receiving Mechanical Ventilation
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Marcelo Navarrete

Profesor Titular

Medicina

Universidad de Magallanes

Punta Arenas, Chile

2
Roberto Uribe

Académico

Ingeniería en Computación

Universidad de Magallanes

Punta Arenas, Chile

1
Alvaro Olivera

Principal Investigator and Assistant Professor

Chemical Engineering and Biotechnology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jenniffer Angulo

Asistente de Investigación

Pediatría e Inmunologia Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

1
Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Jorge González

professor

ESCUELA MEDICINA

Universidad de Magallanes

Punta Arenas, Chile

1
Jaime Silva

Director

Psicología

Universidad del Desarrollo

Santiago, Chile

1
Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile